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Supramolecular Polymerization of Hydrogen-Bonded Trimers in Bulk and Aqueous Medium

第十一届全国免疫学学术大会

作者： Chen Kang Chen Hao Li jiahong Faas Marijke M de haan bart j de Vos Paul Sun jia State Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan University School of Medicine Jiangnan University

Both beneficial and diabetogenic effects have been attributed to consumption of dietary *** fibers may be fermented by gut microbiota to produce health-promoting short chain fatty acids(SCFA)and modulate gut immune **... 详细信息

关键词： Type 1 diabetes nutritional intervention inulin type fructan immunomodulation

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CCS Chemistry 2024年第6期6卷 1458-1465页

作者： Freek V.de Graaf Stef A.H.jansen Sandra M.C.Schoenmakers Bas van Genabeek Marle E.j.Vleugels bart W.L.van den Bersselaar E.W.Meijer Ghislaine Vantomme Institute for Complex Molecular Systems Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Chemistry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthetic molecules that form functional noncovalent assemblies in water have received much attention for their potential applications as *** this work,we introduce a novel water-compatible monomer based on the phthalhydrazide moiety that assembles into hydrogen-bonded trimeric *** bulk,the material exhibits a cylindrical nanostructure in the liquid-crystalline phase at elevated temperatures,morphologically distinct from the crystalline lamellar *** water,these molecules effectively form cylinders in a one-dimensional fashion,yielding fibrous *** formation of these supramolecular polymers follows a cooperative mechanism,as evidenced by denaturation *** trimerized pattern represents a new category of aqueous su pramolecular polymers with future prospects for functional complex molecular systems.

关键词： noncovalent chemistry supramolecular polymers hydrogen bonding cooperativity nanostructure

Inflammatory myofibroblastic tumor from molecular diagnostics to current treatment

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Oncology Research 2024年第7期32卷 1141-1162页

作者： PAULINA CHMIEL ALEKSANDRA SŁOWIKOWSKA ŁUKASZ BANASZEK ANNA SZUMERA-CIEĆKIEWICZ bartŁOMIEj SZOSTAKOWSKI MATEUSZ j.SPAŁEK TOMASZŚWITAj PIOTR RUTKOWSKI ANNA M.CZARNECKA department of Soft Tissue/Bone Sarcoma and Melanoma Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland Faculty of Medicine Medical University of WarsawWarsaw02-091Poland department of Pathology Maria Sklodowska Curie National Research Institute of OncologyWarsaw02-781Poland department of Radiotherapy Maria Sklodowska-Curie National Research Institute of OncologyWarsaw02-781Poland

Inﬂammatory myoﬁbroblastic tumor(IMT)is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic *** challenges arise from the diverse pathological presentation,variable symptomatology,and lack of different imaging ***,IMT is identiﬁed by the fusion of the anaplastic lymphoma kinase(ALK)gene,which is present in approximately 70%of cases,with various fusion partners,including ran-binding protein 2(RANBP2),which allows conﬁrmation of the *** surgery is the preferred approach for localized tumors,the optimal long-term treatment for advanced or metastatic disease is difﬁcult to deﬁ*** therapies are crucial for achieving sustained response to treatment within the context of genetic alteration in ***,an ALK tyrosine kinase inhibitor(TKI),was ofﬁcially approved by the US Food and Drug Administration(FDA)in 2020 to treat IMT with ALK ***,most patients face resistance and disease progression,requiring consideration of sequential *** radiotherapy with targeted therapy appears to be beneﬁcial in this *** promising results have also been achieved with immunotherapy,indicating potential for combined therapy ***,deﬁned recommendations are still *** review analyzes the available research on IMT,including genetic disorders and their impact on the course of the disease,data on the latest targeted therapy regimens and the possibility of developing immunotherapy in this indication,as well as summarizing general knowledge about prognostic and predictive factors,also in terms of resistance to systemic therapy.

关键词： Inﬂammatory myoﬁbroblastic tumor(IMT) Epithelioid inﬂammatory myoﬁbroblastic sarcoma Tyrosine kinase inhibitors(TKI) Anaplastic lymphoma kinase(ALK)

均相和非均相催化微藻脂质提取和酯交换制备生物燃料的研究进展

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Chinese journal of Catalysis 2024年第4期59卷 97-117页

作者： Vinoth Kumar Ponnumsamy Hussein E.Al-Hazmi Sutha Shobana jeyaprakash Dharmaraja Dipak Ashok jadhav Rajesh Banu j Grzegorz Piechota bartłomiej Igliński Vinod Kumar Amit Bhatnagar Kyu-jung Chae Gopalakrishnan Kumar 高雄医科大学药物与应用化学系环境医学研究中心中国台湾高雄高雄医科大学医学研究部中国台湾高雄格但斯克理工大学土木与环境工程学院波兰纳鲁特维察格但斯克范朗大学工程与技术学院建筑绿色技术与可持续发展研究组越南胡志明市工程技术学院科学与人文系化学部印度泰米尔纳德邦韩国海洋大学海洋科学与工程学院环境工程系韩国釜山泰米尔纳德邦中央大学生命科学系印度泰米尔纳德邦 GPCHEM沼气研究与分析实验室波兰尼古拉斯哥白尼大学化学系波兰克兰菲尔德大学水与能源学院英国拉彭兰塔工业大学工程科学学院分离科学系芬兰韩国海洋大学海洋可再生能源工程专业韩国釜山延世大学土木与环境工程学院韩国首尔斯塔万格大学科学技术学院化学、生物科学与环境工程研究所挪威斯塔万格

随着化石燃料燃烧导致的二氧化碳排放不断加剧气候变化,且化石燃料储量日益减少,寻求可再生能源已成为一项紧迫的任务.其中,藻类衍生可持续燃料因具有成本优势和可运输性,在解决全球能源危机方面展现出广阔前景,备受关注.利用化学转化... 详细信息

随着化石燃料燃烧导致的二氧化碳排放不断加剧气候变化,且化石燃料储量日益减少,寻求可再生能源已成为一项紧迫的任务.其中,藻类衍生可持续燃料因具有成本优势和可运输性,在解决全球能源危机方面展现出广阔前景,备受关注.利用化学转化技术从微藻中提取脂质,并通过酯交换反应可以将其转化为脂肪酸甲酯,是生产绿色生物燃料的有效途径.这一过程涉及游离脂肪酸、磷脂和甘油三酯的提取,并且生产过程能耗低,成为满足日益增长的能源需求的一种理想解决方案.本文综述了微藻脂质提取和酯交换制备生物燃料的相关研究进展.首先,介绍了微藻脂质的提取方法,包括溶剂提取法、索氏提取法、布利格和戴耶法、超临界二氧化碳提取以及离子液体溶剂法等,并分析了各方法的优缺点.随后,重点阐述了酯交换技术在微藻脂质转化中的应用,包括酸碱催化、酶催化以及原位酯交换反应等,并探讨了这些技术的反应机理、催化剂选择、反应器设计以及生物油生产工艺等方面的研究进展.通过综述上述研究进展,为微藻脂质的生产和应用提供了理论指导.研究表明,通过优化催化剂种类、反应条件以及提取方法,可以有效提高微藻脂质的转化效率和生物油品质.同时,本文也指出了当前微藻脂质生产中面临的挑战,如微藻栽培和生长条件优化、高效转化技术的开发等.随着可持续能源日益受到重视,微藻脂质作为一种可再生能源具有巨大的发展潜力.未来研究应进一步关注微藻的规模化栽培、生长条件优化以及高效转化技术的研发,以提高微藻脂质的产量和品质.同时,应进一步推动和实现微藻生物燃料的实际应用,从而为应对气候变化和能源危机提供有效的解决方案.

关键词：微藻脂质提取酯交换催化酶催化原位技术

Patterns of forest composition and their long term environmental drivers in the tropical dry forest transition zone of southern Africa

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Forest Ecosystems 2017年第1期4卷 33-44页

作者： Vera de Cauwer Coert j.Geldenhuys Raf Aerts Miya Kabajani bart Muys Namibia University of Science and Technology Faculty of Natural Resources and Spatial SciencesPrivate Bag 13388WindhoekNamibia University of Leuven Division ForestNature and LandscapeCelestijnenlaan 200E box 2411BE-3001 LeuvenBelgium. Forest&Wood Science Stellenbosch Universityc/o Forestwood ccMurrayfieldPretoriaSouth Africa. University of Leuven Division EcologyEvolution and Biodiversity ConservationKasteelpark Arenberg 31-2435BE-3001 LeuvenBelgium.

Background： Tropical dry forests cover less than 13 % of the world＇s tropical forests and their area and biodiversity are declining. In southern Africa, the major threat is increasing population pressure, while drought caused by climate change is a potential threat in the drier transition zones to shrub land. Monitoring climate change impacts in these transition zones is difficult as there is inadequate information on forest composition to allow disentanglement from other environmental drivers. Methods： This study combined historical and modern forest inventories covering an area of 21,000 km2 in a transition zone in Namibia and Angola to distinguish late succession tree communities, to understand their dependence on site factors, and to detect trends in the forest composition over the last 40 years. Results： The woodlands were dominated by six tree species that represented 84 % of the total basal area and can be referred to as Bdikioea - Pterocarpus woodlands. A boosted regression tree analysis revealed that late succession tree communities are primarily determined by climate and topography. The Schinziophyton rautanenfi and Baikiaea plurijuga communities are common on slightly inclined dune or valley slopes and had the highest basal area （5.5 - 6.2 m^2 ha＆-1）. The Burkea africana - Guibourtia coleosperma and Pterocarpus angolensis - Diafium englerianum communities are typical for the sandy plateaux and have a higher proportion of smaller stems caused by a higher fire frequency. A decrease in overall basal area or a trend of increasing domination by the more drought and cold resilient B. africana community was not confirmed by the historical data, but there were significant decreases in basal area for Ochna pulchra and the valuable fruit tree D. englerianum. Conclusions： The slope communities are more sheltered from fire, frost and drought but are more susceptible to human expansion. The community with the important timber tree P. angolensis can best withstand high

关键词： Baikiaea woodland Tree community Namibia boosted regression trees Pterocarpus ango/ensis Disturbance Miombo Ecoregion Climate change

Novel and Simple Calorimetric Methods for Quantifying Losses in Magnetic Core and GaN Transistor in a High Frequency Boost Converter

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Chinese journal of Electrical Engineering 2016年第2期2卷 68-75页

作者： Wenbo Wang Frans Pansier Sjoerd de haan j.A.Ferreira DCE&S Faculty of Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyDelftThe Netherlands

In design and implementation of a boost converter,information on loss characteristics of switching devices and magnetic materials is a prerequisite,especially in high frequency *** gather such information,testing and accurate loss quantification is *** methods for measuring magnetic core loss are either only suitable for sinusoidal wave excitations or cannot separate winding loss from inductor *** addition,existing loss measurement approaches on the newly introduced GaN transistors are not *** this paper,we present a new method to distinguish winding loss from inductor loss under practical *** method utilizes a converter to generate the actual excitation waveforms and uses a calorimetric setup to quantify the *** splitting up the inductor in a converter into an air-core inductor and a magnetic-core inductor,both equipped with exactly the same winding structure,the air-core inductor loss can be used as the reference of the magnetic-core inductor winding *** this way,losses in the magnetic core can be determined in the actual operating condition of a converter in which the inductor is to be ***,a simple calorimetric approach for obtaining loss information of GaN transistors are is also *** methods require simple setup and are easy and convenient to *** methods work well in assessing different high frequency magnetic core materials and measuring losses in GaN transistors at 1MHz.

关键词： Core loss measurement practical excitation high frequency magnetic material practical excitation transistor loss measurement calorimetric method

Reactive Extraction of Alcohols from Apolar Hydrocarbons with Aqueous Solutions

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Tsinghua Science and Technology 2006年第2期11卷 222-227页

作者： Boris Kuzmanovi Norbert j. M. Kuipers André B. de haan Gerard Kwant Akzo Nobel Chemicals Research Arnhem The Netherlands University of Twente Enschede The Netherlands DSM Research Geleen The Netherlands

The aqueous solutions are evaluated as sustainable reactive extraction solvents for the recovery of monohydroxyl alcohols （benzyl alcohol, 1-hexanol, cyclohexanol） present in few-percent concentrations in apolar hydrocarbons （toluene, n-hexane, and cyclohexane） by considering two approaches. An aqueous solution containing a reactive extractant, like borate salts, borate complexes, a monosalt of dicarboxylic acid, hydroxypropyl-cyclodextrins, and silver nitrate, shows limited potential to be used. Another approach, in which the alcohol is chemically modified prior to the extraction into an easy-extractable form, in this case a monoester/carboxylic acid, shows much more potential. An environmentally benign aqueous solution of sodium hydrogen carbonate can provide a distribution ratio of benzyl alcohol up to 200, leaving the solubility of the organic solvent in the aqueous solution unchanged relative to pure water and therefore increasing the selectivity with two orders of magnitude. The modification of aromatic, cyclo-aliphatic, and linear aliphatic alcohols can be performed efficiently in the apolar organic solvent without need for a catalyst. The recovery of the modified alcohol can be performed by back-extraction in combination with a spontaneous hydrolysis.

关键词： reactive extraction alcohol polar hydrocarbons

From Single Droplet to Column design

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Tsinghua Science and Technology 2006年第2期11卷 212-216页

作者： Hans-jrg bart Institute of Thermal Process Engineering TU Kaiserslautern D-67653 Kaiserslautern Germany

The technique state to design counter-current extraction columns is based on the performance of pilot plant experiments. The modelling is then either with the equilibrium or dispersion model, whereas in the latter the dispersion coefficient accounts for all hydrodynamic non-idealities. A new approach uses single droplet experiments to obtain the basic laws and functions governing droplet breakage, coalescence, relative velocity, and axial dispersion when using droplet populance balance models （DPBM）. The hydrodynamics simulation results show that the mean Sauter diameter, hold-up, and concentration profiles could be well predicted, which promotes the use of DPBM models for further applications in industrial scale.

关键词： single droplet column design countercurrent extraction droplet populance balance model

Structure-function Aspects of Extracellular Leucine-rich Repeat-containing Cell Surface Receptors in Plants

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journal of Integrative Plant Biology 2013年第12期55卷 1212-1223页

作者： Zhao Zhang bart P.H.j.Thomma Laboratory of Phytopathology Wageningen University Centre for BioSystems Genomics

Plants exploit several types of cell surface receptors for perception of extracellular signals, of which the extracellular leucine-rich repeat （eLRR）-containing receptors form the major class. Although the function of most plant eLRR receptors remains unclear, an increasing number of these receptors are shown to play roles in innate immunity and a wide variety of developmental processes. Recent efforts using domain swaps, gene shuffling analyses, site-directed mutagenesis, interaction studies, and crystallographic analyses resulted in the current knowledge on ligand binding and the mechanism of activation of plant eLRR receptors. This review provides an overview of eLRR receptor research, specificallysummarizing the recent understanding of interactions among plant eLRR receptors, their co-receptors and corresponding ligands. The functions of distinct eLRR receptor domains, and their role in structure, ligand perception and multimeric complex formation are discussed.

关键词： eLRR receptor-like kinase (RLK) receptor-like protein (RLP) pathogen-associated molecular pattern (PAMP) effector peptide ligand brassinosteroid CLE peptide.

Comparison of the Reynolds-averaged Turbulence Models on Single Phase Flow Simulation in Agitated Extraction Columns

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Chinese journal of Chemical Engineering 2003年第3期11卷 362-366页

作者：尤学一 H.j.bart School of Environmental Science and Engineering Tianjin UniversityTianjin 300072China Lehrstuhl

The flow field of liquid phase (water) of agitated extraction columns is simulated with the help of computational fluid dynamics (CFD). Four kinds of Reynolds-averaged turbulence models, i.e. the standard k-ε model, the RNG (renormalization group) k-s model, the realizable k-ε model and the Reynolds stress model, are compared in detail in order to judge which is the best model in terms of the accuracy, less CPU time and memory required. The performance of the realizable k-s model is obviously improved by reducing the model constant from C2 = 1.90 to C2 = 1.61. It is concluded that the improved realizable k-e model is the optimal model.

关键词： agitated extraction column turbulence models computational fluid dynamics