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Movement analysis in the diagnosis and management of Parkinson’s disease

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Neural Regeneration Research 2025年第2期20卷 485-486页

作者： Johannes Burtscher Nicolas Bourdillon Jules MJanssen Daalen Aurélien Patoz Julien FBally Martin Kopp davide Malatesta Bastiaan RBloem Institute of Sport Sciences University of LausanneLausanneSwitzerland Radboud University Medical Center Department of NeurologyDonders Institute for BrainCognition and BehaviorCenter of Expertise for Parkinson and Movement DisordersNijmegenThe Netherlands Radboud University Medical Center Department of Medical BioSciencesNijmegenThe Netherlands Research and Development Department Volodalen Swiss Sport LabAigleSwitzerland Service of Neurology Department of Clinical NeurosciencesLausanne University Hospital(CHUV)and University of Lausanne(UNIL)LausanneSwitzerland Department of Sport Science University of InnsbruckInnsbruckAustria

Challenges in the diagnosis and treatment of Parkinson’s disease:Parkinson’s disease(PD)is an increasingly prevalent neurodegenerative disease,at first sight primarily characterized by motor symptoms,although non-motor symptoms also constitute a major part of the overall ***,this disease cannot be diagnosed reliably until a large part of the vulnerable dopaminergic neurons has been irretrievably lost,and the disease progresses *** biological criteria for PD have been proposed recently and might eventually improve early diagnosis,but they require further validation,and their use will initially be restricted to a research environment(Darweesh et al.,2024).

关键词： diagnosis Clinical eventually

Multi-revolution low-thrust trajectory optimization using symplectic methods

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Science China(Technological Sciences) 2020年第3期63卷 506-519页

作者： E ZhiBo GUZZETTI davide School of Aerospace Engineering Tsinghua UniversityBeijing 100084China Department of Aerospace Engineering Auburn UniversityAuburn AL 36849USA

Optimization of low-thrust trajectories that involve a larger number of orbit revolutions is considered as a challenging *** paper describes a high-precision symplectic method and optimization techniques to solve the minimum-energy low-thrust multi-revolution orbit transfer problem. First, the optimal orbit transfer problem is posed as a constrained nonlinear optimal control problem. Then, the constrained nonlinear optimal control problem is converted into an equivalent linear quadratic form near a reference solution. The reference solution is updated iteratively by solving a sequence of linear-quadratic optimal control sub-problems, until convergence. Each sub-problem is solved via a symplectic method in discrete form. To facilitate the convergence of the algorithm, the spacecraft dynamics are expressed via modified equinoctial elements. Interpolating the non-singular equinoctial orbital elements and the spacecraft mass between the initial point and end point is proven beneficial to accelerate the convergence process. Numerical examples reveal that the proposed method displays high accuracy and efficiency.

关键词： low-thrust trajectory optimization symplectic method multi-revolution transfers

Activity-dependent mechanisms of neuroprotection:promising avenues against dementia

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Neural Regeneration Research 2024年第7期19卷 1409-1410页

作者： davide Tampellini U1195 INSERM-UniversitéParis-Saclay Le Kremlin-BicêtreFrance Institut Professeur Baulieu Le Kremlin-BicêtreFrance

The study of the brain and its complex functions is highly fascinating and,at the same time,extremely ***,furthering our understanding of the biology of neurons and synapses is a prerequisite to uncover the mechanisms involved in memory formation and the coordination of movement as well as their alterations occurring in several neurological disorders.

关键词： alterations mechanisms neurological

Renewable Energy Penetration Strengthened Using a Reversible Solid Oxide Cell Installed in a Building

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CSEE Journal of Power and Energy Systems 2022年第2期8卷 360-368页

作者： Mario Lamagna davide Astiaso Garcia Astronautical Electrical and Energy Engineering Department(DIAEE)Sapienza University of RomeItaly Planning DesignTechnology of Architecture Department(DPDTA)Sapienza University of RomeItaly

The renewable energy source(RES)penetration in end use must be strengthened to reach the prefixed decarbonization targets.A penetration obstacle is represented by the Power Grid,designed with an architecture disinclined to RES ***,different solutions are available to integrate these latter issues without affecting the Grid,among these,the reversible Solid Oxide Cell(rSOC)promises high efficiencies and the possibility to control energy fluxes in both production and *** this study,a series of hourly simulations based on real data were designed to evaluate the rSOC capacity to integrate a large number of RESs in the end use of three different buildings,through analyzing the possible congestion on the Power *** a rSOC model we chose the Smart Energy Hub proposed by Sylfen while for the buildings we selected a school,a hotel,and an office located in Procida,*** results show the rSOC capacity to integrate RES increased from 40%to 62%according to the storage capacity and the building’s hourly load curve and seasonal consumptions.

关键词： Green hydrogen RES integration rSOC power-to-power

Friction and wear performance of polyether ether ketone(PEEK)polymers in three lubrication regimes

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Friction 2024年第4期12卷 670-682页

作者： davide MASSOCCHI Nora LECIS Marco LATTUADA davide SCAGLIA Steven CHATTERTON Paolo PENNACCHI Department of Mechanical Engineering Politecnico di MilanoMilan 20156Italy Eni SpA Downstream product R&DLombardia 20097Italy Eurobearings S.R.L. Lombardia 29016Italy

This experimental study investigates the friction and wear of three coatings commonly used in industrial applications,particularly in hydrodynamic *** three materials under investigation were Babbitt,polyether ether ketone(PEEK)reinforced with 15%carbon fibers,and PEEK reinforced with 20%carbon *** first polymer material was extruded,while the other was produced by fused deposition modelling(FDM).The materials were subjected to sliding tests in a pin-on-disc configuration,with a steel ball serving as the counter *** tests were conducted at room temperature,with a load of 10 N and under three different lubrication conditions:dry,grease,and *** linear speed was set at 0.3 m/s for the dry and semi-solid lubrication tests,while for the oil tests,the speed was set at 0.25 m/*** greases used had consistency grades of NGLI 000 and NGLI *** ISO VG 68 circulation oil was used for the oil lubrication ***,thermodynamic analyses were performed under the most severe conditions(i.e.,dry)to investigate the steel-Babbitt and steel-PEEK contact.

关键词： hydrodynamic bearings polyether ether ketone(PEEK)polymers additive manufacturing grease lubrication sliding oil lubrication ball-on-disk tribology

Isogeometric analysis of multi-patch solid-shells in large deformation

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Acta Mechanica Sinica 2021年第5期37卷 844-860,I0003页

作者： Qingyuan Hu davide Baroli Shuzhen Rao School of Science Jiangnan UniversityWuxi 214122China AICES-Aachen Institute for Advanced Study in Computational Engineering Science 52062 AachenGermany

In the context of isogeometric analysis(IGA)of shell structures,the popularity of the solid-shell elements benefit from formulation simplicity and full 3D stress *** some basic questions remain unresolved when using solid-shell element,especially for large deformation cases with patch coupling,which is a common scene in real-life *** this research,after introduction of the solid-shell nonlinear formulation and a fundamental 3D model construction method,we present a non-symmetric variant of the standardNitsche’s formulation for multi-patch coupling in associationwith an empirical formula for its stabilization *** selective and reduced integration scheme is also presented to address the locking *** addition,the quasi-Newton iteration format is derived as solver,together with a step length control *** second order derivatives are totally neglected by the adoption of the non-symmetric Nitsche’s formulation and the quasi-Newton *** solid-shell elements are numerically studied by a linear elastic plate example,then we demonstrate the performance of the proposed formulation in large deformation,in terms of result verification,iteration history and continuity of displacement across the coupling interface.

关键词： Isogeometric Solid-shell Nitsche Patch coupling Quasi-Newton

A Geometrical Approach to Compute Upper Limb Joint Stiffness

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Computer Modeling in Engineering & Sciences 2020年第4期123卷 23-47页

作者： davide Piovesan Roberto Bortoletto Biomedical Industrial and Systems EngineeringGannon University109 University SquareEriePA16541USA 2221e Ltd. Piazza dell’Artigianato1035031 Abano Terme(PD)Italy

Exoskeletons are designed to control the forces exerted during the physical coupling between the human and the *** the human is an active system,the control of an exoskeleton requires coordinated action between the machine and the load so to obtain a reciprocal *** in the control loop can be modeled as active mechanical loads whose stiffness is continuously *** direct measurement of human stiffness is difficult to obtain in real-time,thus posing a significant limitation to the design of wearable robotics ***(EMG)recordings can provide an indirect estimation of human muscle force and stiffness,but current methods for the acquisition of the signals limit their use and *** work proposes a hybrid method for the estimation of upper limb joint stiffness during reaching movements that combines EMG-driven muscle models and constrained *** these two stages process,we estimated an optimal joints’stiffness bounded in a physiologically sound variability *** information is crucial when designing exoskeletons user interfaces in which the limb stiffness is an integral part of the control ***-to-point human reaching movements were analyzed to reconstruct the joint stiffness of the upper *** accurate 3D model of the arm,encompassing all bones from the hand to the scapula and the majority of the upper limb muscles,was developed to represent the sliding center of rotation of the joints.A well-posed parallel mechanism between the skeleton and the configuration of the tracking markers was ***,the muscles’force and joint stiffness were calculated using a generalized pseudo-inversion of the Jacobian transformation between the muscles and Cartesian *** maximal and minimal forces exertable by the muscles were set as the boundary condition for the generalized pseudo-inverse by means of a state-of-the-art muscle model.

关键词： Stiffness inverse problem force method constrained optimization EMG.

Diabetic retinopathy: a matter of retinal ganglion cell homeostasis

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Neural Regeneration Research 2020年第7期15卷 1253-1254页

作者： Elisabetta Catalani davide Cervia Department for Innovation in Biological Agro-food and Forest systems (DIBAF) Università degli Studi della Tuscialargo dell’Università snc

Diabetic retinopathy(DR)is the most common complication of diabetes and the leading cause of visual impairment in the working-age population in the Western world(http://***/).One of the earliest events observed in DR is the impairment of retinal perfusion,caused by the constriction of retinal blood vessels,inducing biochemical and metabolic alterations,perycites/endothelial degeneration,and retina ischemia(Wong et al.,2016).Severe stages of DR include proliferative DR,caused by the abnormal growth of new vessels,and diabetic macular oedema in the central part of the *** is strongly associated with a prolonged duration of diabetes,hypertension,and hyperglycaemia but it can persist even after replacement of normal glycaemic status(Wong et al.,2016).

关键词： homeostasis alterations impairment

Silybin and the liver: From basic research to clinical practice

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World Journal of Gastroenterology 2011年第18期17卷 2288-2301页

作者： Carmela Loguercio davide Festi Gastroenterology School-Interuniversity Research Centre on Foods Nutrition and Gastrointestinal Tract (CIRANAD) 2nd University of Naples Department of Clinical Medicine University of Bologna

Herbal products are increasingly used, mainly in chronic liver disease. Extracts of milk thistle, Silymarin and silybin, are the most prescribed natural compounds, with different indications, but with no definitive results in terms of clinical efficacy. This review analyzes the available studies on the effects of the purified product silybin, both as a free and a conjugated molecule, on liver cells or on experimentally induced liver damage, and in patients with liver disease. We searched PUBMED for articles pertaining to the in vitro and in vivo effects of silybin, its antifibrotic, anti-inflammatory, and antioxidant properties, as well as its metabolic effects, combined with the authors’ own knowledge of the literature. Results indicate that the bioavailability of silybin phytosome is higher than that of silymarin and is less influenced by liver damage; silybin does not show significant interactions with other drugs and at doses < 10 g/d has no significant side effects. Experimental studies have clearly demonstrated the antifibrotic, antioxidant and metabolic effects of silybin; previous human studies were insufficient for confirming the clinical efficacy in chronic liver disease, while ongoing clinical trials are promising. On the basis of literature data, silybin seems a promising drug for chronic liver disease.

关键词： Milk thistle Silymarin Liver disease Hepatic fibrosis Hepatic inflammation Radical species