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Mushroom Poisoning Outbreaks—China,2023

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China CDC weekly 2024年第4期6卷 64-68,I0001-I0005页

作者： Haijiao li Yizhe Zhang Hongshun Zhang Jing Zhou Zuohong Chen Jiaqi liang Yu Yin Qian He Shaofeng Jiang Yutao Zhang Yuan Yuan Nan lang Bowen Cheng Jiaju Zhong Zhongfeng li Chengye Sun National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina College of life Sciences Hunan Normal UniversityChangsha CityHunan ProvinceChina

What is already known about this topic?Mushroom poisoning poses a significant food safety concern in China,with a total of 196 species identified in poisoning incidents by the end of *** is added by this report?In 2023,the China CDC conducted an investigation into 505 cases of mushroom poisoning spanning 24 provincial-level administrative *** investigation resulted in 1,303 patients and 16 deaths,yielding a case fatality rate of 1.23%.A total of 97 mushrooms were identified as the cause of 6 distinct clinical disease types,with 12 species newly documented as poisonous mushrooms in *** are the implications for public health practice?Close collaboration among CDC staff,physicians,and mycologists remains crucial for the control and prevention of mushroom poisoning in the future.

关键词： prevention yielding poisoning

A Prediction Model for detecting Dysthyroid Optic Neuropathy Based on Clinical Factors and Imaging Markers of the Optic Nerve and Cerebrospinal Fluid in the Optic Nerve Sheath

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Current Medical Science 2024年第4期44卷 827-832页

作者： Hong-yu WU Ban LUO Gang YUAN Qiu-xia WANG Ping liU Ya-li ZHAO lin-han ZHAI Wen-zhi LV Jing ZHANG lang CHEN department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China department of Ophthalmology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China department of Endocrinology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China department of Medical Imaging Guangdong Second Provincial General HospitalGuangzhou510317China department of Radiology Sir Run Run Shaw Hospital Affiliated with the School of Medicine of Zhejiang UniversityHangzhou310000China department of Artificial Intelligence Julei Technology CompanyWuhan430030China

Objective This study aimed to develop and test a model for predicting dysthyroid optic neuropathy(DON)based on clinical factors and imaging markers of the optic nerve and cerebrospinal fluid(CSF)in the optic nerve *** This retrospective study included patients with thyroid-associated ophthalmopathy(TAO)without DON and patients with TAO accompanied by DON at our *** imaging markers of the optic nerve and CSF in the optic nerve sheath were measured on the water-fat images of each patient and,together with clinical factors,were screened by Least absolute shrinkage and selection ***,we constructed a prediction model using multivariate logistic *** accuracy of the model was verified using receiver operating characteristic curve *** In total,80 orbits from 44 DON patients and 90 orbits from 45 TAO patients were included in our *** variables(optic nerve subarachnoid space and the volume of the CSF in the optic nerve sheath)were found to be independent predictive factors and were included in the prediction *** the development cohort,the mean area under the curve(AUC)was 0.994,with a sensitivity of 0.944,specificity of 0.967,and accuracy of ***,in the validation cohort,the AUC was 0.960,the sensitivity was 0.889,the specificity was 0.893,and the accuracy was *** A combined model was developed using imaging data of the optic nerve and CSF in the optic nerve sheath,serving as a noninvasive potential tool to predict DON.

关键词： dysthyroid optic neuropathy magnetic resonance imaging water-fat sequence optic nerve optic nerve subarachnoid space

基于面部全局抑郁特征局部感知力增强和全局-局部语义相关性特征融合的抑郁强度识别

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电子与信息学报 2024年第5期46卷 2249-2263页

作者：孙强李正何浪西安理工大学自动化与信息工程学院通信工程系西安710048 西安理工大学自动化与信息工程学院电子工程系西安710048 西安邮电大学计算机学院西安710121

现有基于深度学习的大多数方法在实现患者抑郁程度自动识别的过程中,主要存在两大挑战:(1)难以利用深度模型自动地从面部表情有效学习到抑郁强度相关的全局上下文信息,(2)往往忽略抑郁强度相关的全局和局部信息之间的语义一致性。为此,... 详细信息

现有基于深度学习的大多数方法在实现患者抑郁程度自动识别的过程中,主要存在两大挑战:(1)难以利用深度模型自动地从面部表情有效学习到抑郁强度相关的全局上下文信息,(2)往往忽略抑郁强度相关的全局和局部信息之间的语义一致性。为此,该文提出一种全局抑郁特征局部感知力增强和全局-局部语义相关性特征融合(PLEGDF-FGLSCF)的抑郁强度识别深度模型。首先,设计了全局抑郁特征局部感知力增强(PLEGDF)模块,用于提取面部局部区域之间的语义相关性信息,促进不同局部区域与抑郁相关的信息之间的交互,从而增强局部抑郁特征驱动的全局抑郁特征表达力。然后,提出了全局-局部语义相关性特征融合(FGLSCF)模块,用于捕捉全局和局部语义信息之间的关联性,实现全局和局部抑郁特征之间的语义一致性描述。最后,在AVEC2013和AVEC2014数据集上,利用PLEGDF-FGLSCF模型获得的识别结果在均方根误差(RMSE)和平均绝对误差(MAE)指标上的值分别是7.75/5.96和7.49/5.99,优于大多数已有的基准模型,证实了该方法的合理性和有效性。

关键词：抑郁强度人脸图像局部感知力增强全局和局部特征融合语义一致性

Classification and antioxidant assays of polyphenols:a review

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未来食品学报(英文) 2024年第3期4卷 193-204页

作者： Yuxi lang Ningxuan Gao Zhihuan Zang Xianjun Meng Yang lin Shufang Yang Yiyun Yang Zhufeng Jin Bin li College of Food Science Shenyang Agricultural UniversityShenyang 110866China College of Animal Science and Veterinary Medicine Shenyang Agricultural UniversityShenyang 110866China Key Laboratory of Marine Fishery Resources Exploitment&Utilization of Zhejiang Province Hangzhou 310014China Zhejiang Lanmei Technology Co. LtdZhuji 311800China

Polyphenols are widely recognized as the effective antioxidants,which are divided into flavonoids,phenolic acids,stilbenes,lignans,tannins and so *** could regulate internal functions and protect the body from diseases related to oxidative *** to the fact that their antioxidant capacity is influenced by the structure,stability and bioavailability,the detection of their bioactivity should be considered ***,the methods for measuring the antioxidant capacity of phenolic compounds are divided into chemical,cell-based and in vivo *** chemical assays include 2,2-diphenyl-l-picrylhydrazyl(DPPHI),2,2"-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid)(ABTS),ferric reducing/antioxidant power(FRAP),oxygen radical absorbance capacity(ORAC),peroxyI radical scavenging capacity(PSC),which are rapid identification method,but their reaction mechanism has a great gap with the internal body *** cell-based assays are more consistent with biological reaction,but still do not take the bioavailability into *** in vivo assays,which commonly utilized Caenorhabditis elegans or rats as models,are more representative,but these methods are more complex and spend *** review summarizes the antioxidant evaluation methods of phenolic compounds and discusses their advantages and limitations comparatively,which could help discriminate and select the appropriate assay in the actual operation,and facilitate the development of comprehensive approaches as well.

关键词： Polyphenols Classification Antioxidant assays Chemical assays Cell-based assays In vivo assays

Robust Timing Constraints for Granitic Magmatism and Hydrothermal Mineralization in the Tieshanlong W-Sn Ore Field,Eastern Nanling Range,South China

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Acta Geologica Sinica(English Edition) 2024年第5期98卷 1255-1269页

作者： li Wei TANG Juxing GUO Na lang Xinghai SONG Shiwei WU Zhongru PENG linlin FANG Xiang CHEN Binfeng liAN Dunmei LU Jie The Seventh Geological Brigade of Jiangxi Bureau of Geology Key Laboratory of Ionic Rare Earth Resources and EnvironmentGanzhouJiangxi 341000China College of Earth and Planetary Sciences Chengdu University of TechnologyChengdu 610059China Jiangxi Province Key Laboratory of Exploration and development of Critical Mineral Resources Nanchang 330036China MNR Key Laboratory of Metallogeny and Mineral Resource Assessment Institute of Mineral ResourcesCAGSBeijing 100037China Institute of Earth Sciences China University of GeosciencesBeijing 100083China Jiangxi Geological Bureau Nanchang 330036China Chinese Academy of Geological Sciences Beijing 100037China

The Tieshanlong ore field is an important part of the Nanling Range,which is famous worldwide for its W-Sn ***,the mineralization age of the Tieshanlong ore field is not well constrained,and our field investigation reveals that granitic emplacement occurred at different ***,previous studies have not distinguished these multiple stages of *** Tieshanlong granite complex is closely related to the Huangsha quartz vein-type W-Sn deposit and Tongling skarn-type Cu-W-Sn deposit in this *** field investigations and isotopic age analyses,this work studies the relationship between multistage magmatic activity and mineralization in the Tieshanlong ore ***-ICP-MS zircon U-Pb isotope analyses revealed that the first-and second-staged granites formed at 154.2±0.6 Ma(MSDW=1.4)and 151.2±0.4 Ma(MSDW=1.5),with zirconε_(Hf)(t)values ranging from-13.1 to-10.5 and from-14.7 to-11.1,*** data suggest that the Tieshanlong granite complex was derived from the partial melting of ancient crustal ***-ICP-MS U-Pb dating of wolframite and cassiterite reveals that W-Sn mineralization occurred at 160-150 Ma,which agrees well with the U-Pb dating results of the second-staged granite within analytical *** magmatic activity in this ore field can be divided into three stages:175-154 Ma,154-150 Ma and 150-145 *** quartz vein-and skarn-type W-Sn mineralization is closely related to second-staged fine-grained twomica granite,and formed earlier than skarn-type *** study establishes a metallogenic model for the Tieshanlong ore field,and this model has important practical significance for identifying concealed W-Sn(-Cu)deposits around other granitic complexes in the Nanling Range.

关键词： zircon U-Pb-Hf isotopes wolframite U-Pb ages cassiterite U-Pb ages metallogenic model Tieshanlong ore field Nanling Range

Mechanisms of Dangua Fang(丹瓜方)in multi-target and multi-method regulation of glycolipid metabolism based on phosphoproteomics

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Journal of Traditional Chinese Medicine 2024年第2期44卷 334-344页

作者： HENG Xianpei WANG Zhita li liang YANG liuqing HUANG Suping JIN lang HE Weidong department of Endocrinology People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004China Academy of Integrative Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122China Faculty of Humanities and Management Fujian University of Traditional Chinese MedicineFuzhou 350122China department of Geriatrics People's Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350004China

OBJECTIVE:To explore the mechanism of Dangua Fang(丹瓜方,DGR)in multi-target and multi-method regulation of glycolipid metabolism based on ***:Sprague-Dawley rats with normal glucose levels were randomly divided into three groups,including a conventional diet control group(Group A),high-fat-highsugar diet model group(Group B),and DGR group(Group C,high-fat-high-sugar diet containing 20.5 g DGR).After 10 weeks of intervention,the fasting blood glucose(FBG),2 h blood glucose[PBG;using the oral glucose tolerance test(OGTT)],hemoglobin A1c(HbA1c),plasma total cholesterol(TC),and triglycerides(TG)were tested,and the livers of rats were removed to calculate the liver ***,hepatic portal TG were tested using the Gross permanent optimization-participatiory action planning enzymatic method and phosphoproteomics was performed using liquid chromatography with tandem mass spectrometry(LC-MS/MS)analysis followed by database search and bioinformatics ***,cell experiments were used to verify the results of *** mitogen-activated protein kinase kinase kinase kinase 4(MAP4k4)and phosphorylated adducin 1(ADD1)were detected using western ***:DGR effectively reduced PBG,TG,and the liver index(Pdecreased HbA1c,TC,and hepatic portal TG(Plin and eosin(HE)staining,red oil O staining,and Masson staining of liver *** total spectrum was 805334,matched spectrum was 260471,accounting for accounting 32.3%,peptides were 19995,modified peptides were 14671,identified proteins were 4601,quantifiable proteins were 4417,identified sites were 15749,and quantified sites were *** on the threshold of expression fold change(>1.2),DGR upregulated the modification of 228 phosphorylation sites involving 204 corresponding function proteins,and downregulated the modification of 358 phosphorylation sites involving 358 corresponding function proteins,which includ

关键词： phosphoproteomics glycolipid metabolism therapeutic mechanism compound formula Dangua Fang

钴催化α-氯代羰基化合物与酮亚胺的对映选择性还原加成构建β-叔氨基酸类似物

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有机化学 2024年第4期44卷 1379-1381页

作者：田朗李法宝湖北大学化学化工学院武汉430062

手性β-氨基酸广泛存在于天然产物、药物和生物活性分子中[1],其广泛性和重要性鼓励着众多化学家去探索构建手性的方法.合成手性β-仲氨基酸的方法已非常普遍[2-3],然而,合成手性β-叔氨基酸的策略依然稀缺.从α-羰基亲电试剂出发,利用... 详细信息

手性β-氨基酸广泛存在于天然产物、药物和生物活性分子中[1],其广泛性和重要性鼓励着众多化学家去探索构建手性的方法.合成手性β-仲氨基酸的方法已非常普遍[2-3],然而,合成手性β-叔氨基酸的策略依然稀缺.从α-羰基亲电试剂出发,利用α-羰基自由基与酮亚胺进行不对称自由基加成反应有望解决该合成难点,为合成各种手性β-叔氨基酸提供新的途径(Scheme 1)[4-6].

关键词：羰基化合物亲电试剂自由基加成反应天然产物生物活性分子酮亚胺对映选择性还原加成

Unveiling inverse vulcanized polymers as metal-free,visible-light-driven photocatalysts for cross-coupling reactions

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Chinese Chemical Letters 2024年第4期35卷 142-146页

作者： lang Gao Cen Zhou Rui Wang Feng Lan Bohang An Xiaozhou Huang Xiao Zhang Fujian Key Laboratory of Polymer Science Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical EngineeringCollege of Chemistry and Materials ScienceFujian Normal UniversityFuzhou 350007China Fujian Engineering and Research Center of New Chinese Lacquer Materials College of Materials and Chemical EngineeringMinjiang UniversityFuzhou 350108China

Inverse vulcanized polymers(IVPs) that generated from elemental sulfur and smaller amounts of alkenes have found broad promising applications such as cathode materials for li-S batteries, dynamic and repairable materials, optics applications, and metal sorption. However, their exploration in organic synthesis is still unprecedented. Here we first report the application of inverse vulcanized polymers in catalysis for organic transformations. A biomass-derived inverse vulcanized polymer(IVP-EAE) is found to be capable of catalyzing cross-coupling reactions in a transition-metal-free fashion under visible *** method allows the direct C–H functionalization of pyrroles and N-arylacrylamides with(hetero)aryl halides, respectively, leading to the formation of two sets of structurally important scaffolds including pyrrole-containing biaryls and 3,3-disubstituted oxindoles with high selectivity. We anticipate this study will not only unveil the new potential of IVPs, but also offer a distinct type of catalysts for organic transformations.

关键词： Cross coupling Inverse vulcanized polymers Metal free Photocatalyst Visible light

Will the Globe Encounter the Warmest Winter after the Hottest Summer in 2023?

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Advances in Atmospheric Sciences 2024年第4期41卷 581-586页

作者： Fei ZHENG Shuai HU Jiehua MA lin WANG Kexin li Bo WU Qing BAO Jingbei PENG Chaofan li Haifeng ZONG Yao YAO Baoqiang TIAN Hong CHEN Xianmei lang Fangxing FAN Xiao DONG Yanling ZHAN Tao ZHU Tianjun ZHOU Jiang ZHU International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Nansen-Zhu International Research Centre(NZC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Monsoon System Research(CMSR) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China CAS Key Lab of Regional Climate-Environment for Temperate East Asia(RCE-TEA) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

In the boreal summer and autumn of 2023,the globe experienced an extremely hot period across both oceans and *** consecutive record-breaking mean surface temperature has caused many to speculate upon how the global temperature will evolve in the coming 2023/24 boreal *** this report,as shown in the multi-model ensemble mean(MME)prediction released by the Institute of Atmospheric Physics at the Chinese Academy of Sciences,a medium-to-strong eastern Pacific El Niño event will reach its mature phase in the following 2−3 months,which tends to excite an anomalous anticyclone over the western North Pacific and the Pacific-North American teleconnection,thus serving to modulate the winter climate in East Asia and North *** some uncertainty due to unpredictable internal atmospheric variability,the global mean surface temperature(GMST)in the 2023/24 winter will likely be the warmest in recorded history as a consequence of both the El Niño event and the long-term global warming ***,the middle and low latitudes of Eurasia are expected to experience an anomalously warm winter,and the surface air temperature anomaly in China will likely exceed 2.4 standard deviations above climatology and subsequently be recorded as the warmest winter since ***,the necessary early warnings are still reliable in the timely updated mediumterm numerical weather forecasts and sub-seasonal-to-seasonal prediction.

关键词： winter climate El Niño seasonal forecast GMST