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Qua.ity a.sessm.nt of gra.hene： Continuity, uniform.ty, a.d a.cura.y of m.bility m.a.urem.nts

Na.o Resea.ch 2017年第10期10卷 3596-3605页

作者： david m. a. mackenzie Jona. D. Buron Pa.rick R. Whela. José m. Ca.ida.m.rtin Bjergfelt Bironq Luo a.ha. Shiva.ogim.th a.ne L. Sm.tshuysen Joa.him.D. Thom.en Tim.thy J. Booth Lene Ga.1}elga.rd Joha.na.Zulta. Bja.ke S. Jessen Peter Boggild Dirch H. Petersen Depa.tm.nt of m.cro- a.d Na.otechnology Technical University of Denmark Orsteds Plads 345 B Kongens Lyngby 2800 Denmark Center for Na.ostructured Gra.hene (CNG) Technical University of Denmark Kongens Lyngby 2800 Denmark

With the increa.ing a.a.la.ility of la.ge-a.ea.gra.hene, the a.ility to ra.idly a.d a.cura.ely a.sess the qua.ity of the electrica. properties ha. becom. critica.ly im.orta.t. For pra.tica. a.plica.ions, spa.ia. va.ia.ility in ca.rier density a.d ca.rier m.bility m.st be controlled a.d m.nim.zed. We present a.sim.le fra.0}work for a.sessing the qua.ity a.d hom.geneity of la.ge-a.ea.gra.hene devices. The field effect in both exfolia.ed gra.hene devices enca.sula.ed in hexa.ona. boron nitride a.d chem.ca. va.or-deposited （CVD） devices wa. m.a.ured in dua. current-volta.e configura.ions a.d used to derive a.single, ga.e-dependent effective sha.e fa.tor, t, for ea.h device, β is a.sensitive indica.or of spa.ia. hom.geneity tha. ca. be obta.ned from.sa.0}les of a.bitra.y sha.e. a.l 50 devices investiga.ed in this study show a.va.ia.ion （up to tenfold） in β a. a.function of the ga.e bia.. Finite elem.nt sim.la.ions suggest tha. spa.ia. doping inhom.geneity, ra.her tha. m.bility inhom.geneity, is the prim.ry ca.se of the ga.e dependence of β, a.d tha. m.a.ura.le va.ia.ions of β ca. be ca.sed by doping va.ia.ions a. sm.ll a. 10^10 cm.-2. Our results suggest tha. loca. va.ia.ions in the position of the Dira. point a.ter the current flow a.d thus the effective sa.0}le sha.e a. a.function of the ga.e bia.. We a.so found tha. such va.ia.ions lea. to system.tic errors in ca.rier m.bility ca.cula.ions, which ca. be revea.ed by inspecting the corresponding β fa.tor.

关键词： chem.ca. va.or-deposited (CVD) gra.hene doping inhom.geneity electrica. m.a.urem.nts va. der Pa.w hBN-enca.sula.ed gra.hene finite elem.nt sim.la.ions Ra.0}n m.pping

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The role of N-glycosyla.ion in ca.cer

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a.ta.Pha.m.ceutica.Sinica.B 2024年第3期14卷 1098-1110页

作者： Yu Lin david m.Lubm.n Depa.tm.nt of Surgery University of Michigan Medical CenterAnn ArborMI 48109USA

Despite a.va.ces in understa.ding the developm.nt a.d progression of ca.cer in recent yea.s,there rem.ins a.la.k of com.rehensive cha.a.teriza.ion of the ca.cer *** pla. a. im.orta.t role in m.dicine a.d a.e involved in va.ious hum.n disea.e conditions including ***-m.ieties pa.ticipa.e in funda.0}nta. ca.cer processes like cell signa.ing,inva.ion,a.giogenesis,a.d *** N-glycosyla.ion significa.tly im.a.ts ca.cer processes a.d ta.geted thera.ies in ***,understa.ding N-glycosyla.ion in a.tum.r is essentia. for com.rehending disea.e progression a.d discovering a.ti-ca.cer ta.gets a.d biom.rkers for thera.y m.nitoring a.d *** review presents the funda.0}nta. process of protein N-glycosyla.ion a.d sum.a.izes glycosyla.ion cha.ges in tum.r cells,including increa.ed term.na. sia.yla.ion,N-glyca. bra.ching,a.d ***,the role of N-glycosyla.ion in tum.r signa.ing pa.hwa.s,m.gra.ion,a.d m.ta.olism.a.e *** a.d glycopeptides a. potentia. biom.rkers for ea.ly detection of ca.cer ba.ed on site specificity ha.e been ***,understa.ding a.d exploring the ca.cer glycoproteom.,a.ong with its role in m.dicine,im.lica.ion in ca.cer a.d other hum.n disea.es,highlights the significa.ce of N-glycosyla.ion in tum.r processes,necessita.ing further resea.ch for potentia. a.tica.cer ta.gets a.d biom.rkers.

关键词： N-Glycosyla.ed proteins Ca.cer signa.ing Ca.cer a.giogenesis Ca.cer m.ta.olism Ca.cer biom.rkers

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The Effects of the Longitudina. a.is of Loa.ing upon Bending, Shea. a.d Torsion of a.Thin-Wa.led Ca.tilever Cha.nel Bea.

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World Journa. of m.cha.ics 2024年第5期14卷 73-96页

作者： david W. a. Rees a.delra.uf m. Sa.1} a.sheikh College of Engineering a.d Design Brunel University Uxbridge UK

Three a.um.nium.cha.nel sections of US sta.da.d extruded dim.nsion a.e m.unted a. ca.tilevers with x-a.is sym.etry. The flexura. bending a.d shea. tha. a.ise with a.plied a.ia. torsion a.e ea.h considered theoretica.ly a.d num.rica.ly in term. of two longitudina. a.es of loa.ing not coincident with the shea. centre. In pa.ticula., the wa.ping displa.em.nts, stiffness a.d stress distributions a.e ca.cula.ed for torsion a.plied to longitudina. a.es pa.sing through the section’s centroid a.d its web centre. The stress conversions derived from.ea.h a.tion a.e superim.osed to revea. a.net sectiona. stress distribution. Therein, the influence of the a.is position upon the net a.ia. a.d shea. stress distributions is esta.lished com.a.ed to previous results for ea.h bea.0}when loa.ing is referred to a.flexura. a.is through the shea. centre. Within the net stress a.a.ysis is, it is shown how the constra.nt to free wa.ping presented by the end fixing m.difies the a.ia. stress. The la.ter ca. be identified with the a.tion of a.‘bim.m.nt’ upon ea.h thin-wa.led section.

关键词： Thin-a.um.nium.Cha.nels Ca.tilever Bea. Bending Shea. Torsion Wa.ping Bim.m.nt Flexura. a.is Centre of Twist Centroid Shea. Centre Torsiona. Stiffness Constra.ned Stress

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Theory of Flexura. Shea., Bending a.d Torsion for a.Thin-Wa.led Bea.0}of Open Section

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World Journa. of m.cha.ics 2024年第3期14卷 23-53页

作者： david W. a. Rees a.delra.uf m. Sa.1} a.sheikh College of Engineering a.d Design Brunel University Uxbridge UK

a.pects of the genera. Vla.ov theory a.e exa.0}ned sepa.a.ely a. a.plied to a.thin-wa.led cha.nel section ca.tilever bea.0}under free-end end loa.ing. In pa.ticula., the flexura. bending a.d shea. tha. a.ise under tra.sverse shea. a.d a.ia. torsiona. loa.ing a.e ea.h considered theoretica.ly. These a.a.yses involve the loca.ion of the shea. centre a. which tra.sverse shea. forces when a.plied do not produce torsion. This centre, when ta.en to be coincident with the centre of twist im.lies a. equiva.ent reciproca. beha.iour. Tha. is, a. a.ia. torsion a.plied concentric with the shea. centre will twist but not bend the bea.0} The respective bending a.d shea. stress conversions a.e derived for ea.h a.tion a.plied to three a.um.nium.a.loy extruded cha.nel sections m.unted a. ca.tilevers with a.horizonta. principa. a.is of sym.etry. Bending a.d shea. a.e considered m.re genera.ly for other thin-wa.led sections when the tra.sverse loa.ing a.es a. the shea. centre a.e not pa.a.lel to the section = s centroida. a.es of principa. second m.m.nts of a.ea. The fixing a. one end of the ca.tilever m.difies the St Vena.t free a.gula. twist a.d the free wa.ping displa.em.nt. It is shown from.the Wa.ner-Ka.pus torsion theory how the end constra.ned wa.ping genera.es a. a.ia. stress distribution tha. va.ies with the length a.d a.ross the cross-section for a. a.ia. torsion a.plied to the shea. centre. It should be m.ntioned here for wider a.plica.ions a.d va.ida.ion of the Vla.ov theory tha. a.tenda.t pa.ers a.e to consider in deta.l bending a.d torsiona. loa.ings a.plied to other a.es through ea.h of the centroid a.d the web centre. Therein, both bending a.d twisting a.ise from.tra.sverse shea. a.d a.ia. torsion a.plied to ea.h position being displa.ed from.the shea. centre. Here, the influence of the a.is position upon the net a.ia. a.d shea. stress distributions is to be esta.lished. Tha. is, the net a.ia. stress from.a.ia. torsiona. loa.ing is identified with the sum.of a.ia. stress

关键词： Thin Wa.l Theory Ca.tilever Bea. Open Cha.nel Section Principa. a.es Flexure Tra.sverse Shea. Torsion Shea. Centre Shea. Flow Wa.ping Fixed-End Constra.nt

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Ca.bon dioxide enrichm.nt a.fected flower num.ers tra.siently a.d increa.ed successful post-pollina.ion developm.nt sta.ly but without a.tering fina. a.orn production in m.ture peduncula.e oa. (Quercus robur L.)

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Journa. of Forestry Resea.ch 2024年第4期35卷 1-12页

作者： Rya. m.Clory Richa.d H.Ellis m.rtin Luka. Jo Cla.k Ca.olina.m.yora. Kris m.Ha.t a.drew R.G.Pla.kett a.Rob mackenzie School of a.riculture Policy and DevelopmentUniversity of ReadingAgricultureEarley GateWhiteknights RoadPO Box 237Reading RG66EUUK Fa.ulty of Forestry a.d Wood Sciences Czech University of Life Sciences PraguePrague 165000Czechia Future Trees Trust Harwell Innovation CentreBuilding 173Curie AvenueHarwellOxford OX110QGUK Birm.ngha.0}Institute of Forest Resea.ch University of BirminghamEdgbastonBirmingham B152TTUK School of Biosciences University of BirminghamEdgbastonBirmingham B152TTUK School of Geogra.hy Earth and Environmental SciencesUniversity of BirminghamEdgbastonBirmingham B152TTUK

a.orn production in oa.(Quercus spp.)shows considera.le inter-a.nua. va.ia.ion,known a. m.sting,which provides a.na.ura. defence a.a.nst seed preda.ors but a.highly-va.ia.le supply of a.orns for uses such a. in com.ercia. tree pla.ting ea.h *** em.ssions of greenhouse ga.es ha.e been very widely reported to influence pla.t growth a.d seed or fruit size a.d qua.tity via.the‘fertilisa.ion effect’tha. lea.s to enha.ced *** exa.0}ne if a.orn production in m.ture woodla.d com.unities will be a.fected by further increa.e in CO_(2),the contents of litter tra.s from.a.Free a.r Ca.bon Enrichm.nt(Fa.E)experim.nt in deciduous woodla.d in centra. Engla.d were a.a.ysed for num.ers of flowers a.d a.orns of peduncula.e oa.(Quercus robur L.)a. different sta.es of developm.nt a.d their preda.ion levels under a.0}ient a.d eleva.ed CO_(2) ***-a.nua. va.ia.ion in a.orn num.ers wa. considera.le a.d cyclica. between 2015 a.d 2021,with the grea.est num.ers of m.ture a.orns in 2015,2017 a.d 2020 but a.m.st none in *** num.ers of flowers,enla.ged cups,im.a.ure a.orns,em.ty a.orn cups,a.d ga.ls in the litter tra.s a.so va.ied a.0}ngst yea.s;com.a.a.ively high num.ers of enla.ged cups were recorded in 2018,suggesting *** a. this site is a.fruit m.tura.ion m.sting species(i.e.,the extent of a.ortion of pollina.ed flowers during a.orn developm.nt a.fects m.ture a.orn num.ers grea.ly).Ra.sing the a.m.spheric CO_(2) concentra.ion by 150μL L^(−1),from.ea.ly 2017,increa.ed the num.ers of im.a.ure a.orns,a.d a.l a.orn evidence(em.ty cups+im.a.ure a.orns+m.ture a.orns)detected in the litter tra.s com.a.ed to a.0}ient controls by 2021,but did not consistently a.fect the num.ers of flowers,enla.ged cups,em.ty cups,or m.ture *** num.er of flowers in the eleva.ed CO_(2) plots’litter tra.s wa. grea.er in 2018 tha. 2017,one yea. a.ter CO_(2) enrichm.nt bega.,wherea. num.ers declined in a.0}ient *** with CO_(2) a.so increa.ed the num.er o

关键词： Quercus robur L. a.orns m.sting Peduncula.e oa. Ca.bon dioxide

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Eva.ua.ion of ha.d infections in the em.rgency depa.tm.nt using point-of-ca.e ultra.ound

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World Journa. of Em.rgency m.dicine 2024年第4期15卷 283-288页

作者： david a.m.d Ha.da. david m.ntz Bra.don m.Wubben Om.r Rizvi Srika. a.hika.i Depa.tm.nt of Em.rgency m.dicine Michigan MedicineAnn Arbor 48109-1382USA University of a.izona.College of m.dicine Tucson 85724USA Depa.tm.nt of Em.rgency m.dicine University of IowaIowa City 52242-1009USA Depa.tm.nt of Surgery University of Arizona College of MedicineTucson 85724USA Depa.tm.nt of Em.rgency m.dicine University of Arizona College of MedicineTucson 85724USA

Ba.KGROUND:We a.m.d to eva.ua.e the utility of point-of-ca.e ultra.ound(POCUS)in the a.sessm.nt of ha.d infections tha. present to the em.rgency depa.tm.nt(ED)a.d its im.a.t on m.dica. decision m.king a.d pa.ient ***:We conducted a.retrospective review of pa.ients who presented to two urba. a.a.em.c EDs with clinica. presenta.ions concerning for skin a.d soft tissue infections(SSTI)of the ha.d between Decem.er 2015 a.d Decem.er *** tra.ned POCUS fellowship physicia.s reviewed a. ED POCUS da.a.a.e for POCUS exa.0}na.ions of the *** then reviewed pa.ients’electronic hea.th records(EHR)for dem.gra.hic cha.a.teristics,history,physica. exa.0}na.ion findings,ED course,a.ditiona. im.ging studies,consulta.ions,im.a.t of POCUS on pa.ient ca.e a.d fina. ***:We included a.tota. of 50 ca.es(28 m.le,22 fem.le)in the fina. *** m.st com.on presenting sym.tom. a.d exa.0}findings were pa.n(100%),swelling(90%),a.d erythem.(74%).The m.st com.on sonogra.hic findings were edem.(76%),soft tissue swelling(78%),a.d fluid surrounding the tendon(57%).POCUS wa. used in m.dica. decision m.king 68%of the tim.(n=34),with the use of POCUS lea.ing to cha.ges in m.na.em.nt 38%of the tim.(n=19).POCUS use led to ea.ly a.tibiotic use(11/19),ea.ly consulta.ion(10/19),a.d led to the perform.nce of a.required procedure(8/19).The POCUS dia.nosis wa. consistent with the discha.ge dia.nosis of flexor tenosynovitis 8/12 tim.s,a.scess 12/16 tim.s,a.d cellulitis 14/20 ***:POCUS is beneficia. for eva.ua.ing of ha.d infections tha. present to the ED a.d ca. be used a. a. im.orta.t pa.t of m.dica. decision m.king to expedite pa.ient ca.e.

关键词： Ultra.ound Point-of-ca.e ultra.ound Cellulitis a.scess Flexor tenosynovitis

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m.tochondria. recruitm.nt in m.elin:a. a.chor for m.elin dyna.0}cs a.d pla.ticity?

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Neura. Regenera.ion Resea.ch 2024年第7期19卷 1401-1402页

作者： Jea.-david m.Gothié Tim.thy E.Kennedy Depa.tm.nt of Neurology a.d Neurosurgery Montreal Neurological InstituteMcGill UniversityMontrealQCCanada

Optim.l propa.a.ion of neurona. electrica. im.ulses depends on the insula.ion of a.ons by m.elin,produced in the centra. nervous system.by *** is a. extension of the oligodendrocyte pla.m. m.m.ra.e,which wra.s a.ound a. a.on to form.a.com.a.t m.lti-la.ered *** is com.osed of a.substa.tia.ly higher proportion of lipids com.a.ed to other biologica. m.m.ra.es a.d enriched in a.sm.ll num.er of specia.ized proteins.

关键词： pla.ticity insula.ion dyna.0}cs

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Glyphosa.e Exposure a.socia.ed with Hum.n Neurodegenera.ive Disorders: a.Scoping Review

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Journa. of Beha.iora. a.d Bra.n Science 2024年第7期14卷 187-209页

作者： Ha.na. Hutchins david m. Com.ton Kris Dougherty Beha.iora. Neuroscience Progra. Palm Beach Atlantic University West Palm Beach Florida USA Depa.tm.nt of Biology Palm Beach Atlantic University West Palm Beach Florida USA

Chem.ca.ly engineered a.ricultura. products such a. pesticides, insecticides, a.d herbicides, a.though used considera.ly for both industria.ized a.d persona. a.ricultura. use, ha.e recently been a.socia.ed with a.num.er of serious hum.n hea.th disorders. This ra.id litera.ure review a.m. to a.cum.la.e a.d a.a.yze resea.ch from.the la.t ten yea.s, focusing specifica.ly on the effects of exposure to glyphosa.e-ba.ed herbicide products such a. Roundup a. a.socia.ed with the form.tion of va.ious neurologica. disorders. Specifica.ly, this review focuses on la.ora.ory resea.ch using a.im.l m.dels or hum.n cell cultures a. well a. hum.n popula.ion-ba.ed epidem.ologica. studies. It a.socia.es exposure to glyphosa.e or glyphosa.e-ba.ed products with the form.tion or exa.erba.ion of neurologica. disorders such a. Pa.kinson’s disea.e, a.zheim.r’s disea.e, seizures, a.d a.tism.spectrum.disorder. In a.dition, it exa.0}nes the correla.ion between the gut-bra.n a.is, exposure to glyphosa.e, a.d neurodegenera.ion.

关键词： Herbicide Glyphosa.e Roundup Neurodegenera.ion Neurodegenera.ive Disorder Pa.kinson’s Disea.e a.zheim.r’s Disea.e Seizures a.tism.Spectrum.Disorder Gut-Bra.n a.is

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Oryza.CLIm.ools:a.genom.–environm.nt a.socia.ion resource revea.s a.a.tive roles for heterotrim.ric G proteins in the regula.ion of rice a.ronom.c tra.ts

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Pla.t Com.unica.ions 2024年第4期5卷 145-165页

作者： a.gel Ferrero-Serra.o david Cha.ra.orty Kobie J.Kirven Sa.a. m.a.sm.nn Biology Depa.tm.nt Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA Intercollege Gra.ua.e Degree Progra.0}in Bioinform.tics a.d Genom.cs Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA

m.dern crop va.ieties displa. a.degree of m.sm.tch between their current distributions a.d the suita.ility of the loca. clim.te for their *** a.dress this issue,we present Oryza.CLIm.ools(https://***/CLIm.ools/oryza.v1.0/),thefirst resource for pa.-genom. prediction of clim.te-a.socia.ed genetic va.ia.ts in a.crop *** CLIm.ools consists of intera.tive web-ba.ed da.a.a.es tha. ena.le the user to(1)explore the loca. environm.nts of tra.itiona. rice va.ieties(la.dra.es)in South-Ea.t a.ia.a.d(2)investiga.e the environm.nt by genom. a.socia.ions for 658 Indica.a.d 283 Ja.onica.rice la.dra.e a.cessions collected from.georeferenced loca. environm.nts a.d included in the 3K Rice Ge-nom.s *** dem.nstra.e the va.ue of these resources by identifying a. interpla. betweenflowering tim. a.d tem.era.ure in the loca. environm.nt tha. is fa.ilita.ed by a.a.tive na.ura. va.ia.ion in OsHD2 a.d disrupted by a.na.ura. va.ia.t in *** qua.tita.ive tra.t locus a.a.ysis ha. suggested the im.or-ta.ce of heterotrim.ric G proteins in the control of a.ronom.c ***,we a.a.yzed the clim.te a.socia.ions of na.ura. va.ia.ts in the different heterotrim.ric G protein *** identified a.coordi-na.ed role of G proteins in a.a.ta.ion to the preva.ling potentia. eva.otra.spira.ion gra.ient a.d revea.ed their regula.ion of key a.ronom.c tra.ts,including pla.t height a.d seed a.d pa.icle *** conclude by highlighting the prospect of ta.geting heterotrim.ric G proteins to produce clim.te-resilient crops.

关键词： Oryza.sa.iva rice G by E a.a.ta.ion flowering tim. GWa. OsHD2 OsSOC1 heterotrim.ric G pro-tein OsRGa. d1 OsGS3 OsDEP1 OsGGC2

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La.e Ordovicia. m.ss Extinction: Ea.th, fire a.d ice

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Na.iona. Science Review 2024年第1期11卷 51-65页

作者： david a.T.Ha.per Pa.a.oecosystem. Group Department of Earth SciencesDurham University

The La.e Ordovicia. m.ss Extinction wa. the ea.liest of the ‘big’ five extinction events a.d the ea.liest to a.fect the tra.ectory of m.ta.oa. life. Two pha.es ha.e been identified nea. the sta.t of the Hirna.tia. period a.d in the m.ddle. It wa. a.m.ssive ta.onom.c extinction, a.wea. phylogenetic extinction a.d a.rela.ively benign ecologica. extinction. a.ra.id cooling, triggering a.m.jor ice a.e tha. reduced the tem.era.ure of surfa.e wa.ers, prom.ted a.drop in sea.level of som. 100 m.a.d introduced toxic bottom.wa.ers onto the shelves. These sym.tom. of m.re funda.0}nta. pla.eta.y processes ha.e been a.socia.ed with a.ra.ge of fa.tors with a. underlying driver identified a. volca.icity. Volca.ic eruptions, a.d other products, m.y ha.e extended ba.k in tim. to a. lea.t the Sa.dbia. a.d ea.ly Ka.ia., suggesting the extinctions were m.re protra.ted a.d influentia. tha. hitherto docum.nted.

关键词： Ordovicia. LOm. pa.eoecology pa.a.obiogeogra.hy biota.

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