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Friction 2021年第4期9卷 758-773页

作者： Cun-ao FENG de-kun zhang Kai CHEN School of Mechatronic Engineering China University of Mining and TechnologyXuzhou 221116China department of Mechanical Engineering University of British Columbia Vancouver V6T1Z4Canada School of Materials Science and Engineering China University of Mining and Technology Xuzhou 221116China

The mechanism of adhesive friction between viscoelastic materials is a key *** this study,the friction process of the adhesive interface between a friction lining and a wire rope is dynamically observed in real time to analyze the adhesion hysteresis friction intuitively and *** adhesion is determined by the state of motion,while the relative displacement of the wire rope and lining is used to find the magnitude of the adhesive *** hysteresis friction is reflected by the internal deformation of the *** magnitude of the hysteresis friction is determined by the displacement difference(Ax)in the sliding direction of two marked points at different distances from the contact *** results show that the adhesion friction is proportional to the loss modulus and the hysteresis friction is proportional to the ratio of the loss modulus to the square of the storage modulus(E"/(E'^(2))).The frictional vibration first decreases and then increases with the increase in *** K25 lining has the highest adhesion hysteresis friction and minimal frictional *** result provides a simple and intuitive method for research into the friction transmission and vibration of viscoelastic materials.

关键词： adhesion hysteresis friction viscoelasticity frictional vibration dynamic monitoring

Microstructure evolution and passivation quality of hydrogenated amorphous silicon oxide(a-SiOx:H) on〈100〉- and 〈111〉-orientated c-Si wafers

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Chinese Physics B 2020年第3期29卷 480-487页

作者： Jun-Fan Chen Sheng-Sheng Zhao Ling-Ling Yan Hui-Zhi Ren Can Han de-kun zhang Chang-Chun Wei Guang-Cai Wang Guo-Fu Hou § Ying Zhao Xiao-Dan zhang Institute of Photoelectronic Thin Film devices and Technology of Nankai University Tianjin 300350China Key Laboratory of Photoelectronic Thin Film devices and Technology of Tianjin Tianjin 300350China Engineering Center of Thin Film Photoelectronic Technology of Ministry of Education Tianjin 300350China Sino-Euro Joint Research Center for Photovoltaic Power Generation of Tianjin Tianjin 300350China

Hydrogenated amorphous silicon oxide(a-SiOx:H) is an attractive passivation material to suppress epitaxial growth and reduce the parasitic absorption loss in silicon heterojunction(SHJ) solar cells. In this paper, a-SiOx:H layers on different orientated c-Si substrates are fabricated. An optimal effective lifetime(τ(eff)) of 4743 μs and corresponding implied opencircuit voltage(iV(oc)) of 724 mV are obtained on〈100〉-orientated c-Si wafers. While τ(eff) of 2429 μs and iV_(oc) of 699 mV are achieved on 111-orientated substrate. The FTIR and XPS results indicate that the a-SiOx:H network consists of SiOx(Si-rich), Si–OH, Si–O–SiHx, SiO2 ≡ Si–Si, and O3 ≡ Si–Si. A passivation evolution mechanism is proposed to explain the different passivation results on different c-Si wafers. By modulating the a-SiOx:H layer, the planar silicon heterojunction solar cell can achieve an efficiency of 18.15%.

关键词： a-SiO_x:H orientated wafers silicon heterojunction

Effects of Astragalus polysaccharide on immune function in B16 melanoma mice

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TMR Integrative Medicine 2021年第12期5卷 1-6页

作者： Fang-Hua Wu Kui Chen de-kun zhang Chao Gong Jiang-Yue Yu Shen-Zhou Huang Chen-Xin Huang Li-Qun Wang department of General Surgery Fujian Medical University Affiliated Fuzhou First HospitalFuzhou 350009China

Objective:To examine the effects of Astragalus polysaccharide on immune function in B16 melanoma ***:Forty male C57BL/6 mice were divided equally into a control group,model group,Astragalus polysaccharide low-dose group,and Astragalus polysaccharide high-dose group,with 10 mice per group.B16 cells were used to develop a mouse model of *** B16 engraftment,40 mg/kg and 80 mg/kg Astragalus polysaccharide was administered by gavage every day to the Astragalus polysaccharide low-dose group and Astragalus polysaccharide high-dose group,*** index,thymic index,tumor growth curves,and tumor inhibition rates were *** cytometry was used to measure proportions of peripheral blood T lymphocyte *** and eosin staining was used to examine histopathological changes in *** double staining was used to identify myeloid-derived suppressor cells in tumor ***:In the Astragalus polysaccharide high-dose group,splenic and thymic indices were significantly increased and tumor growth was inhibited in melanoma *** cytometry demonstrated increased CD4^(+)and CD4^(+)/CD8^(+)T-cell ratios in the high-dose Astragalus polysaccharide *** staining demonstrated significantly decreased numbers of tumor cells among mice with melanoma in the high-dose Astragalus polysaccharide *** double staining demonstrated significantly decreased numbers of myeloid-derived suppressor cells in tumor tissues in the high-dose Astragalus polysaccharide ***:Astragalus polysaccharide inhibits tumor growth,increases splenic and thymic indices,increases CD4^(+)and CD4^(+)/CD8^(+)T-cell ratios,and decreases myeloid-derived suppressor cell numbers in melanoma *** results indicate Astragalus polysaccharide may enhance immune function resulting in inhibition of tumorigenesis and tumor progression.

关键词： Melanoma Astragalus polysaccharide Tumor Immune function

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin Xuebing Yan kun zhang Central Laboratory and department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu kun-Ning zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi zhang Yu-Ying Tan Li zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Global research status and trends of somatic symptom disorder: A bibliometric study

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World Journal of Psychiatry 2025年第1期15卷 168-178页

作者： Chao Yang kun zhang Qian Wang Shuai Wang Huan Li Kai zhang department of Psychiatry Beijing Luhe HospitalCapital Medical UniversityBeijing 100001China department of Psychiatry Chaohu Hospital of Anhui Medical UniversityHefei 238000Anhui ProvinceChina School of Medicine Jiangxi University of TechnologyNanchang 510001Jiangxi ProvinceChina School of Public Health Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND With the growing scholarly and clinical fascination with somatic symptom dis-order(SSD),a bibliometric analysis is *** To conduct a bibliometric analysis to investigate the current status and frontiers of *** The documents related to SSD are obtained from the web of science core collection database(WoSCC),and VOSviewer 1.6.16 from January 1,2000 to december 31,2023,and the WoSCC’s literature analysis wire were used to conduct the biblio-metric *** A total of 567 documents related to SSD were included,and 2325 authors across 947 institutions from 57 countries/regions have contributed to SSD research,published in 277 *** most productive author,institution,country and journal were Löwe B,University of Hamburg,Germany,and Journal of Psycho-somatic Research *** first high-cited document was published in the Journal of Psychosomatic Research in 2013 by Dimsdale JE and colleagues,which explored the rationale behind the SSD diagnosis introduction in diagnostic and statistical manual of mental *** In conclusion,the main research hotspots and frontiers in the field of SSD are validity and reliability of the SSD criteria,functional impairment of SSD,and the treatment for *** high-quality studies are needed to assess the diagnosis and treatment of SSD.

关键词： Somatic symptom disorder Validity and reliability Functional impairment Treatment Bibliometric analysis

Research on the Long Time Swelling Properties of Poly (vinyl alcohol)/Hydroxylapatite Composite Hydrogel

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Journal of Bionic Engineering 2009年第1期6卷 22-28页

作者： de-kun zhang~(1,3), Da-gang Wang~2, Jun-jie Duan~(1,3), Shi-rong Ge~(2,3)1. School of Materials Science and Engineering, China University of Mining and Technology, Xuzhou 221116, P. R. China2. School of Mechanical and Electrical Engineering, China University of Mining and Technology, Xuzhou 221116, P. R. China3. Biotribology Center, National Key Laboratory of Tribology, Tsinghua University, Beijing 100083, P. R. China School of Materials Science and Engineering China University of Mining and Technology Xuzhou P. R. China Biotribology Center National Key Laboratory of Tribology Tsinghua University Beijing P. R. China School of Mechanical and Electrical Engineering China University of Mining and Technology Xuzhou P. R. China

Poly(vinyl alcohol)/hydroxylapatite(PVA/HA)composite hydrogel was prepared by repeated freezing and *** water loss properties of the resultant hydrogel were investigated by using optical *** time immersion tests of PVA/HA composite hydrogel were carried out in the diluted calf serum solution to study the change laws of swelling properties with the freezing-thawing cycles and HA *** micro-morphologies of PVA/HA composite hydrogel after long time immersion were observed by means of the high-accuracy 3D *** results show that the swelling process of PVA/HA composite hydrogel is the converse process of its water *** time swelling ratio curves of PVA/HA composite hydrogel in the calf serum solution are manifested as four stages of quick increase,decrease,slow decrease and stable balance,and its equilibrium swelling ratio decreases with the increase of freezing-thawing cycles and HA *** is revealed that the network structure of the composite hydrogel immersed for a long period is significantly improved with the increase of HA content. Perfect network structures of PVA/HA composite hydrogel as well as full and equilibrium tissues after swelling equilibrium are obtained when the HA content is 3% and the number of freezing-thawing cycles is 7.

关键词： poly (vinyl alcohol) hydroxyapatite composite hydrogel swelling property morphology

A cellulose-based lithium-ion battery separator with regulated ionic transport and high thermal stability for extreme environments

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Nano Research 2025年第1期18卷 315-322页

作者： kun-Peng Yang Song Xie Zi-Meng Han Hao-Cheng Liu Chong-Han Yin Wen-Bin Sun zhang-Chi Ling Huai-Bin Yang de-Han Li Qing-Fang Guan Shu-Hong Yu department of Chemistry New Cornerstone Science LaboratoryInstitute of Biomimetic Materials&ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsDivision of Nanomaterials&ChemistryHefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

Separators play a critical role in lithium-ion ***,the restrictions of thermal stability and inferior electrical performance in commercial polyolefin separators significantly limit their applications under harsh ***,we report a cellulose-assisted self-assembly strategy to construct a cellulose-based separator massively and *** an ultrahigh ionic conductivity in electrolytes of 3.7 mS·cm^(-1) and the ability to regulate ion transport,the obtained separator is a promising alternative for high-performance lithium-ion *** addition,integrated with high thermal stability,the cellulose-based separator endows batteries with high safety at high temperatures,greatly expanding the application scenarios of energy storage devices in extreme environments.

关键词： lithium-ion batteries bio-inspired materials battery separators cellulose nanofiber ultrahigh ionic conductivity high safety

基于Au纳米颗粒/还原氧化石墨烯C-反应蛋白免疫传感器的研制

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分析测试学报 2017年第3期36卷 349-354页

作者：张茜夏介仁李德蕾张坤蕾白茹燕胡蓉杨云慧云南师范大学化学化工学院云南昆明650500

采用还原氧化石墨烯-金纳米颗粒(RGO-Au NPs)作为免疫传感器的固定基质,将C-反应蛋白(CRP)抗体固定在玻碳电极表面,用蒽醌二羧酸作为标记物,制成夹心型的CRP免疫传感器。在最优实验条件下,通过示差脉冲伏安法对CRP的含量进行检测。该传... 详细信息

采用还原氧化石墨烯-金纳米颗粒(RGO-Au NPs)作为免疫传感器的固定基质,将C-反应蛋白(CRP)抗体固定在玻碳电极表面,用蒽醌二羧酸作为标记物,制成夹心型的CRP免疫传感器。在最优实验条件下,通过示差脉冲伏安法对CRP的含量进行检测。该传感器在0.25~100 ng/m L范围内具有良好的线性关系,检出限为0.08 ng/m L,线性系数为0.997。该传感器为C-反应蛋白的检测提供了一种新的手段。

关键词：夹心型免疫传感器 C-反应蛋白(CRP) 还原氧化石墨烯电化学

Preparation of silver nanoparticles through the reduction of straw-extracted lignin and its antibacterial hydrogel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 504-514页

作者： Lou zhang Shuo Li Fu Tang Jingkai zhang Yuetong Kang Hean zhang Lidong Li State Key Laboratory for Advanced Metals and Materials School of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China

Silver nanoparticles(Ag NPs)have attracted attention in the field of biomaterials due to their excellent antibacterial ***,the reducing and stabilizing agents used for the chemical reduction of Ag NPs are usually toxic and may cause water *** this work,Ag NPs(31.2 nm in diameter)were prepared using the extract of straw,an agricultural waste,as the reducing and stabilizing *** analysis revealed that the straw extract contained lignin,the structure of which possesses phenolic hydroxyl and methoxy groups that facilitate the reduction of silver salts into Ag *** surfaces of Ag NPs were negatively charged due to the encapsulation of a thin layer of lignin molecules that prevented their *** the prepared Ag NPs were added to the precursor solution of acrylamide,free radical polymerization was triggered without the need for extra heating or light irradiation,resulting in the rapid formation of an Ag NP-polyacrylamide composite *** inhibition zone test proved that the composite hydrogel possessed excellent antibacterial ability due to the presence of Ag *** prepared hydrogel may have potential applications in the fabrication of biomedical materials,such as antibacterial dressings.

关键词： silver nanoparticles hydrogel straw extraction antibacterial