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A Bidimensional Finite Element study of Crack Propagation in Austempered Ductile Iron

Computers, Materials & Continua 2023年第11期77卷 1411-1424页

作者： Gustavo von Zeska de França Roberto Luís de Assumpção Marco Antonio Luersen carlos Henrique da silva department of Mechanical Engineering Federal University of Technology–ParanáCuritiba81280-340Brazil

Austempered ductile iron(ADI)is composed of an ausferritic matrix with graphite nodules and has a wide range of applications because of its high mechanical strength,fatigue resistance,and wear resistance compared to other cast *** amount and size of the nodules can be controlled by the chemical composition and austenitizing *** the nodules have lower stiffness than the matrix and can act as stress concentrators,they influence crack ***,the crack propagation mechanism in ADI is not yet fully *** this study,we describe a numerical investigation of crack propagation in ADIs subjected to cyclic *** numerical model used to calculate the stress intensity factors in the material under the given conditions is built with the aid of Abaqus commercial finite element *** crack propagation routine,which is based on the Paris law,is implemented in *** results of the simulation show that the presence of a nodule generates a shear load on the crack ***,even under uniaxial tensile loading,the presence of the nodule yields a non-zero stress intensity factor in mode II,resulting in a deviation in the crack propagation *** is the primary factor responsible for changing the crack propagation direction towards the *** the parameters,for example,increasing the nodule size or decreasing the distance between the nodule and crack tip,can intensify this *** simulations comparing two different ADIs with the same graphite fraction area,the crack in the material with more nodules reaches another nodule in a shorter propagation time(or shorter number of cycles).This suggests that the high fatigue resistance observed in ADIs may be correlated with the number of nodules intercepted by a crack and the additional energy required to nucleate new *** summary,these findings contribute to a better understanding of crack propagation in ADIs,provide insights into the relationship between the presence

关键词： Austempered ductile iron(ADI) fatigue crack propagation graphite nodule

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Partition coefficient prediction of Baker's yeast invertase in aqueous two phase systems using hybrid group method data handling neural network

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Chinese Journal of Chemical Engineering 2017年第5期25卷 652-657页

作者： carlos Eduardo de Araújo Padilha sérgio Dantas de Oliveira Júnior Domingos Fabiano de santana s.uza Jackson Araújo de Oliveira Gorete Ribeiro de Macedo Everaldo silvino dos santos Laboratory of Biochemical Engineering Chemical Engineering DepartmentFederal University of Rio Grande do Norte (UFRN)

A hybrid GMDH neural network model has been developed in order to predict the partition coefficients of invertase from Baker's yeast. ATPs experiments were carried out changing the molar average mass of PEG(1500–6000 Da), p H(4.0–7.0), percentage of PEG(10.0–20.0 w/w), percentage of MgsO_4(8.0–16.0 w/w), percentage of the cell homogenate(10.0–20.0 w/w) and the percentage of MnsO_4(0–5.0 w/w) added as cosolute. The network evaluation was carried out comparing the partition coefficients obtained from the hybrid GMDH neural network with the experimental data using different statistical metrics. The hybrid GMDH neural network model showed better fitting(AARD = 32.752%) as well as good generalization capacity of the partition coefficients of the ATPs than the original GMDH network approach and a BPANN model. Therefore hybrid GMDH neural network model appears as a powerful tool for predicting partition coefficients during downstream processing of biomolecules.

关键词： Partitioning Invertase Aqueous Two Phase system GMDH Neural network

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Prevalence of musculoskeletal injuries and a proposal for neuromuscular training to prevent lower limb injuries in Brazilian Army soldiers:an observational study

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Military Medical Research 2019年第1期6卷 45-52页

作者： Michele Zukauskas de Andrade Gomes carlos Eduardo Pinfildi department of Human Movement science Federal University of Sao Paulo(UNIFESP)Campus Baixada Santista Human Movement science and Rehabilitation Department of Human Movement ScienceFederal University of Sao Paulo-Physical TherapyCampus Baixada Santista

Background: The activities carried out by soldiers in the army involve great physical demands and require intense trainings to perform combat-specific tasks. Musculoskeletal injury is a potential threat to the health and physical integrity of the soldier. This study aimed to evaluate the prevalence of lower limb musculoskeletal injuries among soldiers and to propose a training protocol to prevent the most frequent ***: This observational(cross-sectional) study recruited a sample of 103 soldiers who required medical attention,from a total 202 new battalion soldiers. The medical records(paper and online) had a form of running text. All data collected were recorded by the registered physicians of the battalion medical post. The records were analyzed by the following variables: medical diagnosis, injury site, mechanism, type of treatment, time loss, existence of previous injury,and recurring ***: A total of 112 musculoskeletal injuries were diagnosed in 71 soldiers, and other types of diseases/injuries were diagnosed in the other soldiers. Joint pain accounted for 55.4% of the diagnoses. The knee was the most affected site, while trauma and overload were the most common mechanisms of injury. Drug treatment was used most frequently, accounting for 58% of the cases. The majority of the sample obtained a temporary leave of absence for1 to 6 days or not at all. Previous injuries and recurrence were not presented as risk factors for injury. With the data received, a protocol for the prevention of injuries to the lower limbs was ***: This study indicated that the most frequent site of injury is the knee, and joint pain is the most common diagnosis. These results may support the necessity to develop a neuromuscular training protocol to prevent lower limb injuries, which we suggest to be applied in future studies.

关键词： Physical therapy Wounds and injuries Primary prevention Lower extremity Proprioception Military personnel

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Energy Conversion Factor for Gasoline Engines in Real-World Driving Emission Cycle

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Automotive Innovation 2020年第2期3卷 169-180页

作者： Toshizaemom Noce sérgio de Morais Hanriot Luis carlos Monteiro sales JoséRicardo sodré Matheus Bitarães de Novaes department of Mechanical Engineering Pontifical University of Minas GeraisAv.Dom JoséGaspar 500Belo HorizonteMG 30535-901Brazil school of Engineering&Applied science Aston UniversityAston TriangleBirmingham B47ETUK department of Electrical Engineering Federal University of Minas GeraisAv.Pres.Antônio Carlos6627Belo HorizonteMG 31270-901Brazil

A precise energy conversion factor is required to define the impact of greenhouse gas emissions by gasoline-powered vehi-cles and policies that will guide the application of future *** current energy conversion factor adopted by many countries is based on the Willans line approach,initially proposed in 1888 for steam engines,later adapted for internal combustion *** actual energy conversion factor,which defines the energy conversion for drivers in real traffic,is *** this article,eight world-class engines are tested in an engine bench for the acquisition of specific fuel consumption 3D ***,their energy conversion factors,calculated by dividing the energy output by the energy input,are simulated in real and urban traffic,acquired according to the real driving emissions(Rde)*** addition,a reference vehicle is instrumented to measure the energy input(fuel flow)and the energy output(mechanical energy in the half axles)under the same Rde cycle *** results of both procedures are very similar,respectively,0.405±0.04 L/kWh for the simulation based on eight benchmark engines,and 0.392±0.04 L/kWh for the reference vehicle driven in Rde traffic conditions,with a 95%confidence *** turbocharged engines,the factor attained by the simulation is 0.395±0.04 L/*** values of the energy conversion factor for gasoline engines got in this research are higher than those obtained through the Willans line approach,suggesting a new standard value of 0.405 L/kWh,replacing the current 0.264 L/*** could substantially change the greenhouse gas emissions in a tank-to-wheel approach for the entire vehicle and add-on eco-innovations.

关键词： Energy conversion factor Willans line EC443 Eco-innovation CO_(2)emission

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No evidence of HPv DNA in esophageal squamous cell carcinoma in a population of southern Brazil

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World Journal of Gastroenterology 2013年第39期19卷 6598-6603页

作者： Luís carlos Moreira Antunes Joo carlos Prolla Antonio de Barros Lopes Marta Pires da Rocha Renato Borges Fagundes Programa de Pós-Graduao: Ciências em Gastroenterologia e Hepatologia - Universidade Federal do Rio Grande do sul Porto AlegreRio Grande do Sul 90035-003Brasil Hospital Universitário de santa Maria - Universidade Federal de santa Maria Santa MariaRio Grande do Sul 97119-900Brasil departamento de Clínica Médica - Universidade Federal de santa Maria Santa MariaRio Grande do Sul 97119-900Brasil

AIM:To investigate the association between human papillomavirus(HPv)and esophageal squamous cell carcinoma(EsCC)in southern ***:We studied 189 esophageal samples from125 patients from three different groups:(1)102 biopsies from 51 patients with EsCC,with one sample from the tumor and another from normal esophageal mucosa distant from the tumor;(2)50 esophageal biopsies from 37 patients with a previous diagnosis of head and neck squamous cell carcinoma(HNsCC);and(3)37 biopsies from esophageal mucosa with normal appearance from 37 dyspeptic patients,not exposed to smoking or alcohol ***-polymerase chain reaction(PCR)with the MY09/11 and GP5/6 L1primers was used to detect HPv L1 in samples fixed in formalin and stored in paraffin *** PCR reactions were performed with a positive control(cervicovaginal samples),with a negative control(Human Genomic DNA)and with a blank reaction containing all reagents except *** took extreme care to prevent DNA contamination in sample collection,processing,and ***:The histological biopsies confirmed the diagnosis of EsCC in 52 samples(51 from EsCC group and 1 from the HNsCC group)and classified as well differentiated(12/52,23.1%),moderately differentiated(27/52,51.9%)or poorly differentiated(7/52,13.5%).One hundred twenty-eight esophageal biopsies were considered normal(51 from the EsCC group,42 from the HNsCC group and 35 from dyspeptic patients).Nine had esophagitis(7 from the HNsCC and 2 from dyspeptic patients).Of a total of 189 samples,only 6 samples had insufficient material for PCR analysis:1 from mucosa distant from the tumor in a patient with EsCC,3from patients with HNsCC and 2 from patients without *** 183 samples(96.8%)GAPDH,G3PDH and/orβ-globin were amplified,thus indicating the adequacy of the DNA in those *** DNA was negative in all the 183 samples tested:52 with EsCC,9 with esophagitis and 122 with normal esophageal ***:There was no evidence of HP

关键词： Esophageal cancer Esophageal squamous cell carcinoma Human papillomavirus Head and neck cancer Polymerase chain reactions Nested-polymerase chain reaction

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Theranostic of orthotopic gliomas by core-shell structured nanoplatforms

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Light(science & Applications) 2022年第6期11卷 1034-1035页

作者： Luis D.carlos Phantom-G CICECO-Aveiro Institute of MaterialsPhysics DepartmentUniversity of Aveiro3810-193 AveiroPortugal

smart designed core-shell nanostructures formed by a YvO_(4)∶Nd^(3+) nanoparticle as the core,the sonosensitizer hematoporphyrinmonomethyl ether as the carrier,and MnO_(2) nanosheets as the shell demonstrate bimodal ... 详细信息

关键词： modal glioma orthotopic

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A sIMPLE METHOD TO deTERMINE THE DAYLIGHT FACTOR FROM THE vERTICAL DAYLIGHT FACTOR IN DIFFERENT sTREET CANYON GEOMETRY

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Journal of Green Building 2016年第2期11卷 75-92页

作者： Jorge s.carlos C-MAde Centre of Materials and Building TechnologiesUniversity of Beira InteriorCalçada Fonte do Lameiro6200-358 CovilhãPortugal

This paper investigates the main characteristics of daylight on any window in a street *** sky component and the light reflected from the surroundings are described to determine the vertical daylight factor(vDF).several street canyon types are characterized taking into account their different height/width and any level of the window is analysed.A simple calculation method uses trigonometric equations based on the sky and the geometry of the *** results were previ-ously evaluated considering different daylight procedures obtained by other *** study reveals that the reflectance within an urban canyon plays an important role in the amount of daylight onto any window with more relevance in a deep canyon and low sky *** graphical presentation that result from this investiga-tion can rapidly assist building and urban designers in an early stage design where assumptions and the lay out of the main design take place.

关键词： vertical daylight factor urban canyon configuration factor diffuse light isotropic overcast sky

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OPTIMAL WINDOW GEOMETRY FACTORs FOR ELEMENTARY sCHOOL BUILDINGs IN PORTUGAL

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Journal of Green Building 2018年第1期13卷 185-197页

作者： Jorge s.carlos Centre of Materials and Building Technologies(CMAde-UBI) Universidade da Beira InteriorRua Marquês D’Ávila e Bolama6200-001CovilhãPortugal

INTRODUCTION With respect to thermal performance, windows are the weakest component of the building envelope, essentially because the U-value is usually higher than the opaque envelope. This would allow the highest heat conductance of the building envelope. However, it also helps buildings to gain useful solar heat during winter. Therefore, it has been generally accepted that passive buildings would have small windows towards the poles and large windows facing the equator (Persson, Roos, and Wall 2006). In spite of this guideline, large or fully glazed facades have been used in modern architecture. The intensive use of air conditioning is the result of overheating and high thermal loss problems, which otherwise would lead to thermal discomfort. This extensive use of large windows associated with high energy consumption has motivated researchers to study this building component. Window areas were investigated by Persson et al. (Persson, Roos, and Wall 2006) on 20 terraced houses with larger windows facing the equator and built in Gothenburg. The building envelope was well insulated and fitted with energy efficient windows. It was found that energy efficient windows do not have a major influ-ence on the heating demand in the winter, but it is relevant for the cooling need in summer. Therefore, reduced indoor illuminance due to small windows can be solved by enlarging them in order to obtain relevant daylighting conditions. When efficient windows are designed for a warm climate, as in Mexico, reducing heat flux and solar transmittance indoors was the best option for energy savings (Aguilar et al. 2017). However, reducing solar transmittance influences the indoor illuminance, which was not analyzed.

关键词： school building classroom windows solar heat gain daylight

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A numerical assessment of two geometries for reducing elbow erosion

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Particuology 2020年第2期18卷 117-133页

作者： carlos Antonio Ribeiro Duarte Francisco Joséde s.uza Diego Nei venturi Martin sommerfeld department of Engineering Federal University of Goiás-Regional Catal(a)oAv.Dr.Lamartine Pinto de Avelar1120Catal(a)oGoiásBrazil school of Mechanical Engineering Federal University of Uberl(a)ndiaAv.Joāo Naves de(A)vila2121 Bloco 5PUberl(a)ndiaMinas GeraisBrazil Multiphase Flow systems(MPs) Otto-von-Guericke-University MagdeburgZeppelinstraβe 1D-06130 Halle(Saale)Germany

Elbows in pneumatic conveying systems are normally prone to the erosive effects of conveyed *** are a number of solutions available to reduce such damage.A widely used geometric alternative for replacing the 90°elbow and reducing erosive wear is the plugged *** option,although less commonly used,is the vortex-chamber *** both cases,the effective reduction in erosion brought about is unclear,as it strongly depends on the operating *** present study assesses relative erosion among the plugged tee,vortex-chamber elbow,and standard elbow for a dilute gas-solid multiphase flow.A numerical model is employed to predict the penetration ratio and validated using experimental data for the plugged *** are run for the standard and vortex-chamber elbows and plugged tee under the same conditions to compare the mechanics involved and the relative erosion *** analysis uses variables relating to particle-wall interactions(impact angle,impact velocity,impact frequency)to illustrate the nature of the erosive process in each pipe *** general,the geometric configurations of both the plugged tee and vortex-chamber elbow promote changes in particle dynamics that reduce the rate of *** the basis of the relative erosion of the standard elbow,the plugged tee proves to be an interesting option in cases of a low mass loading,while the vortex-chamber elbow demonstrates its erosion reduction potential for higher mass loading ***,the advantages and disadvantages of each fitting are highlighted.

关键词： Relative erosion Plugged tee Erosion reduction Pipe fitting Computational fluid dynamics

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dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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