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脉冲染料激光联合局部外用钙泊三醇和(或)水杨酸治疗手足银屑病:对41例患者的开放性、前瞻性研究

世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 57-57页

作者： de leeuw j. Tank B. Bj.rring P.j. 刘艳 department of dermatology and Venereology Erasmus MC University Medical Center PO Box 2040 3000 CA Rotterdam NetherlandsDr.

Background: Psoriasis of the hands and feet is a chronic disease which is often resistant to the usual topical therapies. It has considerable morbidity and seriously affects the quality of life of patients. Obj.ctive: We sought to prospectively evaluate the efficacy and safety of pulsed dye laser (PDL) treatment of psoriasis of the hands and feet. Methods: In all, 41 patients with therapy- resistant psoriasis of the hands and feet were treated once every 4 to 6 weeks with PDL at 585- nm wavelength, 450- microsecond pulse duration, 7- mm spot diameter, and 5- to 6.5 j.m2 fluence. Calcipotriol ointment and salicylic acid 5% to 10% ointment were used as keratolytic agents. Treatment efficacy was evaluated by blinded comparison of photographs of the lesions taken before and after PDL treatment in each patient. Results: A good to very good improvement in the lesions was observed in 76% of the patients after treatment. An average duration of remission was 11 months. Side effects were transient purpura, moderate discomfort during the treatment, transient hyperpigmentation or hypopigmentation, and incidental transient crustae. Limitations: This was an open prospective study with a limited number of patients who were concomitantly treated with calcipotriol and salicylic acid ointment. Patients with photointolerance, on medication with phototoxic or photoallergic drugs, and with widespread psoriasis were excluded. Conclusions: Concomitant treatment with PDL and topical calcipotriol, salicylic acid, or both was a satisfactory modality for treating psoriasis of the hands and feet. There was a subj.ctive improvement in the symptoms and quality of life in all patients.

关键词：钙泊三醇银屑病脉冲染料激光角质软化剂泛发性光敏性药物光毒性生活质量慢性疾病色素减退

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Personal control in rehabilitation: An internet platform for patients with schizophrenia and their caregivers

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Open j.urnal of Psychiatry 2012年第4期2卷 355-361页

作者： j. Rob j. de leeuw Peter van Splunteren Ina Boerema j.lius Center for Health Science and Primary Care Utrecht The Netherlands Trimbos Institute of Mental Health and Addiction Utrecht The Netherlands

In order to facilitate optimal quality and continuity of care and self-management of patients with schizophrenia, Personal Control in Rehabilitation (PCR) has been developed, a comprehensive internet-based platform. PCR aims to reach patients with schizophrenia or related psychotic disorders and their (in)formal caregivers. It provides caregivers and patients with a kind of dashboard giving them (tailored) information about the physical and psychosocial situation of the patient, their compliance with treatment, and facilitates optimal self-management for patients. With the use of PCR, informal caregivers have access to information about treatment and can consult formal caregivers, formal caregivers have easy access to the multidisciplinary guideline schizophrenia and to the regional care plans. Patients and their formal and informal caregivers completed questionnaires about empowerment, quality of life, quality of care and workload before the introduction of PCR and nine months later. A sample of them also participates in focus group discussions about the usefulness and usability of PCR and bottle necks in using the platform. Response to the questionnaires, especially at followup, was not adequate for statistical analyses of its results. Therefore, the focus of this paper is on the process evaluation of the implementation of PCR in two large mental health organisations in the Netherlands. Data for this evaluation are results of a number of open questions of the questionnaire and results of the focus group discussions. In these discussions, 19 patients, 12 informal caregivers, 33 formal caregivers and three managers participated. Preliminary results of this study show that the implementation of PCR is feasible and patients, formal and informal caregivers were satisfied with the use of PCR and frequently used PCR to communicate, make appointments, give feedback and look for information about their disease and its treatment. PCR is considered as a help in reaching more

关键词： Schizophrenia Self Management Internet Platform Disease Management

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Performance and calibration of quark/gluon-j.t taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.j. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.j. Addison j. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras j. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuj. X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi j. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.j. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke j.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen j.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki j.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.j. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena j.F. Arguin S. Argyropoulos j.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah j. Assahsah K. Assamagan R. Astalos S. Atashi R.j. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.j. Bailey V.R. Bailey j.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas j. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of j.ts originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rej.cting j.ts from gluon over j.ts from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the j.t,and the other combines several j.t substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the j.t *** in tagging efficiency between data and simulation are provided for j.ts with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS j.T QUARK GLUON TAGGING

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The effect of global warming on beef production in developing countries of the southern hemisphere

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Natural Science 2013年第1期5卷 106-119页

作者： M.M.Scholtz C.McManus K-j.leeuw H.Louvandini L.Seixas C.B.de Melo A.Theunissen F.W.C.Neser ARC-Animal Production Institute IreneSouth Africa University of the Free State BloemfonteinSouth Africa Insituto Nacional de Ciencia e Tecnologia-InformacaoGenetico-Sanitaria da Pecuaria Brasileira Brazil departamento de Zootecnia Universidade Federal de Rio Grande do SulPorto AlegreBrazil Centro de Energia Nuclear na Agricultura Universidade de Sao PauloPiracicabaBrazil Faculdade de Agronomia e Medicina Veterinaria Universidade de BrasiliaBrasiliaBrazil Northern Cape department of Agricultural Land Reform and Rural DevelopmentJan KempdorpSouth Africa

developing countries from the southern hemisphere will be confronted by the same beef production challenges caused by global warming, because these countries are at the same geographical positions in southern latitudes. Global warming is expected to have a more extreme effect on the southern hemisphere than on other continents and will have a negative effect on the beef production environments in these countries. The negative effects will include high ambient temperatures, nutritional stress and altered patterns of animal diseases. Heat stress in beef cattle on veld/savannah is expected to increase as a result of changing weather patterns on a global and regional scale. This may negatively influence food production from beef cattle for the human food chain. Negative effects of increased temperatures and thus heat stress can include lower reproductive rates and weaning weights. The effect of heat stress can be partly addressed by nutritional strategies, such as replacing rapid fermentable carbohydrates with saturated fatty acids and the feeding of more by-pass protein and dietary electrolytes. Global warming will also alter the distribution pattern of animal diseases and the vectors of some of these diseases. This may even include the spread to South American countries. Likewise the nutritional value of natural pastures may be influenced. The effect of global warming on the quality of pastures will depend on whether the global warming is a result of increased carbon dioxide levels or not. An improved understanding of the adaptation of beef cattle to their production environments is important, but adaptation is complex and thus difficult to measure. Fortunately, several proxy-indicators for adaptation such as reproductive, production and health traits are available. The selection of animals and genotypes that are better adapted to the production system, including heat stress, is possible and should be persuade to ensure sustainable beef production in hotter climates.

关键词： Adaptation Animal diseases Heat Stress Mitigation Strategies Nutritional Stress

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热成熟早期阶段未熟干酪根n-C_(37)和n-C_(38)不饱和酮的S、O键合及其碳骨架的释放

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天然气地球科学 1999年第1期10卷 76-81页

作者： M.P.Koopmans C.Schaeffer-Reiss j.W.de leeuw 郑军卫荷兰

对韦纳·德尔·杰索盆地(意大利北部)Gessos-solfifera地层(墨西拿阶)中包含未成熟富硫有机物的沉积岩进行加水热解模拟,在160～330℃的不同温度下加热72h,以研究prymnesinphyte水藻生物合成的n-C_(37)和n-C_(38)二元、三元不饱和甲乙基... 详细信息

对韦纳·德尔·杰索盆地(意大利北部)Gessos-solfifera地层(墨西拿阶)中包含未成熟富硫有机物的沉积岩进行加水热解模拟,在160～330℃的不同温度下加热72h,以研究prymnesinphyte水藻生物合成的n-C_(37)和n-C_(38)二元、三元不饱和甲乙基酮(链烯酮)在成岩过程中的演化结局。原始干酪根样化学降解实验表明,在咸岩作用早期,链烯酮被硫和氧交联键合进干酪根中。实验结果还表明,在自然条件下具有n_C_(37)和n-C38结构的饱和酮可视与烷烃类似。

关键词：未熟干酪根不饱和酮 S,O键合碳骨架油矿床

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先兆子痫患者的微循环结构:小静脉系统的可能作用

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世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 60-61页

作者： Houben A. j. H. M. de leeuw P. W. Peeters L L. H. 奚群英 department of Internal Medicine University Hospital Maastricht Peter Debyelaan 25 6202 AZ Maastricht Netherlands.Dr

目的:验证以下假设,即在先兆子痫时微循环的功能和结构发生紊乱,可引起小静脉阻力升高。方法:在妊娠未3个月时和产后3个月时,对11例患有先兆子痫的女性和9例经产对照女性的皮肤及球结膜的微循环进行研究。使用活体电视显微镜检查确定结... 详细信息

目的:验证以下假设,即在先兆子痫时微循环的功能和结构发生紊乱,可引起小静脉阻力升高。方法:在妊娠未3个月时和产后3个月时,对11例患有先兆子痫的女性和9例经产对照女性的皮肤及球结膜的微循环进行研究。使用活体电视显微镜检查确定结膜内的小动脉和小静脉直径。此外,还测定皮肤毛细血管密度及形态。结果:不论在妊娠期(P<0.01)或产后(P=0.045),

关键词：先兆子痫女性小静脉结膜眼睑静脉系统微循环

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治疗前及治疗过程中多次就诊时白大衣效应的发生率

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世界核心医学期刊文摘（心脏病学分册） 2007年第4期3卷 58-59页

作者： Verberk W.j. Kroon A.A. Thien T. P.W.de leeuw 朱冰坡 FAHA Department of MedicineUniversity Hospital MaastrichtPO Box 58006202 AZ MaastrichtNetherlands Dr.

目的:调查接受与未接受治疗的高血压患者在多次血压测量时白大衣效应(WCE)和白大衣高血压(WCH)的发生率与持续性。设计:在1年时间内,8次就诊(每次就诊共读数3次)均接受诊室血压测量(OBPM)的原发性高血压患者,在每次就诊前自测血压(SBPM)... 详细信息

目的:调查接受与未接受治疗的高血压患者在多次血压测量时白大衣效应(WCE)和白大衣高血压(WCH)的发生率与持续性。设计:在1年时间内,8次就诊(每次就诊共读数3次)均接受诊室血压测量(OBPM)的原发性高血压患者,在每次就诊前自测血压(SBPM)1周(每周42次读数)。

关键词：白大衣效应白大衣高血压诊室血压原发性高血压自测血压血压测量自动血压测量仪动态血压监测

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原发性高血压患者脑微出血的进程:2年的随访研究

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中华高血压杂志 2015年第2期23卷 198-198页

作者： van Dooren M Staals j.de leeuw PW Kroon AA Henskens LH van Oostenbrugge Rj.练桂丽叶鹏

在高血压患者中脑微出血是常见现象，并且与较高的血压水平相关。对于脑微出血危险因素知之甚少，特别是动态血压水平所起的作用。该研究旨在探讨原发性高血压患者中脑微出血进程和血压的相关性。

关键词：原发性高血压患者脑微出血随访研究出血危险因素血压水平相关性

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内皮细胞活化与高血压患者的认知功能有关

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中华高血压杂志 2016年第6期24卷 598-598页

作者： Uiterwij. R Huij.s M Staals j.Rouhl RP de leeuw PW Kroon AA Van Oostenbrugge Rj.陈云叶鹏

高血压与认知功能障碍和痴呆的发生有关,可能是因为高血压是引发脑损伤的一个重要危险因素,脑损伤是脑小血管病的一种表现。已发现内皮细胞活化和炎症在脑小血管病的发病机制中发挥重要作用。该研究调查以几种血管标志物为基础的内皮细... 详细信息

高血压与认知功能障碍和痴呆的发生有关,可能是因为高血压是引发脑损伤的一个重要危险因素,脑损伤是脑小血管病的一种表现。已发现内皮细胞活化和炎症在脑小血管病的发病机制中发挥重要作用。该研究调查以几种血管标志物为基础的内皮细胞活化或炎症的综合积分是否与原发性高血压患者3年后的认知功能有关。

关键词：原发性高血压患者内皮细胞活化认知功能障碍脑损伤血管病危险因素发病机制标志物

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阿尔茨海默病合并2型糖尿病患者的脑皮质萎缩增多

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世界核心医学期刊文摘(神经病学分册) 2006年第8期 55-55页

作者： Biessels G.j. de leeuw F.-E. Lindeboom j. 刘凯 department of Neurology G228 UMC Utrecht PO Box 85500 3508GA Utrecht Netherlands Dr.

Background: The risk of Alzheimer’s disease (AD) is increased in type 2 diabetes (DM2). This increased risk has been attributed to vascular comorbidity, but other mechanisms, such as accelerated ageing of the brain, have also been implicated. Obj.ctive: To determine whether AD in patients with DM2 is associated with an increased occurrence of vascular lesions in the brain, by increased cerebral atrophy, or a combination of both. Methods: In total, 29 patients with AD and DM2 and 58 patients with AD and without DM2 were included in the study. Clinical characteristics were recorded, and a neuropsychological examination and magnetic resonance imaging (MRI) scan were performed. MRI scans were rated for cortical and subcortical atrophy, medial temporal lobe atrophy, white matter lesions, and infarcts. Results: The neuropsychological profiles of the two groups were identical. Patients with AD and DM2 had increased cortical atrophy on MRI (p < 0.05) compared with the non- DM2 group. In addition, infarcts were more common (odds ratio 2.4; 95% CI 0.8 to 7.8), but this effect did not account for the increased atrophy. The other MR measures did not differ between the groups. Conclusion: The results suggest that nonvascular mechanisms, leading to increased cortical atrophy, are also involved in the increased risk of AD in DM2.

关键词：阿尔茨海默病患者 AD DM 神经心理学皮质萎缩

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