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An exploration of the relationship between wastewater viral signals and COVID-19 hospitalizations in Ottawa,Canada

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Infectious Disease Modelling 2023年第3期8卷 617-631页

作者： K.Ken Peng Elizabeth M.Renouf Charmaine B.dean X.Joan Hu Robert Delatolla Douglas G.Manuel Department of Statistics and Actuarial Science Simon Fraser University8888 University DrBurnabyV5A 1S6BCCanada Department of Statistics and Actuarial Science University of Waterloo200 University Ave WWaterlooN2L 3G1ONCanada Department of Civil Engineering University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada The Ottawa Hospital Research Institute 1053 Carling AveOttawaK1Y 4E9ONCanada Department of Family Medicine University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada School of Epidemiology and Public Health University of Ottawa75 Laurier Ave.EOttawaK1N 6N5ONCanada

Monitoring of viral signal in wastewater is considered a useful tool for monitoring the burden of COVID-19,especially during times of limited availability in *** have shown that COVID-19 hospitalizations are highly correlated with wastewater viral signals and the increases in wastewater viral signals can provide an early warning for increasing hospital *** association is likely nonlinear and *** project employs a distributed lag nonlinear model(DlNM)(Gasparrini et al.,2010)to study the nonlinear exposure-response delayed association of the COVID-19 hospitalizations and SARS-CoV-2 wastewater viral signals using relevant data from Ottawa,*** consider up to a 15-day time lag from the average of SARS-CoV N1 and N2 gene concen-trations to COVID-19 *** expected reduction in hospitalization is adjusted for vaccination efforts.A correlation analysis of the data verifies that COVID-19 hospital-izations are highly correlated with wastewater viral signals with a time-varying *** DlNM based analysis yields a reasonable estimate of COVID-19 hospitalizations and enhances our understanding of the association of COVID-19 hospi-talizations with wastewater viral signals.

关键词： Wastewater surveillance COVID-19 vaccination effectiveness Distributed lag nonlinear model Time varying correlation

long-term phenotypic characterization of human bone marrow and adipose tissue derived mesenchymal stromal cells

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Stem Cell Discovery 2013年第2期3卷 99-116页

作者： dean l. Glettig David l. Kaplan Department of Biomedical Engineering Tufts University Medford USA

We present methods to characterize mesenchymal stromal cells (MSC) over long time periods in vitro. The methods entail passaging cells multiple times and performing differentiation studies with the cells at each passage. Using an array of surface markers and flow cytometric quantification, the data can be correlated to traditional measures of differentiation such as PCR and staining. Using these methods to quantify the amount of differentiation, we concluded that many common MSC markers do not specifically define MSCs with true stem cell properties. Additionally, adipose-derived as opposed to bone marrow-derived MSCs show long-term CD34+ labeling. The methods described can be used to help identify stem cell markers and to characterize the state of stem cells in vitro. Compiling these data from multiple laboratories would be helpful to determine source, extraction and culture methods needed to obtain high yields of useful stem cells.

关键词： Stem Cells Adipose Stem Cells Mesenchymal Stem Cells Flow Cytometry Surface Markers Human Cells long-Term Cell Culture

Effect of ethanol on pro-apoptotic mechanisms in polarizedhepatic cells

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World Journal of Gastroenterology 2007年第37期13卷 4960-4966页

作者： Benita l McVicker dean J Tuma Carol A Casey liver Study Unit Department of Veterans Affairs Medical Center and Departments of Internal Medicine and Biochemistry & Molecular Biology University of Nebraska Medical Center Omaha NE 68105 United States

Chronic ethanol consumption is associated with serious and potentially fatal alcohol-related liver injuries such as hepatomegaly, alcoholic hepatitis and cirrhosis. Moreover, it has been documented that the clinical progression of alcohol-induced liver damage may be associated with an increase in hepatocellular death that involves apoptotic mechanisms. Although much information has been learned about the clinical manifestations associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects such as the induction of pro-apoptotic mechanisms and related cell damaging events. As part of the effort to enhance our understanding of those particular cellular pathways and mechanisms associated with ethanol toxicity, researchers over the years have utilized a variety of model systems. Recently, work has come forth demonstrating the utility of a hybrid cell line (WIF-B) as a cell culture model system for the study of alcohol-associated alterations in hepatocellular mechanisms. Success with such emerging model systems could aid in the development of potential therapeutic treatments for the prevention of alcohol- induced apoptotic cell death that may ultimately serve as a significant target in delaying the onset and/or progression of clinical symptoms of alcohol-mediated liver disease. This review article summarizes the current understanding of ethanol-mediated modifications in cell survival and thus the promotion of pro-apoptotic events with emphasis on analyses made in various experimental model systems, particularly the more recently characterized WIF-B cell system.

关键词：肝细胞肝癌细胞酒精细胞凋亡

Is Rotational Trauma the Only Relevant Pathogenic Mechanism in Hemorrhagic Retinopathy of Shaken Baby Syndrome?

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Journal of Forensic Science and Medicine 2018年第2期4卷 104-107页

作者： BS Arushi Tripathy Stephanie dean DO Joyce l de Jong Carl J Schmidt Rudy J Castellani Department of Pathology Western Michigan University Homer Stryker MD School of MedicineKalamazoo Office of the Chief Medical Examiner BaltimoreMaryland Department of Pathology University of MichiganDetroitMichiganUSA

The pathogenesis of ocular hemorrhage in abusive head trauma/shaken baby syndrome(AHT/SBS)is *** severe hemorrhagic retinopathy has a robust association with AHT/SBS,mild disease is less *** report the ocular and cerebral findings in an 8‑month‑old girl with spastic torticollis who presented following confessed,violent sagittal plane acceleration‑deceleration with *** revealed subdural hemorrhage over the convexities,ischemic brain injury,and preexisting *** examination showed extensive but unilateral retinal hemorrhage,extending broadly to the ora serrata,with perimacular retinal folds and *** retina of the right globe was entirely *** findings in this case,suggest that movement of the globe within the orbit with acceleration‑deceleration,in this case greater on one side due to torticollis,may be the primary factor for severe hemorrhagic retinopathy associated with AHT/*** findings argue against putative global mechanisms,such as intracranial hypertension.

关键词： Abusive head trauma forensic neuropathology forensic science hemorrhagic retinopathy retinal hemorrhage retinoschisis shaken baby syndrome

Regioselective oxidation of tetracycline by permanganate through alternating susceptible moiety and increasing electron donating ability

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Journal of Environmental Sciences 2020年第1期32卷 281-288页

作者： Xiaohua Jiang William AJefferson dean Song Hanyang Cheng Fengmin li Zhimin Qiang Aiqian Zhang Huijuan liu Jiuhui Qu College of Environmental Science and Engineering Ocean University of ChinaQingdao 266100China The State Agriculture Ministry laboratory of Quality&Safety Risk Assessment for Tobacco Tobacco Research InstituteChinese Academy of Agricultural SciencesQingdao 266101China Key laboratory of Drinking Water Science and Technology Research Center for Eco-Enuironmental SciencesChinese Academy of SciencesBeijing 100085China

Permanganate has attracted much attention in wide range of chemistry and particularly in degradation of environmental ***,few studies have discussed the feature of regioselective reactivity of permanganate with specific moiety of the target ***,we studied the reaction between permanganate and tetracycline that is an emerging micropollutant with different species containing several electron-rich *** second-order rate constants increased from 6.0 to 9.0 and could be quantitatively modeled by considering the speciation of both reactants,yielding kTC0=11.7(mol/l)^-1 sec^-1,kTC-=35.7(mol/l)^-1 sec^-1,kTC2-=43.1(mol/l)^-1 sec^-1 for individual reaction *** products were then identified as the hydroxylated and demethylated *** result suggested a rate-limiting step of simple hydroxylation at the phenolic and/or alkene moieties,while the demethylation should be caused by the unavoidably formed manganese oxide via single electron *** is supported by the DFT calculation,indicating the primary oxidation of phenolic group of TC0 with activation barrier of 44.5 kcal/mol and of alkene group of TC-and TC2-with activation barriers of 44.0 and 43.4 kcal/mol,*** is in agreement with the experimental results,implying the alternation of regioselectivity associated with the deprotonation *** result was further supported by performing the Fukui function and electrostatic potential analysis,reflecting the more probable site and better electron donating tendency beneficial to the permanganate oxidation.

关键词： Permanganate oxidation of tetracycline Regioselective reactivity Rate-limiting hydroxylation step Altered susceptible moiety Increased electronegativity

A stable CS-FEM for the static and seismic stability of a single square tunnel in the soil where the shear strength increases linearly with depth

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第4期14卷 1253-1265页

作者： H.C.Nguyen l.Nguyen-Son Department of Civil and Environmental Engineering Imperial College LondonLondonUK Department of Civil Engineering and Industrial Design University of LiverpoolLiverpoolUK Faculty of Civil Engineering Ho Chi Minh City University of Technology(HUTECH)Ho Chi Minh CityViet Nam

A numerical procedure using a stable cell-based smoothed finite element method(CS-FEM)is presented for estimation of stability of a square tunnel in the soil where the shear strength increases linearly with *** kinematically admissible displacement fields are approximated by uniform quadrilateral elements in conjunction with the strain smoothing technique,eliminating volumetric locking issues and the singularity associated with the MohreCoulomb ***,a rich set of simulations was performed to compute the static stability of a square tunnel with different geometries and soil *** presented results are in excellent agreement with the upper and lower bound solutions using the standard finite element method(FEM).The stability charts and tables are given for practical use in the tunnel design,along with a newly proposed formulation for predicting the undrained stability of a single square ***,the seismic stability number was computed using the present numerical *** results reveal that the seismic stability number reduces with an increasing value of the horizontal seismic acceleration(a_(h)),for both cases of the weightless soil and the soil with unit ***,the link between the static and seismic stability numbers is described using corrective factors that represent reductions in the tunnel stability due to seismic *** is shown from the numerical results that the corrective factor becomes larger as the unit weight of soil mass increases;however,the degree of the reduction in seismic stability number tends to reduce for the case of the homogeneous ***,this advanced numerical procedure is straightforward to extend to three-dimensional(3D)limit analysis and is readily applicable for the calculation of the stability of tunnels in highly anisotropic and heterogeneous soils which are often encountered in practice.

关键词： Tunnels Stability limit analysis Cell-based smoothed finite element method (CS-FEM) Second-order cone programming(SOCP)

INTRA-ABDOMINAl HAEMORRHAGE THE RESUlT OF THE RUPTURE OF A VARIX ON THE SURFACE OF THE PREGNANT UTERUS

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中华医学杂志(英文版) 1934年第10期48卷 1067-1069页

作者： J.preston MAXWEll Professor of Obstetrics & Gynecology Peiping Union Medical College

Mrs.P.Y.l.,aet 24,Chinese para I,***.43489,was admitted tothe Peiping Union Medical College Hospital on February 8th,1934,in asemicollapsed *** history was as follows:-She was in the 33rd week of what,with the exception of four very slightattacks of vaginal haemorrhage lasting about a day apiece,had been a *** vomiting had been very slight and had quickly *** considered herself to be in perfect *** noon on February 7th,whilst sitting at lunch she was seized withsevere pain in the lower abdomen and *** had three or four moreattacks of pain in the afternoon and evening and was brought to hospitalabout *** had had no vaginal *** had the aspect

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采摘机器人振荡果实匹配动态识别

农业工程学报 2013年第20期29卷 32-39页

作者：吕继东赵德安姬伟常州大学信息科学与工程学院常州213164 江苏大学电气信息工程学院镇江212013

为解决由于果实振荡影响采摘机器人识别定位时间,进而影响采摘速度和效率的问题,对采摘机器人在果实振荡状况下的匹配动态识别方法进行了研究。首先介绍了振荡果实的动态识别流程,确定出采摘目标果实作为后续匹配识别的模板;然后引入去... 详细信息

为解决由于果实振荡影响采摘机器人识别定位时间,进而影响采摘速度和效率的问题,对采摘机器人在果实振荡状况下的匹配动态识别方法进行了研究。首先介绍了振荡果实的动态识别流程,确定出采摘目标果实作为后续匹配识别的模板;然后引入去均值归一化积相关匹配识别算法,采用Fast Inverse Square Root算法和快速哈特莱变换对其进行加速优化,同时借鉴以往旋转无关匹配识别算法进行抗旋转改进;试验结果表明,加速优化后的匹配识别算法能够进行采摘目标果实的匹配识别,单幅平均匹配识别时间为0.33 s,经过抗旋转等改进的匹配识别算法在[-55°,60°]较大范围内旋转无关,可以准确识别振荡果实,加上模板适时更新,能够满足实际需求。该研究可为果蔬采摘的动态识别提供参考。

关键词：图像识别算法采摘机器人振荡模板匹配

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大豆皮在奶牛、肉牛和猪饲养中的应用(1)

饲料广角 2005年第7期 21-22页

作者： R.l.preston 美国得州理工大学

前言大豆作为蛋白质来源已有五千多年的历史.中国首先提倡种植大豆,本世纪初传入美国.起初,人们主要关心大豆的含油量,提出油以后的大豆粕和大豆皮仅仅是副产品.不久,大豆粕中蛋白质的优异品质被人们所认识.从此,大豆粕成了猪、鸡日粮... 详细信息

前言大豆作为蛋白质来源已有五千多年的历史.中国首先提倡种植大豆,本世纪初传入美国.起初,人们主要关心大豆的含油量,提出油以后的大豆粕和大豆皮仅仅是副产品.不久,大豆粕中蛋白质的优异品质被人们所认识.从此,大豆粕成了猪、鸡日粮中补充蛋白质的主要来源.

关键词：大豆皮猪饲养奶牛应用肉牛蛋白质来源大豆粕本世纪含油量副产品鸡