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Alternative stable states in mountain forest ecosystems： the case of European larch(Larix decidua) forests in the western Alps

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Journal of Mountain Science 2017年第5期14卷 811-822页

作者： Jose V.MORIS Giorgio VACCHIANO davide ascoli Renzo MOTTA University of Turin DISAFALargo Paolo Braccini 210095 Grugliasco(TO)Italy

European larch(Larix decidua) forests of the western Alps form extensivecultural landscapes whose resilience to global changes is currently unknown. Resilience describes the capacity of ecological systems to maintain the same state, i.e., the same function, processes, structure, and composition despite disturbances, environmental changes and internal fluctuations. Our aim is to explore the resilience of larch forests to changes in climate and land use in the western Italian *** do so, we examined whether larch forests can be described as an alternative stable state in mountain forest ecosystems. We used tree basal area data obtained from field forest inventories in combination with topography, forest structure, land use, and climate information. We applied three different probabilistic methods: frequency distributions, logistic regressions, and potential analyses to infer the resilience of larch forests relative to that of other forest *** found patters indicative of alternative stable states: bimodality in the frequency distribution of the percent of larch basal area, and the presence of an unstable state, i.e., mixed larch forests, in the potential analyses. We also found:(1) high frequency ofpurelarchforestsathighelevation,(2)the probability of pure larch forests increased mostly with elevation, and(3) pure larch forests were a stable state in the upper montane and subalpine *** study shows that the resilience of larch forests may increase with elevation, most likely due to the altitudinal effect on climate. Under the same climate conditions, land use seems to be the main factor governing the dominance of larch forests. In fact, subalpine larch forests may be more resilient, and natural succession after land abandonment, e.g., towards Pinuscembra forests, seems slower than in montane larch forests. In contrast, in the upper montane belt only intense land use regimes characterized by open canopies and forest grazing may maintain larch *** con

关键词： Resilience Ecosystem bistability Elevation Land use Natural succession Pinuscembra European larch

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Uncovering current pyroregions in Italy using wildfire metrics

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Ecological Processes 2022年第1期11卷 259-275页

作者： Mario Elia Vincenzo Giannico davide ascoli Juan Pablo Argañaraz Marina D’Este Giuseppina Spano Raffaele Lafortezza Giovanni Sanesi Department of Agricultural and Environmental Sciences University of Bari A.MoroVia Amendola 165/A70126 BariItaly Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Braccini 210095 GrugliascoTOItaly Mario Gulich Institute for Advanced Space Studies(CONAE-UNC) CONICETRoute C45km 8CP 5187 Falda del CañeteCórdobaArgentina Department of Geography The University of Hong KongCentennial CampusPokfulam RoadHong KongChina

Background:Pyrogeography is a major field of investigation in wildfire science because of its capacity to describe the spatial and temporal variations of fire *** propose a systematic pyrogeographic analytical approach to cluster regions on the basis of their *** employed the Affinity Propagation algorithm to cluster pyroregions using Italian landscape as a test bed and its current wildfire metrics in terms of density,seasonality and stand replacing fire ratio.A discussion follows on how pyrogeography varies according to differences in the human,biophysical,socioeconomic,and climatic ***:The algorithm identified seven different pyroregion *** main gradients were identified that partly explain the variability of wildfire metrics observed in the current ***,a gradient characterized by increasing temperatures and exposure to droughts,which coincides with a decreasing latitude,and second,a human pressure gradient displaying increasing population density in areas at lower *** drivers exerted a major influence on wildfire density,burnt area over available fuels and stand replacing,which were associated to warmdry climate and high human *** study statistically highlighted the importance of a North–South gradient,which represents one of the most important drivers of wildfire regimes resulting from the variations in climatic conditions but showing collinearity with socioeconomic aspects as ***:Our fully replicable analytical approach can be applied at multiple scales and used for the entire European continent to uncover new and larger *** could create a basis for the European Commission to promote innovative and collaborative funding programs between regions that demonstrate pyrosimilarities.

关键词： Pyrogeography Affinity propagation Forest Mediterranean basin Clustering

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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek W.Wheeler Giorgio A.ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第09期 2697-2705页

作者： Diek W.Wheeler Giorgio A.ascoli Center for Neural Informatics Structures& PlasticityKrasnow Institute for Advanced Study and Bioengineering Department Volgenau School of Engineering George Mason University

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Ultrasensitive detection of Ebola matrix protein in a memristor mode

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Nano Research 2018年第2期11卷 1057-1068页

作者： Bergoi Ibarlucea Teuku Fawzul Akbar Kihyun Kim Taiuk Rim Chang-Ki Baek Alon ascoli Ronald Tetzlaff Larysa Baraban Gianaurelio Cuniberti Institute of Materials Science Max Bergmann Center for Biomaterials Technische Universität Dresden Dresden Germany Center for Advancing Electronics Dresden (CFAED) Technische Universität Dresden Dresden Germany Department of Creative IT Engineering Pohang University of Science and Technology Pohang Republic of Korea Chair of Fundamentals of Electrical Engineering Technische Universität Dresden Dresden Germany

We demonstrate the direct biosensing of the Ebola VP40 matrix protein, using a memristor mode of a liquid-integrated nanodevice, based on a large array of honeycomb-shaped silicon nanowires. To shed more light on the principle of biodetection using memristors, we engineered the opening of the current-minima voltage gap VG by involving the third gap-control electrode （gate voltage, VG） into the system. The primary role of VG is to mimic the presence of the charged species of the desired sign at the active area of the sensor. We further showed the advantages of biodetection with an initially opened controlled gap （Vc~ ~a 0）, which allows the detection of the lowest concentrations of the biomolecules carrying arbitrary positive or negative charges; this feature was not present in previous configurations. We compared the bio-memristor performance, in terms of its detection range and sensitivity, to that of the already-known field-effect transistor （FET） mode by operating the same device. To our knowledge, this is the first demonstration of Ebola matrix protein detection using a nanoscaled electrical sensor.

关键词： memristor biosensor capacitance honeycomb nanowires silicon nanowire fieldeffect transistor VP40 matrix protein Ebola detection

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Sizing up whole-brain neuronal tracing

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Science Bulletin 2022年第9期67卷 883-884,M0003页

作者： Giorgio A.ascoli Bing-Xing Huo Partha P.Mitra Bioengineering Department Volgenau School of Engineering&Center for Neural InformaticsKrasnow Institutes for Advanced StudyGeorge Mason UniversityVirginia 22030USA Cold Spring Harbor Laboratory Cold Spring Harbor 11724USA

After an initial golden age typified by Cajal’s morphological classification of neuronal types based on Golgi’s stain at the turn of the twentieth century,followed by relative doldrums a few decades ago,Neuroanatomy has recently undergone a renaissance,driven by exponential decreases in storage and computing costs as well as major advances in biochemistry and microscopic *** can be seen through citations of the term“connectomics”recently coined to denote the study of neuroanatomical connectivity,which retrieves nearly 8000 hits in PubMed and over 20,000 in Google Scholar in the 15 years since the term appeared in print[1].It is broadly recognized that regional connectivity at the mesoscopic scale underlies distributed brain function and single neuron axonal projections underlie mesoscale connectivity[2,3].

关键词： connectivity exponential 解析技术

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Percutaneous approach to treatment of coronary disease in a patient with uremic cardiomyopathy

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World Journal of Cardiology 2011年第4期3卷 117-120页

作者： Gianluca Petrillo Plinio Cirillo Maria Prastaro Greta Luana D'ascoli Federico Piscione Department of Internal Medicine Cardiovascular and Immunological Sciences University of Naples "Federico II" via Sergio Pansini

Uremic cardiomyopathy is chronic ischemic left ventricular dysfunction characterized by heart failure, myocardial ischemia, hypotension in dialysis and arrhythmia. This nosologic entity represents a leading cause of morbidity and mortality among patients with endstage renal disease receiving long-term hemodialysis. It is intuitive that revascularization in the presence of coronary artery disease in these patients represents an effective option for improving their prognosis. Although the surgical option seems to be followed by the best clinical outcome, some patients refuse this option and others are not good candidates for surgery. The present report describes the case of a patient affected by uremic cardiomyopathy and severe coronary artery disease in whom revascularization with percutaneous coronary angioplasty was followed by a significant improvement in quality of life.

关键词： Coronary artery disease Heart failure Percutaneous coronary intervention Uremic cardiomyopathy

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