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Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms

Stroke & Vascular Neurology 2019年第1期4卷 36-42页

作者： Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez mario Zanaty Jorge A Roa Pascal Jabbour david m hasan Department of Neurology Neurosurgery and RadiologyUniversity of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery Thomas Jefferson UniversityPhiladelphiaPennsylvaniaUSA

Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow *** IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications *** sought to determine the safety of tirofiban and DAPT in these *** We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow *** tirofiban-DAPT protocol used is *** regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and *** One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 *** and major haemorrhagic events were recognised in 20%(30/148)*** 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 *** average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were *** haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was *** administration of heparin did not increase haemorrhagic *** The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was *** and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications.

关键词： aneurysm intracranial infusion

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Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis

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Stroke & Vascular Neurology 2019年第4期4卷 189-197页

作者： Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez Jorge A Roa david m hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira Neurology Neurosurgery and RadiologyUniversity of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurology and Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Radiology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Biostatistics and Public Health University of Iowa Hospitals and ClinicsIowa CityIowaUSA

background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain *** We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral *** mechanism,collateral circulation,and degree and length of stenosis were *** primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or *** outcome variables included modified Rankin Scale(mRS)score on discharge and last *** Of 6369 patients with AIS/TIA,91(1.43%)had ***-three(80.2%)patients presented with AIS and 18(19.8%)with ***-nine(31.9%)were women and the median age was 66.8±13.6 *** mean follow-up time was 2.7 *** most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral *** 13% of patients with ISBAS presented with complete BA *** ISBAS is an uncommon(1.43%)cause of TIA and *** in their 60s are mostly affected,and artery-to artery embolism is the most common stroke ***-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis.

关键词： stenosis basilar artery

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Inflammation in human cerebral aneurysms: pathogenesis, diagnostic imaging, genetics, and therapeutics

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Neuroimmunology and Neuroinflammation 2015年第1期2卷 77-85页

作者： Sarah A.Dooley Joseph S.Hudson david m.hasan Department of Neurosurgery University of Iowa Carver College of MedicineIowa CityIA 52242USA Department of Neurosurgery University of IowaIowa CityIA 52242USA Department of Neurosurgery University of Iowa Hospital and ClinicsIowa CityIA 52240USA

Intracranial aneurysms are a life‑threatening cerebrovascular pathology with a probability of spontaneous *** intervention techniques carry inherent *** investigation has reinforced inflammation’s role in the pathophysiological process of cerebral *** data suggest alternative diagnostic and noninvasive therapeutic ***,novel characteristics of the underlying disease have been elucidated through distinct bioinformatic and gene expression profile *** article will emphasize the most recent investigation,highlighting findings of clinical significance and etiological relevance.

关键词： Diagnostic imaging genetics intracranial aneurysms pathogenesis therape

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Acute ischaemic stroke interventions: large vessel occlusion and beyond

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Stroke & Vascular Neurology 2020年第1期5卷 80-85页

作者： Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg maureen Deprince Jaime Dougherty Dimitri Jean-mickael maamari Stavropoula Tjoumakaris Hekmat Zarzour michael R Gooch Nabeel Herial Victor Romo david m hasan Robert H Rosenwasser Pascal Jabbour Neurosurgery Thomas Jefferson University HospitalPhiladelphiaPennsylvaniaUSA Endocrinology Children’s Hospital of PhiladelphiaPhiladelphiaPennsylvaniaUSA Sydney Kimmel medical College Thomas Jefferson UniversityPhiladelphiaPennsylvaniaUSA School of medicine American University of BeirutBeirutLebanon Anesthesia Thomas Jefferson University-Center City CampusPhiladelphiaPennsylvaniaUSA Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA

Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical *** vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming *** review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke *** addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion.

关键词： acute occlusion breakthrough

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Ru/NimnB spherical cluster pillar for highly proficient green hydrogen electrocatalyst at high current density

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Journal of Energy Chemistry 2025年第1期100卷 397-408页

作者： md Ahasan Habib Shusen Lin mehedi hasan Joni Sumiya Akter Dristy Rutuja mandavkar Jae-Hun Jeong Jihoon Lee Department of Electronic Engineering College of Electronics and Information Kwangwoon University

Advanced OER/HER electrocatalytic alternatives are crucial for the wide adaptation of green hydrogen ***,Ru/NimnB spherical cluster pillar （SCP）,denoted as Ru/NimnB,is synthesized using a combination of electro-deposition and hydrothermal *** investigation of Ru doping in the NimnB matrix revealed significant improvements in electrocatalytic *** Ru/NimnB SCPs demonstrate superior OER/HER activity with low overpotentials of 150 and 103 mV at 50mA/cm2in 1 m KOH,making them highly competitive with state-of-the-art ***,the Ru/NimnB SCPs exhibit a low 2-E cell voltage of 2.80 V at ultra-high current density of 2,000 m A/cm2in 1 m KOH,outperforming the standard benchmark electrodes of RuO2||Pt/C,thereby positioning Ru/NimnB as one of the best bifunctional *** SCPs exhibit exceptional high-current characteristics,stability and corrosion resistance,as evidenced by continuous operation at 1,000 mA/cm2high-current density for over 150 h in 6 m KOH at elevated temperatures under harsh industrial *** a small amount of Ru incorporation significantly enhances the electrocatalytic performances of NimnB,attributed to increased active sites and improved intrinsic properties such as conductivity,adsorption/desorption capability and reaction ***,Ru/NimnB SCPs present a promising bi-functional electrode concept for efficient green H2production.

关键词： Potassium hydroxide

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Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph david Gimbel Jonathan Grossberg Daniel L.Barrow matthew F.Gary Ali m.Alawieh Department of Neurosurgery Emory University School of MedicineAtlantaGAUSA Department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

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Effect of Bohm quantum potential in the propagation of ion–acoustic waves in degenerate plasmas

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Chinese Physics B 2016年第10期25卷 222-229页

作者： m m hasan m A Hossen A Rafat A A mamun Department of Physics Jahangirnagar University

A theoretical investigation has been carried out on the propagation of the ion–acoustic(IA) waves in a relativistic degenerate plasma containing relativistic degenerate electron and positron fluids in the presence of inertial non-relativistic light ion fluid. The Korteweg-de Vries(K-dV), modified K-dV(m K-dV), and mixed m K-dV(mm K-dV) equations are derived by adopting the reductive perturbation method. In order to analyze the basic features(phase speed, amplitude, width,etc.) of the IA solitary waves(SWs), the SWs solutions of the K-dV, m K-dV, and mm K-d V are numerically analyzed. It is found that the degenerate pressure, inclusion of the new phenomena like the Fermi temperatures and quantum mechanical effects(arising due to the quantum diffraction) of both electrons and positrons, number densities, etc., of the plasma species remarkably change the basic characteristics of the IA SWs which are found to be formed either with positive or negative potential. The implication of our results in explaining different nonlinear phenomena in astrophysical compact objects, e.g.,white dwarfs, neutron stars, etc., and laboratory plasmas like intense laser–solid matter interaction experiments, etc., are mentioned.

关键词： Bohm quantum potential degenerate relativistic plasma electron and positron quantum effect

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Rice plant growth and yield: foliar application of plasma activated water

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Plasma Science and Technology 2021年第7期23卷 134-143页

作者： m m RASHID mamunur RASHID m m hasan m R TALUKDER Plasma Science and Technology Lab Department of Electrical and Electronic EngineeringUniversity of RajshahiRajshahi 6205Bangladesh Plant Pathology and mycology Lab Department of BotanyUniversity of RajshahiRajshahi 6205Bangladesh Plant Pathology Lab Department of Agronomy and Agricultural ExtensionUniversity of RajshahiRajshahi 6205Bangladesh

Plasma activated water(PAW)was prepared for 10 min to be applied one toﬁve times as a foliar spray to rice plants,to investigate plant growth,yield and the concentrations of total soluble protein and sugar in the rice grains *** results reveal that(1)the plant height,stem diameter,dry weight,chlorophyll and total carotene concentrations were improved by∼15%,∼25%,∼24%,∼47%and∼45%,respectively,with respect to control,(2)defense mechanisms of the plants treated with PAW were improved,(3)concentrations of total soluble protein and sugar were enhanced in the rice grains of PAW treated plants and(4)yield was increased by∼14%.

关键词： plasma agriculture plasma activated water rice plant growth rice yield total soluble protein

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Dispersion Relations for Isothermal Plasma around the Horizon of Reissner-Nordstroem-de Sitter Black Hole

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Chinese Physics Letters 2009年第10期26卷 220-223页

作者： m. Khayrul hasan m. Hossain Ali Department of mathematics Shahjalal University of Science and Technology Sylhet-3100 Bangladesh Department of Applied mathematics University of Rajshahi Rajshahi-6205 Bangladesh

We formulate the general relativistic magnetohydrodynamic equations for isothermal plasma in spatially fiat Reissner-Nordstroem-de Sitter metric by using 3＋1 split of spacetime. Respective perturbed equations are linearized for rotating magnetized surroundings. These are then Fourier analyzed and the corresponding dispersion relations are obtained. These relations are discussed both analytically and numerically in order to investigate the nature of waves with positive angular frequency around the horizon.

关键词： Plasma physics Gravitation and cosmology Astrophysics and astroparticles

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Radiation induced decontamination of Cr(Ⅵ),Cu(Ⅱ) and phenol in some tannery effluents

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Nuclear Science and Techniques 2007年第4期18卷 212-217页

作者： hasan m. KHAN Abdul mAHmOOD Radiation Chemistry Laboratory National Centre of Excellence in Physical ChemistryUniversity of PeshawarPeshawar 25120Pakistan

Industrialization has led to a number of environmental problems, such as release of toxic metals and other toxic organic and inorganic compounds to the environment. Among all, the rapid expansion of leather related industries in Pakistan have resulted in considerable environmental problems and effluents from processing of both domestic and imported hides and skins have increased pollution to alarming levels. Some tannery effluents of Peshawar area investigated in the present study showed high concentrations of Cr(Ⅵ) (2.7-12.6 mg/L), Cu(Ⅱ) (2.6-11.4 mg/L) and phenol (0.1-4.2 mg/L). These contaminants are very toxic and must be removed from effluents before releasing into water bodies. A new technique of gamma irradiation has been investigated to decrease the load of COD and concentrations of Cr(Ⅵ), Cu(Ⅱ) and phenol associated with tannery effluents to the permitted values. It was observed that concentration of Cr(Ⅵ) in the effluents can be brought to the permitted level by applying radiation dose of 3 kGy. A radiation dose of 2.5 kGy was required to remove more than 95% of Cu(Ⅱ) and 100 % degradation of phenol in tannery effluents could be achieved by only one kGy of radiation dose.

关键词：制革厂污水处理方法环境保护

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