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如何设计高质量针刺临床研究:基于证据的专家共识

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英国医学杂志中文版 2022年第6期25卷 325-337页

作者：张誉清焦睿珉 Claudia m Witt 劳力行刘建平 Lehana Thabane Karen J Sherman mike Cummings dawn P Richards Eun-Kyung Anna Kim Tae-Hun Kim myeong Soo Lee michael E Wechsler Benno Brinkhaus Jun J mao Caroline A Smith 岗卫娟刘保延刘志顺刘岩郑晖吴佳霓 AloBSO Carrasco-Labra mohit Bhandari Philip J Devereaux 景向红 Gordon Guyatt 中国中医科学院针灸研究所中国中医科学院广安门医院中加整合医学循证医学研究合作中心 Department of Health Research methods Evidenceand ImpactMcMaster UniversityHamiltonONCanada 宁波诺丁汉大学宁波诺丁汉GRADE中心中国中医药循证医学中心 Institute for Complementary and Integrative medicine University Hospital Zurich and University of ZurichZurichSwitzerland Virginia University of Integrative medicine FairfaxVAUSA 北京中医药大学循证医学中心北京中医药大学国际循证中医药研究院 Department of medicine Faculty of Health SciencesMcMaster UniversityHamiltonONCanada Kaiser Permanente Washington Health Research Institute Seattle WAUSA Department of Epidemiology University of WashingtonSeattle WAUSA British medical Acupuncture Society LondonUK Patient and Public Engagement Clinical Trials OntarioTorontoONCanada Department of Western medicine Virginia University of Integrative MedicineFairfaxVAUSA Korean medicine Clinical Trial Center SeoulRepublic of Korea Korean medicine Hospital SeoulRepublic of Korea Kyung Hee University SeoulRepublic of Korea Clinical medicine Division Korea Institute of Oriental MedicineDaejeonRepublic of Korea Korean Convergence medicine University of Science and TechnologyDaejeonRepublic of Korea National Jewish Health DenverCOUSA Institute of Social medicine Epidemiology and Health EconomicsCharitéUniversit?ts medizin BerlinFreie Universit?t Berlin and Humboldt-Universittzu BerlinBerlinGermany Integrative medicine Service Memorial Sloan Kettering Cancer CenterBendheim Integrative Medicine CenterNew YorkNY USA Translational Health Research Institute Western Sydney UniversityPenrithNew South WalesAustralia 中国中医科学院中国中医科学院广安门医院北京中医药大学东直门医院中医内科学教育部重点实验室成都中医药大学针灸推拿学院/第三附属医院 Center for Integrative Global Oral Health School of Dental MedicineUniversity of PennsylvaniaPhiladelphiaPAUSA

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究... 详细信息

本针刺随机对照试验(Randomised controlled trials, RCT)专家共识是基于目前针刺试验面临的最普遍、最关键问题,由临床医生、研究人员、从事针灸和外科的临床试验专家、统计专家、临床流行病学和方法学专家以及患者组成的国际临床研究小组联合制订。该共识将有助于临床试验资助者、注册者以及期刊编辑等评估针刺RCT方案及研究结果的相关性、重要性和质量。

关键词：临床流行病学针刺试验临床试验临床医生专家共识随机对照试验资助者期刊编辑

Plasma sheet stretching accompanied by field aligned energetic ion fluxes observed by the NUADU instrument aboard TC-2

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Chinese Science Bulletin 2007年第12期52卷 1719-1723页

作者： LU Li S. mCKENNA-LAWLOR S. BARABASH LIU ZhenXing CAO JinBin J. BALAZ K. KUDELA T. L. ZHANG C. m. CARR Centre for Space Science and Applied Research Chinese Academy of Sciences Beijing 100080 China Space Technology Ireland National University of Ireland Maynooth Co. Kildare Ireland Swedish Institute of Space Physics Kiruna Sweden Institute of Experimental Physics Kosice Slovakia Space Research Institute Austrian Academy of Sciences Graz Austria Imperial College of Science London United Kingdom

NUADU (中立原子察觉者单位) 在 TC-2 上的仪器记录了在 thenear 地球血浆表盘旋在磁场线附近的控告的粒子(E>180 keV ) 的 4nsolid 角度图象(在 ~-7 R_E，赤道的 dawn-to-night 方面) 在地磁气的暴风雨(Dst=-219 nT ) 期间在 2005 年 8... 详细信息

NUADU (中立原子察觉者单位) 在 TC-2 上的仪器记录了在 thenear 地球血浆表盘旋在磁场线附近的控告的粒子(E>180 keV ) 的 4nsolid 角度图象(在 ~-7 R_E，赤道的 dawn-to-night 方面) 在地磁气的暴风雨(Dst=-219 nT ) 期间在 2005 年 8 月 24 日。对称的、似环的、稳固的角度分布在周围的磁场线附近描绘的精力充沛的离子横梁事件被 theTC-2 太空船在血浆表的 34-minutetraversal 期间观察。另外，观察被磁强计实验(FGm ) 在一样的太空船上在血浆表的这些多重十字路口期间监视。在每个十字路口期间，口哨声模式合唱团改进被 TC-2 低频率电磁波察觉者(LFEW/TC-2 ) 就在本地更低的混血儿的上面在频率在各向异性的区域观察波浪。离子的比较与这块地里的改进排列了的周围的磁场表演搭角度分发(垫) 地图精力充沛的离子流动被尾巴病房在血浆表拉长磁场线伴随。相反，垂直离子流动改进被在血浆表显示磁场线的相应收缩的签名伴随。因为平行离子流动和垂直离子流动改进间歇地发生了，数据被解释暗示磁场线的一个动态、摆动的过程(拉长并且缩小)在thenear地球血浆表，它可能行动了帮助在将支持在进行中的磁性的暴风雨期间被触发的连续 aurora-substorm 的这个区域建立一个相互作用区域。Thewhistler 模式合唱团可能在血浆表压缩以后在粒子沥青角度散开期间由于离子旋转罗盘回声被生产了。

关键词：近地等离子体片螺旋角分布离子流氖中立原子探测装置大气科学

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Statistical survey on the magnetic structure in magnetotail current sheets

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中国科学院地质与地球物理研究所第11届（2011年度）学术年会

作者： m.W.Dunlop A.A.Petrukovich E.Lucek Rutherford Appleton Laboratory Didcot UK Space Research Institute moscow Russia Blackett Laboratory Imperial College London LondonUK

[1]On the basis of the multipoint magnetic observations of Cluster in the region 15-19 R downtail,the magnetic field structure in magnetotail current sheet(CS) center is statistically *** is found that the B component(in GSm coordinates) is distributed mainly within |B|mponent is mostly positive and distributes mainly within 10 *** plane of the magnetic field lines(mFLs) is mostly vertical to the equatorial plane,with the radius of curvature(Rc) of the mFLs being directed earthward and the binormal(perpendicular to the curvature and magnetic field direction) being directed azimuthally *** curvature radius of mFLs reaches a minimum,R,at the CS center and is larger than the corresponding local half thickness of the neutral sheet,h. Statistically,it is found that the overall surface of the CS,with the normal pointing basically along the south-north direction,can be approximated to be a plane parallel to equatorial plane,although the local CS may be flapping and is frequently tilted to the equatorial *** tilted CS(normal inclined to the equatorial plane) is apt to be observed near both flanks and is mainly associated with the slippage of magnetic flux *** is statistically verified that the minimum curvature radius,R,half thickness of neutral sheet,h,and the slipping angle of mFLs,8,in the CS satisfies h = R cosδ.The current density,with a mean strength of 4-8 nA/m,basically flows azimuthally and tangentially to the surface of the CS,from dawn side to the dusk *** is an obvious dawn-dusk asymmetry of CS,*** magnetic local times(mLT) 1:00-～01:00, the CS is relatively thinner;the minimum curvature radius of mFLs,R(0.6-1 R) and the half-thickness of neutral sheet,h(0.2-0.4 R),are relatively smaller,and B(3-5 nT) and the minimum magnetic field,B(5-7 nT),are *** is also found that negative B has a higher probability of occurrence and the cross-tail current density j is dominant (2-4 nA/m) in comparison to

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Benchmark Analysis of Bipolar Plates and Ionomer membrane Production Costs for PEFC fuel cell stacks

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Benchmark Analysis of Bipolar Plates and Ionomer Membrane Pr...

2004年国际氢能大会

作者： m.Gebert B.Hohlein D.Stolten Forschungszentrum Jiilich GmbH Institute for Materials and Processes in Energy Systems （IWV 3） D - 52425 Jiilich Federal Republic of Germany Forschungszentrum Jiilich GmbH Institute for Materials and Processes in Energy Systems （IWV 3） D - 52425 Jiilich Federal Republic of Germany Forschungszentrum Jiilich GmbH Institute for Materials and Processes in Energy Systems （IWV 3） D - 52425 Jiilich Federal Republic of Germany

＜正＞At the dawn of fuel cell commercialisation, cost considerations become the decisive factor for a successful market launch. The following contribution addresses two aspects of PEFC stack costs. First, it compares the syntheses of promising membrane polymers and, second, it elucidates cost effects occurring in the production of graphite composite bipolar *** costs for chemical educts are balanced for five different ionomers and represented in terms of euro per kg and euro per m2. Additionally, an estimate is given of the complexity of the chemical plant needed for production. The five ionomers are *** second part of this work shows that moulded bipolar plates can be produced at a cost of 10-20 euros per kW in the case of advanced fuel cell stacks. Additional costs for overheads, profits and taxes have to be added corresponding to company and market conditions.

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欧洲及其邻区mAGSAT卫星磁异常冠谐模型

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地球物理学报 1998年第4期41卷 468-474页

作者：安振昌 N.m.Rotanova S.D.Odintsov 汪鹏程中国科学院地球物理研究所北京100101 俄罗斯科学院

通过对欧洲及其邻近地区 mAGSAT 卫星黎明资料进行了处理,得到1°×1°卫星磁异常网格值。本文使用冠谐分析方法,计算该地区卫星矢量磁异常(ΔX,ΔY,ΔZ)冠谐模型。球冠极点位于33°N和26°E,球冠半角为40°.冠谐模型的截断指数为18。... 详细信息

通过对欧洲及其邻近地区 mAGSAT 卫星黎明资料进行了处理,得到1°×1°卫星磁异常网格值。本文使用冠谐分析方法,计算该地区卫星矢量磁异常(ΔX,ΔY,ΔZ)冠谐模型。球冠极点位于33°N和26°E,球冠半角为40°.冠谐模型的截断指数为18。根据卫星磁异常冠谐模型和地磁场球谐模型 DGRF1980,计算卫星总强度磁异常(ΔF)的冠谐一球谐模型。根据卫星磁异常的理论模型,计算并绘制不同高度(300,400,500km)的理论卫星磁异常图。对冠谐模型和大磁异常进行了分析和讨论。

关键词： mAGSAT卫星磁异常欧洲地磁场冠谐模型

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The magnetic local time distribution of ring current during the geomagnetic storm

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The magnetic local time distribution of ring current during ...

中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： X.D.Zhao A.m.Du W.Y.Xu Institute of Geology and Geophysics Chinese Academy of Sciences Institute of Geophysics China Earthquake Administration

The magnetic local time distribution of the ring current during 879 geomagnetic storms(identified by SYmH < -30 nT) in the 23rd solar cycle(1996-2006) was investigated by using 23 mid-low latitude ground-based *** sto... 详细信息

The magnetic local time distribution of the ring current during 879 geomagnetic storms(identified by SYmH mid-low latitude ground-based *** storms are divided into eight different classes with a step of 20 nT for the statistical *** each class,the dusk side events,for which the H component minimum located in the dusk sector is mostly corresponding to the UT of minimum SYmH index,are about 59.5% of the total *** the noon side events are about 20.0%,the night side events are about 18.7%, and the dawn side events are about 1.8%.The H component distributions with mLT indicate that the magnetic field disturbance during the magnetic storm events is not only related to the symmetrical ring current,but also to the other current,mainly the partial current.A further statistical study of the dusk side events shows that both the symmetric and partial ring currents enhance accompanied by the increase in the storm class during the main *** the partial ring current makes a greater contribution to the main phase of the *** to the interplanetary parameters,the distinction of the solar wind velocity V is more obvious than the interplanetary magnetic field B for the dusk side events in different *** comparisons between dusk side and other side events in the same class indicate that besides the solar wind velocity V,the interplanetary magnetic field B also affects on the disturbance of ring current on the ground in mLT.

关键词： Ring current Storm magnetic local time magnetic field

急性缺血性卒中静脉阿替普酶溶栓治疗的纳入和排除标准的科学依据美国心脏协会/美国卒中协会对医疗卫生专业人员发布的声明(续前)

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国际脑血管病杂志 2016年第5期 385-406页

作者： Demaerschalk Bart m. Kleindorfer dawn O. Adeoye Opeolu m. Demchuk Andrew m. Fugate Jennifer E. Grotta James C. Khalessi Alexander A. Levy Elad I. Palesch Yuko Y. Prabhakaran Shyam Saposnik Gustavo Saver Jeffrey L. Smith Eric E. 南京大学医学院附属鼓楼医院神经内科

19颅内出血史根据最初的FDA标签和2013年AHA/ASA指南[24],颅内出血史是静脉阿替普酶治疗缺血性卒中的一项额外禁忌证或排除标准。最近修订后的标签仅将近期ICH列为一项警告,并且在禁忌证中删除了ICH史。与前面讨论的静脉阿替普酶治疗排...

19颅内出血史根据最初的FDA标签和2013年AHA/ASA指南[24],颅内出血史是静脉阿替普酶治疗缺血性卒中的一项额外禁忌证或排除标准。最近修订后的标签仅将近期ICH列为一项警告,并且在禁忌证中删除了ICH史。与前面讨论的静脉阿替普酶治疗排除标准相似,文献回顾仅在大样本回顾性研究中发现了少量这类病例。缺乏相关数据可能是修订后的

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第十二届全国图象图形学学术会议

作者： m.Reiser

＜正＞ In the year 1965 Gordon moore published a paper stating, that the number of transistors on a chip would double every 12 months, a figure later revised to 18 months. For 40 years, the computing capacity grows at this exponential rate. many times declared dead, moore’s law is well and is expected to be valid for years to *** we look at a related measure, namely the number of computing operations 1000$ will buy, then we see an exponential growth taking place over the whole of the last century and spanning 5 technologies from Hollerith machines over relays, vacuum tubes, discrete transistors to integrated circuits. Clearly, some more fundamental law is fuelling the computing industry. Computing deals with nonmaterial symbols that can be represented by many different technologies. Each technology has an exponential law and will be replaced by a succeeding one once at its *** this talk, we will argue, that moore’s law will continue for a long time. A back of the envelope calculation will yield that our children will have the computing capacity of the human brain in their notebook *** will this mean for the applications possible with such machines? Unlike the hardware, the application paradigms do not progress steadily, nor do they show an exponential growth in power. We see new application epochs approximately every 10 years. Scientific computing, ledger and payroll, manufacturing and airlines and personal computing are examples of such epochs. We argue that we are at dawn of a new era: lifestyle computing and we predict bionic computing as the mega trend in 10 years to *** graphics is a key technology for the lifestyle computing epoch. We look at the recent progress in computer graphics hardware, where the moore constant is not 18 months but more closely 12. We stand at the beginning of photo real real-time actors and will discuss, that the key question in the next years is not photorealism, but rather making the behavior of virtual acto

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High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array

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Horticulture Research 2016年第1期3卷 68-75页

作者： mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter m Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris maliepaard marinus J m Smulders Wageningen UR Plant Breeding Wageningen University&ResearchWageningenNL-6700 AJThe Netherlands Roath BV EindhovenThe Netherlands Pheno Geno Roses D.O.O.Bulevar oslobođenja 65a 21000 Novi SadSerbia

Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted *** tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homolog... 详细信息

Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted *** tetraploid rose,the existing linkage maps includemarkers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New dawn’.The offspring proved to be not from a single bi-parental *** rose breeding,crosses with unintended parents occur *** developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one *** of the inferred populations was consistent with self-fertilization of‘Red New dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New dawn’as the common maternal *** densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cm at an average marker distance of 0.9 *** with the strawberry(Fragaria vesca)genome was *** ICm1 corresponded to *** pseudochromosome 7(Fv7),ICm4 to Fv4,ICm5 to Fv3,ICm6 to Fv2 and ICm7 to *** ICm2 corresponded to parts of *** pseudochromosomes 1 and 6,whereas ICm3 is syntenic to the remainder of Fv6.

关键词： breeding linkage dosage