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Standardization and Identification of Minor Components of Silymarin (MK-001)

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Chinese Herbal Medicines 2012年第3期4卷 237-244页

作者： Yan-ze LIU[a][b] david yue-wei LEE[a] Bioorganic and Natural Product Laboratory McLean Hospital/Harvard Medical SchoolMA 02478USA Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China

Objective To develop a highly effective HPLC method for standardization of silymarin and for characterization of minor components, which has not been reported previously. Methods An HPLC fingerprinting method and 1 H-NMR spectroscopy were employed to provide assurance for a standardized silymarin product (MK-001). Results A total of 18 marker compounds were identified and characterized including ten flavonolignans and eight small molecules including adenine, adenosine, uridine, and 3,5,7-trihydroxychromone which were first isolated and characterized from silymarin. The HPLC fingerprinting method and 1 H-NMR had been established for complete assignments of HPLC peaks with intensity over 1.0%. Conclusion The successfully established HPLC fingerprinting method and 1 H-NMR could be applied for the standardization of commercial silymarin products. MK-001 represents the first standardized silymarin with the highest content of flavonolignans ( > 90%).

关键词： adenine flavonolignans 1 H-NMR HPLC fingerprinting silymarin

Natural Products Derived from Traditional Chinese Medicine for Treating Alcohol and Dr

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Natural Products Derived from Traditional Chinese Medicine f...

Product Form Solution of a Queuing-Inventory System with Lost Sales and Server Vacation

第十四届全国中药和天然药物学术研讨会

作者： david yue-Wei Lee Harvard Medical School

＜正＞Cocaine addiction is a vexing public health problem for which no effective pharmacotherapy *** derived bioactive compounds have been a rich source for modern drug *** evaluation and analysis of herbal remedies that already have proven success in stopping opium smoking in China may lead to identification of promising

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Journal of Systems Science & Complexity 2024年第2期37卷 729-758页

作者： yue Dequan ZHANG Yuying XU Xiuli yue Wuyi School of Science Yanshan UniversityQinhuangdao 066004China School of Economics and Management Yanshan UniversityQinhuangdao 066004China The Kyoto College of Graduate Studies for Informatics Kyoto City 606-8225Japan

In this study,the authors consider an M/M/1 queuing system with attached inventory under an(s,S)control *** server takes multiple vacations whenever the inventory is *** is assumed that the lead time and the vacation time follow exponential *** authors formulate the model as a quasi-birth-and-dearth(QBD)process and derive the stability condition of the ***,the stationary distribution in product form for the joint process of the queue length,the inventory level,and the server’s status is ***,the conditional distributions of the inventory level when the server is on and operational,and when it is off due to a vacation,are *** the stationary distribution,the authors obtain some performance measures of the *** authors investigate analytically the effect of the server’s vacation on the performance ***,several numerical examples are presented to investigate the effects of some parameters on the performance measures,the optimal policy,and the optimal cost.

关键词： Cost function multiple vacations product form solution queuing-inventory system (s S)control policy

In Vivo Controllability of a Metastasizing Cell as an Unstable Nonlinear Distributed System

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In Vivo Controllability of a Metastasizing Cell as an Unstab...

Machine learning-assisted smart epitaxy ofⅢ-Ⅴsemiconductors

第二十三届中国控制会议

作者： D.Dahsoong yue david V.yue Centrust Center for Systems Research P.O.Box 5755 BethesdaMaryland 20824-5755U.S.A.Ph.D.P.E. Centrust Center for Systems Research P.O.Box 5755 BethesdaMaryland 20824-5755U.S.A.

＜正＞ Gradient in vivo control operating in conjunction with boundary control on the cell membrane are shown to render control upon an unstable metastasizing cell described by a nonlinear parabolic distributed system stabilized and bring it under complete control. Similarly, time-rate in vivo control operations are shown to render an unstable nonlinear distributed system in a semi-infinile medium completely controllable. Such control functions in a biological cell are shown to play a vital role in the control of a malignant tumor in a living organism. Application of this new type of mathematical models in clinical oncology will shed new insight into cellular control mechanism in an in vivo biological cell and provide a new clinical tool to cancer management.

关键词： Nonlinear Distributed Systems Unstable Controllability Intracellular Boundary Control Metastasizing Cell Immune Antibody-Antigen Cell Membrane.

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Science China Materials 2024年第9期67卷 3041-3042页

作者： yue Hao Key Laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian UniversityXi’an710071China

Semiconductor epitaxial growth is the front-end process for manufacturing microelectronic and optoelectronic *** beam epitaxy(MBE),capable of precisely controlling atomic layer deposition,has emerged as a crucial technique in chip atomic-level manufacturing[1].However,in semiconductor epitaxy,the heterogeneous nature of materials is complicated,and the growth condition fluctuations poses significant challenges in defect suppression[2],substantially impacting chip performance and yield.

关键词： optoelectronic smart semiconductors

Elite Dung Beetle Optimization Algorithm for Multi-UAV Cooperative Search in Mountainous Environments

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Journal of Bionic Engineering 2024年第4期21卷 1677-1694页

作者： Xiaoyong Zhang Wei yue The College of Marine Electrical Engineering Dalian Maritime UniversityDalian116026China

This paper aims to address the problem of multi-UAV cooperative search for multiple targets in a mountainous environment,considering the constraints of UAV dynamics and prior environmental ***,using the target probability distribution map,two strategies of information fusion and information diffusion are employed to solve the problem of environmental information inconsistency caused by different UAVs searching different areas,thereby improving the coordination of UAV ***,the task region is decomposed into several high-value sub-regions by using data clustering *** on this,a hierarchical search strategy is proposed,which allows precise or rough search in different probability areas by adjusting the altitude of the aircraft,thereby improving the search ***,the Elite Dung Beetle Optimization Algorithm(EDBOA)is proposed based on bionics by accurately simulating the social behavior of dung beetles to plan paths that satisfy the UAV dynamics constraints and adapt to the mountainous terrain,where the mountain is considered as an obstacle to be ***,the objective function for path optimization is formulated by considering factors such as coverage within the task region,smoothness of the search path,and path *** effectiveness and superiority of the proposed schemes are verified by the simulation.

关键词： Mountainous environment Multi-UAV cooperative search Environment information consistency Elite dung beetle optimization algorithm(EDBOA) Path planning

Switching,explosion,and chaos of multi-wavelength soliton states in ultrafast fiber lasers

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 82-90页

作者： Zhi-Zeng Si yue-yue Wang Chao-Qing Dai College of Optical Mechanical and Electrical EngineeringZhejiang A&F UniversityLin’an 311300China

Because of the complexity and difficulty of realizing a multi-wavelength soliton state,reports on its internal dynamic characteristics are *** this study,the switching and periodic soliton explosion processes of the multi-wavelength soliton state in a negative dispersion passively mode-locked fiber laser are *** generation of the multi-wavelength soliton state undergoes the process of noise,oscillation,and stable mode-locking,and the splitting and annihilation of solitons with different group velocities directly impact the generation and disappearance of three *** and negative dispersion lead to different group velocities of *** presence and displacement of solitons with different group velocities cause soliton collisions,which lead to soliton explosions.A soliton experiences relative phase oscillation,chaos,and oscillation,as well as convergence and separation before and after an *** an increase in parameters related to pump power,single-soliton oscillation,multi-wavelength solitons,and chaos are found in experiments and simulations,proving the relevance and reliability between simulation and experimental *** work promotes the dynamical study of multi-soliton collisions in nonlinear science and the development of chaos theory in multi-comb lasers.

关键词： multi-wavelength fiber laser soliton explosion chaos state switching real-time dynamics

双孢菇内生枯草芽孢杆菌AB154中抑制人结肠癌Caco-2活性成分的发现及机理研究

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中国食品学报 2017年第12期17卷 26-34页

作者：刘灿生吉萍 david yue Wei Lee 李小可尚小雅陈林申琳中国农业大学食品科学与营养工程学院北京100083 美国哈佛大学医学院附属麦克林医院马萨诸塞州02478 中国人民大学农业与农村发展学院北京100872

在研究双孢菇的抗肿瘤活性成分时,发现其内生的一个枯草芽孢杆菌AB154的代谢产物,该产物具有较强的抑制人结肠癌Caco-2细胞活性。借助体外多种细胞毒活性跟踪测试,利用硫酸铵沉淀法和DEAESephadex阴离子交换柱层析,从枯草芽孢杆菌AB154... 详细信息

在研究双孢菇的抗肿瘤活性成分时,发现其内生的一个枯草芽孢杆菌AB154的代谢产物,该产物具有较强的抑制人结肠癌Caco-2细胞活性。借助体外多种细胞毒活性跟踪测试,利用硫酸铵沉淀法和DEAESephadex阴离子交换柱层析,从枯草芽孢杆菌AB154发酵液中分离得到抑制人结肠癌Caco-2细胞的活性组分,其IC50为109.94μg/m L,而对人正常支气管上皮细胞(NHBE)的抑制作用较弱。经高效液相色谱(HPLC)制备,结合MALDI-TOF MS、ESI-MS/MS分析和查阅文献,从活性组分中分离鉴定了2个亚组分表面活性肽(surfactin)和丰原素(fengycin)B1类脂肽,其抑制人结肠癌Caco-2细胞的IC_(50)依次为80.7μg/m L和312.5μg/m L。此研究首次发现fengycin B1类脂肽具有抑制人结肠癌Caco-2细胞的活性,机理研究发现fengycin B1在12 h时将细胞周期阻滞在G_0/G_1期,在24 h时阻滞在S期,同时能够损伤肿瘤细胞的细胞核。

关键词：双孢菇内生菌枯草芽孢杆菌丰原素人结肠癌Caco-2细胞

Knittable and washable aerogel fiber inspired by polar bear hair

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Science China Materials 2024年第2期67卷 705-706页

作者： yue Liu Huisheng Peng State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Scienceand Institute of Fiber Materials and DevicesFudan UniversityShanghai 200438China

The advances in chemistry and materials have boosted the development of smart textiles,which are poised to revolutionize human lifestyles through multifunctional integration,such as heating,cooling,sensing and supplying energy^([1,2]).Among them,thermal insulation is an essential function of textiles to protect humans from complex and extreme environments and realize personal thermal management without energy con-sumption^([3]).

关键词： textiles insulation extreme