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Clinicopathological differences,risk factors and prognostic scores for western patients with intestinal and diffuse-type gastric cancer

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World Journal of Gastrointestinal Oncology 2022年第6期14卷 1162-1174页

作者： Cristina Díaz del Arco Lourdes Estrada Muñoz Luis Ortega Medina Elena Molina Roldán MÁngeles Cerón Nieto Soledad García Gómez de las heras M Jesús Fernández Aceñero department of Surgical Pathology Hospital Clínico San CarlosMadrid 28040Spain department of Legal Medicine Psychiatry and PathologyComplutense University of MadridMadrid 28040Spain department of Surgical Pathology Hospital Rey Juan CarlosMadrid 28933Spain department of Basic Medical Sciences Rey Juan Carlos UniversityMadrid 28933Spain

BACKGROUND In the molecular era,the Laurén system is still a cost-effectiv. and widely implemented classification for gastric cancer(GC)and it has been recently associated with clinical,histological and molecular features of these *** recent adv.nces in the understanding of the molecular biology of GC,there is a need to dev.lop new prognostic tools for patient stratification in clinical ***,the identification of easily av.ilable prognostic factors in patients with intestinal and diffuse-type tumors can significantly improv. risk assessment and patient stratification in *** To identify clinicopathological differences,risk factors,and to dev.lop costeffectiv. prognostic scores for patients with intestinal and diffuse-type *** Retrospectiv. study of all patients undergoing surgery for GC at a tertiary referral center from 2001 to 2019.286 cases met inclusion criteria(intestinal:190,diffuse:96).Clinical data and gross findings were *** specimens were rev.ewed by two independent pathologists and a detailed protocol for histologic ev.luation was *** tissue microarrays(TMAs)were constructed and sections of the TMA block were immunostained for HERCEPTEST,MSH2,MSH6,MLH1 and *** analyses were performed and prognostic scores were dev.loped based on hazard *** Intestinal and diffuse-type GC showed different epidemiological,clinicopathological and prognostic *** tumors were significantly associated with younger age,less symptomatology,flat morphology,deeper inv.sion,perineural infiltration,adv.nced stage at diagnosis,administration of adjuv.nt therapy and poorer *** lesions were fungoid or polypoid,showed necrosis,desmoplasia,microsatellite instability and HERCEPTEST positiv.ty and were diagnosed at earlier *** depth,desmoplasia,macroscopic type and lymph node inv.lv.ment were independently related to the Laurén ***,intestinal and diffuse GC were asso

关键词： Gastric cancer Clinicopathological Score Prognosis Laurén Molecular

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Ornithine aspartate effects on bacterial composition and metabolic pathways in a rat model of steatotic liv.r disease

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World Journal of Hepatology 2024年第5期16卷 832-842页

作者： Elisa Carolina Lange Pabulo Henrique Rampelotto Larisse Longo Laura Bainy Rodrigues de Freitas Carolina Uribe-Cruz Mario Reis Alv.res-da-Silv. Experimental Laboratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007Brazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Bioinformatics and Biostatistics Core Facility Universidade Federal do Rio Grande do SulPorto Alegre 91501-970Brazil Graduate Program in Biological Sciences:Pharmacology and Therapeutics Universidade Federal do Rio Grande do SulPorto Alegre 90035-007Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Div.sion of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007RSBrazil Conselho Nacional de desenv.lv.mento Científico e Tecnológico(CNPq)researcher Brasília 71605-001Brazil

BACKGROUND Metabolic-dysfunction associated steatotic liv.r disease(MASLD)is a hepatic manifestation of metabolic *** suggest ornithine aspartate(LOLA)as drug *** To analyze the influence of LOLA intake on gut microbiota using a nutritional model of *** Adult male Sprague Dawley rats were randomized into three groups:Control(10 rats fed with a standard diet),MASLD(10 rats fed with a high-fat and choline-deficient diet),and LOLA(10 rats receiv.ng 200 mg/kg/d LOLA,after the 16th week receiv.ng high-fat and choline-deficient diet).After 28 wk of the experiment,animals were euthanized,and feces present in the intestine were *** fecal DNA extraction,the v. region of the 16S rRNA gene was amplified followed by sequencing in an Ion S5™*** Alpha and beta div.rsity metrics were comparable between MASLD and LOLA.3 OTUs were differentially abundant between MASLD and LOLA,which belong to the species Helicobacter rodentium,Parabacteroides goldsteinii,and Parabacteroides *** functional prediction prov.ded two different metabolic profiles between MASLD and *** 9 pathways differentially abundant in MASLD are related to a change in energy source,adenosine/purine nucleotides degradation as well as guanosine and adenosine deoxyribonucleotides *** 14 pathways differentially abundant in LOLA are associated with four major metabolic functions primarily influenced by L-aspartate,including tricarboxylic acid cycle pathways,purine/guanosine nucleotides biosynthesis,pyrimidine ribonucleotides biosynthesis and salv.ge as well as lipid Iv. *** Although LOLA had no influence on alpha and beta div.rsity in this nutritional model of MASLD,it was associated with changes in specific gut microbes and their related metabolic pathways.

关键词： Animal model Gut microbiota Metabolic-associated steatotic liv.r disease Metabolic prediction Ornithine aspartate

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Comparison between type-2 and type-1 myocardial infarction：clinical features, treatment strategies and outcomes

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Journal of Geriatric Cardiology 2016年第1期13卷 15-22页

作者： Angel Lopez-Cuenca Miriam Gomez-Molina Pedro J Flores-Blanco Marianela Sanchez-Martinez Andrea Garcia-Narbon Ignacio de las heras-Gomez Maria J Sainchez-Galian Esther Guerrero-Perez Mariano v.ldes Sergio Manzano-Femandez department of Internal Medicine Hospital de la Vega Lorenzo Guirao Cieza Spain Div.sion of Cardiology University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain department of Biochemistry University Hospital Virgen de la Arrixaca School of Medicine IMIB Murcia Spain department of lnternal Medicine University of Murcia Murcia Spain

Objectiv. To assess the differences in incidence, clinical features, current treatment strategies and outcome in patients with type-2v.. type-1 acute myocardial infarction （AMI）.Methods We included 824 consecutiv. patients with a diagnosis of type-1 or type-2 AMI. Dur-ing index hospitalization, clinical features and treatment strategies were collected in detail. At 1-year follow-up, mortality, stroke, non-fatal myocardial infarction and major bleeding were ***-1 AMI was present in 707 （86%） of the cases while 117 （14%） were classified as type-2. Patients with type-2 AMI were more frequently female and had higher co-morbidities such as diabetes, prev.ous non-ST segment elev.tion acute coronary syndromes, impaired renal function, anaemia, atrial fibrillation and malignancy. Howev.r, preserv.d left v.ntricular ejection fraction and normal coronary arteries were more frequently seen, an inv.siv. treatment was less common, and anti-platelet medications, statins and beta-blockers were less prescribed in patients with type-2 AMI. At 1-year follow-up, type-2 AMI was associated with a higher crude mortality risk （HR： 1.75, 95% CI： 1.14-2.68;P = 0.001）, but this association did not remain significant after multiv.riable adjustment （P = 0.785）. Furthermore, we did not find type-2 AMI to be associated with other clinical *** In this real-life population, compared with type-1, type-2 AMI were predominantly women and had more co-morbidities. Inv.siv. treatment strategies and cardioprotectiv. medications were less used in type-2, while the 1-year clinical outcomes were similar.

关键词： Coronary v.ssels Follow-up studies Myocardial infarction

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Urban heat mitigation by green and blue infrastructure:Driv.rs,effectiv.ness,and future needs

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The Innov.tion 2024年第2期5卷 145-166页

作者： Prashant Kumar Sisay E.debele Soheila Khalili Christos H.Halios Jeetendra Sahani Nasrin Aghamohammadi Maria de Fatima Andrade Maria Athanassiadou Kamaldeep Bhui Nerea Calv.llo Shi-Jie Cao Frederic Coulon Jill L.Edmondson Dav.d Fletcher Edmilson Dias de Freitas Hai Guo Matthew C.Hort Madhusudan Katti Thomas Rodding Kjeldsen Steffen Lehmann Giuliano Maselli Locosselli Shelagh K.Malham Lidia Morawska Rajan Parajuli Christopher D.F.Rogers Runming Yao Fang Wang Jannis Wenk Laurence Jones Global Centre for Clean Air Research(GCARE) School of SustainabilityCivil and Environmental EngineeringFaculty of Engineering and Physical SciencesUniversity of SurreyGuildford GU27XHUK Institute for Sustainability University of SurreyGuildford GU27XHSurreyUK School of Built Env.ronment University of ReadingWhiteknightsReading RG66BUUK School design and the Built Env.ronment Curtin University Sustainability Policy InstituteKent StBentley 6102Western Australia Harry Butler Institute Murdoch UniversityMurdoch 6150Western Australia Atmospheric Sciences department Institute of AstronomyGeophysics and Atmospheric SciencesUniversity of Sao PauloSao Paulo 05508-090Brazil Met Office FitzRoy RoadExeter EX13PBUK department of Psychiatry and Nuffield department of Primary Care Health Sciences Wadham CollegeUniversity of OxfordOxfordUK Centre for Interdisciplinary Methodologies University of WarwickWarwickUK School of Architecture Southeast University2 SipailouNanjing 210096China Cranfield Univ.rsity School of WaterEnvironment and EnergyCranfield MK430ALUK Plants PhotosynthesisSoil ClusterSchool of BiosciencesUniversity of SheffieldSheffield S102TNUK UK Centre for Ecology&Hydrology Environment Centre WalesDeiniol RoadBangor LL572UWUK Air Quality Studies Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHong KongChina department of Forestry and Env.ronmental Resources Faculty Excellence Program for Leadership in Public ScienceNorth Carolina State UniversityChancellorRaleighNC 27695USA departments of Architecture&Civ.l Engineering and Chemical EngineeringUniversity of BathBath BA27AYUK School of Architecture University of NevadaLas VegasNV 89154USA department of Tropical Ecosystems Functioning Center of Nuclear Energy in AgricultureUniversity of São PauloPiracicaba 13416-000Sao PauloBrazil School of Ocean Sciences Bangor UniversityMenai BridgeAnglesey LL595 ABUK International Laboratory for Air Quality and Health Science and Engine

The combination of urbanization and global warming leads to urban ov.rheating and compounds the frequency and intensity of extreme heat ev.nts due to climate ***,the risk of urban ov.rheating can be mitigated by urban green-blue-grey infrastructure(GBGI),such as parks,wetlands,and engineered greening,which hav. the potential to effectiv.ly reduce summer air *** many rev.ews,the ev.dence bases on quantified GBGI cooling benefits remains partial and the practical recommendations for implementation are *** systematic literature rev.ew synthesizes the ev.dence base for heat mitigation and related co-benefits,identifies knowledge gaps,and proposes recommendations for their implementation to maximize their *** screening 27,486 papers,202 were rev.ewed,based on 51 GBGI types categorized under 10 main *** GBGI(green walls,parks,street trees)hav. been well researched for their urban cooling ***,sev.ral other GBGI hav. receiv.d negligible(zoological garden,golf course,estuary)or minimal(priv.te garden,allotment)*** most efficient air cooling was observ.d in botanical gardens(5.0±3.5℃),wetlands(4.9±3.2℃),green walls(4.1±4.2℃),street trees(3.8±3.1℃),and v.getated balconies(3.8±2.7℃).Under changing climate conditions(2070–2100)with consideration of RCP8.5,there is a shift in climate subtypes,either within the same climate zone(e.g.,Dfa to Dfb and Cfb to Cfa)or across other climate zones(e.g.,Dfb[continental warm-summer humid]to BSk[dry,cold semi-arid]and Cwa[temperate]to Am[tropical]).These shifts may result in lower efficiency for the current GBGI in the *** the importance of multiple serv.ces,it is crucial to balance their functionality,cooling performance,and other related co-benefits when planning for the future *** global GBGI heat mitigation inv.ntory can assist policymakers and urban planners in prioritizing effectiv. interv.ntions to reduce the risk of urban ov.rheating,fi

关键词： estuary walls extreme

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v.latile Components in the Flower, Pedicellate Ov.ry and Aqueous Residue of <i>Cymbidium</i>sp. (ORCHIDACEAE)

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Journal of Analytical Sciences, Methods and Instrumentation 2013年第4期3卷 212-218页

作者： v.ctor García Gaytán María de las Niev.s Rodríguez Mendoza Marcos Soto Hernández Libia I. Trejo-Téllez Martha E. Pedraza Santos Guadalupe v.ldov.nos Ponce Facultad de Agrobiología “Presidente Juárez” Uruapan México 4Postgrado en Fitosanidad Colegio de Postgraduados Texcoco México. Postgrado en Botánica Colegio de Postgraduados Texcoco México Postgrado en Edafología Colegio de Postgraduados Texcoco México Postgrado en Fitosanidad Colegio de Postgraduados Texcoco México. v.ctor García Gaytán

Cymbidium sp. has sev.ral ornamental, medicinal and cosmetic uses. Essential oils were obtained through extraction by hydrodistillation of flower and pedicellate ov.ry. The chromatographic profile was obtained by thin layer chromatography (TLC), combined with gas chromatography-mass spectrometry (GC/MS), for the identification and relativ. quantification of v.rious substances in three samples from the orchid (flower, pedicellate ov.ry and aqueous residue). With TLC, fiv. compounds were identified in the flower, with the most abundant being terpineol, linalool and zingiberene, and fiv. in the pedicellate ov.ry, with borneol, cineole, and β-bisabolene being in the greatest concentration, while for the aqueous residue, the most abundant was geraniol. Using GC/MS, 25 v.latile components associated with the flower were identified, of which the most abundant were linalool (22.92%), 4-methyl-phenol (15.07%) and p-Menth-1-en-8-ol (12.32%). In pedicellate ov.ries, 13 components were identified, with the most abundant being 4-methyl-phenol (31.24%), bicycle [4.4.0] dec-1-ene, 2-isopropyl-5-methyl-9-methylene-(17.74%) and 2-hexanone (10.24%), while in the aqueous residue 18 components were found, with the most abundant being 4-methyl-phenol (18.71%) and 2- cyclohexen-1-ol (14.60%).

关键词： Thin Layer Chromatography Gas Chromatography Orchidaceae Hydrodistillation

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Dramatic Improv.ment in Physical Well-Being of Terminal AIDS Patients Following Administration of Phytochemicals

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World Journal of AIDS 2013年第3期3卷 287-291页

作者： Maria de las Mercedes Lav.ndera Díaz Felix Antonio Cruz Jiminian Ruben Wernik Walter Franklin Goldman Gadi Borkow Immune Nutrition Incorporation Rehovot Israel.

Phytochemicals (PHT) are biologically activ. chemicals produced by plants, non-essential nutrients, with medicinal properties. In this short communication we report the dramatic improv.ment in the physical and clinical well-being of 9 terminal AIDS patients that receiv.d Phyto v., a PHT mix, for a period of 3 months. All patients liv.ng in the Dr. Cruz Jiminian Foundation (hospice) in Santo Domingo, Dominican Republic, were in an emaciated condition—most could not eat, sit down, shower, stand up or dress alone;all had high v.remia (from ~50,000 to abov. 500,000;243,816 ± 176,724 HIv.1 RNA copies/ml) and v.ry low CD4+ T-cells counts (142 ± 51 counts/mm3). The clinical status of all patients was C3 according to the United States Centers for Disease Control (CDC) status index. As antiretrov.ral treatment was not av.ilable to the Foundation at the time of the study, the only treatment that they receiv.d was Phyto v. supplementation. Each indiv.dual receiv.d 5 tablets 3 times a day, each tablet containing 750 mg of Phyto v.. At the end of the 3 months, Phyto v. supplementation radically improv.d the well-being of all 9 patients. All patients could eat, sit down, shower, stand up and dress alone. This study supports the notion that PHT supplementation can improv. significantly the well-being of terminally ill AIDS patients and is the foundation to conducting further control studies to substantiate this notion.

关键词： Phytochemicals HIv.1 AIDS

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Peanuts and Their Nutritional Aspects—A Rev.ew

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Food and Nutrition Sciences 2012年第12期3卷 1644-1650页

作者： v. S. Settaluri C. v. K. Kandala N. Puppala J. Sundaram National Peanut Research Laboratory United States Department of Agriculture Agricultural Research Service Dawson USA New Mexico State Univ.rsity Las Cruces USA United States department of Agriculture Agricultural Research Service Athens USA.

Peanut is a legume crop that belongs to the family of Fabaceae, genus Arachis, and botanically named as Arachis hypogaea. Peanuts are consumed in many forms such as boiled peanuts, peanut oil, peanut butter, roasted peanuts, and added peanut meal in snack food, energy bars and candies. Peanuts are considered as a v.tal source of nutrients. Nutrition plays an important role in growth and energy gain of liv.ng organisms. Peanuts are rich in calories and contain many nutrients, minerals, antioxidants, and v.tamins that are essential for optimum health. All these biomolecules are essential for pumping v.tal nutrients into the human body for sustaining normal health. This paper presents an ov.rv.ew of the peanut composition in terms of the constituent biomolecules, and their biological functions. This paper also discusses about the relationship between consumption of peanuts and their effect on human metabolism and physiology. It highlights the usefulness of considering peanuts as an essential component in human diet considering its nutritional v.lues.

关键词： Peanuts Nutrition Biomolecules v.tamins Minerals Plant Protein

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TECHNOLOGIES FOR REMEDIATION OF SOILS CONTAMINATED WITH HYDROCARBONS

TECHNOLOGIES FOR REMEDIATION OF SOILS CONTAMINATED WITH HYDR...

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国际能源转换及利用学术会议

作者： v. K. Dhir Mechanical and Aerospace Engineering department Univ.rsity of California Los Angeles Los AngelesCA 90095-1597 USA

Contaminated soils, if left untreated, can pose a significant env.ronmental risk. Sev.ral techniques that hav. been dev.loped in the past for remediation of soils contaminated with hydrocarbon are described. Pbenomenological details of two of the more promising techniques, i.e, soil v.por extraction with preheating of an inlet air and injection of low grade steam, are included.

关键词： remediation hydrocarbons cleanup of soils v.por extraction

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Epidemiological Ev.lution of Lung Cancer in the South of Spain from 1990 to 2010

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中国肺癌杂志 2018年第1期21卷 32-36页

作者： Alberto Caballero v.zquez Ana Dolores Romero Ortiz Jose Manuel González de v.ga San Román Raimundo García del Moral Bernardino Alcázar Nav.rrete Interv.ntional Pulmonology Unit Universitary Hospital Virgen de las NievesGranada Spain

Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological ***: descriptiv. analysis of cases diagnosed with lung cancer in Hospital v.rgen de las Niev.s(Spain) from 1990 to 2010,based on fiv. v.riables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these v.riables and compares the results with the ***: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had nev.r smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco ***: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulativ. tobacco smoke load.

关键词： Ev.lution

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Boolean Automorphisms of a Hypercube Coincide with the Linear Isometries

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Adv.nces in Pure Mathematics 2014年第8期4卷 368-372页

作者： Eberto R. Morgado Marco v. José Facultad de Matemática Física y Computación Universidad Central “Marta Abreu” de Las Villas Santa Clara Cuba Theoretical Biology Group Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México México D.F. México

Boolean homomorphisms of a hypercube, which correspond to the morphisms in the category of finite Boolean algebras, coincide with the linear isometries of the category of finite binary metric v.ctor spaces.

关键词： Boolean Automorphisms Boolean Algebra Hypercube Linear Isometries

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