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Predictors of survival in autoimmune liver disease overlap syndromes

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World Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis Calzadilla-Bertot Malik Janjua Bastiaan de boer John Joseph Wendy Cheng Simon Hazeldine Briohny W Smith Gerry C MacQuillan Michael C Wallace George Garas Leon A Adams Gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BACKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBC)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSC)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBC,27%AIH-PSC).There was no significant difference in survival between AIH-PBC and *** was a significant predictor of liver-related mortality(P<0.05)in patients with AIH-PBC(n=14)but not AIH-PSC(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBC patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's C-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBC *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

Endo-microscopy beyond the Abbe and Nyquist limits

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Light(Science & Applications) 2020年第1期9卷 1246-1257页

作者： Lyubov V.Amitonova Johannes F.de boer LaserLaB Department of Physics and AstronomyVrije Universiteit AmsterdamDe Boelelaan 10811081 HV AmsterdamThe Netherlands Advanced Research Center for Nanolithography(ARCNL) Science Park 1061098 XG AmsterdamThe Netherlands

For several centuries,far-field optical microscopy has remained a key instrument in many scientific disciplines,including physical,chemical,and biomedical ***,far-field imaging has many limitations:the spatial resolution is controlled by the diffraction of light,and the imaging speed follows the Nyquist–Shannon sampling *** recent development of super-resolution techniques has pushed the limits of spatial ***,these methods typically require complicated setups and long acquisition times and are still not applicable to deeptissue ***,we report imaging through an ultra-thin fibre probe with a spatial resolution beyond the Abbe limit and a temporal resolution beyond the Nyquist limit simultaneously in a simple and compact *** use the random nature of mode coupling in a multimode fibre,the sparsity constraint and compressive sensing *** new approach of super-resolution endo-microscopy does not use any specific properties of the fluorescent label,such as depletion or stochastic activation of the molecular fluorescent state,and therefore can be used for label-free *** demonstrate a spatial resolution more than 2 times better than the diffraction limit and an imaging speed 20 times faster than the Nyquist *** proposed approach can significantly expand the realm of the application of nanoscopy for bioimaging.

关键词： beyond limit fibre

demonstration of tantalum as a structural material for MEMS thermal actuators

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Microsystems & Nanoengineering 2021年第1期7卷 85-97页

作者： Longchang Ni Ryan M.Pocratsky Maarten P.de boer CMU Mechanical Engineering dept. 5000 Forbes Ave.PittsburghPA 15213USA Present address:Fischione Instruments 9003 Corporate CirExportPA 15632USA

This work demonstrates the processing,modeling,and characterization of nanocrystalline refractory metal tantalum(Ta)as a new structural material for microelectromechanical system(MEMS)thermal actuators(TAs).Nanocrystalline Ta films have a coefficient of thermal expansion(CTE)and Young’s modulus comparable to bulk Ta but an approximately ten times greater yield *** mechanical properties and grain size remain stable after annealing at temperatures as high as 1000°*** has a high melting temperature(Tm=3017℃)and a low resistivity(ρ=20µΩcm).Compared to TAs made from the dominant MEMS material,polycrystalline silicon(polysilicon,Tm=1414℃,ρ=2000µΩcm),Ta TAs theoretically require less than half the power input for the same force and displacement,and their temperature change is half that of *** TAs operate at a voltage 16 times lower than that of other TAs,making them compatible with complementary metal oxide semiconductors(CMOS).We selectα-phase Ta and etch 2.5-μm-thick sputterdeposited films with a 1μm width while maintaining a vertical sidewall profile to ensure in-plane movement of TA *** is 25 times thicker than the thickest reactive-ion-etchedα-Ta reported in the technical *** stress sensitivities to sputter parameters and to hydrogen incorporation are investigated and ***,a V-shaped TA is fabricated and tested in *** conventional actuation by Joule heating and passive self-actuation are as predicted by models.

关键词： thermal structural thick

Influence of Non-Magnetic Substitutional Atoms on Spontaneous Moment and Curie Temperature of Ce_2Co_(17) Compounds

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Journal of Rare Earths 2002年第4期20卷 273-277页

作者：胡社军刘正义 de boer F R Buschow K H J Faculty of Materials and Energy Guangdong University of Technology Guangzhou 510643 China

The structure and magnetic properties of Ce 2Co 17-xM x(M=Ga,Al and Si) compounds for M concentrations up to x=5 were studied by means of X-ray diffraction and magnetic measurements. The experimental results show that the Curie temperatures and Co spontaneous magnetization decrease significantly with increasing the addition of non-magnetic substitutional atoms, and that Si which has a minimum solid solubility in Ce 2Co 17 causes a largest reduction of Curie temperature, spontaneous magnetization and moment per Co atom compared with Ga and Al.

关键词： rare earths Ce 2Co 17 compounds Curie temperature spontaneous magnetization

Conflict resolution for connected automated vehicles at unsignalized roundabouts considering personalized driving behaviours

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Green Energy and Intelligent Transportation 2022年第1期1卷 26-36页

作者： Peng Hang Yiran Zhang Niels de boer Chen Lv School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore Energy Research Institute(ERIAN) Nanyang Technological UniversitySingapore

To address the driving conflicts of connected automated vehicles(CAVs)at unsignalized roundabouts,a cooperative decision-making framework is *** personalized driving preferences of CAVs are considered in the decision-making algorithm,which are reflected by different driving styles.A motion prediction algorithm is used to improve the decision-making *** effect of the motion prediction algorithm on the decisionmaking performance is evaluated,including the advancement of driving safety and the computational load for the *** cooperative game theoretic approach is applied to the interaction modelling and collaborative decision making of ***,hardware-in-the-loop(HIL)tests are carried out to evaluate the feasibility and real-time performance of the proposed algorithm.

关键词： decision making Connected automated vehicles Conflict resolution Cooperative game theory Unsignalized roundabout

How small could a pup sound？ The physical bases of signaling body size in harbor seals

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Current Zoology 2017年第4期63卷 457-465页

作者： Andrea RAVIGNANI Stephanie GROSS Maxime GARCIA Ana RUBIO-GARCIA Bart de boer Veterinary & Research department Sealcentre Pieterburen Hoofdstraat 94a Pieterburen AG 9968 The Netherlands Artificial Intelligence Laboratory Vrije Universiteit Brussel Pleinlaan 2 Brussels 1050 Belgium Language and Cognition department Max Planck Institute for Psycholinguistics Wundtlaan 1 Nijmegen XD 6525 The Netherlands Institute for Terrestrial and Aquatic Wildlife Research University of Veterinary Medicine Hannover Foundation Werftstrasse 6 Buesum 25761 Germany ENES Lab/Neuro-PSI CNRS UMR9197 University of Lyon/Saint Etienne 23 rue Paul Michelon 42023 Saint-Etienne cedex 2 France

Vocal communication is a crucial aspect of animal behavior. The mechanism which most mam- mals use to vocalize relies on three anatomical components. First, air overpressure is generated in- side the lower vocal tract. Second, as the airstream goes through the glottis, sound is produced via vocal fold vibration. Third, this sound is further filtered by the geometry and length of the upper vocal tract. Evidence from mammalian anatomy and bioacoustics suggests that some of these three components may covary with an animal＇s body size. The framework provided by acoustic al- Iometry suggests that, because vocal tract length （VTL） is more strongly constrained by the growth of the body than vocal fold length （VFL）, VTL generates more reliable acoustic cues to an animal＇s size. This hypothesis is often tested acoustically but rarely anatomically, especially in pinnipeds. Here, we test the anatomical bases of the acoustic allometry hypothesis in harbor seal pups Phoca vitulina. We dissected and measured vocal tract, vocal folds, and other anatomical features of 15 harbor seals post-mortem. We found that, while VTL correlates with body size, VFL does not. This suggests that, while body growth puts anatomical constraints on how vocalizations are filtered by harbor seals＇ vocal tract, no such constraints appear to exist on vocal folds, at least during puppy- hood. It is particularly interesting to find anatomical constraints on harbor seals＇ vocal tracts, the same anatomical region partially enabling pups to produce individually distinctive vocalizations.

关键词： acoustic allometry honest signaling larynx pinniped vocal tract.

Binaural masking level difference for pure tone signals

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Journal of Otology 2023年第3期18卷 160-167页

作者： Eva Ignatious Sami Azam Mirjam Jonkman Friso de boer College of Engineering and IT Charles Darwin UniversityCasuarinaAustralia

The binaural masking level difference(BMLD)is a psychoacoustic method to determine binaural interaction and central auditory *** BMLD is the difference in hearing thresholds in homophasic and antiphasic *** duration,phase and frequency of the stimuli can affect the *** main aim of the study is to evaluate the BMLD for stimuli of different durations and frequencies which could also be used in future electrophysiological *** this end we developed a GUI to present different frequency signals of variable duration and determine the *** different durations and five different frequencies are *** results of the study confirm that the hearing threshold for the antiphasic condition is lower than the hearing threshold for the homophasic condition and that differences are significant for signals of 18ms and 48ms *** objective binaural processing studies will be based on 18ms and 48ms stimuli with the same frequencies as used in the current study.

关键词： Binaural hearing BMLD Auditory evoked potentials Binaural interaction Brain processing Phases

Transient mixed lubrication model of the human knee implant

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Biosurface and Biotribology 2021年第4期7卷 206-218页

作者： Hamza Butt Lee Nissim Leiming Gao Connor Myant Greg de boer Robert Hewson department of Aeronautics Imperial College LondonLondonUK department of Mechanical Engineering University of BathBathUK department of Engineering Nottingham Trent UniversityNottinghamUK Dyson School of design Engineering Imperial College LondonLondonUK School of Mechanical Engineering University of LeedsLeedsUK

The human knee implant is computationally modelled in the mixed lubrication regime to investigate the tribological performance of the *** model includes the complex geometry of the implant components,unlike elliptical contact models that approximate this *** thickness and pressure results are presented for an ISO gait cycle to determine the lubrication regime present within the implant during its *** was found that it was possible for the lubrication regime to span between elastohydrodynamic,mixed and boundary lubrication depending on the operating conditions of the *** was observed that the tribological conditions present in one condyle were not necessarily representative of the *** points of contact were found within the same condyle,which cannot be computed by the elliptical contact *** model can be used to balance forces in all directions,instead of only the normal loads,as often done in elliptical contact *** work is an initial step towards understanding the role of the complex geometry in the tribological characteristics of the human knee implant when operating in physiological conditions.

关键词： complex geometry knee implant mixed lubrication modelling surface roughness transient

The role of forensic anthropology in disaster victim identification(DVI):recent developments and future prospects

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Forensic Sciences Research 2019年第4期4卷 303-315页

作者： Hans H.de boer Soren Blau Tania delabarde Lucina Hackman Netherlands Forensic Institute The HagueThe Netherlands department of Pathology Academic Medical CentreUniversity of AmsterdamAmsterdamThe Netherlands department of Forensic Services Victorian Institute of Forensic MedicineMelbourneVictoriaAustralia department of Forensic Medicine Monash UniversityMonashAustralia Institute of Legal Medicine ParisFrance Centre for Anatomy and Human ID(CAHID) University of DundeeDundeeUK

Forensic anthropological knowledge has been used in disaster victim identification(DVI)for over a century,but over the past decades,there have been a number of disaster events which have seen an increasing role for the forensic *** experiences gained from some of the latest DVI operations have provided valuable lessons that have had an effect on the role and perceived value of the forensic anthropologist as part of the team managing the DVI *** paper provides an overview of the ways in which forensic anthropologists may contribute to DVI with emphasis on how recent experiences and developments in forensic anthropology have augmented these ***,this paper reviews the value of forensic anthropological expertise at the disaster scene and in the mortuary,and discusses the way in which forensic anthropologists may use imaging in DVI ***-sampling strategies for DNA analysis,especially in the case of disasters with a large amount of fragmented remains,are also ***,consideration is given to the identification of survivors;the statistical basis of identification;the challenges related to some specific disaster scenarios;and education and *** forensic anthropologists can play a valuable role in different phases of a DVI operation,they never practice in *** DVI process requires a multidisciplinary approach and,therefore,has a close collaboration with a range of forensic specialists.

关键词： Forensic science forensic anthropology disaster victim human identification mass fatality Bayes radiology dead body management