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小车运行状态下岸桥结构动力响应分析

振动工程学报 2024年第7期37卷 1200-1210页

作者：胡雄董凯郑培孙志伟穆森上海海事大学物流工程学院上海201306

本文对在役岸桥整机金属结构的动力学响应机理进行分析。基于Euler-Bernoulli梁理论建立起重机单梁结构数值模型,分析不同工况对梁结构动力响应的影响,并分析动力学方程中“离心加速度项”对岸桥的动力学响应的影响。利用一岸桥结构数... 详细信息

本文对在役岸桥整机金属结构的动力学响应机理进行分析。基于Euler-Bernoulli梁理论建立起重机单梁结构数值模型,分析不同工况对梁结构动力响应的影响,并分析动力学方程中“离心加速度项”对岸桥的动力学响应的影响。利用一岸桥结构数据建立包含结构重要分析部位如铰点、轨道梁等结构的几何特征的整机精细化数值模型。以简化质量点模拟小车,将质量与板壳单元接触,实现小车与大梁的相互作用,并应用于岸桥结构动力学分析中,考虑轨道梁非中心受力,计算得到大梁铰点的加速度响应,与实测信号结果基本一致。经计算分析发现,岸桥大梁铰点处测点的加速度实测信号频谱和计算信号频谱均表明小车运行对岸桥结构的主要影响为经过轨道接头时产生的高频冲击。同时,岸桥模型大梁上10个测点及小车的位移结果表明,当小车带额定载荷以额定速度匀速运行时,岸桥前大梁前端产生垂向拟静态位移,位移频谱表明小车主要受到垂向强迫振动。

关键词：岸边集装箱起重机小车运行质量-板壳接触法非中心受力动力响应

多肽靶向嵌合体通过促进tau蛋白特异性去磷酸化治疗阿尔茨海默病和其他tau蛋白病

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Science Bulletin 2024年第8期69卷 1137-1152页

作者：苏静芬肖越魏林郁雷慧杨孙飞王围霞尹君熊瑞李师宏张配周颖王小川郑杰王建枝 department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430030China Sino-UK Joint Laboratory of Brain Function and Injury of Henan Province Department of Physiology and PathophysiologySchool of Basic Medical SciencesXinxiang Medical UniversityXinxiang 453003China department of Pathophysiology School of Basic Medical SciencesWuhan UniversityWuhan 430030China department of Anesthesiology The First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China The Core Facility and Technical Support Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430030China Research Center for Medicine and Structural Biology Wuhan UniversityWuhan 430030China Neuroscience Research Institute and department of Neurobiology School of Basic Medical SciencesPeking UniversityKey Laboratory for NeuroscienceMinistry of Education/National Health CommissionBeijing 100083China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Abnormal hyperphosphorylation and accumulation of tau protein play a pivotal role in neurodegeneration in Alzheimer’s disease(AD)and many other *** elimination of hyperphosphorylated tau is promising for the therapy of these *** have conceptualized a strategy,named dephosphorylation-targeting chimeras(dePTACs),for specifically hijacking phosphatases to tau to debilitate its ***,we conducted the step-by-step optimization of each constituent motif to generate dePTACs with reasonable effectiveness in facilitating the dephosphorylation and subsequent clearance of pathological ***,for one of the selected chimeras,D16,we demonstrated its significant efficiency in rescuing the neurodegeneration caused by neurotoxic K18-tau seeds in ***,intravenous administration of D16 also alleviated tau pathologies in the brain and improved memory deficits in AD *** results suggested dePTACs as targeted modulators of tau phosphorylation,which hold therapeutic potential for AD and other tauopathies.

关键词： tau dephosphorylation-targeting chimeras Therapeutic potential Tauopathy

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua Zhang Shui-Hong Zhou Wei-Hong Jiang Yan Jiang Jing-Wu sun Qin-Tai Yang Xue-Zhong Li Ya-Nan sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen Xiao-Shu Zhang Hong-Quan Wei Shao-Qing Yu Dong-Dong Zhu Luo Ba zhi-Wei Cao Xu-Ping Xiao Xin Wei zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye zheng Liu Yu Xu Xiao Cai Wei Huang Ru-Xin Zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao Jia-Hong pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate School of Beijing University of Chinese Medicine BeijingChina department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between december 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

Pore structure evolution of lacustrine organic-rich shale from the second member of the Kongdian formation in the Cangdong Sag,Bohai Bay Basin,China

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Petroleum Science 2022年第2期19卷 459-471页

作者： Xiao-Ping Liu Ming Guan zhi-jun Jin Zhe Cao Jin Lai Lun-ju zheng Wen-Qi Li Biao sun Shan-Yong Chen State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Petroleum Exploration and development China National Petroleum CorporationBeijing100083China Institute of Energy Peking UniversityBeijing100871China State Key Laboratory of Shale Oil and Gas Enrichment Mechanisms and Effective development Beijing100083China Sinopec Petroleum Exploration and Production Research Institute Beijing102206China Wuxi Petroleum Geology Institute Research Institute of Petroleum Exploration and DevelopmentSinopecWuxiJiangsu 214126China Petro China Dagang Oil Field Company Tianjin300280China

Pyrolysis experiments were conducted on lacustrine organic-rich shale from Cangdong Sag in Bohai Bay Basin,China,to investigate the impact of hydrocarbon generation on shale pore structure *** evolution is found to control the transformation of organic matter,hydrocarbon products characteristics,and pore structure ***,pore volume and specific surface area increase with increasing *** low-mature stage,the retained oil content begins to increase,pore volumes show slight changes,and primary pores are occluded by the generated crude oil of high molecular weight and *** the oil-window stage,the retained oil content rapidly increases and reaches maximum,and pore volumes gradually increase with increasing thermal *** high mature stage,the retained oil content begins to decrease,and the pore volume increases considerably owing to the expulsion of liquid *** over mature stage,natural gas content significantly increases and kerogen transforms to *** organic pores are formed and the pore size gradually increases,resulting from the connection of organic pores caused the increasing thermal *** study lays a foundation for understanding variation of hydrocarbon products during the thermal evolution of lacustrine shales and its relationship with the evolution of shale reservoirs.

关键词： Lacustrine shale Pyrolysis Thermal maturity Pore structure evolution Hydrocarbon generation evolution

贝类毒素检测方法研究进展及其国内外限量要求比较分析

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食品安全质量检测学报 2024年第12期15卷 1-9页

作者：刘培海高尧华孙灿卢志晓张彩丽李林杰苏征雷质文日照海关综合技术服务中心日照276826 青岛海关技术中心青岛266002

贝类毒素是贝类产品的重要危害因子,其不仅对人类健康造成严重威胁,也影响到海产品加工及出口贸易的健康发展。许多国家和地区制定了相应的贝类毒素检测方法,并规定了贝类产品中毒素的限量要求。本文主要综述了小鼠生物法、酶联免疫吸... 详细信息

贝类毒素是贝类产品的重要危害因子,其不仅对人类健康造成严重威胁,也影响到海产品加工及出口贸易的健康发展。许多国家和地区制定了相应的贝类毒素检测方法,并规定了贝类产品中毒素的限量要求。本文主要综述了小鼠生物法、酶联免疫吸附法、液相色谱法、液相色谱-串联质谱法、生物传感器法等5种常用的贝类毒素检测方法,并分析了其发展趋势;梳理了我国及美国、欧盟、日本、韩国、澳大利亚、新西兰、西班牙等国家和地区的贝类毒素官方检测方法和限量要求,并对我国贝类毒素风险监测工作提出建议,为我国贝类产品质量安全提供数据和资源支持,对保障我国贝类产品养殖业及出口贸易的稳定发展具有重要意义。

关键词：贝类毒素检测方法限量

Nanostructured Polyelectrolyte-surfactant Complex Pervaporation Membranes for Ethanol Recovery:the Relationship between the Membrane Structure and Separation Performance

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Chinese Journal of Polymer Science 2018年第1期36卷 25-33页

作者： pei-Yao zheng Ping Zhang zhi-Wei sun Chen-Hui Zhu Quan-Fu An Ministry of Education Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science&EngineeringZhejiang UniversityHangzhou 310027China Materials Science Division of Lawrence Berkeley National Laboratory BerkeleyCA 94720USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Beijing Key Laboratory for Green Catalysis and Separation College of Environmental and Energy EngineeringBeijing University of TechnologyBeijing100124China

Polyelectrolyte-surfactant complexes（PESCs） were fabricated through the interaction of poly（acrylic acid） and four different cationic surfactants or their mixtures. PESC membranes were prepared by solution casting method and were applied in ethanol recovery from aqueous solution via pervaporation. Elemental analysis（EA）, Fourier transform infrared spectroscopy（FTIR）, water contact angle（CA） measurement, differential scanning calorimetry（DSC） and X-ray scattering were employed to characterize the composition, structure and properties of PESCs. The results reveal that the investigated PESCs are similar in hydrophobicity but different in hierarchical nanostructures. In separating 5 wt% ethanol/water mixture, PESC membranes with high crystallinity will have both low flux and ethanol selectivity because of the high packing density and low permeability of crystalline regions. Meanwhile, the hierarchical nanostructures of PESC membranes change under pervaporation environment as was revealed by in situ synchrotron radiation X-ray scattering measurement. That is, the crystalline region could melt at high temperature in swelling state, thus consequently enhancing the ethanol selectivity.

关键词： Polyelectrolyte-surfactant complex Pervaporation Ethanol recovery Crystallinity

水稻黄化早抽穗突变体hz1的基因鉴定及功能分析

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生物技术通报 2024年第7期40卷 125-136页

作者：庞梦真徐汉琴刘海燕宋娟王佳涵孙丽娜姬佩梅尹泽芝胡又川赵晓萌梁闪闪张泗举栾维江天津师范大学生命科学学院天津300387 天津市动植物抗性重点实验室天津300387

【目的】水稻的抽穗期对水稻地域适应性及水稻产量至关重要,对水稻抽穗期基因进行鉴定及功能分析,可以为水稻育种提供优异的基因资源。【方法】通过BSA-seq方法对一个黄化早抽穗突变体hz1(huangzao1)进行基因定位克隆及连锁分析;利用RT-... 详细信息

【目的】水稻的抽穗期对水稻地域适应性及水稻产量至关重要,对水稻抽穗期基因进行鉴定及功能分析,可以为水稻育种提供优异的基因资源。【方法】通过BSA-seq方法对一个黄化早抽穗突变体hz1(huangzao1)进行基因定位克隆及连锁分析;利用RT-qPCR技术分析目的基因HZ1的表达谱,并用水稻原生质体瞬时转化查明HZ1的亚细胞定位;对突变体的抽穗期、叶绿素含量、过氧化氢含量等生理指标进行测定,详细分析其表型变化。【结果】田间表型观察发现hz1表现早抽穗,长日照(long-day,LD)及短日照(short-day,SD)条件下hz1的抽穗期相同,分别比野生型(wild type,WT)早抽穗43 d和26 d,表明hz1是一个光周期不敏感的突变体。同时hz1表现黄化表型,相比WT,叶绿素含量下降。遗传分析表明hz1由隐性单基因控制,F2混池高通量测序将目的基因定位于水稻第6染色体上17.8 Mb区间内,分析发现该区间内一个T-DNA插入位点LOC_Os06g40080与hz1目标性状完全连锁,LOC_Os06g40080为已知的SE5基因,编码血红素加氧酶1(heme oxygenase 1,HO1)。HZ1/SE5在叶片中高表达,在LD及SD条件下具有昼夜节律性表达。亚细胞定位发现HZ1/SE5蛋白定位于叶绿体中。表达调控分析表明HZ1/SE5主要通过调控水稻成花素Hd3a和RFT1的表达来调控水稻的抽穗期;并通过调控叶绿素合成途径相关基因的表达水平影响水稻叶绿素水平变化。【结论】黄化早抽穗突变体hz1由于血红素加氧酶编码基因SE5突变导致其对光周期不敏感,HZ1/SE5基因通过调控水稻成花素基因及叶绿素合成途径相关基因的表达而影响水稻的抽穗期及叶片的黄化。

关键词：水稻黄化早抽穗突变体基因克隆血红素加氧酶1

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Twist drill craniostomy for traumatic acute subdural hematoma in the elderly: case series and literature review

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Chinese Neurosurgical Journal 2019年第2期5卷 121-128页

作者： pei-kun Huang Yong-zhong sun Xue-ling Xie de-zhi Kang Shu-fa zheng pei-sen Yao Fujian Medical University Fuzhou 350004China department of Neurosurgery Hui'an County HospitalHui'an 362100China department of Neurosurgery The First Affiliated Hospital of Fujian Medical UniversityNO.20 Chazhong RoadTaijiang DistrictFuzhou 350004China The First Clinical Medical College of Fujian Medical University NO.20 Chazhong RoadTaijiang DistrictFuzhou 350004China

Background:A large craniotomy is usually the first choice for removal of traumatic acute subdural hematoma (TASDH).To date,few studies have reported that TASDH could be successfully treated by twist drill craniostomy (TDC) alone or combined with instillation of *** aimed to define the TDC for the elderly with TASDH and performed literature *** presentation:A total of 7 TASDH patients,who were presented and treated by TDC in this retrospective study between January 2009 and May 2017,consisted of 5 men and 2 women,ranging in age from 65 to 89 (average,78.9) *** patients' baseline characteristics,including age,sex,medical history,received ventriculoperitoneal shunt for hydrocephalus or not,reason for avoiding or refusing large craniotomy,preoperative Glasgow Coma Scale (GCS),suffered from cerebral herniation or not,the location of TASDH,imaging characteristics of TASDH in CT scan,injury/surgery time interval,midline shift,preoperative neurologic deficit,operation time,and infusions of urokinase or not,were *** postoperative GCS,postoperative neurologic deficit,rebleeding or not,intracranial infection,and modified Rankin Scale (mRS) at 6 months after surgery were analyzed to access the safety and efficacy of evacuation with *** results showed that the mean time interval from injury to TDC was 68.6 min (30-120 min).The mean distance of midline shift was 14.6 mm (10-20 mm).The preoperative GCS in all patients ranged from 4 to 13(median,9).The mean duration of the operation was 14.4 min (6-19 min).Postoperative CT scan showed that hematoma evacuation rate was more than 70% in all *** were no cases of acute rebleeding and intracranial infection after *** cases presented with chronic SDH at the ipsilateral side within 6 months after being treated by TDC alone or combined with instillation of *** outcomes were shown in all cases (mRS scores 0-2) at 6 months after ***:TASDH in the elderly could be

关键词： Traumatic acute subdural hematoma Cerebral herniation Twist drill craniostomy Pre-injury antiplatelet therapy The elderly

High-temperature polymer-based nanocomposites for high energy storage performance with robust cycling stability

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Rare Metals 2023年第11期42卷 3682-3691页

作者： Yi-Fan Chen Yan-Tao zheng Feng-Yuan Zhang zhi-Gang Liu Ling-Yu Zhang Lu Yang Xin-Di sun Yuan deng Yao Wang School of Materials Science and Engineering Beihang UniversityBeijing100191China department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen518055China Hangzhou Innovation Institute Beihang UniversityHangzhou310052China

High-power capacitors are highly demanded in advanced electronics and power systems,where rising concerns on the operating temperatures have evoked the attention on developing highly reliable high-temperature dielectric ***,polyetherimide(pei)filled with highly insulating Al_(2)O_(3)(AO)nanoparticles dielectric composite films have been fabricated aiming for high thermal stability and reliability operated under high cycling electric field and elevated *** room temperature,incorporating a small fraction of 0.5 vol%AO nanoparticles gives rise to a highest discharged energy density(U_(e))of 5.57 J·cm^(-3)and efficiency(η)of 90.9%at650 MV·m^(-1),and a robust cycling stability up to 10^(7) cycles at 400 MV·m^(-1).Due to the substantially reduced dielectric loss,2.0 vol%AO/pei nanocomposite film exhibits excellent high-temperature capacitive performances,delivering U_(e)~7.33 J·cm^(-3)withη~88.8%under 700 MV·m^(-1),and cycling stability up to 10^(6) cycles under 400 MV·m^(-1)at 100℃,and U_(e)~5.57 J·cm^(-3)withη~84.7%under 620 MV·m^(-1)at 150℃.Molecular dynamic simulations are performed to understand the microscopic mechanism via revealing the polymer relaxation process in the AO/pei composite at elevated *** results are therefore very encouraging for high-temperature high-power capacitor application.

关键词： Polymer-based nanocomposites Dielectric Energy storage Temperature stability