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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 118-128页

作者： Xiaoshuang Li Dmitry sukhomlinov Zaiqing que Aerosint sA B-4040 HerstalBelgium Aalto University Department of Chemical and Metallurgical EngineeringEspoo 02150Finland VTT technical Research Centre of Finland Espoo 02044Finland

Multi-material laser-based powder bed fusion (PBF-LB) allows manufacturing of parts with 3-dimensional gradient and additional functionality in a single step. This research focuses on the combination of thermally-conductive CuCr1Zr with hard M300 tool *** interface configurations of M300 on CuCr1Zr and CuCr1Zr on M300 were investigated. Ultra-fine grains form at the interface due to the low mutual solubility of Cu and steel. The material mixing zone size is dependent on the configurations and tunable in the range of0.1–0.3 mm by introducing a separate set of parameters for the interface layers. Microcracks and pores mainly occur in the transition *** of these defects, the thermal diffusivity of bimetallic parts with 50vol% of CuCr1Zr significantly increases by 70%–150%compared to pure M300. The thermal diffusivity of CuCr1Zr and the hardness of M300 steel can be enhanced simultaneously by applying the aging heat treatment.

关键词： multi-material additive manufacturing laser-based powder bed fusion thermal diffusivity dissimilar metals copper alloy

Combustion mechanism of benzene in iron ore sintering process:experimental and simulation

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Journal of Iron and steel Research International 2024年第1期31卷 195-203页

作者： Zhi-gang que Jin-ming shi Xian-bin Ai Institute of Energy Research Jiangxi Academy of ScienceNanchang330096JiangxiChina Jiangxi Carbon Neutralization Research Center Nanchang330096JiangxiChina

Benzene is a typical component of volatile organic compounds(VOCs)in the iron ore sintering flue *** combustion behavior of benzene directly affects the emission of VOCs in iron ore sintering *** effects of temperature,benzene,and oxygen concentrations on the conversion ratio of benzene were investigated by experiments and numerical *** experiments were carried out in a tube reactor at temperatures of 773-1098 K,benzene concentrations of 0.01-0.03 vol.%,and oxygen concentrations of 10-21 vol.%.The numerical simulation was performed with the plug flow model in the CHEMKIN program based on a kinetic model that consists of 132 chemical species and 772 elementary step-like *** experimental results reveal that increasing the temperature and benzene concentration could signifi-cantly promote benzene *** is attributed to the increase in the reaction rates of all steps in the pathway for forming CO_(2)and H_(2)*** addition,due to the large equivalent ratio of oxygen to benzene,the conversion ratio of benzene remained constant at different oxygen *** simulation results were in good agreement with the experimental results and indicated that six elementary reactions dominated the formations of CO_(2)and H_(2)*** oxidations of C_(6)H_(5)O,CO,and C_(5)H_(4)O intermediates to CO_(2)were the limiting steps in the reaction pathways.

关键词： Benzene Volatile organic compound Iron ore sinter Combustion simulation temperature Oxygen

Fantastic voyage: The journey of NLRP3 inflammasome activation

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Genes & Diseases 2024年第2期11卷 819-829页

作者： Xiangyong que sihao Zheng Qibin song Huadong Pei Pingfeng Zhang Cancer Center Renmin Hospital of Wuhan UniversityWuhanHubei 430060China department of Oncology Georgetown Lombardi Comprehensive Cancer CenterGeorgetown University Medical CenterWashingtonDC 20057USA

NLRP3 inflammasome,an intracellular multiprotein complex,can be activated by a range of pathogenic microbes or endogenous hazardous *** activation results in the release of cytokines such as IL-1β and IL-18,as well as Gasdermin D which eventually causes *** activation of NLRP3 inflammasome is under strict control and regulation by numerous pathways and *** excessive activation can lead to a persistent inflammatory response,which is linked to the onset and progression of severe *** studies have revealed that the subcellular localization of NLRP3 changes significantly during the activation *** this review,we review the current understanding of the molecular mechanism of NLRP3 inflammasome activation,focusing on the subcellular localization of NLRP3 and the associated regulatory *** aim to provide a comprehensive understanding of the dynamic transportation,activation,and degradation processes of NLRP3.

关键词： Inflammasome activation Innate immunity NLRP3 NLRP3 inflammasome subcellular localization

An improved deviation model for transonic stages in axial compressors

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Chinese Journal of Aeronautics 2024年第7期37卷 93-108页

作者： Xiaochen WANG Xuesong LI Xiaodong REN Chunwei GU Xiaobin que Guoyu ZHOU department of Energy and Power Engineering Tsinghua UniversityBeijing 100084China China United Gas Turbine technology Co.Ltd. Beijing 102209China

deviation model is an important model for through-flow analysis in axial *** analysis in classical deviation models is developed under the assumption of onedimensional flow,which is controlled by the continuity *** consider three-dimensional characteristics in transonic flow,this study proposes an improved theoretical analysis method combining force analysis of the blade-to-blade flow with conventional analysis of the continuity *** of shock structures on transverse force,streamwise velocity and streamline curvature in the blade-to-blade flow are analyzed,and support the analytical modelling of density flow ratio between inlet and outlet ***,a novel deviation model for transonic stages in axial compressors is proposed in this *** empirical coefficients are corrected based on the experimental data of a linear cascade,and the prediction accuracy is validated with the experimental data of a three-stage transonic *** novel model provides accurate predictions for meridional flow fields at the design point and performance curves at design speed,and shows obvious improvements on classical models by Carter and C¸etin.

关键词： Axial compressor Transonic flow deviation model Through-flow method Aerodynamic performance

Infiltration,runoff,and slope stability behaviors of infinite slope with macropores based on an improved Green–Ampt model

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Journal of Mountain science 2024年第7期21卷 2220-2235页

作者： LI shanghui WU Guoxiong que Yun JIANG Zhenliang CHENG Gaoyun College of Intelligent Construction Fuzhou University of International Studies and TradeFuzhou 350202China College of Civil Engineering Chongqing Jiao Tong UniversityChongqing 400074China Chongqing Vocational College of Architectural Engineering Chongqing 400072China College of Civil Engineering Fuzhou UniversityFuzhou 350000China department of Civil and Environmental Engineering Hong Kong University of Science and TechnologyHong Kong 999077China T.Y.Lin International Engineering Consulting(China)Co.Ltd Chongqing 401120China

Infiltration–runoff–slope instability mechanism of macropore slope under heavy rainfall is *** paper studied its instability mechanism with an improved Green–Ampt(GA)model considering the dual-porosity(i.e.,matrix and macropore)and ponding condition,and proposed the infiltration equations,infiltration–runoff coupled model,and safety factor calculation *** show that the infiltration processes of macropore slope can be divided into three stages,and the proposed model is rational by a comparative *** wetting front depth of the traditional unsaturated slope is 17.2%larger than that of the macropore slope in the early rainfall stage and 27%smaller than that of the macropore slope in the late rainfall ***,macropores benefit the slope stability in the early rainfall but not in the *** flow does not occur initially but becomes pronounced with increasing rainfall *** equal depth of the wetting front in the two domains is regarded as the onset criteria of macropore *** analysis shows that macropore flow is delayed by increasing proportion of macropore domain(ω_(f)),whereas promoted by increasing ratio of saturated permeability coefficients between the two domains(μ).The increasing trend of ponding depth is sharp at first and then grows ***,when rainfall duration is less than 3 h,ωf andμhave no significant effect on the safety factor,whereas it decreases with increasingωf and increases with increasingμunder longer duration(≥3 h).With the increase ofω_(f),the slope maximum instability time advances by 10.5 h,and with the increase ofμ,the slope maximum instability time delays by 3.1 h.

关键词： Macropore slope Green–Ampt infiltration model Equivalent wetting front Ponding response time slope stability

Characteristics and influencing factors of CO_(2) emission from inland waters in China

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science China Earth sciences 2024年第6期67卷 2034-2055页

作者： Ting ZHOU Xiaofeng WANG Zuolin XIAO Zhaoyin QING Xianxiang LI Jilong WANG Ziyi que Chongqing Key Laboratory of Carbon Cycling and Carbon Regulation in Mountainous Ecosystems Chongqing 401331China school of Geography and Tourism Chongqing Normal UniversityChongqing 401331China Chongqing Field Observation and Research station of Earth surface Ecological Processes in Three Gorges Reservoir Area Chongqing 405400China school of Earth system science Tianjin UniversityTianjin 300072China

Inland water bodies,being the most active biogeochemical cycle reactors,play a pivotal role in the global carbon cycle and CO_(2) *** study integrates existing observation dataset of CO_(2) flux(fCO_(2))in rivers,lakes and reservoirs in China,to elucidate their spatial-temporal patterns and key influencing factors and to reappraise the significance for regional carbon *** showed that,the fCO_(2) in rivers,lakes and reservoirs in China presented significant variability with large range of-379.3-4947.6,-160.1-785.0 and -74.0-1603.1 mg CO_(2)m-2h^(-1),*** median of the fCO_(2) in rivers was of 228.5 mg CO_(2)m^(-2)h^(-1),observably higher than these in lakes and reservoirs(26.0 and 28.3 mg CO_(2)m^(-2)h^(-1),respectively).The fCO_(2)in rivers and reservoirs exhibited similar decreasing trend from south to north as a result of universal climate restraint,the averaged fCO_(2) in Pearl River and Yangtze River basins showed much higher than that in Northeastern ***,the averaged fCO_(2) in the Mongolia-Xinjiang lake district and the Northeast lake district were higher than other lake districts,followed by the Qinghai-Xizang lake district,and the Eastern and Yungui lake district were generally low,contradicting the climatic *** water primary production enhancement resulting from human activities was the main driver of spatial variation in the fCO_(2) in ***,the fCO_(2) in rivers presented seasonal pattern with higher wet season than dry season,while opposite patterns were found in lakes and *** temperature,precipitation and water primary production were main ***,it showed pH was a key factor indicating the variability of the fCO_(2) levels either in rivers,lakes or in *** lakes,the fCO_(2) is closely linked to chlorophyll a(Chl-a)and dissolved oxygen(DO),whereas,the fCO_(2) in rivers is primarily associated with organic carbon(OC)and total nitrogen(TN),highlighting the dive

关键词： Rivers/lakes/reservoirs CO_(2) emission spatio-temporal variability Influence factors Regional contribution

Manipulator tracking technology based on FsRUKF

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Journal of systems Engineering and Electronics 2024年第2期35卷 473-484页

作者： sHI Guoqing ZHANG Boyan ZHANG Jiandong YANG Qiming HUANG Xiaofeng que Jianyao PU Junwei GENG Xiutang school of Electronics and Information Northwestern Polytechnical UniversityXi’an 710072China Northwest Institute of Mechanical&Electrical Engineering Xianyang 712000China

Aiming at the shortcoming that the traditional industrial manipulator using off-line programming cannot change along with the change of external environment,the key technologies such as machine vision and manipulator control are studied,and a complete manipulator vision tracking system is ***,denavit-Hartenberg(D-H)parameters method is used to construct the model of the manipulator and analyze the forward and inverse kinematics equations of the *** the same time,a binocular camera is used to obtain the threedimensional position of the ***,in order to make the manipulator track the target more accurately,the fuzzy adaptive square root unscented Kalman filter(FsRUKF)is proposed to estimate the target ***,the manipulator tracking system is built by using the position-based visual *** simulation experiments show that FsRUKF converges faster and with less error than the square root unscented Kalman filter(sRUKF),which meets the application requirements of the manipulator tracking system,and basically meets the application requirements of the manipulator tracking system in the practical experiments.

关键词： square root unscented Kalman filter(sRUKF) fuzzy inference manipulator visual servo

sugarcane transcription factor scWRKY4 negatively regulates resistance to pathogen infection through the JA signaling pathway

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The Crop Journal 2024年第1期12卷 164-176页

作者： Dongjiao Wang Wei Wang shoujian Zang Liqian Qin Yanlan Liang Peixia Lin Yachun su Youxiong que Key Laboratory of sugarcane Biology and Genetic Breeding Ministry of Agriculture and Rural AffairsKey Laboratory of GeneticsBreeding and Multiple Utilization of CropsMinistry of EducationCollege of AgricultureFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina National Key Laboratory for Tropical Crop Breeding Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesSanya 572024HainanChina

WRKY transcription factors,transcriptional regulators unique to plants,play an important role in defense response to pathogen ***,the resistance mechanisms of WRKY genes in sugarcane remain *** the present study,gene ontology(GO)enrichment analysis revealed that WRKY gene family in sugarcane was extensively involved in the response to biotic stress and in defense *** identified gene scWRKY4,a classⅡc member of the WRKY gene family,in sugarcane cultivar *** gene was induced by salicylic acid(sA)and methyl jasmonate(MeJA)***,expression of scWRKY4 was down-regulated in smut-resistant sugarcane cultivars but up-regulated in smutsusceptible sugarcane cultivars infected with sporisorium ***,stable overexpression of the scWRKY4 gene in Nicotiana benthamiana enhanced susceptibility to Fusarium solani *** and caused down-regulated expression of immune marker-related *** analysis indicated suppressed expression of most JAZ genes in the signal transduction ***4 interacted with scJAZ13 to repress its *** thus hypothesized that the scWRKY4 gene was involved in the regulatory network of plant disease resistance,most likely through the JA signaling *** present study depicting the molecular involvement of scWRKY4 in sugarcane disease resistance lays a foundation for future investigation.

关键词： Disease resistance Expression profile Transcriptome analysis WRKY transcription factors

Research on the Index system of Old Neighborhood Renovation Based on Green Building Evaluation standard

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Journal of Architectural Research and development 2024年第3期8卷 140-146页

作者： Yufei que school of Architecture Chang’an UniversityXi’an 710061Shaanxi ProvinceChina

With the advancement of the transformation,the contradiction between the residents’demand for a better living environment and the convenience of living in the settlements comes to the *** identification,organic integration,timely adoption,and correct decision-making for the transformation of old neighborhoods are pressing issues in the transformation of old ***,this paper takes the green building evaluation standards of various countries as the research basis and support for the construction of the transformation strategy of old *** the collection and comparative analysis of the indicators of green building evaluation standards,the index system of transformation is formed,and it also provides a certain foundation for the subsequent related research.

关键词： Old neighborhoods Green building evaluation standards Renovation Criteria

small molecule conjugates with selective estrogen receptor β agonism promote anti-aging benefits in metabolism and skin recovery

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Acta Pharmaceutica sinica B 2024年第5期14卷 2137-2152页

作者： Tarik Zahr Vijay K.Boda Jian Ge Lexiang Yu Zhongzhi Wu Jianwen que Wei Li Li Qiang Naomi Berrie Diabetes Center Columbia UniversityNew YorkNY 10032USA department of Molecular Pharmacology and Therapeutics Columbia UniversityNew YorkNY 10032USA department of Pharmaceutical sciences College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Drug Discovery Center College of PharmacyUniversity of Tennessee Health Science CenterMemphisTN 38163USA Division of Digestive and Liver Diseases Columbia UniversityNew YorkNY 10032USA Center for Human development Columbia UniversityNew YorkNY 10027USA department of Pathology and Cell Biology Columbia UniversityNew YorkNY 10032USA department of Medicine Columbia UniversityNew YorkNY 10032USA

Estrogen is imperative to mammalian reproductivity,metabolism,and ***,the hormone activating estrogen receptor(ERs)αcan cause major safety concerns due to the enrichment of ERαin female tissues and certain *** contrast,ERβis more broadly expressed in metabolic tissues and the ***,it is desirable to generate selective ERβagonist conjugates for maximizing the therapeutic effects of ERs while minimizing the risks of ERα***,we report the design and production of small molecule conjugates containing selective non-steroid ERβagonists Gtx878 or *** of aged mice with our synthesized conjugates improved aging-associated declines in insulin sensitivity,visceral adipose integrity,skeletal muscle function,and skin health,with validation in *** further uncovered the benefits of ERβconjugates in the skin using two inducible skin injury mouse models,showing increased skin basal cell proliferation,epidermal thickness,and wound ***,our ERβ-selective agonist conjugates offer novel therapeutic potential to improve aging-associated conditions and aid in rejuvenating skin health.

关键词： Estrogen receptorβ Aging Metabolism skin injury Muscle metabolism small molecule conjugates Regeneration Adiposity