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Wheat zinc finger protein TaZF interacts with both the powdery mildew AvrPm2 protein and the corresponding wheat Pm2a immune receptor

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Plant Communications 2024年第5期5卷 25-41页

作者： Beatrice Manser Helen Zbinden Gerhard Herren Joel Steger Jonatan Isaksson Stephanie Braunlich thomas Wicker Beat Keller Department of Plant and Microbial Biology University of ZurichZollikerstrasse 1078008 ZurichSwitzerland Agroscope Route de Duillier 501260 NyonSwitzerland BIOREBA AG Christoph Merian-Ring 74153 ReinachSwitzerland

Plant defense responses to pathogens are induced after direct or indirect perception of effector proteins or their activity on host *** fungal–plant interactions,relatively little is known about whether,in addi-tion to avirulence effectors and immune receptors,other proteins contribute to specific *** nucleotide-binding leucine-rich repeat(NLR)immune receptor Pm2a in wheat recognizes the fungal pow-dery mildew effector *** found that the predicted wheat zincfinger TaZF interacts with both the fungal avirulence protein AvrPm2 and the wheat NLR *** further demonstrated that the virulent AvrPm2-H2 variant does not interact with *** silencing in wheat resulted in a reduction but not a loss of Pm2a-mediated powdery mildew *** studies showed that the leucine-rich repeat domain of Pm2a is the mediator of the interaction with *** recruits both Pm2a and AvrPm2 from the cytosol to the nucleus,resulting in nuclear localization of Pm2a,TaZF,and AvrPm2 in *** propose that TaZF acts as a facilitator of Pm2a-dependent AvrPm2 effector *** highlight the importance of identifying effector host targets for characterization of NLR-mediated effector recognition.

关键词： plant immunity plant-fungal interactions pathogen effectors nucleotide-binding leucine-rich repeat immune receptor NLR wheat powdery mildew

Practice of Barrier Measures against COVID-19 Among Diabetic People Followed at Departmental University Hospital Center Ouémé-Plateau, Benin, in 2021

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Open Journal of Epidemiology 2024年第2期14卷 249-259页

作者： Yèssito Corine Nadège Houehanou Armand Wanvoègbe Akouodé thomas Hounto Luc Béhanzin Maurice Agonnoudé david Houéto Thierry Adoukonou National School of Public Health (ENATSE) University of Parakou Parakou Benin Department of Internal Medicine University Departmental Hospital Ou&#233me-Plateau Porto-Novo Benin

Introduction: COVID-19 is a pandemic disease caused by the coronavirus SARS-COV2 appeared in China in 2019. The aim of the study was to evaluate the practice of barrier measures against COVID-19 and to identify associated factors among diabetics followed at Departmental University Hospital Center Ouémé-Plateau, Benin, in 2021. Methods: This was a cross-sectional study conducted from June to August 2021, including diabetics aged 18 and over, hospitalized or received for medical visits in the department of medicine at the target hospital. Data were collected during an interview with each participant thanks to a questionnaire. “Good practice” was defined as regular practice of at least two of three barrier measures: hand washing, physical distancing and mask-wearing. Results: A total of 110 diabetics were included with a female predominance (55.5%) and a mean age of 57 ± 11.3 years. Among them, 89.1% washed their hands, 41.8% respected physical distancing and 12.7% wore a mask. The proportion of good practice was 47.3%. Only 5 practiced the three barrier measures. Only age group was associated with good practice. Conclusion: The study showed a low proportion of good practice of barrier measures against COVID-19 among diabetic people surveyed. It is important to continue the action for COVID-19 prevention among diabetic people in the targeted hospital and in other hospitals in Benin.

关键词： COVID-19 Barrier Measures Practice Diabetic People Benin

Bacterial plant pathogens affect the locomotor behavior of the insect vector:a case study of Citrus volkameriana-Triozae erytreae-Candidatus Liberibacter asiaticus system

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Insect Science 2024年第3期31卷 901-910页

作者： Arnaud Ameline Alain Karkach thomas Denoirjean Martial Grondin Florencia Molinari Patrick Turpin Helene Delatte Bernard Reynaud UMR CNRS 7058 EDYSAN(Ecologie et Dynamique des Systemes Anthropises) Universite de Picardie Jules VerneAmiensCedexFrance UMR PVBMT(Peuplements végétaux et bioagresseurs en milieu tropical) Universitéde la RéunionSaint PierreLa RéunionFrance

Plant pathogens can alter the behavior of their insect vectors as well as their survival and *** African psyllid,Trioza erytreae,is one of the vectors of Huanglongbing,a citrus disease caused mainly by"Candidatus Liberibacter asiaticus"(CLas).The purpose of this study was to characterize the effects of CLas on the psyllid,*** using Citrus volkamerina plants as the study *** study focused more specifically on the CLas effects prior to and after its acquisition by the psyllid *** results did not support the hypothesis that CLas effects psyllid probing behavior prior to acquisition;few differences were observed between uninfected *** feeding on CLas-infected versus control *** the other hand,compared to psyllids that had completed their development on control plants,the ones that had completed their development on a CLas-infected plant exhibited changes in their behavior(greater velocity),physiology(smaller mass)and biochemistry(lower water and lipid content).Altogether,our results confirm the existence of a marked postacquisition effect on the vector locomotor behavior and a minor preacquisition effect of CLas on the vector behavior,which can be partially explained by physiological and biochemical changes.

关键词： electrical penetration graph Huanglongbing locomotory behavior lipid biomass probing behavior vector manipulation

Information Management: Knowledge, Emancipation, and Metaphysics in the 21st Century

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Philosophy Study 2024年第3期14卷 106-122页

作者： thomas Vezas 11th Primary School in N.Ionia AthensGreece

This text is trying to discuss an approximation to the concept of human emancipation,as part of our well-being,in terms of Education and *** abandoning our metaphysical perception of wholeness,as an extension of the continuity principle which connects our conscious and unconscious world,emancipation is considered as a personal struggle against all *** of these are grounded in our inner *** accordance with the Enlightenment request,reasoning and knowledge can help us to structure new forms of acceptances which are shaping our own emancipatory *** the impact of social influence and personal interpretation,the perceived knowledge is considered as a mental tool containing an upgraded valid *** under consideration that this validity is not able to overcome the metaphysical origins of human thought,it is suggested that when this mental tool is functioning in a self-transformative,self-constructed,and flexible form,human intelligence is structuring a compatible information management mechanism,which can enable us to formulate our personal acceptances,bridge our empirical and hyper-empirical inner world,and enlighten our request for self-criticism,self-determination,and above all emancipation.

关键词： knowledge metaphysics emancipation education well-being information technology

Femoral Access with Ultrasound-Guided Puncture and Z-Stitch Hemostasis for Adults with Congenital Heart Diseases Undergoing Electrophysiological Procedures

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Congenital Heart Disease 2024年第1期19卷 85-92页

作者： Fu Guan Matthias Gass Florian Berger Heiko Schneider Firat Duru thomas Wolber Arrhythmia and Electrophysiology Division Department of CardiologyUniversity Heart Center ZurichZurichSwitzerland Children’s Research Center Zurich University Children’s HospitalZurichSwitzerland Center for Integrative Human Physiology University of ZurichZurichSwitzerland

Aims:Although the application of ultrasound-guided vascular puncture and Z-stitch hemostasis to manage femoral access has been widely utilized,there is limited data on this combined application in adult congenital heart disease(ACHD)patients undergoing electrophysiological(EP)*** sought to evaluate the safety and efﬁcacy of ultrasound-guided puncture and postprocedural Z-stitch hemostasis for ACHD patients under-going EP *** and Results:The population of ACHD patients undergoing transfemoral EP pro-cedures at the University of Zurich Heart Center between January 2019 and December 2022 was observed and *** the study period,femoral access(left/right,arterial/venous)was performed under real-time ultrasound *** the end of the procedure,a single Z-stitch was performed at the puncture *** eval-uated the incidence of in-hospital complications associated with femoral access puncture in this *** 101 patients who had a total of 147 previous ipsilateral vascular punctures(mean 1.5 per person),100 patients underwent successful femoral vascular access for EP *** median age of the patients was 47±15 years and 34(34%)were male.Z-stitches were performed after the procedure in 100 patients with 303 femoral vascular accesses(mean 3 punctures per person).No patient developed vascular puncture relevant inguinal hematoma,pseudo aneurysm,arteriovenousﬁstula,venous or arterial ***:In ACHD patients undergoing EP procedures,optimal femoral access management can be achieved with ultra-sound-guided puncture and postprocedural Z-stitch hemostasis.

关键词： Congenital heart disease cardiac electrophysiology cardiac catheterization femoral access hemostasis

The 5C Model of Linguistic Creativity:Construction Grammar as a Cognitive Theory of Verbal Creativity

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Journal of Foreign Languages and Cultures 2024年第1期8卷 139-154页

作者： thomas HOFFMANN Catholic University Eichstatt-Ingolstadt

Creativity is a design feature of human *** paper presents a cognitive model of verbal creativity that draws on insights from the psychological research into creativity-particularly Glaveanu's 5A model that distinguishes five crucial perspectives on a creative act(actors,audience,artefacts,actions and affordances).The paper will outline a linguistic version of this model that adopts Construction Grammar as its theoretical *** resulting"5C model of constructional creativity"argues that the central elements of linguistic creativity are constructors,co-constructors,constructs,constructional blending and the constructional network.

关键词： creativity construction grammar cognitive linguistics blending 5C model of constructional creativity cognition constructional networks

Characteristics of patients with wilson disease in the United States: An insurance claims database study

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World Journal of Hepatology 2024年第5期16卷 791-799页

作者： thomas Daniel-Robin Pradeep Kumar Bernard Benichou Jean-Philippe Combal Vivet Therapeutics Paris 75008France Clarivate Noida 201301Uttar PradeshIndia

BACKGROUND wilson disease(WD)is a progressive,potentially fatal degenerative disease affecting the liver and central nervous *** its low prevalence,collecting data on large cohorts of patients with WD is *** insur-ance claims databases provide powerful tools to collect retrospective data on large numbers of patients with rare *** To describe patients with WD in the United States,their treatment and clinical outcome,using a large insurance claims *** This retrospective,longitudinal study was performed in the Clarivate Real-World Data Product *** patients with≥2 claims associated with an Interna-tional Classification of Diseases 10(ICD-10)diagnostic code for WD(E83.01)between 2016 and 2021 were included and followed until death or study *** were divided into two groups by whether or not they were documented to have received a specific treatment for *** manifestations,hospital-isations,liver transplantation and death were *** Overall,5376 patients with an ICD-10 diagnostic code for WD were *** mean age at inclusion was 41.2 years and 52.0%were men.A specific WD treatment was documented for 885 patients(15.1%),although the number of patients taking zinc salts may be underestimated due to over the counter *** inclusion,the mean age of patients with a documented treatment was 36.6±17.8 years vs 42.2±19.6 years in those without a documented *** follow-up,273 patients(5.1%)*** with the American general population,the standardised mortality ratio was *** proportion of patients with a documented WD-specific treatment who died during follow-up was 4.0%and the mean age at death 52.7 *** Patients treated for WD in the United States had an excess early mortality compared with the American *** findings indicate that there is a significant unmet need for effective treatment for WD in the United States.

关键词： wilson disease Mortality Treatment Copper chelators Zinc acetate United States

Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear two-axis tribometer

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Friction 2024年第3期12卷 539-553页

作者： Agnese FRAGASSI Antonietta GRECO Martina DI FRANCESCO Luca CESERACCIU Aiman ABU AMMAR Israel DVIR thomas Lee MOORE Haytam KASEM Paolo DECUZZI Laboratory of Nanotechnology for Precision Medicine Fondazione Istituto Italiano di TecnologiaGenova 16163Italy Department of Chemistry and Industrial Chemistry University of GenovaGenoa 16146Italy Materials Characterization Facility Istituto Italiano di TecnologiaGenova 16163Italy Department of Pharmaceutical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel Department of Mechanical Engineering Azrieli College of Engineering JerusalemJerusalem 9103501Israel

Nano-and micro-particles are being increasingly used to tune interfacial frictional properties in diverse applications,from friction modifiers in industrial lubrication to enhanced biological fluids in human osteoarthritic ***,we assessed the tribological properties of a simulated synovial fluid enriched with non-spherical,poly lactic-co-glycolic acid(PLGA)microparticles(μPL)that have been previously demonstrated for the pharmacological management of osteoarthritis(OA).Three different μPL configurations were fabricated presenting a 20μm×20μm square base and a thickness of 5μm(thin,5H μPL),10μm(10H μPL),and 20μm(cubical,20H μPL).After extensive morphological and physicochemical characterizations,the apparent Young’s modulus of the μPL was quantified under compressive loading returning an average value of~6 kPa,independently of the particle ***,using a linear two-axis tribometer,the static(μ_(s))and dynamic(μ_(d))friction coefficients of the μPL-enriched simulated synovial fluid were determined in terms of particle configuration and concentration,varying from 0(fluid only)to 6×10^(5) μPL/*** particle morphology had a modest influence on friction,possibly because the μPL were fully squeezed between two mating surfaces by a 5.8 N normal load realizing boundary-like lubrication ***,friction was observed to depend on the dimensionless parameterW,defined as the ratio between the total volume of the μPL enriching the simulated synovial fluid and the volume of the fluid *** coefficients of friction were documented to grow withWreaching a plateau of μ_(s)~0.4 and μ_(d)~0.15,already at Ω~2×10^(-3).Future investigations will have to systematically analyze the effect of sliding velocity,normal load,and rigidity of the mating surfaces to elucidate in full the tribological behavior of μPL in the context of osteoarthritis.

关键词： osteoarthritis microparticles tribology synovial fluid pin on plate

Characterizations That Help Explain Particle and Cosmic Data

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 1304-1357页

作者： thomas Joel Buckholtz Ronin Institute for Independent Scholarship Montclair USA

This paper suggests explanations for otherwise seemingly unexplained data about elementary particles and cosmology. The explanations have bases in coordinate-based modeling and in integer-based characterizations for some catalogs. One catalog features properties—including charge, mass, and angular momentum—of objects. Another catalog features all known and some possible elementary particles. Assumptions include that multipole-expansion mathematics has uses regarding long-range interactions, such as gravity, and that nature includes six isomers of all elementary particles other than long-range-interaction bosons. One isomer associates with ordinary matter. Five isomers are associated with dark matter. Multipole notions help explain large-scale aspects such as the rate of expansion of the universe.

关键词： Elementary Particles Dark Matter Rate of Expansion of the Universe Galaxy Formation Neutrino Masses Vacuum Energy Dark Energy Quantum Gravity