检索结果-南通市图书馆

c-Jun N-terminal kinase 3 deficiency protects axotomized retinal ganglion cells via affecting mitochondria involved apoptosis pathway

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2019年第1期12卷 30-37页

作者： Rong-Rong wang Cheng-Fang Li de-zu wang Cheng-Wu Zhang Gui-Xiang Liu Qingdao University department of Ophthalmology Jimo Traditional Chinese Medicine Hospital department of Ophthalmology Affiliated Qingdao Hiser Hospital of Qingdao University Institute of Advanced Materials Nanjing Tech University department of Ophthalmology Affiliated Hospital of the Medical College of Qingdao University

AIM: To illustrate the isoform-specific role and mechanism of c-Jun N-terminal kinases(JNKs) in mouse optic nerve axotomy induced neurotrauma. METHODS: We firstly investigated the expression of JNK1, JNK2, and JNK3 in the retinal ganglion cells(RGCs) by double-immunofluorescent staining. Then we created optic nerve axotomy model in wild type as well as JNK1, JNK2, JNK3, isoform specific gene deficiency mice. With that, we checked the protein expression profile of JNKs and its active form, and quantified the survival RGCs number by immunofluorescence staining. We further explored the molecules underlying isoform specific protective effect by real-time polymerase chain reaction(PCR) and Western blotting assay. RESULTS: We found that all the three isoforms of JNKs were expressed in the RGCs. deficiency of JNK3, but not JNK1 or JNK2, significantly alleviated optic nerve axotomyinduced RGCs apoptosis. We further established that expression of Noxa, a pro-apoptotic member of BH3 family, was significantly suppressed only in JNK3 gene deficiency mice. But tumor necrosis factor receptor 1(TNFR1) and Fas, two key modulators of death receptor mediated apoptosis pathway, did not display obvious change in the expression. CONCLUSION: It is suggested that mitochondria mediated apoptosis, but not death receptor mediated apoptosis got involved in the JNK3 gene deficiency induced RGCs protection. Our study provides a novel insight into the isoform-specific role of JNKs in neurotrauma and indicates some cues for its therapeutics.

关键词： retinal ganglion cells c-Jun N-terminal kinases optic nerve mitochondria Noxa neurotrauma

Two New Dammarane Glycosides from the Acid Hydrolysis Product of Panax Notoginseng

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2001年第3期12卷 239-242页

作者： Rong Wei TENG Hai Zhou LI Xue Mei ZHANG Xi Kui LIU de zu wang Chong Ren YANG Kunming Institute of Botany Chinese Academy of SciencesKunming 650204

Two new dammarane glycosides named notoginsenoside T-1 and T-2 were isolated from the mild acid hydrolysis products of the root saponins of Panax notoginseng. On the basis of spectroscopic evidences, their structures were elucidated to be 6-O-beta -D-glucopyranosyl-24(25)-epoxy-3 beta ,6 alpha ,12 beta ,23 xi -tetrahydroxydammar-20(22)(E)-ene 1 and 6-O-beta -D-glucopyranosyl-24(25)-epoxy-23 xi -methoxyl-3 beta ,6 alpha ,12 beta -trihydroxydamm-ar-20(22)(E)-ene 2, respectively.

关键词： Panax notoginseng dammarane glycosides notoginsenoside T1 T2.

Two Triterpenoid Saponins from Lonicera Japonica

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2000年第4期11卷 337-340页

作者： Rong Wei TENG de zu wang Chang Xiang CHEN (Kunming Institute of Botany. Chinese Academic of Sciences. Kunming 650204) Kunming Institute of Botany Chinese Academic of Sciences Kunming 650204 China

A new triterpenoid saponin, together with a known saponin. was isolated from the flowers of Lonicera Japonica Thunb. Using chemical and spectroscopic methods, mainly 2D NMR technique, their structures were deduced to be 3-beta-D-glucopyranosyl-(1 --> 4)-beta-D-glucopyranosyl-(1 --> 3)-alpha-L-rhamnospyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl hederagenin 28-O-beta-D-glucopyranosyl-(l --> 6)-beta-D-glucopyranoside and 3-alpha-L-rhamnospyranosyl-(1 --> 2)-alpha-L-arabinopyranosyl hederagenin 28-O-alpha-L-rhamnospyranosyl- (1 --> 2)-[beta-D-xylcopyranosyl-( 1 --> 6)]-beta-D-glucopyranoside, respectively.

关键词： triterpnoid saponin Lonicera Japonica 2D NMR

Leiocyclocin A and B, Two Cyclopeptides from Goniothalamus leiocarpus

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2001年第7期12卷 607-610页

作者： Qing MU Rong Wei TENG Chao Ming LI de zu wang Yu WU Han Dong SUN Chang Qi HU Phytochemistry Laboratory Kunming Institute of BotanyChinese Acadmy of SciencesKunming 650204 School of Pharmacy Fudan UniversityShanghai 200032

Two new cyclopeptides, leiocyclocin A (1); B (2), were isolated from the seeds of Goniothalanus leiocarpus. Their structures were elucidated by means of spectral and chemical methods.

关键词： Annonaceae Goniothalamus G. Leiocarpus cyclopeptide leiocyclocin A and B

Piezoelectric properties of human dentin

在线全文

学校读者我要写书评

暂无评论

Piezoelectric properties of human dentin

HETEROPHYLLIN-A AND B,TWO CYCLOPEPTIdeS,FROM THE ROOTS OF PSEUDOSTELLARIA HETEROPHYLLA

第八届全国生物力学学术会议

作者： FENG zu-de,wang Ting (department of Materials Science and Engineering,Xiamen University,Xiamen 361005,China)

The ability of converting a mechanical stress into an electrical signal has been observed in a variety of biological tissues,primarily in connective *** phenomenon interested biologists because of its probable significance to the biological *** piezoelectricity in bone,cartilage and elephant is well documented in ***,to the knowledge of the authors,there is no report concerning

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1992年第8期3卷 629-632页

作者： Ning Hua TAN Shou Xun ZHAO a department of Phytochemistry,China Pharmaceutical University,Nanjing,210009 Jun ZHOU Hong Jie ZHANG de zu wang Chang Xiang CHEN Xiao Zhu LIU b Laboratory of Phytochemistry,Kunming Institute of Botany,Academia Sinica,Kunming,650204

Two cyclopeptides,heterophyllin A and B,have been isolated from the roots of Pseudostellaria *** structures were elucidated by chemical, spectroscopic,and enzymatic methods.

关键词： MS FAB HETEROPHYLLIN-A AND B,TWO CYCLOPEPTIdeS,FROM THE ROOTS OF PSEUDOSTELLARIA HETEROPHYLLA Gly

青岛地区糖尿病视网膜病变严重程度的相关危险因素（英文）

在线全文

学校读者我要写书评

暂无评论

国际眼科杂志 2018年第7期18卷 1174-1179页

作者：王荣荣王德祖孙金涛刘桂香山东省青岛市即墨区中医医院眼科 266200 山东省青岛市即墨区中医医院放射科 266200 山东省青岛市西海岸新区中心医院 266555 山东省青岛市青岛大学附属医院眼科 266200

目的:调查和分析青岛地区糖尿病视网膜病变的发病率及其严重程度的危险因素。方法:该调查研究分两部分:调查青岛地区2859名60岁以上的社区居民和4275名30岁以上的2型糖尿病住院患者。对所有研究对象进行眼科检查,血压及糖化血红蛋白测定... 详细信息

目的:调查和分析青岛地区糖尿病视网膜病变的发病率及其严重程度的危险因素。方法:该调查研究分两部分:调查青岛地区2859名60岁以上的社区居民和4275名30岁以上的2型糖尿病住院患者。对所有研究对象进行眼科检查,血压及糖化血红蛋白测定,并通过调查问卷获得其年龄,性别,糖尿病病程,血糖控制情况及他们对糖尿病视网膜病变的了解情况。对所有的糖尿病视网膜病变(DR)患者进行眼底检查并照相,按EDTR标准对DR严重程度分级。重度非增殖期及增殖期DR,有临床意义的糖尿病黄斑水肿患者均归为需治疗组;而轻中度非增殖期DR及无临床意义的糖尿病黄斑水肿均归为需观察组。对所得数据进行相关和回归分析以确定糖尿病视网膜病变的需治疗率和危险因素。Logistic回归模型用于估计调整患者年龄,性别,病程后的优势比(OR)和95%可信区间(CI)。结果:2859名60岁以上居民中有334例(11.68%)患有糖尿病视网膜病变,其中48(14.81%)名居民需治疗;4275名住院2型糖尿病患者中,1097例(25.66%)患有糖尿病视网膜病变,172(15.68%)例住院患者需要接受眼底激光或手术治疗。单变量和多变量回归分析显示,以下因素与糖尿病视网膜病变的需治疗率明显相关,包括:年龄(51～60岁:OR,1.68;95%CI:1.21～1.72;61～70岁:OR,1.55;95%CI:1.38～1.76);病程(11～15年:OR,2.61;95%CI:1.51～4.72;超过15年病程:OR,4.15;95%CI:2.32～5.77);血糖控制情况:(血糖控制一般:OR,2.51;95%CI:1.98～3.92;血糖控制差:OR,4.69;95%CI:3.39～6.95);对糖尿病视网膜病变的了解情况(完全不了解:OR,1.45;95%CI:1.21～1.95)。而性别,31～50岁及70岁以上年龄,<10年的糖尿病病程,高血压和胰岛素治疗均与DR的需治疗率无关。结论:青岛地区糖尿病视网膜病变的发病率和需治疗率较高。51～70岁年龄,超过10年的糖尿病病程,血糖控制欠佳,对糖尿病视网膜病变不了解是DR患者视网膜病变需治疗率的潜在危险因素。加强对51～70岁的2型糖尿病患者关于糖尿病视网膜病变的宣传教育,建立规范的社区糖尿病筛查系统,对早期防控DR的高发病率和致盲率至关重要。

关键词：糖尿病视网膜病变糖尿病发病率病程年龄

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li zu-Cheng Ye Daijun Zha department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

细菌视紫红质激子的饱和密度及激子长度的研究

在线全文

学校读者我要写书评

暂无评论

中国激光 2001年第3期28卷 269-271页

作者：黄燕萍陈树德王祖赓李庆国国家教委华东师范大学量子光学开放实验室华东师范大学物理系上海200062 复旦大学生物物理系上海200433

对光能转换生物分子细菌视紫红质 (bR)作前向立体简并四波混频实验所测得的三阶非线性电极化率和它们的时间响应 ,用光循环结构模拟的三能级模型予以解释 ,并用位相空间充满理论模拟得到激子饱和密度和激子长度。

关键词：细菌视紫红质光敏生物分子激子饱和密度激子长度