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Cabazitaxel in castration resistant prostate cancer with brain metastases: 3 case reports

World Journal of Clinical Cases 2014年第6期2卷 228-231页

作者： Sabino De Placido Pasquale Rescigno Piera Federico Carlo Buonerba davide bosso Livio Puglia Michela Izzo Tania Policastro Giuseppe Di Lorenzo Genitourinary Cancer Section Medical Oncology Department of Clinical Medicine Federico Ⅱ University

Prostate cancer is the most common non-cutaneous malignancy for men. The skeleton is the most common metastatic site but, following an improvement in survival, metastases in uncommon sites are being found more frequently in clinical practice, especially brain metastases. Despite the new drugs now available for metastatic castration resistant prostate cancer, no clinical evidence exists about their effectiveness on brain metastases. We describe the clinical history of 3 patients treated with cabazitaxel plus whole brain radiotherapy. These case reports demonstrate that cabazitaxel is highly active and well tolerated in brain metastases.

关键词： Cabazitaxel Brain metastases Prostate cancer

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Locally advanced nasopharyngeal carcinoma:Current and emerging treatment strategies

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World Journal of Clinical Oncology 2011年第12期2卷 377-383页

作者： Francesco Perri davide bosso Carlo Buonerba Giuseppe Di Lorenzo Giuseppina Della Vittoria Scarpati Oncology Division Division INT Fondazione“G.Pascale”80131 NaplesItaly Oncology and Rare Cancer Center FedericoⅡUniversity80131 NaplesItaly

Although nasopharyngeal carcinoma(NPC)is a widespread malignant tumor,it is particularly frequent in Southeast *** T1 tumors can be effectively controlled with exclusive radiotherapy,this treatment modality is insufficient for most NPC patients,who present with locally advanced disease at *** fact,for stages ranging from T2b N0 to T4 N3,definitive scientific evidence supports the use of concurrent platinum-based chemotherapy with standard external beam *** treatment approach has shown a statistically significant advantage in terms of overall survival,with respect to radiotherapy *** trials have also investigated the use of neoadjuvant and adjuvant chemotherapy in combination with radiotherapy or *** compounds,anthracyclines and taxanes are among the chemotherapy agents *** review focuses on the clinical results obtained in the field of adjuvant/concurrent/neoadjuvant chemotherapy for locally advanced NPC,for which exclusive concurrent chemo-radiotherapy currently represents the standard treatment approach.

关键词： Chemotherapy Nasopharyngeal carcinoma Radiotherapy Treatment

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World Journal of Clinical Oncology 2013年第2期4卷 52-57页

作者： Pasquale Rescigno Rossella Di Trolio Carlo Buonerba Gaia De Fata Piera Federico davide bosso Antonella Virtuoso Michela Izzo Tania Policastro Luca Vaccaro Gianfranco Cimmino Francesco Perri Elide Matano Mario Delfino Sabino De Placido Giovannella Palmieri Giuseppe Di Lorenzo Genitourinary Cancer Section and Rare-Cancer Center Medical Oncology DivisionUniversity Federico II80131 NapoliItaly Department of Dermatology University Federico II of Naples80131 NapoliItaly

AIM:To evaluate the outcomes and potential prognostic factors in patients with non-acquired immunodeficiency syndrome(AIDS)-related Kaposi’s sarcoma(KS).METHODS:Patients with histologically proven non-AIDS-related KS treated with systemic chemotherapy were included in this retrospective *** some cases,the human herpes virus 8 status was assessed by *** patients were staged according to the Mediterranean KS staging system.A multivariable model was constructed using a forward stepwise selection procedure.A P value<0.05 was considered statistically significant,and all tests were ***:Thirty-two cases were included in this *** average age at diagnosis was 70 years,with a male/female ratio of approximately 2:***-four percent of the cases had classic *** patients received systemic chemotherapy containing one of the following agents:vinca alkaloid,taxane,and pegylated liposomal *** patients(31.5%)experienced a partial response,and a complete response was achieved in four patients(12.4%)and stable disease in sixteen cases(50%).Two patients(6.2%)were refractory to the systemic *** median progression-free survival(PFS)was 11.7 mo,whereas the median overall survival was 28.5 *** multivariate analysis,the presence of nodular lesions(vs macular lesions only)was significantly related to a lower PFS(hazard ratio:3.09;95%CI:1.18-8.13,P=0.0133).CONCLUSION:Non-AIDS-related KS appears mostly limited to the skin and is well-responsive to systemic *** data show that nodular lesions may be associated with a shorter PFS in patients receiving chemotherapy.

关键词： Kaposi’s sarcoma Human herpes virus 8 Paclitaxel Pegylated liposomal doxorubicin Vinblastine

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