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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Frontiers of Medicine 2010年第2期4卷 177-184页

作者： Ya-Song WU xin-Yue chen Ying SHI Hao WU de-xi chen Yu SUN Fu-Jie ZHANG Division of Treatment and Care National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Center for Infectious Diseases Beijing You’an HospitalCapital Medical UniversityBeijing 100069China Beijing Ditan Hospital Beijing 100015China

Potent combination antiretroviral therapy(cART)has signiﬁcantly improved the life expectancy of people living with human immunodeﬁciency virus(HIV),but it has many side effects such as lipodystrophy(LD),hepatic steatosis,and lactic *** reverse transcriptase inhibitors(NRTIs)could damage the mito-chondria by inhibiting the human DNA polymerase gamma,leading to mtDNA ***,it remains uncertain whether NRTIs could induce the hypervariable region(HV)mutations of the D loop of mitochondria in Chinese HIV/AIDS patients,and whether that effect is different between individuals with and without ***,30 Chinese AIDS patients who were receiving antiretroviral drugs were recruited,among which 16 had symptomatic LD and 14 did *** samples were collected prior to and after 96 weeks of *** DNA was extracted from peripheral blood mononuclear cells(PBMCs).Fragments of 728 bp in length containing HV 2 were ampliﬁed by standard polymerase chain reaction(PCR).Direct DNA-sequencing analysis techni-ques were used to detect mitochondrial sequence variants between paired longitudinal *** were compared with the revised Cambridge Reference Sequence(rCRS)to determine mutation or *** showed that two years after ART,totally seven cases exhibited sequence variations,ﬁve individuals showed 73 A!G revised variation(two with and three without LD),while two cases of LD were found to have other nucleotide *** was no new alteration in individuals without *** conclusion,NRTIs could induce mutation of mtDNA HV 2,which might contribute to the development of LD.

关键词： nucleoside reverse transcriptase inhibitors human immunodeﬁciency virus mitochondrial DNA D loop mutation

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Preparation of the Phosphors BaAl_2O_4:Eu, RE (RE=Dy, Ho) by Microwave Heating Technique and Observation of Long Phosphorescence

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Chinese Chemical Letters 1999年第8期10卷 709-712页

作者： Ying Liang LIU xiao Ming TANG xi de chen Bing Fu LEI de xiong FENG (department of Chcmistry. Jinan University. Guangzhou 510632) department of Chemistry Jinan University Guangzhou 510632 China

The phosphors BaAl2O4: Eu2+. RE (RE=Dy. Ho) have been prepared by the microwave heating technique. The long-lasting phosphorescence in the phosphors of the barium aluminate activated with europium and other rare ear... 详细信息

关键词： Barium aluminate microwave heating technique europium(Ⅱ) Phosphorescence

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Autophagy in anti-apoptotic effect of augmenter of liver regeneration in HepG2 cells

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World Journal of Gastroenterology 2015年第17期21卷 5250-5258页

作者： Hong-Bo Shi Hai-Qing Sun Hong-Lin Shi Feng Ren Yu chen de-xi chen Jin-Li Lou Zhong-Ping Duan Beijing Youan Hospital Capital Medical University Beijing Institute of Hepatology

AIM:To investigate the role of autophagy in the antiapoptotic effect of augmenter of liver regeneration(ALR).METHODS:Autophagy was induced through serum *** ALR-expressing plasmid was transfected into HepG2 cells,and autophagic flux was determined using fluorescence microscopy,electron microscopy,Western blot and quantitative polymerase chain reaction(q PCR) *** ALR-expressing plasmid transfection,an autophagy inhibitor [3-methyladenine(3-MA)] was added to HepG2 cells,and apoptosis was observed using fluorescence microscopy and flow ***:Autophagy was activated in HepG2 cells,peaking at 24 h after serum *** protein light chain three-II levels were higher in HepG2 cells treated with ALR than in control cells,fluorescence microscopy,electron microscopy and q PCR studies showed the similar trend,and p62 levels showed the opposite trend,which indicated that ALR may play an important role in increasing autophagy *** numbers of apoptotic cells were substantially higher in HepG2 cells treated with both ALR and 3-MA than in cells treated with ALR ***,the protective effect of ALR was significantly attenuated or abolished when autophagy was inhibited,indicating that the anti-apoptotic effect of ALR may be related to ***:ALR protects cells from apoptosis partly through increased autophagy in HepG2 cells and may be valuable as a new therapeutic treatment for liver disease.

关键词： Autophagy Augmenter of liver regeneration Apoptosis HepG2 cells

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Antiviral drug resistance increases hepatocellular carcinoma:A prospective decompensated cirrhosis cohort study

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World Journal of Gastroenterology 2013年第45期19卷 8373-8381页

作者： Lei Li Wei Liu Yu-Han chen Chun-Lei Fan Pei-Ling Dong Fei-Li Wei Bing Li de-xi chen Hui-Guo Ding department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated with Capital Medical University department of Internal Medicine Beijing Ji Shui Tan HospitalAffiliated with Peking University Viral Laboratory of Liver Diseases Research Institute Capital Medical University

AIM:To study the clinical outcome of antiviral therapy in hepatitis B-related decompensated cirrhotic ***:Three hundred and twelve patients with decompensated hepatitis B cirrhosis were evaluated in a prospective *** two years of follow-up,198patients in the group receiving antiviral therapy with nucleos(t)ide analogues and 39 patients in the control group without antiviral treatment were ***:Among the antiviral treatment patients,162had a complete virological response(CVR),and 36 were drug-resistant(DR).The two-year cumulative incidence of hepatocellular carcinoma(HCC)in the DR patients(30.6%)was significantly higher than that in both the CVR patients(4.3%)and the control group(10.3%)(Pdence of HCC was 55.6%(5/9)in those who failed rescue therapy,which was extremely *** rtA181T mutation was closely associated with rescue therapy failure(P=0.006).The Child-Pugh scores of the CVR group were significantly decreased compared with the baseline(8.9±2.3 vs 6.0±1.3,P=0.043).CONCLUSION:This study showed that antiviral drug resistance increased the risk of HCC in decompensated hepatitis B-related cirrhotic patients,especially in those who failed rescue therapy.

关键词： Hepatitis B decompensated cirrhosis Nucleos(t)ide analogues Hepatocellular carcinoma Drug resistance

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Multiple Arthroplasty in a Patient with Alkaptonuric Arthritis

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Chinese Medical Journal 2015年第17期128卷 2404-2405页

作者： chen-Yi Ye de-Ting Xue xi chen Rong-xin He department of Orthopedic Surgery Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310009 China

Alkaptonuria （AKU） is an extremely rare autosomal recessive metabolic disorder characterized by a triad of homogentisic aciduria, arthritis, and ochronosis, affecting only 2 5 in a million individuals. The management of AKU is usually symptomatic. However, surgical intervention necessitates in cases of signiticant arthritis, Here, we presented a 64-year-old female who underwent bilateral total hip and right total knee arthroplasties achieving a successful clinical outcome throughout the 3 years of follow-up.

关键词： Alkaptonuria Ochronosis Ochronotic Arthritis Total Hip Replacement

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： xihang chen Zhifeng chen Menghua Li Weiwei Guo Shuolong Yuan Liangwei Xu Chang Lin xi Shi Wei chen Shiming Yang Senior department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

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Recent advances in recurrent hepatocellular carcinoma therapy

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World Journal of Hepatology 2023年第4期15卷 460-476页

作者： Yu-Xue Gao Qi-Qi Ning Peng-xiang Yang Yuan-Yue Guan Peng-xiang Liu Meng-Lu Liu Lu-xin Qiao xiang-Hua Guo Tong-Wang Yang de-xi chen Beijing Institute of Hepatology Beijing You An HospitalCapital Medical UniversityBeijing 100069China Beijing Precision Medicine and Transformation Engineering Technology Research Center of Hepatitis and Liver Cancer Beijing 100069China Academician Workstation Changsha Medical UniversityChangsha 410219Hunan ProvinceChina Hunan Key Laboratory of the Research and development of Novel Pharmaceutical Preparations Changsha Medical UniversityChangsha 410219Hunan ProvinceChina

Hepatocellular carcinoma(HCC)is the most prevalent form of primary liver cancer,accounting for 75%-85%of *** treatments are given to cure early-stage HCC,up to 50%-70%of individuals may experience a relapse of the illness in the liver after 5 *** on the fundamental treatment modalities for recurrent HCC is moving significantly *** precise selection of individuals for therapy strategies with established survival advantages is crucial to ensuring better *** strategies aim to minimize substantial morbidity,support good life quality,and enhance survival for patients with recurrent *** individuals with recurring HCC after curative treatment,no approved therapeutic regimen is currently available.A recent study presented novel approaches,like immunotherapy and antiviral medication,to improve the prognosis of patients with recurring HCC with the apparent lack of data to guide the clinical *** data supporting several neoadjuvant and adjuvant therapies for patients with recurring HCC are outlined in this *** also discuss the potential for future clinical and translational investigations.

关键词： Recurrent hepatocellular carcinoma Liver transplantation Therapy Immunotherapy Neoadjuvant and adjuvant therapy

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Mechanistic insight into the synergy between nickel single atoms and nanoparticles on N-doped carbon for electroreduction of CO2

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Journal of Energy Chemistry 2025年第1期100卷 327-336页

作者： Mingdong Sun Wenwen Guan Cailing chen Chao Wu xiaoling Liu Biao Meng Tao chen Yu Han Jun Wang Shibo xi Yu Zhou State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University Advanced Membranes and Porous Materials Center Physical Sciences and Engineering Division King Abdullah University of Science and Technology Institute of Sustainability for Chemicals Energy and Environment A*STAR (Agency for Science Technology and Research) College of Materials Science and Engineering Sichuan University

The synergy of single atoms （SAs） and nanoparticles （NPs） has demonstrated great potential in promoting the electrocatalytic carbon dioxide reduction reaction （CO2RR）;however,the rationalization of the SAs/NPs proportion remains one challenge for the catalyst ***,a Ni2+-loaded porous poly（ionic liquids）(PIL) precursor synthesized through the free radical self-polymerization of the ionic liquid monomer,1-allyl-3-vinylimidazolium chloride,was pyrolyzed to prepare the Ni,N co-doped carbon materials,in which the proportion of Ni SAs and NPs could be facilely modulated by controlling the annealing *** catalyst Ni-NC-1000 with a moderate proportion of Ni SAs and NPs exhibited high efficiency in the electrocatalytic conversion of CO2into *** Ni K-edge X-ray absorption near-edge structure （XANES） spectra and theoretical calculations were conducted to gain insight into the synergy of Ni SAs and *** charge transfer from Ni NPs to the surrounding carbon layer and then to the Ni SAs resulted in the electron-enriched Ni SAs active *** the electroreduction of CO2,the coexistence of Ni SAs and NPs strengthened the CO2activation and the affinity towards the key intermediate of*COOH,lowering the free energy for the potential-determining*CO2→*COOH step,and therefore promoted the catalysis efficiency.

关键词： Activation energy

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稀土元素La对Ni_(75)B_(17)Si_8非晶合金形成能力和热稳定性的影响

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物理学报 1993年第3期42卷 465-469页

作者：邢力谦赵德乾陈希成陈熙琛杨根仓周尧和中国科学院物理研究所北京100080 西北工业大学西安710072

本文发现微量稀土元素在某些合金中可不呈均匀固溶态分布,而与母合金某些原子反应生成高熔点化合物,或吸附于合金中异质核心表面改变其异质形核的活性。当稀土元素以这种状态存在时,不但失去稳定非晶相的作用,而且促进异质形核,降低合... 详细信息

本文发现微量稀土元素在某些合金中可不呈均匀固溶态分布,而与母合金某些原子反应生成高熔点化合物,或吸附于合金中异质核心表面改变其异质形核的活性。当稀土元素以这种状态存在时,不但失去稳定非晶相的作用,而且促进异质形核,降低合金的非晶形成能力和热稳定性。

关键词：稀土族金属玻璃热稳定性形成

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Copper chelation by trientine dihydrochloride inhibits liver RFA-induced inflammatory responses in vivo

Copper chelation by trientine dihydrochloride inhibits liver...

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2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Ji-ming Yin Li-bo Sun Jia-sheng Zheng xin-xin Wang de-xi chen Ning Li

Objective: Hepatocellular carcinoma(HCC) is the fifth most common cancer and the third most common cause of cancer-related death worldwide. Radiofrequency ablation(RFA) is currently performed widely for managing HCC. RFA treatment causes damage around the ablation. Trientine dihydrochloride has been used to reduce the copper in liver. Methods: The rats were treated with trientine dihydrochloride for 5 days before liver-RFA. Liver function, copper concentration, inflammation biomarkers and MDA, SOD were analyzed after RFA treatment for 2 hours, 2 days and 5 days. Results: The results indicated that trientine dihydrochloride reduced the copper in plasma and liver tissue significantly. And trientine dihydrochloride significantly inhibited RFA-induced inflammatory gene expression in liver. Similar inhibitory effects of trientine dihydrochloride were observed on ROS-induced malondialdehyde production in liver tissues. Conclusion: The results suggest that pre-treatment with the selective copper chelator trientine dihydrochloride can inhibit inflammatory response effectively during and after liver RFA in vivo. Chelation of copper to a lower level before liver-RFA may be a novel strategy to prevent or ameliorate inflammatory responses in liver induced by RFA and to protect the parenchyma tissues in liver during and after RFA in HCC patients.

关键词： liver radiofrequency ablation trientine dihydrochloride inflammation hepatocellular carcinoma

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