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Sound waves and solutions:Point-of-care ultrasonography for acute kidney injury in cirrhosis

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World Journal of Critical Care medicine 2024年第2期13卷 83-92页

作者： david Aguirre-Villarreal mario Andrés de Jesús Leal-Villarreal Ignacio García-Juárez Eduardo R Argaiz Abhilash Koratala Departamento de Gastroenterología Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Cardiología Instituto Nacional de Cardiología Ignacio ChávezMexico City 14080Mexico Unidad de Hepatología y Trasplante Departamento de GastroenterologíaInstituto Nacional de Ciencias Medicas y Nutricion Salvador ZubiranMexico City 14080Mexico Departamento de Nefrología y metabolismo mineral Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Tecnológico de monterrey Escuela de Medicina y Ciencias de la SaludMexico City 64710Mexico Department of Nephrology Medical College of WisconsinMilwaukeeWI 53226United States

This article delves into the intricate challenges of acute kidney injury(AKI)in cirrhosis,a condition fraught with high morbidity and *** complexities arise from distinguishing between various causes of AKI,particularly hemodynamic AKI,in cirrhotic patients,who experience hemodynamic changes due to portal *** term"hepatocardiorenal syndrome"is introduced to encapsulate the intricate interplay among the liver,heart,and *** narrative emphasizes the often-overlooked aspect of cardiac function in AKI assessments in cirrhosis,unveiling the prevalence of cirrhotic cardiomyopathy marked by impaired diastolic *** conventional empiric approach involving volume expansion and vasopressors for hepatorenal syndrome is critically analyzed,highlighting potential risks and variable patient *** advocate for a nuanced algorithm for AKI evaluation in cirrhosis,prominently featuring point-of-care ultrasonography(POCUS).POCUS applications encompass assessing fluid tolerance,detecting venous congestion,and evaluating cardiac function.

关键词： Point-of-care ultrasonography Bedside ultrasound Cirrhosis Congestion Acute kidney injury Congestive nephropathy

Scaffold-regulation buffered moS_(2)anode kinetics for high-performance Na-/K-ion storage

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Journal of materials Science & Technology 2023年第14期145卷 14-24页

作者： Tuzhi Xiong Xincheng Yao david Adekoya Hao Yang m-Sadeeq Balogun College of materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan UniversityChangsha 410082China Centre for Clean Environment and Energy Griffith School of EnvironmentGold Coast CampusGriffith UniversityQLD4222Australia Guangxi Key Laboratory of Electrochemical Energy materials School of Chemistry&Chemical EngineeringGuangxi UniversityNanning 530004China

Designing a highly conductive scaffold with unique function has great significance in elevating the stor-age properties of molybdenum sulfide(moS_(2))for sodium-and potassium-ion ***,we show that forming a three-dimensional(3D)highly conductive dual backbone that consists of titanium nitride nanowires(TiN)coated on 3D carbon fiber(CF)could suppress the poor conductivity of moS_(2).Theo-retical calculations predict that both TiN and CF boost the electronic conductivity,while the moS_(2)will promote high ionic adsorption owing to the suitable adsorption *** as-prepared CF@TiN/moS_(2),with mass loading up to 12.5 mg cm^(−2),achieves a high areal capacity of up to 5.40 mAh cm^(−2)under the current density of 0.6 mA cm^(−2)for sodium *** excellent performance of the hybrid can be attributed to buffer and conductivity enhancer features,allowing Na-ion to directly have contact with the CF@TiN/moS_(2)hybrid.A series of electrochemical analyses including cyclic voltammetry and symmetric cell analyses affirm the significant improvement in transport *** importantly,the CF@TiN/moS_(2)also achieves a high areal capacity of 3.29 mAh cm^(−2)under the current density of 0.3 mA cm^(−2)as anode material for potassium ion batteries(PIBs),demonstrating that the scaffold-regulated strategy is a feasible strategy to enhance the kinetics of moS_(2)-based anodes for secondary-ion batteries and beyond.

关键词： moS_(2)nanosheets Flexible conductive TiN nanowires Kinetics High areal capacity Sodium-and potassium-ion batteries

Low back pain and osteoarthritis pain:a perspective of estrogen

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骨研究:英文版 2023年第3期11卷 443-456页

作者： Huiwen Pang Shihui Chen david m.Klyne david Harrich Wenyuan Ding Sidong Yang Felicity Y.Han Australian Institute for Bioengineering and Nanotechnology The University of QueenslandSt.LuciaBrisbaneQLD 4072Australia NHmRC Centre of Clinical Research Excellence in Spinal Pain Injury and HealthThe University of QueenslandSt.LuciaBrisbaneQLD 4072Australia Department of Cell and molecular Biology QIMR Berghofer Medical Research InstituteHerstonQLD 4006Australia Department of Spine Surgery The Third Hospital of Hebei Medical University139 Ziqiang RoadShijiazhuang 050051China Hebei Joint International Research Center for Spinal Diseases 139 Ziqiang RoadShijiazhuang 050051China

Low back pain(LBP)is the world's leading cause of disability and is increasing in prevalence more rapidly than any other pain *** disc(IVD)degeneration and facet joint osteoarthritis(FJOA)are two common causes of LBP,and both occur more frequently in elderly women than in other ***,osteoarthritis(OA)and OA pain,regardless of the joint,are experienced by up to twice as many women as men,and this difference is amplified during *** in estrogen may be an important contributor to these pain *** for estrogen have been found within IVD tissue and nearby joints,highlighting the potential roles of estrogen within and surrounding the IVDs and *** addition,estrogen supplementation has been shown to be effective at ameliorating IVD degeneration and OA progression,indicating its potential use as a therapeutic agent for people with LBP and OA *** review comprehensively examines the relationship between estrogen and these pain conditions by summarizing recent preclinical and clinical *** potential molecular mechanisms by which estrogen may relieve LBP associated with IVD degeneration and FJOA and OA pain are discussed.

关键词： agent degeneration pain

Evaluation of Human Impacts on Bartlett Pond Ecosystem, Laredo, Southern Texas, USA, through Empirical modeling

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Journal of Environmental Protection 2024年第4期15卷 497-526页

作者： maya P. Bhatt Amede Rubio Ganesh B. malla Cristobal Lopez Virginia morales Erick Vazquez Cano david marquez Orlando Berumen Alvarez Alfred Addo-mensah Department of Biology and Chemistry Texas A&M International University Laredo USA Department of mathematics Computer Geology and Physics University of Cincinnati-Clermont College Batavia USA

The trace elements chemistry of Bartlett Pond, a small shallow wetland pond in Laredo, Southern Texas, was sampled to evaluate the dynamics of trace elements impacts on water quality and ecosystems ecology of the pond. Two types of fish (bass and tilapia) were also sampled to see the trace element accumulation in different parts of their body. The concentrations of trace elements in water samples were found in the following order: Fe ≫Sb > Pb > As ≫Co > Tl > Cr > Cd within Bartlett Pond. Overall, the water quality of the pond is unacceptable for drinking and any other purposes as trace element concentrations (e.g. As, Cd, Co, Cr, Pb, Fe, Sb and Tl) are exceedingly higher (several fold) than the WHO and US EPA guidelines. Predictive and correlation analysis shows that most trace elements exhibit a strong positive correlation among them indicating the same anthropogenic sources and biogeochemical processes regulate these trace elements within the pond. Distributions of the trace elements in water exhibit different shapes mostly as positively skewed distribution for As, Cd, Co, Cr, and Tl, symmetrical distribution for Fe and almost symmetrical distribution for Pb and Sb. Concentrations of As, Co and Tl accumulated much higher in different parts of the Bass than Tilapia fish. The concentrations of As, Tl, Co, and Sb appeared significantly higher in different parts of the body of both Bass and Tilapia than the maximum SRm certified values. Accumulation of these contaminants in fish tissues pose increased health risks to humans who consume these contaminated fish although fishing is prohibited. Anthropogenic activities in the region primarily degrade the whole pond ecosystem ecology of the Bartlett Pond and waters of this pond to be not recommended for any use. These findings may be useful for the scientific community and concerned authorities to improve understanding about these precious natural resources and conservation of the ecosystem ecology.

关键词： Trace Elements Bartlett Pond Laredo Southern Texas Wetlands Ecosystem Ecology

Problematic Use of Video Games in Schools in Northern Benin (2023)

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Open Journal of Psychiatry 2024年第2期14卷 120-141页

作者： Ireti Nethania Elie Ataigba david Sinet Koivogui Damega Wenkourama marcos Tohou Eurydice Elvire Djossou Anselme Djidonou Francis Tognon Tchegnonsi Prosper Gandaho Josiane Ezin Houngbe Faculté de médecine & Institut de Formation en Soins Infirmiers et Obstétricaux Université de Parakou Parakou Bénin Service de Psychiatrie Centre Hospitalier Universitaire Départemental du Borgou Alibori Parakou Bénin Organisation Non Gouvernementale de Soutien Réhabilitation Insertion et Réinsertion (SouRIR ONG) Parakou Bénin Faculté des Sciences et Techniques de Santé Université Gamal Abder Nasser de Conakry Conakry Guinée Faculté des Sciences de la Santé Université de Kara Kara Togo Service de Psychiatrie Centre Hospitalier Universitaire de Kara Kara Togo Facultés des Sciences de la Santé Université d’Abomey-Calavi Cotonou Bénin Centre Nationale Hospitalier Universitaire Hubert Koutoucou maga de Cotonou Cotonou Bénin

Objective: To study the problematic use of video games among secondary school students in the city of Parakou in 2023. methods: Descriptive cross-sectional study conducted in the commune of Parakou from December 2022 to July 2023. The study population consisted of students regularly enrolled in public and private secondary schools in the city of Parakou for the 2022-2023 academic year. A two-stage non-proportional stratified sampling technique combined with simple random sampling was adopted. The Problem Video Game Playing (PVP) scale was used to assess problem gambling in the study population, while anxiety and depression were assessed using the Hospital Anxiety and Depression Scale (HADS). Results: A total of 1030 students were included. The mean age of the pupils surveyed was 15.06 ± 2.68 years, with extremes of 10 and 28 years. The [13 - 18] age group was the most represented, with a proportion of 59.6% (614) in the general population. Females predominated, at 52.8% (544), with a sex ratio of 0.89. The prevalence of problematic video game use was 24.9%, measured using the Video Game Playing scale. Associated factors were male gender (p = 0.005), pocket money under 10,000 cfa (p = 0.001) and between 20,000 - 90,000 cfa (p = 0.030), addictive family behavior (p monogamous family (p = 0.023), good relationship with father (p = 0.020), organization of video game competitions (p = 0.001) and definite anxiety (p Conclusion: Substance-free addiction is struggling to attract the attention it deserves, as it did in its infancy everywhere else. This study complements existing data and serves as a reminder of the need to focus on this group of addictions, whose problematic use of video games remains the most frequent due to its accessibility and social tolerance. Preventive action combined with curative measures remains the most effective means of combating the problem at national level.

关键词： Gaming Problem Video Games Benin 2023

PCR-HRm for Genomic Surveillance of SARS-CoV-2: A Variant Detection Tool in Côte d’Ivoire, West Africa

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American Journal of molecular Biology 2024年第3期14卷 166-185页

作者： Aboubacar Sylla Solange Kakou-Ngazoa Tata Gniré Safiatou Coulibaly Yakoura Karidja Ouattara mireille Sylvie Kouamé-Sina Zeinab Ouattara david Ngolo Coulibaly Brice Kouakou Bla mireille Dosso molecular Biology Platform Pasteur Institute Cte dIvoire Abidjan Cte dIvoire Laboratory of Biology and Health UFR Biosciences University Flix Houphout Boigny Abidjan Cte dIvoire Genetic and Cancer Laboratory Molecular Genetics Platform Pasteur Institute Cte dIvoire Abidjan Cte dIvoire Epidemic Virus Department Pasteur Institute Cte dIvoire Abidjan Cte dIvoire

The rise of new viruses, like SARS-CoV-2 causing the COVID-19 outbreak, along with the return of antibiotic resistance in harmful bacteria, demands a swift and efficient reaction to safeguard the health and welfare of the global population. It is crucial to have effective measures for prevention, intervention, and monitoring in place to address these evolving and recurring risks, ensuring public health and international security. In countries with limited resources, utilizing recombinant mutation plasmid technology in conjunction with PCR-HRm could help differentiate the existence of novel variants. cDNA synthesis was carried out on 8 nasopharyngeal samples following viral RNA extraction. The P1 segment of the SARS-CoV-2 Spike S protein was amplified via conventional PCR. Subsequently, PCR products were ligated with the pGEm-T Easy vector to generate eight recombinant SARS-CoV-2 plasmids. Clones containing mutations were sequenced using Sanger sequencing and analyzed through PCR-HRm. The P1 segment of the S gene from SARS-CoV-2 was successfully amplified, resulting in 8 recombinant plasmids generated from the 231 bp fragment. PCR-HRm analysis of these recombinant plasmids differentiated three variations within the SARS-CoV-2 plasmid population, each displaying distinct melting temperatures. Sanger sequencing identified mutations A112C, G113T, A114G, G214T, and G216C on the P1 segment, validating the PCR-HRm findings of the variations. These mutations led to the detection of L452R or L452m and F486V protein mutations within the protein sequence of the Omicron variant of SARS-CoV-2. In summary, PCR-HRm is a vital and affordable tool for distinguishing SARS-CoV-2 variants utilizing recombinant plasmids as controls.

关键词： Genomic Surveillance SARS-CoV-2 PCR-HRm Variants Côte d’Ivoire

Experimental verification of ill-defined topologies and energy sinks in electromagnetic continua

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Advanced Photonics 2022年第3期4卷 97-104页

作者： david E.Fernandes Ricardo A.m.Pereira Sylvain Lannebère Tiago A.morgado mário G.Silveirinha University of Coimbra Instituto de Telecomunicações and Department of Electrical EngineeringCoimbraPortugal University of Aveiro Instituto de TelecomunicaçõesDepartment of ElectronicsTelecommunications and InformaticsAveiroPortugal University of Lisbon Instituto Superior Técnico and Instituto de TelecomunicaçõesDepartment of Electrical EngineeringLisboaPortugal

.It is experimentally verified that nonreciprocal photonic systems with continuous translation symmetry may have an ill-defined *** topological classification of such systems is only feasible when the material response is regularized with a spatial-frequency *** experimentally demonstrate that adjoining a small air layer to the relevant material interface may effectively imitate an idealized spatial cutoff that suppresses the nonreciprocal response for short wavelengths and regularizes the ***,it is experimentally verified that nonreciprocal systems with an ill-defined topology may be used to abruptly halt the energy flow in a unidirectional waveguide due to the violation of the bulk-edge *** particular,we report the formation of an energy sink that absorbs the incoming electromagnetic waves with a large field enhancement at the singularity.

关键词： topological photonics nonreciprocity topological singularities bulk edge correspondence.

The Shishugou Fauna of the middle-Late Jurassic Transition Period in the Junggar Basin of Western China

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Acta Geologica Sinica(English Edition) 2022年第4期96卷 1115-1135页

作者： XU Xing James m.CLARK david A.EBERTH Philip J.CURRIE Centre for Vertebrate Evolutionary Biology Yunnan UniversityKunming 650500China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Department of Biological Sciences George Washington UniversityWashington DC20052USA Royal Tyrrell museum of Palaeontology Box 7500DrumhellerAlberta T0J 0Y0Canada Department of Biological Sciences University of Alberta 116 Street and 85 AvenueEdmontonAB T6G 2R3Canada

The middle-Late Jurassic transition period is a critical period for the evolution of terrestrial vertebrates,but the global fossil record from this time is relatively *** Shishugou Fauna of this period has recently produced significant fossil remains of dinosaurs and other vertebrate groups,some representing the earliest known members of several dinosaurian groups and other vertebrate groups and some representing the best-known specimens of their *** discoveries are significant for our understanding of the origin and evolution of several vertebrate *** dating indicates that the fauna is aged approximately 159-164 *** with other similarly-aged terrestrial faunas such as Shaximiao and Yanliao show both taxonomic similarities and differences between these faunas and indicate that the Junggar deposits might have preserved the most complete vertebrate fossil record for a middle-Late Jurassic Laurasian terrestrial fauna.

关键词： middle-Late Jurassic Shishugou Fauna Shishugou Formation terrestrial ecosystem Shaximiao Yanliao Junggar Basin

Towards standardizing retinal optical coherence tomography angiography:a review

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Light(Science & Applications) 2022年第4期11卷 520-541页

作者： Danuta m.Sampson Adam m.Dubis Fred K.Chen Robert J.Zawadzki david D.Sampson Surrey Biophotonics Centre for VisionSpeech and Signal Processing and School of Biosciences and MedicineThe University of SurreyGuildford GU27XHUK NIHR Biomedical Research Centre at moorflelds Eye Hospital NHS Trust and UCL Institute of Ophthalmology London EC1V 2PDUK. Centre for Ophthalmology and Visual Science(incorporating Lions Eye Institute) The University of Western AustraliaNedlandsWestern Australia 6009Australia. Department of Ophthalmology Royal Perth HospitalPerthWestern Australia 6000Australia. Ophthalmology Department of SurgeryUniversity of MelbourneMelbourneVictoria 3002Australia. Department of Ophthalmology&Vision Science University of California DavisSacramentoCA 95817USA. Surrey Biophotonics Advanced Technology InstituteSchool of Physics and School of Biosciences and MedicineUniversity of SurreyGuildfordSurrey GU27XHUK

The visualization and assessment of retinal microvasculature are important in the study,diagnosis,monitoring,and guidance of treatment of ocular and systemic *** the introduction of optical coherence tomography angiography(OCTA),it has become possible to visualize the retinal microvasculature volumetrically and without a contrast *** lab-based and commercial clinical instruments,imaging protocols and data analysis methods and metrics,have been applied,often inconsistently,resulting in a confusing picture that represents a major barrier to progress in applying OCTA to reduce the burden of *** data and software sharing,and cross-comparison and pooling of data from different studies are *** inabilities have impeded building the large databases of annotated OCTA images of healthy and diseased retinas that are necessary to study and define characteristics of specific *** paper addresses the steps needed to standardize OCTA imaging of the human retina to address these *** review of the OCTA literature,we identify issues and inconsistencies and propose minimum standards for imaging protocols,data analysis methods,metrics,reporting of findings,and clinical practice and,where this is not possible,we identify areas that require further *** hope that this paper will encourage the unification of imaging protocols in OCTA,promote transparency in the process of data collection,analysis,and reporting,and facilitate increasing the impact of OCTA on retinal healthcare delivery and life science investigations.

关键词： transparency steps inconsistent