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Pretreatment and analysis techniques development of TKIs in biological samples for pharmacokinetic studies and therapeutic drug monitoring

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Journal of Pharmaceutical Analysis 2024年第4期14卷 439-459页

作者： Lan Chen Yuan Zhang Yi-Xin Zhang Wei-Lai Wang de-mei sun Peng-Yun Li Xue-Song Feng Yue Tan School of Pharmacy China Medical UniversityShenyang110122China Institute of Pharmacology and Toxicology Institution National Engineering Research Center for Strategic DrugsBeijing100850China department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang110022China

Tyrosine kinase inhibitors(TKIs)have emerged as the first-line small molecule drugs in many cancer therapies,exerting their effects by impeding aberrant cell growth and proliferation through the modulation of tyrosine kinase-mediated signaling ***,there exists a substantial inter-individual variability in the concentrations of certain TKIs and their metabolites,which may render patients with compromised immune function susceptible to diverse infections despite receiving theoretically efficacious anticancer treatments,alongside other potential side effects or adverse ***,an urgent need exists for an up-to-date review concerning the biological matrices relevant to bioanalysis and the sampling methods,clinical pharmacokinetics,and therapeutic drug monitoring of different *** paper provides a comprehensive overview of the advancements in pretreatment methods,such as protein precipitation(PPT),liquid-liquid extraction(LLE),solid-phase extraction(SPE),micro-SPE(μ-SPE),magnetic SPE(MSPE),and vortex-assisted dispersive SPE(VA-DSPE)achieved since *** also highlights the latest analysis techniques such as newly developed high performance liquid chromatography(HPLC)and high-resolution mass spectrometry(HRMS)methods,capillary electrophoresis(CE),gas chromatography(GC),supercritical fluid chromatography(SFC)procedures,surface plasmon resonance(SPR)assays as well as novel nanoprobes-based biosensing *** addition,a comparison is made between the advantages and disadvantages of different approaches while presenting critical challenges and prospects in pharmacokinetic studies and therapeutic drug monitoring.

关键词： TKIs Microextraction technique HRMS methods Pharmacokinetic studies Therapeutic drug monitoring

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A Weakly-Supervised Crowd density Estimation Method Based on Two-Stage Linear Feature Calibration

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 965-981页

作者： Yong-Chao Li Rui-Sheng Jia Ying-Xiang Hu Hong-mei sun the College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao 266590 the Faculty of Information Science and Engineering Ocean University of ChinaQingdao 266000China the College of Computer Science and Engineering Shandong University of Science and TechnologyQingdao 266590China the College of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210000China

In a crowd density estimation dataset,the annotation of crowd locations is an extremely laborious task,and they are not taken into the evaluation *** this paper,we aim to reduce the annotation cost of crowd datasets,and propose a crowd density estimation method based on weakly-supervised learning,in the absence of crowd position supervision information,which directly reduces the number of crowds by using the number of pedestrians in the image as the supervised *** this purpose,we design a new training method,which exploits the correlation between global and local image features by incremental learning to train the ***,we design a parent-child network(PC-Net)focusing on the global and local image respectively,and propose a linear feature calibration structure to train the PC-Net simultaneously,and the child network learns feature transfer factors and feature bias weights,and uses the transfer factors and bias weights to linearly feature calibrate the features extracted from the Parent network,to improve the convergence of the network by using local features hidden in the crowd *** addition,we use the pyramid vision transformer as the backbone of the PC-Net to extract crowd features at different levels,and design a global-local feature loss function(L2).We combine it with a crowd counting loss(LC)to enhance the sensitivity of the network to crowd features during the training process,which effectively improves the accuracy of crowd density *** experimental results show that the PC-Net significantly reduces the gap between fullysupervised and weakly-supervised crowd density estimation,and outperforms the comparison methods on five datasets of Shanghai Tech Part A,ShanghaiTech Part B,UCF_CC_50,UCF_QNRF and JHU-CROWD++.

关键词： Crowd density estimation linear feature calibration vision transformer weakly-supervision learning

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Asymmetric two-dimensional diffraction grating via a vortex field in an inverted-Ytype atomic system

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Communications in Theoretical Physics 2024年第5期76卷 77-85页

作者： Duo Zhang Ke Wang Kunpeng Zhao mei Wang Zhaoyu sun School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhan 430023China

We propose a theoretical scheme to realize a two-dimensional(2D)diffraction grating in a four-level inverted-Y-type atomic system coupled by a standing-wave(SW)field and a Laguerre-Gaussian(LG)vortex *** to asymmetric spatial modulation of the LG vortex field,the incident probe field can be lopsidedly diffracted into four domains and an asymmetric 2D electromagnetically induced grating is *** adjusting the detunings of the probe field and the LG vortex field,the intensities of the LG vortex field and the coherent SW field,as well as the interaction length,the diffraction properties and efficiency,can be effectively *** addition,the effect of the azimuthal parameter on the Fraunhofer diffraction of the probe field is also *** asymmetric 2D diffraction grating scheme may provide a versatile platform for designing quantum devices that require asymmetric light transmission.

关键词： asymmetric diffraction grating standing-wave field Laguerre-Gaussian vortex field diffraction property

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Research progress on short-term mechanical properties of FRP bars and FRP-reinforced concrete beams

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 245-270页

作者： Lili Xing Shengjiang sun Kuihua mei Yiping Guo Zhenhong Yang School of Highway Chang'an UniversityXi'an 710064China

Fiber-reinforced polymer(FRP)bars have been increasingly recognized in the field of civil engineering due to their advantages of light weight,high strength and excellent *** bars can replace steel bars in concrete beams and effectively improve the durability of *** this paper,the literature relevant to the short-term mechanical properties of FRP bars and FRP-reinforced concrete beams was reviewed based on previous studies and practical engineering ***,the mechanical properties of FRP bars were *** types of fibers or steel and fibers can be combined to obtain hybrid fiber-reinforced polymer(HFRP)or steel-fiber composite bars(SFCB)with excellent mechanical performance,*** bond performance and bond-slip model between FRP bars and concrete were *** common bond-slip models were usually used to study the bond performance between carbon fiber-reinforced polymer(CFRP)bars or glass fiber-reinforced polymer(GFRP)bars and concrete,but changing the type of FRP bars will lead to larger ***,the experimental studies,theoretical calculation methods and finite element simulation methods of flexural/shear behavior of FRP-reinforced concrete beams were ***,their applications in practical engineering were discussed and the prospects of further research were *** is pointed out that FRP-reinforced ultra-high performance concrete(UHPC)beams,FRP-reinforced geopolymer concrete(GPC)beams,engineered cementitious composites(ECC)-FRP-reinforced concrete beams,prestressed FRP-reinforced concrete beams and steel/FRP hybrid-reinforced concrete beams can effectively improve the deformation resistance and poor ductility of pure FRP-reinforced concrete beams.

关键词： FRP bars Bond performance Flexural/shear behavior Civil engineering

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Role of adaptation measures in addressing heatwave exposure in China

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Advances in Climate Change Research 2024年第1期15卷 148-157页

作者： Qin-mei HAN Qing-Chen CHAO Shao sun Pei-Jun SHI National Climate Centre China Meteorological AdministrationBeijing 100081China State Key Laboratoryof Severe Weather Chinese Academy of Meteorological Sciences Beijing 0o08lChina Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China

Heatwave exposure has increased dramatically because of climate warming and population growth,along with their interactive ***,effective adaptation measures can reduce these ***,the dynamic changes,regional inequality in adaptive capacity and their potential contributions to reducing exposure in the future remain *** study quantifies the impact of adaptive capacity and underscores regional variations in heatwave magnitudes,population exposure and adaptation levels in *** projected the future adaptive capacity using air-conditioner penetration,factoring in climate cooling requirements and individuals'purchasing *** population and gross domestic product(GDP)data from four Shared Socioeconomic Pathways(SSP1,SSP2,SSP3 and SSP5)and daily temperature data from four SSP-based emission scenarios(SSP1-2.6,SSP2-4.5,SSP3-7.0 and SSP5-8.5),we estimated heatwave duration,population exposure and avoided impacts through adaptation across China and its *** show a substantial increase in heatwave duration in Southwest and Southern China,especially under the SSP5-8.5 scenario,with a projection of 163.2±36.7 d during *** the SSP3|SSP3-7.0 scenario,total exposure reaches 156.4±76.8 billion person d per year,which is the highest among all scenarios and 23 times greater than that in 1986-2005 without *** considering adaptation measures,a noteworthy reduction in population exposure is observed,especially in the SSP3|SSP3-7.0 and SSP5JSSP5-8.5 scenarios,with reductions of(62.6±3.9)%and(65.8±5.1)%,respectively,compared with the scenario without adaptation during *** regional disparities in avoided impacts are also evident,with variations of up to 50%across different *** implementation of effective and environmentally friendly adaptation measures can notably address climate change,thereby alleviating the profound threats posed to human well-being.

关键词： Heatwaves Population exposure Adaptation Future projection China

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New record of the feather star Palaeocomatella hiwia(Echinodermata:Crinoidea:Comatulida)from Zhenbei Seamount in South China Sea:new insights into the taxonomic position of Palaeocomatella

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Journal of Oceanology and Limnology 2024年第1期42卷 244-251页

作者： Shao’e sun Zijie mei Zhongli SHA Jing WANG Nansheng CHEN department of Marine Organism Taxonomy and Phylogeny Institute of OceanologyChinese Academy of SciencesQingdao 266071China CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China Shandong Province Key Laboratory of Experimental Marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

One specimen belonging to the family Comatellinae was collected from the Zhenbei Seamount(332.5–478.2 m)in the South China Sea in July *** on the morphological characters,the specimen was identified as Palaeocomatella hiwia McKnight,*** is first recorded from China Sea and redescribed in *** specimen differs from the original description from New Zealand for never showing syzygy at br4+5 or br5+6 on interior and br1+2 on exterior ***,it is much conform to the redescription to specimens from Indonesia,with only differences in position of the second syzygy and distalmost pinnule *** is deposited in the Institute of Oceanology,Chinese Academy of *** analyses based on the mitochondrial c oxidase subunit I(COI)and 16S rRNA genes indicated that *** was nested within the tribe Phanogeniini and clustered with Aphanocomaster ***,*** showed same morphological features in terms of mouth placement,comb location,and number of comb teeth rows as other genera of ***,we suggest that the genus Palaeocomatella should be put in the tribe Phanogeniini.

关键词： new record Palaeocomatella hiwia McKnight 1977 South China Sea phylogenetic relationship taxonomy

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眼眶淋巴瘤的临床特点及诊断进展

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中华实验眼科杂志 2024年第8期42卷 774-779页

作者：孙梅首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科学与视觉科学重点实验室北京

眼眶淋巴瘤(OLs)是眼部淋巴瘤常见的类型。该病是一种结外恶性肿瘤, 既可原发于眼眶, 也可为全身淋巴瘤继发眼眶受累。OLs多发于女性, 通常表现为单侧眼球突出和眶周肿胀。惰性病变的症状持续时间较长, 而侵袭性病变往往发展较快还可伴... 详细信息

眼眶淋巴瘤(OLs)是眼部淋巴瘤常见的类型。该病是一种结外恶性肿瘤, 既可原发于眼眶, 也可为全身淋巴瘤继发眼眶受累。OLs多发于女性, 通常表现为单侧眼球突出和眶周肿胀。惰性病变的症状持续时间较长, 而侵袭性病变往往发展较快还可伴有疼痛和炎症反应。当肿瘤累及眶内不同组织时可出现上睑下垂、复视以及视力障碍等症状。其临床特征和影像学表现均不具有特异性, 需与多种眼眶疾病鉴别。因此, 当患者出现某些非特异性眼眶症状时, 需行眼眶CT、MRI等影像学检查以了解眼眶内情况, 再行进一步手术活检, 以早期确诊。目前, OLs诊断的金标准是组织病理学检查, 其分型分期则依赖于免疫组织化学分析和PET-CT。疾病的临床分期直接影响治疗方案的制定和预后结果, 因此一旦确定诊断并完成OLs的分型分期即可尽早制定合适的治疗方案。本文对近年来OLs的临床表现及诊断相关研究进行综述, 以期进一步了解该病并为临床工作提供参考。

关键词：眼眶淋巴瘤症状病理学影像学分期诊断

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Femtosecond laser fabrication of 3D vertically aligned micro-pore network on thick-film Li_(4)Ti_(5)O_(12)electrode for high-performance lithium storage

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Journal of Energy Chemistry 2024年第8期95卷 250-262,I0006页

作者： Quansheng Li Xiaofei sun Xuesong mei Lingzhi Wang Minxing Yang Jianlei Cui Wenjun Wang State Key Laboratory for Manufacturing System Engineering Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina Shaanxi Key Laboratory of Intelligent Robots Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina School of Mechanical Engineering Xi'an Jiaotong UniversityXi'an 710049ShaanxiChina

The development of energy storage devices with high energy density relies heavily on thick film electrodes,but it is challenging due to the limited ion transport kinetics inherent in thick ***,we report on the preparation of a directional vertical array of micro-porous transport networks on LTO electrodes using a femtosecond laser processing strategy,enabling directional ion rapid transport and achieving good electrochemical performance in thick film *** three-dimensional(3D)vertically aligned micro-pore networks are innovatively designed,and the structure,kinetics characteristics,and electrochemical performance of the prepared ion transport channels are analyzed and discussed by multiple characterization and testing ***,the rational mechanisms of electrode performance improvement are studied experimentally and simulated from two aspects of structural mechanics and transmission *** ion diffusion coefficient,rate performance at 60 C,and electrode interface area of the laser-optimized 60-15%micro-porous transport network electrodes increase by 25.2 times,2.2 times,and 2.15 times,respectively than those of untreated ***,the preparation of 3D micro-porous transport networks by femtosecond laser on ultra-thick electrodes is a feasible way to develop high-energy *** addition,the unique micro-porous transport network structure can be widely extended to design and explore other high-performance energy materials.

关键词： Femtosecond laser Micro-porous transport networks Laser processing Thick film electrodes Ion transport kinetics

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Strain-enhanced polarization sensitivity inβ-Ga_(2)O_(3)photodetector

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 126-137页

作者： Yonghui Zhang Huili Liang Fei Xing Qiqian Gao Yu Feng Yuping sun Zengxia mei School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China

Polarization-sensitive photodetection and imaging have great application value in fields such as polarization division multiplexing optical communication,remote sensing,near-field imaging and military *** a high polarization ratio has always been the research hotspot in polarization-sensitive *** this paper,we report a compression strain enhanced polarization ratio inβ-gallium oxide(β-Ga_(2)O_(3))single crystal flake.A rigorous crystallographic analysis confirmed its high crystalline quality and ***-resolved polarization Raman spectroscopy(ARPRS)was adopted to study the anisotropy of its optical *** ARPRS measurements and theoretical calculation consistently demonstrate the strong optical anisotropy in the high-qualityβ-Ga_(2)O_(3)flake.A polarization ratio of 0.96 was obtained in the flatβ-Ga_(2)O_(3)***,mechanical strain of±0.7%was introduced intoβ-Ga_(2)O_(3).An increased polarization ratio of 0.98 was achieved in the case of 0.7%compression strain,which is,to the best of our knowledge,the highest value for UVC polarization-sensitive *** corresponds to an improved polarization rejection ratio of *** work proposed a new path towards improving polarization sensitivity by applying strain engineering in the active material.

关键词： gallium oxide polarization photodetector anisotropy strain

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Effect of safety valve types on the gas venting behavior and thermal runaway hazard severity of large-format prismatic lithium iron phosphate batteries

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Journal of Energy Chemistry 2024年第2期89卷 195-207,I0006页

作者： Zhuangzhuang Jia Yuanyuan Min Peng Qin Wenxin mei Xiangdong Meng Kaiqiang Jin Jinhua sun Qingsong Wang State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026AnhuiChina Gotion High-Tech Co. Ltd.Hefei 230012AnhuiChina

The safety valve is an important component to ensure the safe operation of lithium-ion batteries(LIBs).However,the effect of safety valve type on the thermal runaway(TR)and gas venting behavior of LIBs,as well as the TR hazard severity of LIBs,are not *** this paper,the TR and gas venting behavior of three 100 A h lithium iron phosphate(LFP)batteries with different safety valves are investigated under *** to previous studies,the main contribution of this work is in studying and evaluating the effect of gas venting behavior and TR hazard severity of LFP batteries with three safety valve *** significant results are obtained:(Ⅰ)the safety valve type dominates over gas venting pressure of battery during safety venting,the maximum gas venting pressure of LFP batteries with a round safety valve is 3320 Pa,which is one order of magnitude higher than other batteries with oval or cavity safety valve;(Ⅱ)the LFP battery with oval safety valve has the lowest TR hazard as shown by the TR hazard assessment model based on gray-fuzzy analytic hierarchy *** study reveals the effect of safety valve type on TR and gas venting,providing a clear direction for the safety valve design.

关键词： Lithium iron phosphate battery Safety valve Thermal runaway Gas venting behavior Thermal runaway hazard severity Gray-fuzzy analytic hierarchy process

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