检索结果-南通市图书馆

Functional mechanism study of the allelochemical myrigalone A identifies a group of ultrapotent inhibitors of ethylene biosynthesis in plants

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2024年第6期5卷 246-262页

作者： George Heslop-Harrison Kazumi Nakabayashi Ana Espinosa-Ruiz Francesca Robertson Robert Baines Christopher R.l.Thompson Katrin Hermann david Alabadí Gerhard leubner-Metzger Robin S.B.Williams Centre for Biomedical Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Centre for Plant Molecular Sciences Department of Biological SciencesRoyal Holloway University of LondonEgham TW200EXUK Instituto de Biología Molecular y Celular de Plantas(CSIC-UPV) 46022 ValenciaSpain Centre for life’s Origins and Evolution Department of GeneticsEvolution and EnvironmentUniversity College LondonLondonUK Syngenta Crop Protection AGSteinSwitzerland

Allelochemicals represent a class of natural products released by plants as root,leaf,and fruit exudates that interfere with the growth and survival of neighboring *** how allelochemicals function to regulate plant responses may provide valuable new approaches to better control plant *** such allelochemical,Myrigalone A(MyA)produced by Myrica gale,inhibits seed germination and seedling growth through an unknown ***,we investigate MyA using the tractable modelDictyostelium discoideum and reveal that its activity depends on the conserved homolog of the plant ethylenesynthesis protein 1-aminocyclopropane-1-carboxylic acid oxidase(ACO).Furthermore,in silico modeling predicts the direct binding of MyA to ACO within the catalytic *** ***,ablation of ACO mimics the MyA-dependent developmental delay,which is partially restored by exogenous ethylene,and MyA reduces ethylene *** Arabidopsis thaliana,MyA treatment delays seed germination,and this effect is rescued by exogenous *** also mimics the effect of established ACO inhibitors on root and hypocotyl extension,blocks ethylenedependent root hair production,and reduces ethylene ***,in silico binding analyses identify a rangeof highlypotentethylene inhibitorsthatblock ethylene-dependent responseand reduce ethyleneproduction in ***,we demonstrate a molecular mechanism by which the allelochemical MyA reduces ethylene biosynthesis and identify a range of ultrapotent inhibitors of ethylene-regulated responses.

关键词： 1-aminocyclopropane-1-carboxylic acid ACC ACC oxidase ACO allelochemicals ethylene synthesis inhibitors structure-activity relationship

Why China Will lead The World With EVs

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Beijing Review 2024年第10期67卷 23-23页

作者： david morris Center for China and Globalization

Abattle is underway to determine which country will lead in the transition to zero-emission *** electric vehicle(EV)sector is expected to be a major pillar of the new green ***,Germany,where the petrolguzzling car was... 详细信息

关键词： World sector leader

Dose-response effect of pre-exercise carbohydrates under muscle glycogen unavailability:Insights from McArdle disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 398-408页

作者： Pedro l.Valenzuela Alfredo Santalla lidia B.Alejo Andrea Merlo Asuncion Bustos laura Castellote-Belles Roser Ferrer-Costa Nicola A.Maffiuletti david Barranco-Gil Tomas Pinos Alejandro lucia Physical Activity and Health Research Group(“PaHerg”) Research Institute of Hospital“12 de Octubre”(“imas12”)Madrid 28041Spain Department of Systems Biology University of AlcalaMadrid 28871Spain Department of Sport and Computer Science Section of Physical Education and SportsFaculty of SportUniversidad Pablo de OlavideSevilla 41013Spain EVOPRED Research Group Universidad Europea de CanariasTenerife 38300Spain Faculty of Sport Sciences Universidad Europea de MadridMadrid 28670Spain Gait&Motion Analysis laboratory Sol et Salus HospitalTorre Pedrera di Rimini(RN)47922Italy Department of Clinical Biochemistry Laboratoris ClınicsHospital Universitari Vall d’HebronBarcelona 08035Spain Human Performance lab Schulthess ClinicZurich 8008Switzerland Biomedical Research Networking Center on Rare Disorders(CIBERER) Barcelona 08035Spain Mitochondrial and Neuromuscular Disorders Unit Vall d’Hebron Institut de RecercaUniversitat Autonoma de BarcelonaBarcelona 08035Spain

Background:This study aimed to determine the effect of different carbohydrate(CHO)doses on exercise capacity in patients with McArdle disease—the paradigm of“exercise intolerance”,characterized by complete muscle glycogen unavailability—and to determine whether higher exogenous glucose levels affect metabolic responses at the McArdle muscle cell(in vitro)***:Patients with McArdle disease(n=8)and healthy controls(n=9)underwent a 12-min submaximal cycling constant-load bout followed by a maximal ramp test 15 min after ingesting a non-caloric *** a randomized,double-blinded,cross-over design,patients repeated the tests after consuming either 75 g or 150 g of CHO(glucose:fructose=2:1).Cardiorespiratory,biochemical,perceptual,and electromyographic(EMG)variables were ***,glucose uptake and lactate appearance were studied in vitro in wild-type and McArdle mouse myotubes cultured with increasing glucose concentrations(0.35,1.00,4.50,and 10.00 g/l).Results:Compared with controls,patients showed the“classical”second-wind phenomenon(after prior disproportionate tachycardia,myalgia,and excess electromyographic activity during submaximal exercise,all platory threshold and55%peak power output,both pless of the CHO dose(placebo),CHO intake increased blood glucose and lactate levels,decreased fat oxidation rates,and attenuated the second wind in the ***,only the higher dose increased ventilatory threshold(+27%,p=0.010)and peak power output(+18%,p=0.007).In vitro analyses revealed no differences in lactate levels across glucose concentrations in wild-type myotubes,whereas a doseresponse effect was observed in McArdle ***:CHO intake exerts beneficial effects on exercise capacity in McArdle disease,a condition associated with total muscle glycogen *** of these benefits are dose dependent.

关键词： Endurance Glycogen storage disease Glycogenosis Nutrition Supplement

Cognitive function among military veterans with STEM occupations

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2024年第2期11卷 308-310页

作者： Justin T.McDaniel Kevin N.Hascup Erin R.Hascup Ugochukwu G.Ezigbo Amanda M.Weidhuner Harvey Henson david l.Albright Dale and Deborah Smith Center for Alzheimer's Research and trEatment(CARE) Southern Illinois University School of MedicineSpringfieldIL 62794USA STEM Education Research Center Southern Illinois UniversityCarbondaleIL 62901USA Department of Political Science The University of AlabamaTuscaloosaAL 35487USA

Dear Editor,There is limited research on the relationship between science,technology,engineering,and mathematics(STEM)occupational history and cognitive function in later life,especially among military veterans,who may be at greater risk for later-life cognitive *** study examines a nationally representative sample of military veterans to address this gap in knowledge.

关键词： Alzheimer's disease Veterans Science technology engineering and mathematics(STEM) Animal fluency test Dementia

Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第11期19卷 2532-2542页

作者： Aina Bellver-Sanchis Pedro AAvila-lópez Iva Tic david Valle-García Marta Ribalta-Vilella luis labrador Deb Ranjan Banerjee Ana Guerrero Gemma Casadesus Coralie Poulard Mercè Pallàs Christian Grinán-Ferré Department of Pharmacology and Therapeutic Chemistry Institut de Neurociències-Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Molecular Genetics Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Institute of Biotechnology National Autonomous University of MexicoCuernavacaMexico Department of Pharmacology and Therapeutics Health Science Center-University of FloridaGainesvilleFLUSA Department of Chemistry National Institute of Technology DurgapurM G AvenueDurgapurWest BengalIndia Cancer Research Cancer lyon Universitéde LyonLyonFrance Inserm U1052 Centre de Recherche en Cancérologie de LyonLyonFrance CNRS UMR5286 Centre de Recherche en Cancérlogie de LyonLyonFrance Centro de Investigación en Red Enfermedades Neurodegenerativas(CIBERNED)Instituto de Salud Carlos IIIMadridSpain Neuroimmunology Department National Institute of Neurology and Neurosurgery“Manuel Velasco Suárez”Mexico CityMexico

Dysregulation of G9a,a histone-lysine N-methyltransferase,has been observed in Alzheimer’s disease and has been correlated with increased levels of chronic inflammation and oxidative ***,microRNAs are involved in many biological processes and diseases playing a key role in pathogenesis,especially in multifactorial diseases such as Alzheimer’s ***,our aim has been to provide partial insights into the interconnection between G9a,microRNAs,oxidative stress,and *** better understand the biology of G9a,we compared the global microRNA expression between senescence-accelerated mouse-prone 8(SAMP8)control mice and SAMP8 treated with G9a inhibitor *** found a downregulation of miR-128 after a G9a inhibition treatment,which interestingly binds to the 3′untranslated region(3′-UTR)of peroxisome-proliferator activator receptor γ(PPARG)***,Pparg gene expression levels were higher in the SAMP8 group treated with G9a inhibitor than in the SAMP8 control *** also observed modulation of oxidative stress responses might be mainly driven Pparg after G9a *** confirm these antioxidant effects,we treated primary neuron cell cultures with hydrogen peroxide as an oxidative *** this setting,treatment with G9a inhibitor increases both cell survival and antioxidant ***,up-regulation of PPARγby G9a inhibitor could also increase the expression of genes involved in DNA damage responses and *** addition,we also described that the PPARγ/AMPK axis partially explains the regulation of autophagy markers ***,PPARγ/GADD45αpotentially contributes to enhancing synaptic plasticity and neurogenesis after G9a ***,we propose that pharmacological inhibition of G9a leads to a neuroprotective effect that could be due,at least in part,by the modulation of PPARγ-dependent pathways by miR-128.

关键词： aging cognitive decline epigenetics G9a inhibition microRNAs miR-128 peroxisome-proliferator activator receptorγ(PPARγ) PPARG SAMP8

在线全文

学校读者我要写书评

暂无评论

中国户籍登记系统漏登合成估计方法研究

系统科学与数学 2024年

作者：黄艳华 lópez-carr david 胡桂华重庆工商大学成渝地区双城经济圈建设研究院 University of California Santa Barbara Department of Geography 重庆工商大学数学与统计学院统计智能计算与监测重庆市重点实验室

中国户籍登记系统存在漏登人口问题,但政府部门尚未开展户籍漏登估计工作.联合国统计司建议各国采用的单重漏登估计量未覆盖全部漏登人口,低估漏登率.本文提出用合成漏登估计量替代单重漏登估计量,并通过案例研究,比较了合成漏登估计量... 详细信息

中国户籍登记系统存在漏登人口问题,但政府部门尚未开展户籍漏登估计工作.联合国统计司建议各国采用的单重漏登估计量未覆盖全部漏登人口,低估漏登率.本文提出用合成漏登估计量替代单重漏登估计量,并通过案例研究,比较了合成漏登估计量与单重漏登估计量.实证研究结果表明:四种合成漏登估计量估计的漏登率均高于单重漏登估计量;除其中一种合成漏登估计量估计的漏登率的抽样标准差略高于单重漏登估计量外,其他三种合成漏登估计量估计结果的抽样标准差均小于单重漏登估计量.研究结果为统计局和公安部未来制定户籍登记系统漏登估计方案提供重要参考,提高方案的科学性和可操作性.

关键词：抽样调查事后分层三系统估计量刀切法

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

人口统计分析模型与人口普查净误差估计

系统科学与数学 2024年

作者：余鲁李婷 david lópez-Carr 胡桂华吴笛漆莉重庆工商大学数学与统计学院 Department of Geography America University of California 重庆工商大学统计智能计算与监测重庆市重点实验室

本文旨在引入美国的人口统计分析模型,建立适合于在我国应用的人口统计分析模型.采取文献解读法和概率模型法,研究人口统计分析模型及其相关问题.研究结果表明:人口统计分析模型在我国的研究尚处于起步阶段,建立我国的人口统计分析模型... 详细信息

本文旨在引入美国的人口统计分析模型,建立适合于在我国应用的人口统计分析模型.采取文献解读法和概率模型法,研究人口统计分析模型及其相关问题.研究结果表明:人口统计分析模型在我国的研究尚处于起步阶段,建立我国的人口统计分析模型,不能照搬美国的人口统计分析模型,而应该结合我国实际情况有所改进与创新;建立人口统计分析模型分为两个层次,一是建立基于全面资料的人口统计分析模型,无需计算抽样方差,二是建立基于抽样调查资料的人口统计分析模型,需采用刀切法近似计算其抽样方差;人口统计分析模型的优势是,充分利用了出生、死亡及国际迁移等人口行政记录资料,节约了数据采集成本,与人口普查独立,劣势是,估计结果具有不确定性,尤其是其中的国际净迁移人数的估计结果差异较大.人口统计分析模型有望应用于我国2030年人口普查净误差估计,开创我国在该领域使用人口统计分析模型的先河.

关键词：人口普查人口普查质量评估行政记录抽样调查刀切法

Protective effects of cyclosporine and its analog NIM-811 in a murine model of hepatic ischemia-reperfusion injury

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

liver Research 2024年第1期8卷 46-53页

作者： Joshua Hefler Rena Pawlick Braulio A.Marfil-Garza Aducio Thiesen Nerea Cuesta-Gomez Sanaz Hatami Darren H.Freed Constantine Karvellas david l.Bigam A.M.James Shapiro Department of Surgery Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada Department of Medicine Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada CHRISTUS-latAm Hub Excellence&Innovation Center MonterreyMexico Alberta Diabetes Institute University of AlbertaEdmontonABCanada Clinical Islet Transplant Program University of AlbertaEdmontonABCanada Department of laboratory Medicine&Pathology Faculty of Medicine&DentistryUniversity of AlbertaEdmontonABCanada

Background and aim:The liver is susceptible to ischemia-reperfusion injury(IRI)during hepatic surgery,when the vessels are compressed to control bleeding,or liver transplantation,when there is an obligate period of *** hallmark of IRI comprises mitochondrial dysfunction,which generates reactive oxygen species,and cell death through necrosis or ***(CsA),which is a well-known immunosuppressive agent that inhibits calcineurin,has the additional effect of inhibiting the mito-chondrial permeability transition pore(mPTP),thereby,preventing mitochondrial swelling and ***-811,which is the nonimmunosuppressive analog of CsA,has a similar effect on the *** this study,we tested the effect of both agents on mitigating warm hepatic IRI in a murine *** and methods:Before ischemic insult,the mice were administered with intraperitoneal normal saline(control);CsA at 2.5,10,or 25 mg/kg;or NIM-811 at 10 mg/***,the mice were subjected to partial warm hepatic ischemia by selective pedicle clamping for 60 min,followed by 6 h of recovery after *** alanine transaminase(AlT)was measured,and the liver tissue was examined histologically for the presence of apoptosis and the levels of inflammatory ***:Compared with the control mice,the mice treated with 10 and 25 mg/kg of CsA and NIM-811 had significantly lower AlT levels(Ply).Moreover,the liver tissue showed reduced histological injury scores after treatment with CsA at 2.5,10,and 25 mg/kg and NIM-811(P=0.041,ly)and significant decrease in apoptosis after treatment with CsA at all doses(P=0.012,0.007,andly).levels of the pro-inflammatory cyto-kines,particularly interleukin(Il)-1β,Il-2,Il-4,Il-10,and keratinocyte chemoattractant/human growth-regulated oncogene significantly decreased in the mice treated with the highest dose of CsA(25 mg/kg)than those in the control ***

关键词： Cyclosporine(CsA) Cyclosporine analogue liver surgery Ischemia-reperfusion injury(IRI) Animal model NIM-811

Efficiency improvement by using metal–insulator‑semiconductor structure in InGaN/GaN micro‑light‑emitting diodes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Optoelectronics 2024年第1期17卷 77-84页

作者： Jian Yin david Hwang Hossein Zamani Siboni Ehsanollah Fathi Reza Chaji Dayan Ban Department of Electrical and Computer Engineering Waterloo Institute NanotechnologyUniversity of WaterlooWaterlooON N2L 3G1Canada Vuereal InC. 440 Philip StreetUnit 100WaterlooON N2L 5R9Canada

InGaN/GaN micro-light-emitting diodes(micro-lEDs)with a metal–insulator-semiconductor(MIS)structure on the sidewall are proposed to improve *** this MIS structure,a sidewall electrode is deposited on the insulating layer-coated sidewall of the device mesa between a cathode on the bottom and an anode on the ***(El)measurements of fabricated devices with a mesa diameter of 10μm show that the application of negative biases on the sidewall electrode can increase the device external quantum efficiency(EQE).In contrast,the application of positive biases can decrease the *** band structure analysis reveals that the EQE is impacted because the application of sidewall electric fields manipulates the local surface electron density along the mesa sidewall and thus controls surface Shockley–Read–Hall(SRH)*** suggested strategies,reducing insulator layer thickness and exploring alternative materials,can be implemented to further improve the EQE of MIS micro-lEDs in future fabrication.

关键词： Micro-lED GaN EQE improvement Micro-fabrication