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Exertional heat illness risk factors and physiological responses of youth football players

Journal of Sport and Health Science 2021年第1期10卷 91-98页

作者： Susan W.Yeargin John J.Dickinson dawn m.emerson Jessica Koller Toni m.Torres-mcGehee Zachary Y.Kerr Department of Exercise Science University of South CarolinaColumbiaSC 29208USA Palmetto Health/USC Orthopedic Center Keenan High SchoolColumbiaSC 29203USA Department of Health Sportand Exercise SciencesUniversity of KansasLawrenceKS 66045USA Surgi-Care Inc. BostonMA 02115USA Department of Exercise and Sport Science University of North CarolinaChapel HillNC 27599-8700USA

Objective:To determine which intrinsic and extrinsic exertional heat illness(EHI)risk factors exist in youth American football players and observe perceptual and physiological responses of players during events(games and practices).methods:Cross-sectional cohort study observing 63 youth football players,varying in *** variables were league(weightrestricted(WR,n=27)and age-restricted(AR,n=36))and event *** variables were anthropometrics,work-to-rest ratio,and wet bulb globe *** variables included preparticipation examination and uniform configuration.A subset of 16 players participated in physiological variables(heart rate and gastrointestinal temperature).Data collection occurred on 7 AR and 8 WR nonconsecutive practices and the first 3 games of the ***:mean values for anthropometric variables were higher(pme(χ^2(1,111)=4.232;p=0.039)and rest time(χ^2(1,111)=43.41;pmes,but ratios were significantly higher for practices(χ^2(1,111)=40.62;pmajority of events(77%)observed were in black and red flag wet bulb globe temperature risk categories.A total of 57%of the players had a preparticipation examination,and up to 82%of events observed were in full *** gastrointestinal temperature and heart rate responses ranged widely and no players reached critical ***:Extrinsic(disproportionate work ratios,environmental conditions)and intrinsic(higher body mass index)EHI risk factors exist in youth *** risk factors may be influenced by event and league *** youth football organizations need to create thorough guidelines that address EHI risk factors for local leagues to adopt.

关键词： Adolescents Anthropometrics Core temperature Heat exchange Pediatric Wet bulb globe temperature

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An acute naproxen dose does not affect core temperature or Interleukin-6 during cycling in a hot environment

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Sports medicine and Health Science 2021年第4期3卷 243-251页

作者： dawn m.emerson Stephen CL.Chen Toni m.Torres-mcGehee Craig E.Pfeifer Charles C.emerson J.mark Davis Department of Physical Therapy Rehabilitation Scienceand Athletic TrainingSchool of Health ProfessionsUniversity of Kansas Medical Center3901 Rainbow BlvdMS 2002Kansas CityKansas66160USA. Division of Exercise and Sport Science Bob Jones University1700 Wade Hampton BlvdGreenvilleSouth Carolina29614USA. Department of Exercise Science Arnold School of Public HealthUniversity of South Carolina921 Assembly StreetColumbiaSC29208USA Applied Sport and Exercise Sciences The ParkUniversity of GloucestershireCheltenham GL502RHUnited Kingdom. Department of Athletics 5100 Rockhill Rd SRC 201University of Missouri-Kansas CityKansas CityMissouri64110USA.

Non-steroidal anti-inflammatory drugs’anti-pyretic and anti-inflammatory effects has led some individuals to theorize these medications may blunt core body temperature(Tc)increases during *** utilized a double-blind,randomized,and counterbalanced cross-over design to examine the effects of a 24-h naproxen dose(3–220 mg naproxen pills)and placebo(0 mg naproxen)on Tc and plasma interleukin-6(IL-6)concentrations during cycling in a hot or ambient ***(n=11;6 male,5 female;age=27.8±6.5 years,weight=79.1±17.9 kg,height=177±9.5 cm)completed 4 conditions:1)placebo and ambient(Control);2)placebo and heat(Heat);3)naproxen and ambient(Npx);and 4)naproxen and heat(NpxHeat).Dependent measures were taken before,during,and immediately after 90 min of cycling and then 3 h after ***,Tc significantly increased pre-(37.1±0.4℃)to post-cycling(38.2±0.3℃,F_(1.7,67.3)=150.5,pmaximum Tc were not significantly different between ***-6 increased pre-(0.54±0.06 pg/ml)to post-exercise(2.46±0.28 pg/ml,pmained significantly higher than pre-at 3 h post-(1.17±0.14 pg/ml,95%CI=-1.01 to-0.23,p=0.001).No significant IL-6 differences occurred between conditions.A 24-h,over-the-counter naproxen dose did not significantly affect Tc or IL-6 among males and females cycling in hot or ambient environments.

关键词： Cytokine Exertional heat illness NSAIDs Thermoregulation Exercise

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A 24 hour naproxen dose on gastrointestinal distress and performance during cycling in the heat

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Sports medicine and Health Science 2020年第1期2卷 19-24页

作者： dawn m.emerson J.mark Davis Stephen CL.Chen Toni m.Torres-mcGehee Craig E.Pfeifer Charles C.emerson Joseph D.Bivona Justin V.Stone Department of Health Sportand Exercise SciencesUniversity of KansasLawrenceKansasUSA Department of Exercise Science University of South CarolinaColumbiaSCUSA Division of Exercise and Sport Science Bob Jones UniversityGreenvilleSouth CarolinaUSA Applied Sport and Exercise Sciences The ParkUniversity of GloucestershireCheltenham GL502RHUnited Kingdom Department of Athletics University of Missouri-Kansas CityKansas CityUSA

Using a double-blind,randomized and counterbalanced,cross-over design,we assessed naproxen's effects on gastrointestinal(GI)distress and performance in eleven volunteers(6 male,5 female).Participants completed 4 trials:1)placebo and ambient);2)placebo and heat;3)naproxen and ambient;and 4)naproxen and *** variables were one placebo or 220 mg naproxen pill every 8 h(h)for 24 h and ambient(22.7±1.8℃)or thermal environment(35.7±1.3℃).Participants cycled 80 min at a steady heart rate then 10 min for maximum *** exertion was measured throughout *** distress was assessed pre-,during,post-,3 h post-,and 24 h post-cycling using a GI index for upper,lower,and systemic *** statistically significant differences occurred between conditions at any time for GI symptoms or perceived exertion,distance,or heart rate during maximum effort.A 24 h naproxen dose did not significantly affect performance or cause more frequent or serious GI distress when participants were euhydrated and cycling at moderate intensity in a thermal environment.

关键词： NSAID Gastrointestinal bleeding Heart rate Perceived exertion

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Climate-influenced vector-borne diseases in Africa: a call to empower the next generation of African researchers for sustainable solutions

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贫困所致传染病(英文) 2024年第2期13卷 1-10页

作者： Obame-Nkoghe Judica?l Agossou Adjoavi Esse mboowa Gerald Kamgang Basile Caminade Cyril Duke dawn C. Githeko Andrew Karanja Ogega Obed m. Elloué Nestor Engone Sarr Fatou Bintou Nkoghe Dieudonné Kengne Pierre Ndam Nicaise T. Paupy Christophe Bockarie moses Otomo Patricks Voua molecular and Cellular Biology Laboratory (LabmC) Biology Department University of Science and Technology of Masuku BP Franceville Gabon Ecology and Health Research Unit Interdisciplinary Center for Medical Research of Franceville BP Franceville Gabon Department of Zoology and Entomology Faculty of Natural and Agricultural Sciences University of the Free State Private Bag x13 Phuthaditjhaba Republic of South Africa Laboratory of Pharmacology and Improved Traditional medicines Department of Animal Physiology Faculty of Science and Technology University of Abomey-Calavi BP Cotonou Benin The African Center of Excellence in Bioinformatics and Data-Intensive Sciences Infectious Diseases Institute College of Health Sciences Makerere University P. O Box Kampala Uganda Africa Centers for Disease Control and Prevention African Union Commission Roosevelt Street P.O. Box WKAddis Ababa Ethiopia Centre for Research in Infectious Diseases P.O. Box Yaoundé Cameroon Earth System Physics Department The Abdus Salam International Centre for Theoretical Physics Trieste Italy Africa Research Excellence Fund Charterhouse Street London EC1MHR UK Community Health Support Program P.O. Box Kisumu Kenya The African Academy of Sciences Nairobi Kenya Center for Phylosophical Studies and Research (CERP) Omar Bongo University (UOB) BP Libreville Gabon UmRED Health Training and Research Unit University of Iba Der Thiam of Thiès BP Thiès Senegal National Parasitic Diseases Control Program Ministry of Health Libreville Gabon mIVEGEC Univ. Montpellier CNRS IRD Montpellier France mERIT IRD Paris Cité University Paris France Department of Parasitology Noguchi Memorial Institute for Medical Research University of Ghana LG Accra Ghana School of Community Health Sciences Njala University Bo Sierra Leone

We look at the link between climate change and vector-borne diseases in low- and middle-income countries in Africa. The large endemicity and escalating threat of diseases such as malaria and arboviral diseases, intensified by climate change, disproportionately affects vulnerable communities globally. We highlight the urgency of prioritizing research and development, advocating for robust scientific inquiry to promote adaptation strategies, and the vital role that the next generation of African research leaders will play in addressing these challenges. Despite significant challenges such as funding shortages within countries, various pan-African-oriented funding bodies such as the African Academy of Sciences, the Africa Research Excellence Fund, the Wellcome Trust, the U.S. National Institutes of Health, and the Bill and melinda Gates Foundation as well as initiatives such as the African Research Initiative for Scientific Excellence and the Pan-African mosquito Control Association, have empowered (or are empowering) these researchers by supporting capacity building activities, including continental and global networking, skill development, mentoring, and African-led research. This article underscores the urgency of increased national investment in research, proposing the establishment of research government agencies to drive evidence-based interventions. Collaboration between governments and scientific communities, sustained by pan-African funding bodies, is crucial. Through these efforts, African nations are likely to enhance the resilience and adaptive capacity of their systems and communities by navigating these challenges effectively, fostering scientific excellence and implementing transformative solutions against climate-sensitive vector-borne diseases.

关键词： Climate change Vector-borne diseases Africa Environmental justice Research and development Pan-African funding initiatives

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Historical trends of degradation,loss,and recovery in the tropical forest reserves of Ghana

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International Journal of Digital Earth 2022年第1期15卷 30-51页

作者： michael C.Wimberly Francis K.Dwomoh Izaya Numata Foster mensah Jacob Amoako dawn m.Nekorchuk Andrea mcmahon Department of Geography and Environmental Sustainability University of OklahomaNormanOKUSA Department of Geography and Geospatial Sciences South Dakota State UniversityBrookingsSDUSA Centre for Remote Sensing and Geographic Information Services University of GhanaAccraGhana The Forestry Commission of Ghana AccraGhana

The Upper Guinean Forest region of West Africa,a globally significant biodiversity hotspot,is among the driest and most human-impacted tropical *** used Landsat to study forest degradation,loss,and recovery in the forest reserves of Ghana from 2003 to *** canopy cover maps were generated using random forests and results were temporally segmented using the LandTrendr *** cover was predicted with a predicted-observed r2 of 0.76,mean absolute error of 12.8%,and mean error of 1.3%.Forest degradation,loss,and recovery were identified as transitions between closed(>60%cover),open(15–60%cover)and low tree cover(m 2003 to 2015,but there was more disturbance than recovery resulting in a gradual decline in closed canopy *** 2016,widespread fires associated with El Niño drought caused forest loss and degradation across more than 12%of the moist semi-deciduous and upland evergreen forest *** workflow was implemented in Google Earth Engine,allowing stakeholders to visualize the results and download *** about historical disturbances will help to prioritize locations for future studies and target forest protection and restoration activities aimed at increasing resilience.

关键词： Landsat random forests machine learning time series LandTrendr drought wildfire

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Chronic Pain 2nd ed. 2009

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丛书名： Current Clinical Practice

2009年

作者： dawn marcus

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Chronic Pain 2005

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丛书名： Current Clinical Practice

2005年

作者： dawn marcus

ISBN: (数字)9781592598823

ISBN: (纸本)9781588295019

Leading pain specialist dawn A. marcus, mD, offers primary care clinicians practical, clear, and succinct evidence-based approaches to the diagnosis and treatment of the painful conditions they see in their offices every day. The author simplifies the often complex care of patients with chronic pain by providing practical strategies for targeting important symptoms, establishing realistic treatment goals, and managing patients with instructional sheets that can be copied directly from the book and used for both education and the monitoring of therapeutic compliance and response. Numerous case-oriented practical applications illustrate the evaluation, diagnosis, and treatment of patients with chronic pain in the context of a busy office practice. Important sections on opioid therapy and special patient groups are also included. Supplementary features include a value-added compact disk containing an ebook version of the book or use in the reader's computer or PDA, and continuing medical education (CmE) questions that provide the opportunity to acquire 5 AmA/PRA category 1 credits

关键词： Pain

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Constraints and Opportunities for Detecting Land Surface Phenology in Drylands

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Journal of Remote Sensing 2021年第1期2021卷 332-346页

作者： Shawn D.Taylor dawn m.Browning Ruben A.Baca Feng Gao US Department of Agriculture Agricultural Research ServiceJornada Experimental RangeNew Mexico State UniversityLas CrucesNew Mexico 88003USA Oak Ridge Institute for Science and Education(ORISE) Oak RidgeTennessee 37830USA US Department of Agriculture Agricultural Research ServiceHydrology and Remote Sensing LaboratoryBeltsvilleMaryland 20705USA

Land surface phenology(LSP)enables global-scale tracking of ecosystem processes,but its utility is limited in drylands due to low vegetation cover and resulting low annual amplitudes of vegetation indices(VIs).Due to the importance of drylands for biodiversity,food security,and the carbon cycle,it is necessary to understand the limitations in measuring dryland ***,using simulated data and multitemporal unmanned aerial vehicle(UAV)imagery of a desert shrubland,we explore the feasibility of detecting LSP with respect to fractional vegetation cover,plant functional types,VI uncertainty,and two different detection *** simulated data,we found that plants with distinct VI signals,such as deciduous shrubs,can require up to 60%fractional cover to consistently detect *** plants,with lower seasonal VI amplitude,require considerably higher cover and can have undetectable phenology even with 100%vegetation *** evaluation of two algorithms showed that neither performed the best in all *** with adequate cover,biases in phenological metrics can still exceed 20 days and can never be 100%accurate due to VI uncertainty from shadows,sensor view angle,and atmospheric *** showed how high-resolution UAV imagery enables LSP studies in drylands and highlighted important scale effects driven by within-canopy VI *** high-resolution imagery,the open canopies of drylands are beneficial as they allow for straightforward identification of individual plants,enabling the tracking of phenology at the individual *** thus have the potential to become an exemplary environment for future LSP research.

关键词： fractional straight imagery

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Effect of Helicobacter pylori cdrA on interleukin-8 secretions and nuclear factor kappa B activation

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World Journal of Gastroenterology 2012年第5期18卷 425-434页

作者： Hiroaki Takeuchi Ya-Nan Zhang dawn A Israel Richard m Peek Jr mikio Kamioka Hideo Yanai Norihito morimoto Tetsuro Sugiura Department of Clinical Laboratory medicine Kochi Medical School Kohasu Oko-cho Nankoku-city Kochi783-8505 Japan Laboratory Department Beijing Tiantan Hos-pital Affiliated of Capital Medical University Beijing 100050China Department of Internal medicine Kanmon Medical Center 1-1-1 Ushiroda-cho Shimonoseki Yamaguchi 751-8501 Japan

AIm:To investigate genetic diversity of Helicobacter pylori (***) cell division-related gene A (cdrA) and its effect on the host ***:Inactivation of *** cdrA,which is involved in cell division and morphological elongation,has a role in chronic persistent *** property of *** cdrA was evaluated using polymerase chain reaction and sequencing in 128 (77 American and 51 Japanese) clinical isolates obtained from 48 and 51 patients,***-linked immunosorbent assay was performed to measure interleukin-8 (IL-8) secretion with gastric biopsy specimens obtained from American patients colonized with cdrA-positive or-negative strains and AGS cells cocultured with wild-type HPK5 (cdrA-positive) or its derivative HPKT510 (cdrA-disruptant).Furthermore,the cytotoxin-associated gene A (cagA) status (translocation and phosphorylation) and kinetics of transcription factors [nuclear factor-kappa B (NF-κB) and inhibition kappa B] were investigated in AGS cells co-cultured with HPK5,HPKT510 and its derivative HPK5CA (cagA disruptant) by western blotting analysis with ***:Genetic diversity of the *** cdrA gene demonstrated that the cdrA status segregated into two categories including four allele types,cdrA-positive (allele types;Ⅰand Ⅱ) and cdrA-negative (allele types;Ⅲ and Ⅳ) categories,*** all Japanese isolates were cdrA-positive (Ⅰ:7.8% and Ⅱ:90.2%),whereas 16.9% of American isolates were cdrA-positive (Ⅱ) and 83.1% were cdrA-negative (Ⅲ:37.7% and Ⅳ:45.5%),indicating extended diversity of cdrA in individual American *** of each isolate from different regions (antrum and corpus) in the stomach of 29 Americans revealed that cdrA status was identical in both isolates from different regions in 17 ***,12 cases had a different cdrA allele and 6 of them exhibited a different cdrA category between two regions in the ***,in 5 of the 6 cases possessing a

关键词： IL-8 分泌物核因子κB 酶联免疫吸附试验聚合酶链反应遗传多样性幽门螺杆菌持续性感染

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Association between admission haematocrit and mortality among men with acute ischaemic stroke

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Stroke & Vascular Neurology 2018年第3期3卷 160-168页

作者： Jason J Sico Laura J myers Brenda J Fenton John Concato Linda S Williams dawn m Bravata Neurology Service VA Connecticut Healthcare SystemWest HavenConnecticutUSA Department of Neurology Center for NeuroEpidemiological and Clinical Neurological ResearchYale University School of MedicineNew HavenConnecticutUSA Department of Internal medicine Yale University School of MedicineNew HavenConnecticutUSA Clinical Epidemiology Research Center(CERC) VA Connecticut Healthcare SystemWest HavenConnecticutUSA Pain Research InformaticsMultimorbidities and Education(PRIME)Center of InnovationVA Connecticut Healthcare SystemWest HavenConnecticutUSA Communication and the HSR&D Stroke Quality Enhancement Research Initiative(QUERI) Richard L Roudebush VA Medical CenterIndianapolisIndianaUSA VA Health Services Research and Development(HSR&D) Center for Healthcare InformaticsRichard L Roudebush VA Medical CenterIndianapolisIndianaUSA Division of Chronic Disease Epidemiology Yale School of Public HealthWest HavenConnecticutUSA medical Service VA Connecticut Healthcare SystemWest HavenConnecticutUSA Regenstrief Institute IndianapolisIndianaUSA Department of Neurology Indiana University School of MedicineIndianapolisIndianaUSA Department of Internal medicine Indiana University School of MedicineIndianapolisIndianaUSA

Objective Anaemia is associated with higher mortality among patients with non-stroke cardiovascular conditions;less is known regarding the relationship between anaemia and mortality among patients with acute ischaemic *** medical records were abstracted for n=3965 veterans from 131 Veterans Health Administration facilities who were admitted with ischaemic stroke in fiscal year *** values within 24 hours of admission were classified as≤27%,28%-32%,33%-37%,38%-42%,43%-47% or≥48%.multivariate logistic regression was used to examine the relationship between anaemia and in-hospital,30-day,6-month and 1-year mortality,adjusting for age,medical comorbidities,modified Acute Physiology and Chronic Health Evaluation-III and stroke *** factors were calculated to standardise comparisons between haematocrit tier and other *** Among n=3750 patients included in the analysis,the haematocrit values were≤27%in 2.1%(n=78),28%-32% in 6.2%(n=234),33%-37%in 17.9%(n=670),38%-42% in 36.4%(n=1366),43%-47% in 28.2%(n=1059)and≥48% in 9.1%(n=343).Patients with haematocrit≤27%,compared with patients in the 38%-42% range,were more likely to have died across all follow-up intervals,with statistically significant adjusted ORs(aORs)ranging from 2.5 to *** with polycythaemia(ie,haematocrit≥48%)were at increased risk of in-hospital mortality(aOR=2.9;95%CI 1.4 to 6.0),compared with patients with mid-range admission *** differences between patients receiving and not receiving blood transfusion limited our ability to perform a propensity *** factors in the 1-year mortality model were 0.46(severe anaemia),0.06(cancer)and 0.018(heart disease).Conclusions Anaemia is independently associated with an increased risk of death throughout the first year post stroke;high haematocrit is associated with early poststroke *** anaemia is associated with 1-year mortality to a greater degree than cancer or heart dise

关键词： mortality admitted transfusion

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