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Past,present and future of cyanide antagonism research:From the early remedies to the current therapies

World Journal of Methodology 2015年第2期5卷 88-100页

作者： Ilona Petrikovics Marianna Budai Kristof Kovacs david E Thompson Department of Chemistry Sam Houston State University Department of Pharmaceutics Semmelweis University

This paper reviews milestones in antidotal therapies for cyanide(CN) spanning early remedies,current antidotal systems and research towards next generation *** has been a part of plant defense mechanisms for millions of *** became industrially important in the nineteenth century with the advent of CN assisted gold mining and the use of CN as a pest control *** biochemical basis of CN poisoning was actively studied and key mechanisms were understood as early as *** fundamental studies led to a variety of antidotes,including indirect CN binders that generate methemoglobin,direct CN binders such as hydroxocobalamin,and sulfur donors that convert CN to the less toxic *** on blood gases at the end of the twentieth century shed new light on the role of nitric oxide(NO) in the *** discovery of NO's ability to compete with CN for enzymatic binding sites provided a previously missed explanation for the rapid efficacy of NO generating antidotes such as the *** used CN therapies include:methemoglobin/NO generators(e.g.,sodium nitrite,amyl nitrite,and dimethyl aminophenol),sulfur donors(e.g.,sodium thiosulfate and glutathione),and direct binding agents [(e.g.,hydroxocobalamin and dicobalt salt of ethylenediaminetetraacetic acid(dicobalt edetate)].A strong effort is being made to explore novel antidotal systems and to formulate them for rapid administration at the point of intoxication in mass casualty *** antidotes,formulations,and delivery systems are enhancing bioavailability and efficacy and hold promise for a new generation of improved CN countermeasures.

关键词： Cyanide Hydrocyanic acid Antagonist Antidote Cobinamide Sulfanegen Sulfane sulfur donor

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Effect of Enriched Cattle Manure on Soil Nutrient Status, Nitrogen Uptake and Yield of Tea （Camellia sinensis）

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Journal of Agricultural Science and Technology(A) 2014年第2期4卷 123-128页

作者： Vivian Moroamoche Kekana Isaiah Tabu david Kamau Robert Obura Department of Crops Horticulture and Soils Egerton University Egerton 20115 Kenya Department of Chemistry Tea Research Foundation of Kenya Kericho 20200 Kenya

Inorganic fertilizer NPK （nitrogen, phosphorus and potassium）（S） 25：5：5：5 is generally recommended for optimum yield and quality of tea （Camellia sinensis）. Non-judicious use of this inorganic fertilizer however acidifies the soils and pollutes the environment. Integrated soil fertility management （ISFM） which involves the combined use of organic and inorganic fertilizer is recommended for improved crop yield and soil health. An experiment was carried out to determine the effect of enriching cattle manure with different ratios of inorganic fertilizers （OM： NPKS at ratios 1：2 and 1：4）, and rates on soil nutrient status, nitrogen uptake and yield of tea in the east of Rift Valley, Kenya. Enriching manures and organic manure up to a rate of 150 kg N/ha increased the level of P mature leaf. A higher N and K level in the mature leaf was observed when NPKS was applied at higher rates. In the soil, fertilizer rate up to 150 kg N/ha showed higher pH and K where organic manure and enriched manures were applied while NPKS treatment showed higher P content throughout the soil depths. Enriching organic manures with inorganic fertilizers increased yield significantly.

关键词： Cattle manure enrichment nitrogen tea (Camellia sinensis) yield inorganic fertilizer ISFM

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Abdominal obesity adversely affects bone mass in children

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World Journal of Clinical Pediatrics 2018年第1期7卷 43-48页

作者： Sowmya Krishnan Michael P Anderson david A Fields Madhusmita Misra Department of Pediatrics University of Oklahoma Health Sciences Center Harold Hamm Diabetes Center College of Public Health University of Oklahoma Health Science Center Massachusetts General Hospital for Children and Harvard Medical School

AIM To determine the effect of childhood obesity and insulin resistance on bone health. METHODS We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/obese or normal weight. Participants were Tanner 3 or above for pubertal stage, and had fasting blood work done to measure glucose, insulin, C-reactive protein and lipid levels. Homeostatic model of insulin resistance(HOMA-IR) was calculated using the formula(Fasting Blood Glucose *Insulin/405). Body composition and bone mineral density were measured using dual energy X-ray absorptiometry(DXA; Hologic QDR 4500, Waltham, MA, United Kingdom). RESULTS Percent trunk fat was associated inversely with whole body bone mineral content(BMC), whereas HOMA-IR was associated positively with whole body *** Our results suggest that abdominal adiposity may have an adverse effect on whole body bone parameters and that this effect is not mediated by insulin resistance.

关键词： Obesity Bone mineral density Insulin resistance

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Lattice Theory for Finite Dimensional Hilbert Space with Variables in Z<sub>d</sub>

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Journal of Quantum Information Science 2019年第2期9卷 111-121页

作者： Semiu Oladipupo Oladejo Adediran Dauda Adeshola Adedayo david Adeniyi Department of Mathematics Faculty of Science Gombe State University Gombe Nigeria Department of Statistical and Mathematical Science College of Pure and Applied Science Kwara State University Ilorin Nigeria

In this work, join and meet algebraic structure which exists in non-near-linear finite geometry are discussed. Lines in non-near-linear finite geometry ?were expressed as products of lines in near-linear finite geometry ?(where?p?is a prime). An existence of lattice between any pair of near-linear finite geometry ?of ?is confirmed. For q|d, a one-to-one correspondence between the set of subgeometry ?of ?and finite geometry ?from the subsets of the set {D(d)}?of divisors of d?(where each divisor represents a finite geometry) and set of subsystems {∏(q)}?(with variables in Zq) of a finite quantum system ∏(d)?with variables in Zd?and a finite system from the subsets of the set of divisors of d?is established.

关键词： Lattice Join Meet Least Upper Bound (LUB) Greatest Lower Bound (GLB) Partially Ordered Set (POSET)

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你期望医生能做什么？与患者接触的六个好习惯

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中国全科医学 2014年第1期17卷 7-8页

作者： david Loxterkamp 周文娇(翻译) Seaport家庭医学诊所美国缅因州贝尔法斯特市中国全科医学杂志社

期望是美国医疗保健危机的核心。在以消费者为中心的社会,医生们无法控制患者的不合理需求,但是我们可以思考我们想从医生那里获得什么。想让医生能认真倾听我们的诉说,让我们尽量多地表达自己?想让医生不仅仅关心某一疾病的病程和结局... 详细信息

期望是美国医疗保健危机的核心。在以消费者为中心的社会,医生们无法控制患者的不合理需求,但是我们可以思考我们想从医生那里获得什么。想让医生能认真倾听我们的诉说,让我们尽量多地表达自己?想让医生不仅仅关心某一疾病的病程和结局,还要关心患者本身的整体状况?其实,大部分患者并不追求完美,也不追求完全治愈。患者真正需要的是和医生建立关系进行沟通——这本身就可以减轻病痛。作者在文中列举了医生应该拥有的6个好习惯,以促进更健康、更良好的医患接触。

关键词：医患关系沟通患者满意度

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Applications of Pueraria lobata in treating diabetics and reducing alcohol drinking

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Chinese Herbal Medicines 2019年第2期11卷 141-149页

作者： Jing Liu Yeu-Ching Shi david Yue-Wei Lee Bio-Organic and Natural Products Research Laboratory Mailman Research Center McLean Hospital/Harvard Medical School Belmont MA 02478 USA Taiwan lndigena Botanica Taipei 10684 China

Pueraria lobata is one of the most important medicinal herbs used traditionally in China. According to Shanghan Lun(Treatise on Exogenous Febrile Disease), it has been used traditionally to relieve body heat,eye soring, dry mouth, headache associated with high blood pressure, and stiff neck problems. Modern studies in the 1970 s revealed that isoflavonoids extracted from P. lobata were the bioactive components of an herbal remedy namely Yufeng Ningxin Tablets for the treatment of patients after stroke. This article reviews recent application of P. lobota in the treatment of diabetics and in reducing alcohol drinking. In view of its low toxicity profile, P. lobota stands an excellent chance to be developed as a phytomedicine for treating human diseases.

关键词： diabetics Pueraria lobata(Willd) Ohwi reducing alcohol drinking

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Pollen morphology in Saxifraga(Saxifragaceae) from Ny-Alesund, Svalbard, Arctic, and its taxonomic significance

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Advances in Polar Science 2014年第2期25卷 105-112页

作者： YAO Yifeng Bera Subir Ferguson david Kay LI Chengsen State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Department of Botany University of Calcutta Department of Paleontology University of Vienna

Pollen morphology of eight species of Saxifraga, i.e.S, cespitosa, S. oppositifolia, S. cernua, S. nivalis, S. aizoides, S. rivularis, S. hieraciifolia, and S. hirculus, collected from Ny-Alesund, Svalbard, Arctic was examined using light and scanning electron microscopy. Pollen grains of Saxifraga species are subprolate or prolate, 3-colpate, 15.4-44.4 μm in the polar axis, 11.4 34.6 μm in the equatorial axis, and show a P/E ratio 1.19-1.40. On the basis of exine ornamentation, four pollen types, viz., the S. oppositifolia type （striate without scabrae on the muff）, S. cernua type （striate with scabrae on the muri）, S. nivalis type （microreticulate and operculum absent）, and S. cespitosa type （microechinate and operculum present）, were recognized. Hierarchical cluster analysis of the pollen morphological characters indicated that pollen morphology supports the infrageneric classification of the genus Saxifraga.

关键词： Arctic Ny-Alesund pollen morphology Saxifraga Svalbard

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Bioinformatics:sequence and genome analysis 2nd ed.

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丛书名：国外生命科学优秀教材

2006年

作者： david W. Mount[] 曹志伟编

当前生物信息学研究重点是对基因组序列、蛋白质组学和数组技术所产生的大量数据的计算分析。本书对DNA、RNA和蛋白质数据的计算提供了丰富的演算方法，并指出了在解决生物学问题中这些方法的优缺点及应用策略。　　本书的第一版是在Mo... 详细信息

ISBN: (纸本)9787030176400

当前生物信息学研究重点是对基因组序列、蛋白质组学和数组技术所产生的大量数据的计算分析。本书对DNA、RNA和蛋白质数据的计算提供了丰富的演算方法，并指出了在解决生物学问题中这些方法的优缺点及应用策略。　　本书的第一版是在Mount博士讲稿的基础上进行整理出版的，在全球范围内用作教材。第二版对内容进行了全面的修订，由专业教师提供导读，最大程度地适用本科生和研究生教学。　　本书为高等院校生物信息学专业本科生和研究生提供理想的学习材料。同时，本书也适宜科研人员、信息专家自学使用。

关键词： Genetics

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Urbanization and Flood Risk： Implication for Coping in Coastal Zones of Nigeria

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Sociology Study 2013年第11期3卷 889-896页

作者： Agnes Philip-Ogoh david Babatunde Akinola Regina Umana Udontia FCT College of Education Zuba-Abuja Nigeria University of Abuja Nigeria Local Education Authority Abuja Nigeria

This study looked at rapid urbanization and the flood risk it portends with a view to identifying mechanisms for coping in coastal zones of Nigeria. Flooding is one of the various ecological problems that has taken its toll on the quality of the environment, human health, and economic growth in parts of Africa and the coastal zones of Nigeria in particular. Rapid urbanization has been seen to result in changes in land use patterns which can adversely affect the hydrological processes in a catchment leading to a deteriorating water environment. warning systems are identified and discussed in the paper Structural and non-structural approach as well as flood early as flood risks coping mechanisms, It also discusses the policy implications that government through its relevant agencies must be up to its game by monitoring precursors, forecasting of probable floods and notification of alerts, It concludes and recommends that an active involvement of communities at risks is required and public education and awareness of risks should be facilitated through effective dissemination, as well as ensuring that there is a constant preparedness,

关键词： Urbanization flooding flood risk coastal zones coping

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网页制作宝典 G

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丛书名：美国计算机“宝典”丛书

2002年

作者：（美）david Crowder （美）Rhonda Crowder 闫隽等译

本书全面介绍进行Web站点设计和页面制作所应具备的各项知识。本书从创建一个Flash Web站点的具体例子开始，介绍了如何利用最新的Web技术迅速、方便地建立起出色的Web站点。

ISBN: (数字)7505372912

ISBN: (纸本)7505372912

关键词：制作网页软件工具

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