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New paradigm of oral rehydration in patients affected by irritable bowel syndrome with chronic diarrhea

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World Journal of gastrointestinal Pharmacology and Therapeutics 2024年第1期15卷 1-4页

作者： Marco Chiarelli Matilde de simone gerardo Cioffi Ugo Cioffi department of Emergency and Robotic Surgery A.Manzoni Hospital–ASST LeccoLecco 23900Italy department of Surgery University of MilanVia F.Sforza 3520122 MilanoMilano 20122Italy department of Sciences and Technologies UnisannioBenevento 82100Italy department of Surgery University of MilanMilano 20122Italy

Irritable bowel syndrome with diarrhea is a very frequent clinical condition characterized by disabling intestinal *** disease presents with daily abdominal pain for at least 3 months related to defecation and associated with a change in the frequency of bowel movements and the shape of the *** surveys about this disease report a global prevalence of about 1.5%.A new amino acid based electrolyte solution has recently been commercialized for oral rehydration in *** is composed of water,electrolytes,and five selected amino acids that function as sodium co-transporters without containing *** recent years,some studies explored the effectiveness of the amino acid based electrolyte beverage in oncologic patients with gastrointestinal mucositis,reporting good ***,a prospective study to evaluate the clinical impact of the amino acid based medical beverage was conducted in patients with diarrhea predominant irritable bowel *** research was based on a real-life methodology minimizing the disruption of the routine *** hundred patients suffering from irritable bowel syndrome with diarrhea drank a solution based on selected amino acids twice a day for 2 *** enrolled patient completed the study and showed a significant response rate with regard to stool consistency and pain *** on this data,we can hypothesize that the amino acid based oral rehydration solution could be a valid tool in the treatment of patients affected by irritable bowel syndrome with *** is certainly necessary to plan highquality clinical trials comparing glucose based oral solutions and amino acid based solutions in patients with persisting *** in the near future all oral rehydration solutions will contain amino acids.

关键词： Diarrhea Irritable bowel syndrome Diarrhea-predominant irritable bowel syndrome Medical food Amino acid beverage formulation

主动脉根部扩张与接受治疗的高血压患者心血管事件发生率有关：Campania Salute网络

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中华高血压杂志 2019年第9期27卷 898-898页

作者： Canciello g Mancusi C Losi MA Izzo R Trimarco B de simone g de Luca N 陈云(译) 叶鹏(校) 不详

在基于人群的研究中发现,位于主动脉窦的主动脉根部内径(aortic root dimension,ARD)与心血管事件发生率相关,但这样的影响可能是因为左心室质量增加导致的。目前主动脉根部扩张也没有明确的定义。因此,本研究分析Campania Salute网络... 详细信息

在基于人群的研究中发现,位于主动脉窦的主动脉根部内径(aortic root dimension,ARD)与心血管事件发生率相关,但这样的影响可能是因为左心室质量增加导致的。目前主动脉根部扩张也没有明确的定义。因此,本研究分析Campania Salute网络登记处的研究对象,旨在:①建立ARD评估标准;②提出主动脉根部扩张的临界值;

关键词：主动脉根部扩张高血压患者心血管事件 Campania Salute

Distributed Adaptive Resource Allocation:An Uncertain Saddle-Point Dynamics Viewpoint

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IEEE/CAA Journal of Automatica Sinica 2023年第12期10卷 2209-2221页

作者： Dongdong Yue simone Baldi Jinde Cao Qi Li Bart de Schutter the School of Mathematics Southeast UniversityNanjing 210096China IEEE the Yonsei Frontier Laboratory Yonsei UniversitySeoul 03722South Korea the School of Automation Southeast UniversityNanjing 210096China the delft Center for Systems and Control Delft University of TechnologyDelft 2628 CDThe Netherlands

This paper addresses distributed adaptive optimal resource allocation problems over weight-balanced *** leveraging state-of-the-art adaptive coupling designs for multiagent systems,two adaptive algorithms are proposed,namely a directed-spanning-tree-based algorithm and a node-based *** benefits of these algorithms are that they require neither sufficiently small or unitary step sizes,nor global knowledge of Laplacian eigenvalues,which are widely required in the *** is shown that both algorithms belong to a class of uncertain saddle-point dynamics,which can be tackled by repeatedly adopting the Peter-Paul inequality in the framework of Lyapunov *** to this new viewpoint,global asymptotic convergence of both algorithms can be proven in a unified *** effectiveness of the proposed algorithms is validated through numerical simulations and case studies in IEEE 30-bus and 118-bus power systems.

关键词： Adaptive systems directed graphs resource alloca-tion saddle-point dynamics

Dysfunction of the adhesion g protein-coupled receptor latrophilin 1(ADgRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany german Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.g protein-coupled receptors(gPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some gPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion gPCR latrophilin 1(ADgRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADgRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

The Magical-Sophistical delusion:Third-Wave-Feminism and Its Philosophical Roots

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Journal of Sociology Study 2024年第2期14卷 119-128页

作者： Claudia simone Dorchain Independent scholar Heining-les-BouzonvilleFrance

The content of current third-wave feminism differs significantly from that of previous feminist movements,which sought equal human and civil rights for *** third-wave feminism,gender is primarily understood as a social category that is linguistically *** now classic work gender Trouble(1990)by philosopher Judith Butler is decisive for this“linguistic turn”in the social ***,Butler’s work is systematically based on two philosophical traditions that are already highly controversial in themselves:sophism and existentialism,linked to a pre-modern magical *** following essay is a critique of these lines of tradition,followed by the question of the extent to which they can serve citizens of an enlightened society in naming and constructively addressing actual social grievances.

关键词： third-wave feminism emancipation Judith Butler sophistry existentialism

Corrigendum to ‘Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes’ [gene Dis (10) (2023),1187–1189]

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genes & Diseases 2024年第2期11卷 1084-1084页

作者： giovanna Forte Filomena Cariola Antonia Lucia Buonadonna Anna Filomena guglielmi Andrea Manghisi Katia de Marco Valentina grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo Nicoletta Resta Vittoria Disciglio Cristiano simone Medical genetics National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Medical genetics Department of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J) University of Bari Aldo Moro Bari 70124 Italy

在动脉性高血压患者中,是否心脏收缩和舒张功能信息有助于预测由左心室肥大而造成的心血管事件?

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中华高血压杂志 2010年第10期18卷 969-969页

作者：张玲玉叶鹏 de simone g Izzo R Chinali M de Marco M Casalnuovo g Rozza F girfoglio D Iovino gL Trimarco B de Lu-ca N

左心室质量（left ventricular mass，LVM）是高血压患者超声心电图检查中最重要的指标。但独立于LVM，左心室功能也能够预测心血管风险。目前没有证据表明，与单纯的LVM相比，左心室功能联合LVM能够显著提高对心血管风险的预测价值。... 详细信息

左心室质量（left ventricular mass，LVM）是高血压患者超声心电图检查中最重要的指标。但独立于LVM，左心室功能也能够预测心血管风险。目前没有证据表明，与单纯的LVM相比，左心室功能联合LVM能够显著提高对心血管风险的预测价值。因此，在无常见心血管疾病的高血压门诊病人5380例（女性2336例，糖尿病298例，肥胖者1315例）中，

关键词：高血压患者预测价值心血管事件左心室肥大功能信息心脏收缩动脉性心血管风险

3D bioprinting:current status and trends-a guide to the literature and industrial practice

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Bio-design and Manufacturing 2022年第1期5卷 14-42页

作者： Silvia Santoni simone g.gugliandolo Mattia Sponchioni Davide Moscatelli Bianca M.Colosimo department of Mechanical Engineering Politecnico di MilanoVia La Masa120156 MilanItaly department of Chemistry Materials and Chemical Engineering“Giulio Natta”Politecnico di MilanoPiazza Leonardo da Vinci3220133 MilanItaly

The multidisciplinary research field of bioprinting combines additive manufacturing,biology and material sciences to cre-ate bioconstructs with three-dimensional architectures mimicking natural living *** high interest in the possibility of reproducing biological tissues and organs is further boosted by the ever-increasing need for personalized medicine,thus allowing bioprinting to establish itself in the field of biomedical research,and attracting extensive research efforts from companies,universities,and research institutes *** this context,this paper proposes a scientometric analysis and critical review of the current literature and the industrial landscape of bioprinting to provide a clear overview of its fast-changing and complex *** scientific literature and patenting results for 2000-2020 are reviewed and critically analyzed by retrieving 9314 scientific papers and 309 international patents in order to draw a picture of the scientific and industrial landscape in terms of top research countries,institutions,journals,authors and topics,and identifying the technology hubs *** review paper thus offers a guide to researchers interested in this field or to those who simply want to under-stand the emerging trends in additive manufacturing and 3D bioprinting.

关键词： Additive manufacturing 3D bioprinting Biofabrication Organ-on-a-chip Tissue engineering

A Bioinspired Robot growing like Plant Roots

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Journal of Bionic Engineering 2023年第5期20卷 2044-2058页

作者： giovanni Bianchi Aldo Agoni simone Cinquemani department of Mechanics Politecnico di MilanoVia La Masa 1Milano20156LombardiaItaly

Plants are usually considered static organisms,but they can perform a wide range of movements that can be a source of inspiration for *** roots’growing motion is the most noteworthy since they are excellent diggers that can move in unstructured environments and navigate past ***,root growth has a high energy efficiency since it penetrates the soil at its tip,adding new material without displacing the already grown portion,minimizing the energy dissipation due to friction and lowering the inertia.A robot inspired by the growth of roots could be used in search and rescue or environmental *** design of a soft robot inspired by root growth is presented in this *** robot body consists of a cylindrical plastic membrane folded inside *** robot body is inflated,and its tip is everted,expanding its length as air is blown from the *** straps are placed on the membrane’s exterior surface to keep it *** head is positioned inside the tip,which houses the mechanism that controls the growth *** consists of housing for two balloons that are selectively inflated,and their expansion applies pressure on the exterior surface,opening the Velcro straps and determining the growth *** robot was constructed,and a kinematic model of its motion in the plane was created and compared with experimental *** error in predicting the turning angle is only 5%,and the resulting predicted position differs on average by 55 mm on a total length of 850 mm.

关键词： Soft robot Pneumatic actuation Bioinspired robot growing robot Plant root