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j.urnal of Earth Science 2016年第1期27卷 9-14页

作者： Yang Yang Theodore A. Endreny david j. nowak USDA Forest Service Northern Research Station & the Davey Institute Syracuse NY 13210 USA Environmental Resource Engineering SUNY ESF Syracuse NY 132 10 USA USDA Forest Service Northern Research Station Syracuse NY 13210 USA

Flood wave propagation modeling is of critical importance to advancing water resources management and protecting human life and property. In this study, we investigated how the advection-diffusion routing model performed in flood wave propagation on a 16 km long downstream section of the Big Piney River, MO. Model performance was based on gaging station data at the upstream and downstream cross sections. We demonstrated with advection-diffusion theory that for small differences in watershed drainage area between the two river cross sections, inflow along the reach mainly contributes to the downstream hydrograph＇s rising limb and not to the falling limb. The downstream hydrograph＇s falling limb is primarily determined by the propagated flood wave originating at the upstream cross section. This research suggests the parameter for the advectiondiffusion routing model can be calibrated by fitting the hydrograph falling limb. Application of the advection diffusion model to the flood wave of j.nuary 29, 2013 supports our theoretical finding that the propagated flood wave determines the downstream cross section falling limb, and the model has good performance in our test examples.

关键词： advection-diffusion equation hydrograph flood wave propagation recession limb.

Fluid dynamic and thermal comfort analysis in an actual operating room with unidirectional airflow system

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Building Simulation 2021年第4期14卷 1127-1146页

作者： Nicola Massarotti Alessandro Mauro Salahudeen Mohamed Andrzej.j.nowak Domenico Sainas Dipartimento di Ingegneria Universitàdegli Studi di Napoli“Parthenope”Centro DirezionaleIsola C480143NapoliItaly Institute of Thermal Technology Silesian University of TechnologyKonarskiego 2244-100GliwicePoland

Air velocity and temperature distributions inside operating rooms (ORs) play a crucial role to reduce the risk of infections and to ensure adequate comfort conditions for patient and medical staff. In this work, the authors have developed a three-dimensional thermo-fluid dynamic model to simulate airflow and thermal comfort in an actual OR equipped with High-Efficiency Particulate Air (HEPA) filters. The model takes into account the presence of surgical lights, people and equipment within the room. An experimental campaign is carried out inside the actual OR to measure velocity and temperature, to be employed as boundary conditions for the numerical model. The experimental data have also been used to validate the numerical results. The validated model has been used to analyze the effects of human shape, thermal boundary conditions and buoyancy forces on the main thermal and fluid dynamic quantities in the OR. The thermal comfort is evaluated based on Predicted Mean Vote (PMV) and Predicted Percentage of Dissatisfied (PPD) indices. The results prove that the present experimental-numerical approach is useful to analyze and improve the thermal comfort conditions for medical staff and patient.

关键词： heat and mass transfer thermal comfort operating room LAF system human body validation

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芍药切花冷藏技术的研究

园艺学报 1990年第2期17卷 149-152页

作者： j.nowak 陈秀华果树花卉研究所中国农科院蔬菜花卉研究所

本文观察研究了STS预处理和保鲜液对干贮2-4个月后芍药切花开花率、花朵直径、品质及瓶插寿命的影响。结果:1、保鲜液对改善开花率、花朵直径、品质及瓶插寿命约有明显效果; 2、 STS预处理有保持开花率、改善花朵直径及品质的效果,但未... 详细信息

本文观察研究了STS预处理和保鲜液对干贮2-4个月后芍药切花开花率、花朵直径、品质及瓶插寿命的影响。结果:1、保鲜液对改善开花率、花朵直径、品质及瓶插寿命约有明显效果; 2、 STS预处理有保持开花率、改善花朵直径及品质的效果,但未能延长瓶插寿命;3、经STS预处理再插在保鲜液中开放的切花最好,冷藏3个月后,其开花率、花朵直径、品质及瓶插寿命仍与插在保鲜液中的未贮花相近。

关键词：芍药 STS预处理保鲜液瓶插寿命

运输应激猪骨骼肌中热应激蛋白HSP_(70)和HSP_(90)家族的表达

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南京农业大学学报 2001年第1期24卷 81-84页

作者：鲍恩东 K R Sultan B nowak j.Hartung 南京农业大学动物医学院南京210095 DeptoftheScienceofFoodofAnimalOrigin FacultyofVeterinaryMedicineUniversityofUtrechtTheNetherlands DeptofFood MeatHygieneandTechnology InstituteofAnimalHygieneandAnimalWelfare HannoverSchoolofVeterinaryMedicineHannoverGermany

利用Westernblot技术 ,检测长途运输试验猪骨骼肌 (背最长肌和臀大肌 )中分属于HSP70 家族和HSP90 家族的 4种应激蛋白 (HSP70 ,HSP72 ,HSP86和HSP90 )的表达。所有运输应激猪和对照猪肌肉组织中均检测到了上述 4种HSP。对照猪组织中HS... 详细信息

利用Westernblot技术 ,检测长途运输试验猪骨骼肌 (背最长肌和臀大肌 )中分属于HSP70 家族和HSP90 家族的 4种应激蛋白 (HSP70 ,HSP72 ,HSP86和HSP90 )的表达。所有运输应激猪和对照猪肌肉组织中均检测到了上述 4种HSP。对照猪组织中HSP的表达说明HSP除了在受应激的细胞内行使生理功能外 ,还具有独立于应激刺激应答以外的其它作用。6h的长途运输后 ,HSP的表达量明显不同 ,HSP70 和HSP72 在肌肉组织中的表达虽然有一定的增加 ,但统计学分析差异不显著 (P >0 0 5 ) ;而HSP86和HSP90 在骨骼肌中的表达明显下降 ,尤以HSP90 下降最为显著 (P <0 0 1)。提示HSP90 家族成员与肉品品质相关。

关键词：猪运输应激骨骼肌热应激蛋白 HSP70 HSP90家族肉品品质

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运输应激猪肝脏中热应激蛋白的定位与表达

中国农业科学 2002年第9期35卷 1130-1133+1169页

作者：鲍恩东 Sultan K R nowak B Hartung j Department of Food Department of the Science Food of Animal Origin Faculty of Veterinary Medicine Germany Hannover School of Veterinary Medicine Institut Meat Hygiene and Technology University of Utrecht the Netherlands 南京农业大学动物医学院

利用免疫组织化学定位方法和Westernblot技术 ,对长途运输试验猪肝脏中 5种不同分子量的热应激蛋白HSP70 、HSP72 、HSP86、HSP90 和HSP2 7进行定位和表达。所有长途运输后应激猪和对照猪肝脏组织中均同时检测到了上述 5种HSP。肝细胞... 详细信息

利用免疫组织化学定位方法和Westernblot技术 ,对长途运输试验猪肝脏中 5种不同分子量的热应激蛋白HSP70 、HSP72 、HSP86、HSP90 和HSP2 7进行定位和表达。所有长途运输后应激猪和对照猪肝脏组织中均同时检测到了上述 5种HSP。肝细胞胞浆和胞核均显示阳性信号 ,但HSPs在肝细胞中的定位有差异 ,大多数HSP70 、HSP72 和HSP2 7主要分布于肝细胞胞浆内 ,而HSP90 和HSP86阳性颗粒在核内的分布比其在胞浆中的分布更为明显。肝小叶周边区有明显颗粒变性和脂肪变性的肝细胞中HSPs的阳性染色信号较弱。 6h的长途运输应激后 ,与对照组相比 ,HSPs在肝脏组织中的表达量存在差异 ,表现为HSP70 家族的HSP70 和HSP72 的表达没有明显的升高 (P >0 .0 5 ) ,HSP90 家族的HSP90 的表达出现极显著的增加 (P <0 .0 1) ,然而 ,HSP90 家族的HSP86和小分子量家族的HSP2 7的表达量呈现明显的下降 (P <0 .0 5 )。

关键词：猪运输应激应激蛋白肝脏

Corticospinal excitability and hand motor recovery after stroke

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中华物理医学与康复杂志 2018年第8期40卷 633-633页

作者： Veldema j.B?sl K nowak DA

BACKGROUND AND OBj.CTIVE Approximately half of stroke victims retain permanent motor deficits, despite rehabilitation. This study compared the changes in cortical excitability to motor recovery of a hand affected by a *** Subj.cts were patients with ischemic lesions in the middle cerebral artery territory, with no contraindication for transcranial

关键词：中风患者运动障碍临床分析

Docosahexaenoic acid suppresses arachidonic acid-induced proliferation of LS-174T human colon carcinoma cells

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World j.urnal of Gastroenterology 2009年第9期15卷 1079-1084页

作者： Piet Habbel Karsten H Weylandt Katj. Lichopoj.j.hannes nowak Martin Purschke j.ng-Dong Wang Cheng-Wei He Daniel C Baumgart j.ng X Kang Department of Medicine Massachusetts General Hospital and Harvard Medical School Boston MA 02114 United States Department of Medicine Division of Gastroenterology and Hepatology Charité Medical Center-Virchow-Hospital Medical School of the Humboldt-University of Berlin 13344 Berlin Germany

AIM： To investigate the impact of arachidonic acid （AA） and docosahexaenoic acid （DHA） and their combination on colon cancer cell growth. METHODS： The LS-174T colon cancer cell line was used to study the role of the prostaglandin precursor AA and the omega-3 polyunsaturated fatty acid DHA on cell growth. Cell viability was assessed in XTT assays. For analysis of cell cycle and cell death, flow cytometry and DAPI staining were applied. Expression of cyclooxygenase-2 （COX-2）, p21 and bcl-2 in ceils incubated with AA or DHA was examined by real-time RT-PCR. Prostaglandin E2 （PGE2） generation in the presence of AA and DHA was measured using a PGE2- ELISA. RESULTS： AA increased cell growth, whereas DHA reduced viability of LS 174T cells in a time- and dosedependent manner. Furthermore, DHA down- regulated mRNA of bcl-2 and up-regulated p21. Interestingly, DHA was able to suppress AA-induced cell proliferation and significantly lowered AA-derived PGE2 formation. DHA also down-regulated COX-2 expression. In addition to the effect on PGE2 formation, DHA directly reduced PGE2-induced cell proliferation in a dosedependent manner. CONCLUSION： These results suggest that DHA can inhibit the pro-proliferative effect of abundant AA or PGE2.

关键词： Colorectal carcinoma Colon cancer Omega-3 Omega-6 Polyunsaturated fatty acids Arachidonic acid Docosahexaenoic acid ProstaglandinE2 Cyclooxygenase-2 Apoptosis

Functional recovery after peripheral nerve inj.ry via sustained growth factor delivery from mineral-coated microparticles

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Neural Regeneration Research 2021年第5期16卷 871-877页

作者： Daniel j.Hellenbrand Clayton L.Haldeman j.e-Sung Lee Angela G.Gableman Elena K.Dai Stephen D.Ortmann j.rrod CGotchy Kierra K.Miller Adrianna M.Doucas Nicole C.nowak William L.Murphy Amgad S.Hanna Department of Neurological Surgery University of WisconsinMadisonWIUSA Department of Biomedical Engineering University of WisconsinMadisonWIUSA Department of Orthopedics and Rehabilitation University of Wisconsin Madison WIUSA

The gold standard for treating peripheral nerve inj.ries that have large nerve gaps where the nerves cannot be directly sutured back together because it creates tension on the nerve,is to incorporate an autologous nerve ***,even with the incorporation of a nerve graft,generally patients only regain a small portion of function in limbs affected by the ***,there has been some promising results using growth factors to induce more axon growth through the nerve graft,many of these previous therapies are limited in their ability to release growth factors in a sustained manner and tailor them to a desired time *** ideal drug delivery platform would deliver growth factors at therapeutic levels for enough time to grow axons the entire length of the nerve *** hypothesized that mineral coated microparticles(MCMs)would bind,stabilize and release biologically active glial cell-derived neurotrophic factor(GDNF)and nerve growth factor(NGF)in a sustained ***,the obj.ctive of this study was to test the ability of MCMs releasing growth factors at the distal end of a 10 mm sciatic nerve graft,to induce axon growth through the nerve graft and restore hind limb *** sciatic nerve grafting in Lewis rats,the hind limb function was tested weekly by measuring the angle of the ankle at toe lift-off while walking down a *** weeks after grafting,the grafts were harvested and myelinated axons were analyzed proximal to the graft,in the center of the graft,and distal to the *** physiological conditions in vitro,the MCMs delivered a burst release of NGF and GDNF for 3 days followed by a sustained release for at least 22 *** vivo,MCMs releasing NGF and GDNF at the distal end of sciatic nerve grafts resulted in significantly more myelinated axons extending distal to the graft when compared to rats that received nerve grafts without growth factor *** rats with nerve grafts incorporated with MCMs releasing NGF and G

关键词： autografts axon growth drug delivery glial cell-derived neurotrophic factor growth factors mineral coatings nerve grafting nerve growth factor

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热应激蛋白在运输应激的猪肾脏中的表达

农业生物技术学报 2001年第3期9卷 230-232页

作者：鲍恩东,Karim R.Sultan,B.nowak,j.Hartung 南京农业大学动物医学院 Department of the Science of Food of Animal Origin Faculty of　Veterinary Medicine University of Utrecht Department of Food Meat Hygiene and Technology Hannover School of　Veterinary Medicine Institute of Animal Hygiene and Animal W

利用Ｗｅｓｔｅｒｎ　ｂｌｏｔ技术，研究了长途运输实验猪肾脏中５种不同分子量的热应激蛋白ＨＳＰ７０　、ＨＳＰ７２、ＨＳＰ８６、ＨＳＰ９０和ＨＳＰ２７的表达。所有长途运输后应激猪和对照猪肾脏组织中均检测到了上述５种ＨＳＰ... 详细信息

利用Ｗｅｓｔｅｒｎ　ｂｌｏｔ技术，研究了长途运输实验猪肾脏中５种不同分子量的热应激蛋白ＨＳＰ７０　、ＨＳＰ７２、ＨＳＰ８６、ＨＳＰ９０和ＨＳＰ２７的表达。所有长途运输后应激猪和对照猪肾脏组织中均检测到了上述５种ＨＳＰ，对照猪肾脏组织中ＨＳＰ的表达说明ＨＳＰ具有独立于应激刺激应答以外的在细胞内行使正常生理功能的作用；６　ｈ的长途运输应激后，ＨＳＰ在肾脏组织中的表达量发生明显改变，但不同家族的ＨＳＰ的表达量显著不同，表现为ＨＳＰ７０家族的ＨＳＰ７０（Ｐ＜０．０１）、ＨＳＰ７２（Ｐ＞０．０５）和ＨＳＰ９０家族的ＨＳＰ８６（Ｐ＞０．０５）、ＨＳＰ９０（Ｐ＜０．０１）的表达明显下降，提示肾脏组织在长途运输中病理损伤的可能性。实验结果也显示ＨＳＰ２７的表达量略有升高（Ｐ＜０．０５），说明在应激反应中不同家族的ＨＳＰ可能有不同的生理作用。

关键词：猪运输应激应激蛋白肾脏

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合肥城市森林减少大气污染的效果

中国城市林业 2003年第1期1卷 39-43页

作者：吴泽民 j.eR.McBride david j.nowak 杨军 Sheauchi Cheng 安徽农业大学森林利用学院 230036 美国加州大学伯克莱分校环境科学、政策、管理系美国农业部林务局东北实验站美国农业部林务局太平洋西南实验站

树木主要通过气孔吸收气态污染物,同时通过滞留空气中的微粒而减轻污染,树木较高的覆盖率可能会减少挥发性有机物的释放量,定量研究表明,合肥市1998年吸收空气污染物约为151.5t,树木7月份(着叶季节)吸收污染量高达20t,具有相对较低臭氧... 详细信息

树木主要通过气孔吸收气态污染物,同时通过滞留空气中的微粒而减轻污染,树木较高的覆盖率可能会减少挥发性有机物的释放量,定量研究表明,合肥市1998年吸收空气污染物约为151.5t,树木7月份(着叶季节)吸收污染量高达20t,具有相对较低臭氧生成潜力的植物有香樟属、女贞属、紫薇属、罗汉松属和李属。合肥城市森林总体的臭氧指标得分值为92.4。

关键词：合肥市城市森林大气污染环境保护空气质量臭氧生成速率生态效益