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A re-evaluation of the average chain length of lacustrine sedimentary n-alkanes as a paleoproxy on the Qinghai-Tibet Plateau

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Frontiers of Earth Science 2023年第4期17卷 905-919页

作者： Mingda WANG Qin LI Jaime TONEY david henderson Juzhi HOU School of Geography Liaoning Normal UniversityDalian 116029China Alpine Paleoecology and Human Adaptation(ALPHA)Group State Key Laboratory of Tibetan Plateau Earth SystemResources and EnvironmentInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China School of Geographical and Earth Sciences University of GlasgowGlasgow G128QQScotlandUK CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China

Long-chain n-alkanes are one of the most common organic compounds in terrestrial plants and they are well-preserved in various geological archives.n-alkanes are relatively resistant to degradation and thus they can provide high-fidelity records of past vegetation and climate ***,previous studies have shown that the interpretation of n-alkane proxies,such as the average chain length(ACL),is often ambiguous since this proxy depends on more than one *** vegetation and climate could exert controls on the n-alkane ACL,and hence its interpretation requires careful consideration,especially in regions like the Qinghai-Tibet Plateau(QTP)where topography,biome type and moisture source are highly *** further evaluate the influences of vegetation and climate on the ACL in high-elevation lakes,we examined the n-alkane distributions of the surface sediments of 55 lakes across the *** results show that the ACL across a climatic gradient is significantly affected by precipitation,rather than by *** positive correlation between ACL and precipitation may be because of the effect of microbial degradation during ***,we suggest that more caution is needed in the interpretation of ACL data in different regions.

关键词： ACL average chain length n-alkanes leaf wax lake sediments Qinghai-Tibet Plateau

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Metabolomics in Schizophrenia and Major Depressive Disorder

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Frontiers in Biology 2016年第3期11卷 222-231页

作者： Ira Petrovchich Alexandra Sosinsky Amsh Konde Abigail Archibald david henderson Mirjana Maletic-Savatic Snezana Milanovic Massachusetts General Hospital Department of Psychiatry MGH Clinical Trials Network Institute MGH Division of Global Psychiatry MGH Depression Clinical and Research Program Boston MA 02114 USA School of Nursing University of California San Francisco (UCSF) San Francisco CA 94143 USA Massachusetts General Hospital Department of Psychiatry MGH Center for Women's Mental Health Boston MA 02114 USA Louisiana State University Health Science Center Department of Internal-Medicine Lafayette LA 70112 USA Massachusetts General Hospital Department of Psychiatry MGH Depression Clinical and Research Program Boston MA 02114 USA Boston Medical Center Department of Psychiatry Boston MA 02118 USA Baylor College of Medicine Neurology Research Institute Houston TX77030 USA

Defining pathophenotype, a systems level consequence of a disease genotype, together with environmental and stochastic influences, is an arduous task in psychiatry. It is also an appealing goal, given growing need for appreciation of brain disorders biological complexity, aspiration for diagnostic tests development and ambition to identify novel drug targets. Here, we focus on the Schizophrenia and Major Depressive Disorder and highlight recent advances in metabolomics research. As a systems biologytool, metabolomics holds a promise to take part in elucidating interactions between genes and environment, in complex behavioral traits and psychopathology risk translational research.

关键词： Schizophrenia Major Depressive Disorder omics metabolomics systems biology

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The Link Between Internet Financial Reporting and Information Asymmetry for American Depository Receipts

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Journal of Modern Accounting and Auditing 2011年第9期7卷 947-965页

作者： Jocelyn Evans david henderson Brad Trinkle College of Charleston USA University of Mary Washington USA

We provide evidence on the effect of the presentation format and information content of Internet financial reporting on the market value of American Depository Receipts and on country-specific variables that drive Internet financial reporting. A two-stage Heckman approach was used to determine if Internet financial reporting adds incremental value to firms beyond the decision to cross-list in the United States. The results indicate that investors more highly value firms that provide information in multiple formats. We also find that country-specific variables affect the information content, but not the presentation format of disclosures on corporate websites. The results uncover a disconnection between what the market values （presentation format） and what the firms believe the market values （information content）. This implies that firms are not entirely aware of investors＇ information wants and that they are not utilizing their resources in the manner that will have the most impact on their market value.

关键词： intemet financial reporting web-based disclosure American depository receipt web-based financial reporting international transparency cross-list information content emerging markets

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雅思口语高分21天修炼手册

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作者： (英)安大卫(Angus henderson david Cargill)，王丽娟

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用于微型车的头颈约束系统的设计(英文)

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汽车安全与节能学报 2016年第3期7卷 254-264页

作者：杨刚周青清华大学汽车安全与节能国家重点实验室北京100084

微型车在城市通勤中有多种优势,近年来在欧洲、日本和中国的使用不断在增加。另一方面,由于尺寸小,微型车的碰撞保护面临很大的挑战。本文开发了一种适用于普通汽车环境的新型头颈部约束系统,旨在碰撞中实现类似赛车系统对头颈部运动的... 详细信息

微型车在城市通勤中有多种优势,近年来在欧洲、日本和中国的使用不断在增加。另一方面,由于尺寸小,微型车的碰撞保护面临很大的挑战。本文开发了一种适用于普通汽车环境的新型头颈部约束系统,旨在碰撞中实现类似赛车系统对头颈部运动的约束。给出了此头颈部约束系统的设计概念和碰撞保护原理,建立了相应的刚体模型;根据在侧碰过程中该头颈保护系统快速展开到位的要求,进行了能量分析。结果表明:当气囊以约4倍于前碰气囊的充气速度展开时,驱动支撑于车顶的头颈保护系统,可在15 ms以内到位。该新型头颈约束系统还需要进一步设计和验证,才能应用。

关键词：汽车安全微型车头部约束配置时间侧面碰撞

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笔记本电脑Modem评测报告

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互联网周刊 2000年第7期 40-41页

作者： david Jenkins Warren L henderson 测试工程师 Jr报告撰稿人

本次测试工作由henderson通讯实验室(henderson COMMUNICA-TIONS LABORATORlES,HCL)完成。测试时使用的设备能够生成所有在美国大陆地区的PSTN网络(公共交换式电话网络)中常见的各类线路损伤。测试中考察到的每一种线路损伤都对应着一个... 详细信息

本次测试工作由henderson通讯实验室(henderson COMMUNICA-TIONS LABORATORlES,HCL)完成。测试时使用的设备能够生成所有在美国大陆地区的PSTN网络(公共交换式电话网络)中常见的各类线路损伤。测试中考察到的每一种线路损伤都对应着一个LOO值(可能出现机率)。该值代表着在任意一次给定的modem呼叫过程中发生此类线路损伤的机率。为了准确地模拟出PSTN网络中的真实情况,针对每一种参评modem都需要对160种线路损伤逐项进行考察。测试结果将依照所得连接速度从快到慢的顺序列出,并根据其LOO值的不同进行加权和图表化。本次评测使用3种著名的远程接入服务器来对每一种调制解调器进行测试,它们分别是——3Com公司的Total Control RAS、Ascend公司的Max 2000 RAS以及Lucent公司的PortMaster 3 RAS。这三种远程接入服务器准确地代表了现实世界中这些调制解调器的一般使用条件。

关键词：笔记本电脑 Modem 测试方法测试标准

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日抛硅水凝胶隐形眼镜的表现

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中国眼镜科技杂志 2017年第9期 66-67页

作者： david Ruston Kurt Moody Terri henderson

近几年隐形眼镜从水凝胶软镜向硅水凝胶软镜的转变速度相当快，目前全球市场大约半数以上的隐形眼镜处方为硅水凝胶镜片。过去10年，日抛隐形眼镜的使用持续快速增长，尤其是在英国市场，目前大约半数的隐形眼镜新客户和超过1／3的老客... 详细信息

近几年隐形眼镜从水凝胶软镜向硅水凝胶软镜的转变速度相当快，目前全球市场大约半数以上的隐形眼镜处方为硅水凝胶镜片。过去10年，日抛隐形眼镜的使用持续快速增长，尤其是在英国市场，目前大约半数的隐形眼镜新客户和超过1／3的老客户选择日抛镜片。

关键词：隐形眼镜水凝胶硅全球市场镜片客户

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Inverse relationship of interleukin-6 and mast cells in children with inflammatory and non-inflammatory abdominal pain phenotypes

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World Journal of Gastrointestinal Pathophysiology 2012年第6期3卷 102-108页

作者： Wendy A henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero david E Kleiner Kevin H Kim Nader N Youssef Department of Health and Human Services Intramural Research Program National Institutes of Health Bethesda MD 20892 United States Department of Health and Human Services Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda MD 20892 United States School of Psychology in Education University of Pittsburgh Pittsburgh PA 15260 United States Digestive Healthcare Center Hillsborough NJ 08844 United States

AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation.

关键词： Histopathology Colon Interleukin-6 Mast cells Substance P

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Global land mapping of satellite-observed CO_(2)total columns using spatio-temporal geostatistics

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International Journal of Digital Earth 2017年第4期10卷 426-456页

作者： Zhao-Cheng Zeng Liping Lei Kimberly Strong Dylan B.A.Jones Lijie Guo Min Liu Feng Deng Nicholas M.Deutscher Manvendra K.Dubey david W.T.Griffith Frank Hase Bradley henderson Rigel Kivi Rodica Lindenmaier Isamu Morino Hirofumi Ohyama Christof Petri Ralf Sussmann Voltaire A.Velazco Paul O.Wennberg Hui Lin Institute of Space and Earth Information Science The Chinese University of Hong KongHong KongPeople’s Republic of China Key Laboratory of Digital Earth Science Institute of Remote Sensing and Digital EarthChinese Academy of SciencesBeijingPeople’s Republic of China Department of Physics University of TorontoTorontoOntarioCanada Institute of Environmental Physics(IUP) University of BremenBremenGermany School of Chemistry University of WollongongWollongongAustralia Los Alamos National Laboratory Los AlamosNMUSA Karlsruhe Institute of Technology Institute for Meteorology and Climate Research(IMK-ASF)Germany FMI Arctic Research Center SodankyläFinland National Institute for Environmental Studies(NIES) TsukubaIbarakiJapan Earth Observation Research Center Japan Aerospace Exploration Agency(JAXA)Tsukuba-cityIbarakiJapan Karlsruhe Institute of Technology IMK-IFUGarmisch-PartenkirchenGermany California Institute of Technology PasadenaCAUSA Department of Geography and Resource Management The Chinese University of Hong KongHong KongPeople’s Republic of China PNNL RichmondWA 99352USA. The Solar-Terrestrial Environment Laboratory Nagoya UniversityJapan

This study presents an approach for generating a global land mapping dataset of the satellite measurements of CO_(2)total column(XCO_(2))using spatio-temporal geostatistics,which makes full use of the joint spatial and temporal dependencies between *** mapping approach considers the latitude-zonal seasonal cycles and spatio-temporal correlation structure of XCO_(2),and obtains global land maps of XCO_(2),with a spatial grid resolution of 1°latitude by 1°longitude and temporal resolution of 3 *** evaluate the accuracy and uncertainty of the mapping dataset in the following three ways:(1)in cross-validation,the mapping approach results in a high correlation coefficient of 0.94 between the predictions and observations,(2)in comparison with ground truth provided by the Total Carbon Column Observing Network(TCCON),the predicted XCO_(2)time series and those from TCCON sites are in good agreement,with an overall bias of 0.01 ppm and a standard deviation of the difference of 1.22 ppm and(3)in comparison with model simulations,the spatio-temporal variability of XCO_(2)between the mapping dataset and simulations from the CT2013 and GEOS-Chem are generally *** generated mapping XCO_(2)data in this study provides a new global geospatial dataset in global understanding of greenhouse gases dynamics and global warming.

关键词： XCO_(2) ACOS-GOSAT Spatio-temporal geostatistics global mapping geospatial dataset

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为规范处方行为开个处方——一些医学生并不具备熟练开处方的能力

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英国医学杂志中文版 2007年第1期10卷 5-6页

作者： Jeffrey K Aronson Graeme henderson david J Webb Michael D Rawlins 肖月（译） British Pharmacological Society London EC1V 2SC Chairman of the committee of heads and professors of clinical pharmacology Wolfson Unit of Clinical Pharmacology University of NewcastleNewcastle upon Tyne NE2 4HH 不详

每年的这个时候，新分配来的医生上岗了，老的担心又出现了——他们受过良好的培训了吗？特别令人担忧的是：他们在临床药物治疗和开处方方面是否受过合格的培训？我们认为培训未必合格。

关键词：处方行为医学生能力药物治疗新分配培训

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