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Efficacy of nonsolvent flower pollen extracts in healthy women with urinary incontinence:A randomized,double-blind,placebo-controlled,parallel study

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Current Urology 2024年第3期18卷 203-211页

作者： Marc Moulin Erin D.lewis david C.Crowley Colleen E.May Malkanthi Evans KGK Science Inc. LondonOntarioCanada Graminex L.L.C.SaginawMIUSA

Background Urinary incontinence(UI)is a debilitating and common condition that adversely affects quality of *** and surgical approaches for managing UI symptoms may result in undesirable risks and *** randomized,double-blind,placebo-controlled,parallel study investigated the efficacy of 2 nonsolvent flower pollen extracts on UI in healthy *** and methods One-hundred and fourteen women aged 40–75 years who scored≥5 on the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-SF)were randomized to receive either Graminex®RCT Fem™UI,Graminex®PollenBerry®,or placebo for 24 *** primary outcome was the change in the ICIQ-SF score between the trial and placebo groups after 24 weeks of *** secondary outcomes included changes in the frequency of nocturia(recorded in 3-day void diaries)and 24-hour leakage volume(assessed via pad weight)after 6,12,18,and 24 weeks of supplementation and changes in stress-induced urinary leakage volume(after completion of a provocative maneuver challenge)after 24 weeks of *** All the groups demonstrated improvement in ICIQ-SF scores at week 24(p<0.001).The RCT Fem™UI group had the greatest improvement in ICIQ-SF scores(−4.07±3.4),followed by the PollenBerry®group(−3.34±2.87)and placebo group(−2.61±3.52).The RCT Fem™UI group had corresponding improvements in 24-hour leakage volume(−17.68±39.84 g)and frequency of nocturia(−0.52±1.26)(p≤0.05).PollenBerry®supplementation significantly improved stress-induced urinary leakage volume(−7.12±15.64 g)at week *** study products demonstrated safe hematological and chemical *** RCT Fem™UI supplementation resulted in significant and clinically meaningful reductions in UI severity,with corresponding improvements in daily urinary leakage volume and frequency of ***®significantly improved stress-induced urinary leakage volume,suggesting that it may be eff

关键词： Urinary incontinence Pollen extract Healthy women Dietary supplement ICIQ-SF Urinary leakage

Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： lewis A Hall Duncan Loader Santiago Gouveia Marta Burak James Halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari Keith J Roberts Syed S Raza Michail Papamichail david C Bartlett Robert P Sutcliffe Nikolaos A Chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dCCA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dCCA and present the experience of a highvolume tertiary-centre managing dCCA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dCCA who received *** patients from 2017 to 2022 who were referred for NAT for dCCA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dCCA was *** studies reported outcomes for 9 patients who received NAT for dCCA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dCCA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dCCA is *** propose using the established National-Comprehensive-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review

Description of a novel robotic early post-prostatectomy anastomotic repair technique and institutional outcomes

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Asian Journal of Urology 2024年第3期11卷 366-372页

作者： david Strauss Eric Cho Matthew Loecher Matthew Lee Daniel Eun Department of Urology Lewis Katz School of MedicineTemple UniversityPhiladelphiaPAUSA

Objective:A vesicourethral anastomotic leak(VUAL)is a known complication following robotic-assisted radical *** natural history of a VUAL has been well described and is frequently managed with prolonged *** increasing emphasis on patient reported outcomes,catheter duration and VUAL are associated with significant short-term quality of life *** aimed to present a case series of our robotic early post-prostatectomy anastomotic repair technique,defined as revision within 6 weeks from index ***:A single institution prospective database identified eleven patients with a VUAL from July 2016 to October 2022 who underwent robotic early post-prostatectomy anastomotic repair by a single *** were diagnosed with a VUAL on pre-operative CT urogram or CT/fluoroscopic *** primary outcome was resolution of the anastomotic leak,defined as no contrast extravasation on post-operative *** outcomes included post-repair catheter duration and continence on the last follow-up defined as pad(s)per ***:The mean time to intervention after robotic-assisted radical prostatectomy was 21 *** of the eleven(72.7%)patients had no evidence of extravasation on postrepair *** range from intervention to first cystogram was 7e20 *** median catheter duration for those with successful intervention was 10 *** median catheter duration for those with the leak on initial post-operative cystogram was 20 *** a mean follow-up time of 25 months,eight(72.7%)patients reported using no pads per day,and three(27.3%)patients reported one pad per ***:Management of a VUAL has traditionally relied on prolonged catheter drainage and the tincture of *** the role of robotic reconstruction has been shown to be a viable modality for management of bladder neck contracture,it is important to reconsider prior dogmas of urologic *** case series suggests that an early repair is saf

关键词： Minimallyinvasive surgery Vesicourethral anastomotic leak Robotic-assisted laparoscopic reconstruction

Role of buccal mucosa graft ureteroplasty in the surgical management of pyeloplasty failure

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Asian Journal of Urology 2024年第3期11卷 373-376页

作者： Matthew Lee Elizabeth Nagoda david Strauss Matthew Loecher Michael Stifelman Lee Zhao Department of Urology Lewis Katz School of MedicineTemple UniversityPhiladelphiaPAUSA Department of Urology Hackensack Meridian School of MedicineHackensack University Medical CenterHackensackNJUSA Department of Urology New York University Grossman School of MedicineNew York University Langone Health SystemNew YorkNYUSA

Objective:Secondary pyeloplasty for recurrent ureteropelvic junction obstructions may be a safe and feasible surgical option for *** study aimed to demonstrate outcomes of utilizing a non-transecting buccal mucosa graft ureteroplasty for management of recurrent ureteropelvic junction obstruction after prior failed ***:We performed a retrospective review of our Collaborative of Reconstructive Robotic Ureteral Surgery database for all consecutive patients who underwent buccal mucosa graft ureteroplasty between April 2012 and June 2022 for management of recurrent ureteropelvic junction obstructions after prior failed *** primary outcome included surgical success which was defined as the absence of flank pain and no obstruction on ***:Overall,ten patients were included in our *** median stricture length was 2.5(interquartile range[IQR]1.8-4.0)*** median operative time was 230.5(IQR 199.5-287.0)min and median estimated blood loss was 50.0(IQR 28.8-102.5)*** a median follow-up of 10.3(IQR 6.2-14.8)months,80%of patients were surgically successful and there were no major(ClavieneDindo Grade>2)***:Buccal mucosa graft ureteroplasty is a valuable non-transecting surgical option for patients with recurrent ureteropelvic junction obstructions who failed prior pyeloplasty and has comparable outcomes to the literature regarding standard transecting techniques.

关键词： Ureteral obstruction Buccal mucosagraft Pyeloplasty Robotic Stricture

Practical Art of Motion Picture Sound

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High performance flexible metal oxide/silver nanowire based transparent conductive films by a scalable lamination-assisted solution method

2012年

作者： david lewis Yewdall

ISBN: (纸本)9780240812403

Practical Art of Motion Picture Sound, 4th edition relies on the professional experience of the author and other top sound craftspeople to provide a comprehensive explanation of film sound, including mixing, dubbing, workflow, budgeting, and digital audio techniques. Practically grounded with real-world stories from the trenches throughout, the book also provides relevant technical data, as well as an appreciation of all the processes involved in creating optimal motion picture sound. New to this edition are exclusive sound artist lessons from the field (including 2 new production cases studies), including insight from craftspeople who have worked on the latest Harry Potter and Batman films. All technological changes have been updated to reflect the most current systems. **Due to a manufacturing error, the Yewdall Sound FX Library is not available on the DVD included with the book. Please visit the book’s website, to download the full library.**

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Journal of Materiomics 2017年第1期3卷 77-82页

作者： Hua Yu Andrew J.Stapleton david A.lewis Lianzhou Wang a Nanomaterials Centre School of Chemical Engineering and Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandBrisbaneQLD4072Australia Flinders Centre for NanoScale Science and Technology Flinders UniversityGPO Box 2100AdelaideSA 5001Australia CSIRO Materials Science and Engineering Private Bag 33Clayton SouthVictoria 3169Australia

Flexible MoO_(3)/silver nanowire(AgNW)/MoO_(3)/TiO_(2)/Epoxy electrodes with comparable performance to ITO were fabricated by a scalable solution-processed method with lamination assistance for transparent and conductive *** nanoparticle-based electrodes were also prepared for *** a simple spin-coating and lamination-assisted planarization method,a full solution-based approach allows preparation of AgNW-based composite electrodes at temperatures as low as 140℃.The resulting flexible AgNW-based electrodes exhibit higher transmittance of 82%at 550 nm and lower sheet resistance about 12-15Ωsq^(-1),in comparison with the values of 68%and 22-25Ωsq^(-1) separately for AgNP based *** electron microscopy(SEM)and Atomic force microscopy(AFM)reveals that the multi-stacked metal-oxide layers embedded with the AgNWs possess lower surface roughness(<15 nm).The AgNW/MoO_(3) composite network could enhance the charge transport and collection efficiency by broadening the lateral conduction range due to the built of an efficient charge transport network with long-sized *** consideration of the manufacturing cost,the laminationassisted solution-processed method is cost-effective and scalable,which is desire for large-area *** in view of the materials cost and comparable performance,this AgNW-based transparent and conductive electrodes is potential as an alternative to ITO for various optoelectronic applications.

关键词： Silver nanowires Transparent conductive film MoO_(3) Solution processed Lamination

Is there a role for serum endothelin in predicting the severity of acute pancreatitis?

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Hepatobiliary & Pancreatic Diseases International 2006年第2期5卷 290-293页

作者： John Bennett david Cooper Anita Balakrishnan Michael Rhodes Michael lewis Department of Surgery Norfolk and Norwich University Hospital Colney LaneNorwichNorfolkNR4 7UYEngland

BACKGROUND: Acute pancreatitis remains a common presentation to acute surgical units and carries significant morbidity and mortality. The progression of the disease to necrotizing pancreatitis and multi-organ dysfunction syndrome (MODS) is associated with a very poor clinical outcome, and persistendy high mortality. Increases in serum endothelin (ET) have been seen in animal models of acute pancreatitis and this study aims to investigate whether there is a change in serum ET-1 in patients with acute pancreatitis and whether any such change is linked to disease severity. METHODS: All patients admitted with acute pancreatitis were prospectively recruited from die emergency admissions at the Norfolk and Norwich University Hospital. Serum ET levels were determined on admission, at 24 hours and 5 days post admission. Healthy adult controls were recruited from dermatology outpatients. RESULTS: A total of 21 patients joined the trial after giving informed consent. There were 3 men and 18 women with a median age of 65 years (range 26-87 years). Serum ET levels were significantly higher in acute pancreatitis patients than in normal controls (P <0. 05). An association was seen between persistendy raised serum ET levels and progression to MODS. CONCLUSIONS: The study does demonstrate a correlation between the circulating levels of ET and acute pancreatitis in humans, although it does not elicit its involvement in the pathogenesis of the disease. The observation that a persistendy high level of circulating ET-1 is associated with progression to MODS may indicate a role for ET in the monitoring of acute pancreatitis patients for recovery or progression to MODS.

关键词： endothelin acute pancreatitis

When It Strikes,Are We Ready?Lessons Identified at the 7th Planetary Defense Conference in Preparing for a Near-Earth Object Impact Scenario

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International Journal of Disaster Risk Science 2022年第1期13卷 151-159页

作者： Shirish Ravan Tom De Groeve Lara Mani Einar Bjorgo Richard Moissl Jose Miguel Roncero Katherine Rowan david Schuld Leviticus A.lewis Romana Kofler United Nations Office for Outer Space Affairs(UNOOSA) United Nations1220 ViennaAustria European Commission Joint Research Centre 21027 IspraItaly Centre for the Study of Existential Risk University of CambridgeCambridge CB21SBUK Division for Satellite Analysis United Nations Institute for Training and Research(UNITAR)1202 GenevaSwitzerland European Space Agency/European Space Research and Technology Centre(ESA/ESTEC) 2201 AZ NoordwijkThe Netherlands Security and Situational Awareness Unit European Commission's Directorate-General for European Civil Protection and Humanitarian Aid Operations1049 BrusselsBelgium Department of Communication George Mason UniversityFairfaxVA 22030USA Hagerty Consulting EvanstonIL 60201USA Response Operations Division Federal Emergency Management AgencyWashingtonDC 20024USA

Near-Earth object(NEO)impact is one of the examples of high impact and low probability(HILP)event,same as the Covid-19 pandemic the world faces since the beginning of *** 7 th Planetary Defense Conference held by the International Academy of Astronautics(IAA)in April 2021 included an exercise on a hypothetical NEO impact event,allowing the planetary defense community to discuss potential *** the span of the 4-day conference this exercise connected disaster response and management professionals to participate in a series of panels,providing feedback and perspective on the unfolding crisis *** hypothetical but realistic asteroid threat scenario illustrated how such a short-warning threat might *** scenario utilized during the conference indicates a need to prepare now for what might come in the future,because even with advance notice,preparation time might be *** scenario chose Europe for the impact,which may likely cope with such a disaster,through the Union Civil Protection Mechanism(UCPM)and other solidarity and support mechanisms within the European Union(EU),as well as with potential support from international *** short article raises concern about other areas in the world on how they may access NEO impact information and cope with such *** also provides an idea on vast scale of such disaster vis-a-vis the current capacity of response systems to cope with a larger event in Europe or *** scenario showed that planetary defense is a global *** engagement of the planetary defense and disaster response communities is essential in order to keep the world safe from potential disasters caused by NEO impacts.

关键词： Asteroid threats Disaster risk reduction Planetary defense Risk management and prevention

Towards intelligent geospatial data discovery:a machine learning framework for search ranking

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International Journal of Digital Earth 2018年第9期11卷 956-971页

作者： Yongyao Jiang Yun Li Chaowei Yang Fei Hu Edward MArmstrong Thomas Huang david Moroni lewis J.McGibbney Christopher J.Finch NSF Spatiotemporal Innovation Center and Department of Geography and GeoInformation Science George Mason UniversityFairfaxVAUSA NASA Jet Propulsion Laboratory California Institute of TechnologyPasadenaCAUSA

Current search engines in most geospatial data portals tend to induce users to focus on one single-data characteristic dimension(*** and release date).This approach largely fails to take account of users’multidimensional preferences for geospatial data,and hence may likely result in a less than optimal user experience in discovering the most applicable *** study reports a machine learning framework to address the ranking challenge,the fundamental obstacle in geospatial data discovery,by(1)identifying a number of ranking features of geospatial data to represent users’multidimensional preferences by considering semantics,user behavior,spatial similarity,and static dataset metadata attributes;(2)applying a machine learning method to automatically learn a ranking function;and(3)proposing a system architecture to combine existing search-oriented open source software,semantic knowledge base,ranking feature extraction,and machine learning *** show that the machine learning approach outperforms other methods,in terms of both precision at K and normalized discounted cumulative *** an early attempt of utilizing machine learning to improve the search ranking in the geospatial domain,we expect this work to set an example for further research and open the door towards intelligent geospatial data discovery.

关键词： Learning to rank semantic search user behavior search engine big data metadata data relevancy data portal