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Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

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Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Pedro AAvila-lópez Iva Tic david Valle-García Marta Ribalta-Vilella luis labrador Deb Ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré Department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMP8)control mice and SAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG SAMP8

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On the functions of astrocyte-mediated neuronal slow inward currents

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Neural Regeneration Research 2024年第12期19卷 2602-2612页

作者： Balázs Pál Department of Physiology Faculty of MedicineUniversity of DebrecenDebrecenHungary

Slow inward currents are known as neuronal excitatory currents mediated by glutamate release and activation of neuronal extra synaptic N-met hyl-D-aspartate receptors with the contribution of *** events are significantly slower than the excitatory postsynaptic *** of slow inward currents are determined by seve ral factors including the mechanisms of astrocytic activation and glutamate release,as well as the diffusion pathways from the release site towards the extra synaptic recepto *** are stimulated by neuronal network activity,which in turn excite neurons,forming an astrocyte-neuron feedback *** as a consequence of brain edema,astrocytic swelling can also induce slow inward currents under pathological *** is a growing body of evidence on the roles of slow inward currents on a single neuron or local network *** events often occur in synchro ny on neurons located in the same astrocytic *** synchronization of neuronal excitability,slow inward currents also set synaptic strength via eliciting timing-dependent synaptic *** addition,slow inward currents are also subject to non-synaptic plasticity triggered by long-la sting stimulation of the excitatory *** note,there might be important regionspecific differences in the roles and actions triggering slow inward *** greater networks,the pathophysiological roles of slow inward currents can be better understood than physiological *** inward currents are identified in the pathophysiological background of autism,as slow inward currents drive early hypersynchrony of the neural *** inward currents are significant contributors to paroxysmal depolarizational shifts/interictal *** events are related to epilepsy,but also found in Alzheimer's disease,Parkinson's disease,and stroke,leading to the decline of cognitive *** with features overlapping with slow inward currents(excitatory,N-methyl-Dasp

关键词： astrocyte cortical spreading depolarization gliotransmission glutamate neural synchronization NMDA receptor paroxysmal depolarizational shift slow inward current

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On calculating glacial isostatic adjustment

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Geodesy and Geodynamics 2024年第5期15卷 441-452页

作者： l.M.Cathles Cornell University IthacaNY 14853USA

Modeling the earth's fluid and elastic response to the melting of the glaciers of the last ice age is the most direct way to infer the earth's radial viscosity ***,we compare two methods for calculating the viscoelastic response to surface *** one,the elastic equation of motion is converted to a viscoelastic equation using the Correspondence *** the other,elastic deformation is added to the viscous flow as isostatic adjustment *** two modeling methods predict adjustment histories that are different enough to potentially impact the interpretation of the observed glacial isostatic adjustment(GIA).The differences arise from buoyancy and whether fluid displacements are subjected to hydrostatic *** methods agree if they use the same equations and boundary *** origin of the differences is determined by varying the boundary conditions and pre-stress application.

关键词： Glacial isostatic adjustment Viscoelastic normal modes Hydrostatic pre-stress Elastic buoyancy Correspondence principle

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Effect of radiative loss mechanisms on FIR thermometric parameters of Nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： C.Y.Morassuti A.P.l Silva l.A.O.Nunes S.M.lima l.H.C.Andrade Optical and Photothermal Spectroscopy Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Archer Information Technology Center Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physics of São Carlos University of São PauloSão CarlosSPBrazil

Nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluorescence intensity ratio(FIR)***,at high Nd^(3+)concentrations,energy transfer(ET)processes such as optical reabsorption and cross-relaxation can affect the Nd^(3+)emission,which has been little explored in the ***,the present work investigated the use of Nd^(3+)-doped tellurite glass(samples doped with Nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluorescence thermometers,in the temperature range from 299 to 371 *** results indicate a strong dependence of the FIR parameters on the Nd^(3+)concentration,due to changes in the emission band profiles caused by optical reabsorption of the Nd^(3+)emissions and cross-relaxation processes.A decrease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of Nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,which is the highest value among the reported Nd^(3+)ions.

关键词： Nd^(3+)-doped tellurite glass Fluorescence intensity ratio Optical thermometry Judd-Ofelt Rare earths

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中国户籍登记系统漏登合成估计方法研究

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系统科学与数学 2024年

作者：黄艳华 lópez-carr david 胡桂华重庆工商大学成渝地区双城经济圈建设研究院 University of California Santa Barbara Department of Geography 重庆工商大学数学与统计学院统计智能计算与监测重庆市重点实验室

中国户籍登记系统存在漏登人口问题,但政府部门尚未开展户籍漏登估计工作.联合国统计司建议各国采用的单重漏登估计量未覆盖全部漏登人口,低估漏登率.本文提出用合成漏登估计量替代单重漏登估计量,并通过案例研究,比较了合成漏登估计量... 详细信息

中国户籍登记系统存在漏登人口问题,但政府部门尚未开展户籍漏登估计工作.联合国统计司建议各国采用的单重漏登估计量未覆盖全部漏登人口,低估漏登率.本文提出用合成漏登估计量替代单重漏登估计量,并通过案例研究,比较了合成漏登估计量与单重漏登估计量.实证研究结果表明:四种合成漏登估计量估计的漏登率均高于单重漏登估计量;除其中一种合成漏登估计量估计的漏登率的抽样标准差略高于单重漏登估计量外,其他三种合成漏登估计量估计结果的抽样标准差均小于单重漏登估计量.研究结果为统计局和公安部未来制定户籍登记系统漏登估计方案提供重要参考,提高方案的科学性和可操作性.

关键词：抽样调查事后分层三系统估计量刀切法

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Non-adhesive and adhesive contacts of an elastic quarter-or eighth-space with freely sliding sides

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Friction 2024年第9期12卷 2052-2063页

作者： Qiang lI Valentin l.POPOV Technische Universität Berlin Berlin 10623Germany

The contact of an elastic quarter-or eighth-space is studied under the condition that the movement of the side surface of the quarter-space is constrained:It can slide freely along the plane of the side surface but its normal movement is blocked(for example,by a rigid wall).The solution of this contact problem can be easily achieved by additionally applying a mirrored load to an elastic ***-adhesive contact and the Johnson–Kendall–Roberts(JKR)-type adhesive contact between a rigid sphere and an elastic quarter-space under such a boundary condition is numerically simulated using the fast Fourier transform(FFT)-assisted boundary element method(BEM).Contacts of an elastic eighth-space are investigated using the same *** on the position of the sphere relative to the side edge,different contact behavior is *** the case of adhesive contact,the force of adhesion first increases with increasing the distance from the edge of the quarter-space,achieves a maximum,and decreases further to the JKR-value in large distance from the *** enhancement of the force of adhesion compared to the half-space-contact is associated with the pinning of the contact area at the *** provide the maps of the force of adhesion and their analytical approximations,as well as pressure distributions in the contact plane and inside the quarter-/eighth-space.

关键词： quarter-space eighth-space adhesion edge effect boundary element method(BEM)

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Quantum vortices get stretched

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Frontiers of physics 2024年第3期19卷 225-227页

作者： Emanuel A.l.Henn São Carlos Institute of Physics University of São Paulo-PO Box 36913560-970São CarlosBrazil

Since its discovery, superfluidity [1,2] remains one of the most remarkable phenomena in quantum physics. The onset of the quantum regime in liquid helium is visually striking, when the fluid flows without dissipation or detaches from a rotating bucket, remaining still upon soft rotations. The same phenomenon is present in the context of ultracold bosonic quantum gases where, most of the time, superfluidity walks hand-in-hand with the transition to Bose−Einstein condensation [3].

关键词： quantum rotating rotation

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Time-inconsistent stochastic linear-quadratic control problem with indefinite control weight costs

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Science China Mathematics 2024年第1期67卷 211-236页

作者： Qi lü Bowen Ma School of Mathematics Sichuan UniversityChengdu 610064China

A time-inconsistent linear-quadratic optimal control problem for stochastic differential equations is *** introduce conditions where the control cost weighting matrix is possibly *** such conditions,we obtain a family of closed-loop equilibrium strategies via multi-person differential *** result extends Yong’s work(2017) in the case of stochastic differential equations,where a unique closed-loop equilibrium strategy can be derived under standard conditions(namely,the control cost weighting matrix is uniformly positive definite,and the other weighting coefficients are positive semidefinite).

关键词： linear-quadratic optimal control problem time-inconsistent cost functional generalized Riccati equation indefinite control weight cost closed-loop equilibrium strategy

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Rogue wave solutions and rogue-breather solutions to the focusing nonlinear Schr?dinger equation

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Communications in Theoretical Physics 2024年第3期76卷 33-41页

作者： Si-Jia Chen Xing lü College of Science Tianjin University of TechnologyTianjin 300384People's Republic of China Department of Mathematics Beijing Jiaotong UniversityBeijing 100044People's Republic of China Beijing laboratory of National Economic Security Early-warning Engineering Beijing Jiaotong UniversityBeijing 100044People's Republic of China

Based on the long wave limit method,the general form of the second-order and third-order rogue wave solutions to the focusing nonlinear Schr?dinger equation are given by introducing some arbitrary *** interaction solutions between the first-order rogue wave and one-breather wave are constructed by taking a long wave limit on the two-breather *** applying the same method to the three-breather solutions,two types of interaction solutions are obtained,namely the first-order rogue wave and two breather waves,the second-order rogue wave and one-breather wave,*** influence of the parameters related to the phase on the interaction phenomena is graphically *** occur among the rogue waves and breather *** the collisions,the shape of them remains *** abundant interaction phenomena in this paper will contribute to a better understanding of the propagation and control of nonlinear waves.

关键词： nonlinear Schrodinger equation rogue wave solutions interaction solutions

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人口统计分析模型与人口普查净误差估计

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系统科学与数学 2024年

作者：余鲁李婷 david lópez-Carr 胡桂华吴笛漆莉重庆工商大学数学与统计学院 Department of Geography America University of California 重庆工商大学统计智能计算与监测重庆市重点实验室

本文旨在引入美国的人口统计分析模型,建立适合于在我国应用的人口统计分析模型.采取文献解读法和概率模型法,研究人口统计分析模型及其相关问题.研究结果表明:人口统计分析模型在我国的研究尚处于起步阶段,建立我国的人口统计分析模型... 详细信息

本文旨在引入美国的人口统计分析模型,建立适合于在我国应用的人口统计分析模型.采取文献解读法和概率模型法,研究人口统计分析模型及其相关问题.研究结果表明:人口统计分析模型在我国的研究尚处于起步阶段,建立我国的人口统计分析模型,不能照搬美国的人口统计分析模型,而应该结合我国实际情况有所改进与创新;建立人口统计分析模型分为两个层次,一是建立基于全面资料的人口统计分析模型,无需计算抽样方差,二是建立基于抽样调查资料的人口统计分析模型,需采用刀切法近似计算其抽样方差;人口统计分析模型的优势是,充分利用了出生、死亡及国际迁移等人口行政记录资料,节约了数据采集成本,与人口普查独立,劣势是,估计结果具有不确定性,尤其是其中的国际净迁移人数的估计结果差异较大.人口统计分析模型有望应用于我国2030年人口普查净误差估计,开创我国在该领域使用人口统计分析模型的先河.

关键词：人口普查人口普查质量评估行政记录抽样调查刀切法

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