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Diabetic retinopathy: a matter of retinal ganglion cell homeostasis

Neural Regeneration Research 2020年第7期15卷 1253-1254页

作者： Elisabetta Catalani davide cervia Department for Innovation in Biological Agro-food and Forest systems (DIBAF) Università degli Studi della Tuscialargo dell’Università snc

Diabetic retinopathy(DR)is the most common complication of diabetes and the leading cause of visual impairment in the working-age population in the Western world(http://***/).One of the earliest events observed in DR is the impairment of retinal perfusion,caused by the constriction of retinal blood vessels,inducing biochemical and metabolic alterations,perycites/endothelial degeneration,and retina ischemia(Wong et al.,2016).Severe stages of DR include proliferative DR,caused by the abnormal growth of new vessels,and diabetic macular oedema in the central part of the *** is strongly associated with a prolonged duration of diabetes,hypertension,and hyperglycaemia but it can persist even after replacement of normal glycaemic status(Wong et al.,2016).

关键词： homeostasis alterations impairment

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Novel emphasis on somatostatinergic system in retinal ganglion cell neuroresilience

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Neural Regeneration Research 2024年第1期19卷 148-149页

作者： Elisabetta Catalani davide cervia Department for Innovation in Biological Agro-food and Forest Systems(DIBAF)Universitàdegli Studi della Tuscialargo dell’UniversitàsncViterboItaly

The neuromodulatory peptide somatostatin(somatotropin release inhibiting factor,SRIF)-14 acts at multiple levels through five SRIF receptor subtypes(sst1 to sst5).SRIF-28 is also derived from a common propeptide translated from a single SRIF gene,although SRIF-14 is the predominant form in the mammalian nervous *** to its short half-life,synthetic SRIF analogs have been developed over the years and are available for therapeutic approaches.

关键词： life system predominant

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A Drosophila perspective on retina functions and dysfunctions

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Neural Regeneration Research 2022年第2期17卷 341-343页

作者： Elisabetta Catalani Federica Silvestri davide cervia Department for Innovation in Biological Agro-food and Forest Systems(DIBAF)Universitadegli Studi della Tuscialargo dell’UniversitasncViterboItaly

Due to the high degree of conservation of genes and mechanisms, the fruit fly Drosophila melanogaster is a powerful experimental in vivo tool to investigate complex diseases, thus complementing traditional vertebrate systems. Drosophila is also an advantageous system regarding the animal husbandry and the short generation time and lifespan.

关键词： Drosophila husbandry functions

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Recent advances in cellular and molecular aspects of mammalian retinal ischemia

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World Journal of Pharmacology 2012年第2期1卷 30-43页

作者： davide cervia Giovanni Casini Department for Innovation in Biological Agro-food and Forest systems University of Tuscia

Retinal ischemia is a common clinical entity and, due to relatively ineffective treatment, remains a common cause of visual impairment and blindness. Generally, ischemic syndromes are initially characterized by low homeostatic responses which, with time, induce injury to the tissue due to cell loss by apoptosis. In this re-spect, retinal ischemia is a primary cause of neuronal death. It can be considered as a sort of fnal common pathway in retinal diseases and results in irreversible morphological and functional changes. This review summarizes the recent knowledge on the effects of ischemia in retinal tissue and points out experimental strategies/models performed to gain better compre-hension of retinal ischemia diseases. In particular, the nature of the mechanisms leading to neuronal damage （i.e., excess of glutamate release, oxidative stress and infammation） will be outlined as well as the potential and most intriguing retinoprotective approaches and the possible therapeutic use of naturally occurring molecules such as neuropeptides. There is a general agreement that a better understanding of the funda-mental pathophysiology of retinal ischemia will lead tobetter management and improved clinical outcome. In this respect, to contrast this pathological state, spe-cifc pharmacological strategies need to be developed aimed at the many putative cascades generated during ischemia.

关键词： Cell death Glutamate Hypoxia Inflam-mation Neurodegeneration Neuropeptides Oxidative stress Retinopathies

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