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cancer Biology & Medicine 2016年第4期13卷 426-442页

作者： david Li david c.Madoff Department of Radiology Division of Interventional Radiology New York-Presbyterian Hospital Weill Cornell Medical Center

The ability to modulate the future liver remnant(FLR) is a key component of modern oncologic hepatobiliary surgery practice and has extended surgical candidacy for patients who may have been previously thought unable to survive liver resection. Multiple techniques have been developed to augment the FLR including portal vein embolization(PVE), associating liver partition and portal vein ligation(ALPPS), and the recently reported transhepatic liver venous deprivation(LVD). PVE is a well-established means to improve the safety of liver resection by redirecting blood flow to the FLR in an effort to selectively hypertrophy and ultimately improve functional reserve of the FLR. This article discusses the current practice of PVE with focus on summarizing the large number of published reports from which outcomes based practices have been developed. Both technical aspects of PVE including volumetry, approaches, and embolization agents; and clinical aspects of PVE including data supporting indications, and its role in conjunction with chemotherapy and transarterial embolization will be highlighted. PVE remains an important aspect of oncologic care; in large part due to the substantial foundation of information available demonstrating its clear clinical benefit for hepatic resection candidates with small anticipated FLRs.

关键词： Portal vein embolization future liver remnant hypertrophy liver regeneration liver cancer hepatocellular carcinoma liver metastases

Targeted principle component analysis:A new motion artifact correction approach for near-infrared spectroscopy

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 98-105页

作者： Meryen A.Yücel Julitte Selb Robert J.c.ooper david A.Boas Athinoula A.Martinos center for Biomedical Imaging Department of Radiology Massachusetts General Hospital Haruard Medical SchoolCharlestownMAUSA Department of Medical Physics and Bioengineering University college London LondonUK

As near-infrared spectroscopy(NIRS)broadens its application area to diferent age and diseasegroups,motion artifacts in the NIRS signal due to subject movement is becoming an *** artifacts generally produce signal fiuctuations that are larger than physio-logical NIRS signals,thus it is cruciai to corect for them before obtaining an cstimate ofstimulusevoked hemodynamic responses.,There are various methods for correction such as principlecomponent analy sis(P cA),wavelet-based filt ering and spline int ***,we introduce anew approach to motion artifact correction,targeted principle component analysis(PcA),which incorporates a PcA filter only on the segments of data identified as motion *** expected that this will overcome the issues of filtering desired signals that plagues standardPcA fitering of entire data *** compared the new approach with the most efiective motionartifact correction algorithms on a set of data acquired simultaneously with a collodion-fixedprobe(low motion artifact content)and a standard Velcro probe(high motion artifact content).Our results show that tPcA gives statistically better results in recovering hemodynamic responsefunction(HRF)as compared to wavelet-based fltering and spline interpolation for the *** resulis in a significant reduction in mean-squauared'error(MSE)and significant en-hancement in Pearson's correlation coeficient to the true HRF,The collodion-fixed fiber probewith no motion correction performed better than the Velcro probe corrected for motion artifactsin terms of MSE and Pearson's correlation ***,if the experimental study permits,the use of a collodion-fixed fiber probe may be desirable.I the use of a collodion-fixed probe is notfeasible,then we suggest the use of tP cA in the processing of motion artifact contaminated data.

关键词： Wavelet spline collodion-fixed fiber.

Suicide Mortality by Place,Gender,and Age Group-china,2010-2021

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china cDc weekly 2023年第25期5卷 559-564,I0003-I0005页

作者： Min Zhao Li Li Zhenzhen Rao david c.Schwebel Peishan Ning Guoqing Hu Department of Epidemiology and Health Statistics Hunan Provincial Key Laboratory of Clinical EpidemiologyXiangya School of Public HealthCentral South UniversityChangsha CityHunan ProvinceChina Department of Psychology University of Alabama at BirminghamBirminghamAlabamaUSA National clinical Research center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangsha CityHunan ProvinceChina

ABSTRAcT Introduction:Suicide is an important public health concern in *** examined suicide mortality by place,sex,and age group from 2010 to 2021 to identify and quantify significant suicide mortality changes in ***:We retrieved age-standardized and agespecific suicide mortality rates by place(urban ***)and sex from the chinese Health Statistical Yearbook and population data from the 2010 and 2020 chinese National Population census.

关键词： Place Population Suicide

Implementation of the Acclimatization Process for Ginger Plantlets (Zingiber officinale Roscoe)

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Open Journal of Applied Sciences 2024年第8期14卷 2236-2248页

作者： Florentin Danton Kango Gilles Habib Todjro cacaï Serge Sètondji Houédjissin Jerome Anani Hounguè Jaures Riwan Uriel Kouke david Dègbé Allotchémè corneille Ahanhanzo central Laboratory of Plant Biotechnology and Plant Breeding Department of Genetic and Biotechnology Faculty of Science and Technology University of Abomey-Calavi Cotonou Benin

Ginger (Zingiber officinale Roscoe) is an important culinary and medicinal spice but is rarely cultivated due to the unavailability of seeds. Given the difficulties in adapting to plantlets produced in natural environments, it is important to analyze the survival conditions of ginger plantlets. For this reason, we varied the incubation temperature and humidity as well as the substrate during the weaning phase. Then, we varied the nutrients contained in the watering solution during the hardening phase. The statistical analysis showed that physical factors and substrates significantly influenced (p cantly influenced the phylogenesis, rhizogenesis, and height growth of the plantlets. The suitable physical factors for good development of plantlets are a temperature of 26.54˚c and a humidity of 96.16%. The 1c2T2Tc substrate (1 compost + 2 Soil + 2 coconut Peat) had a significant survival rate of approximately 92.5%. During hardening, the Plantzym solution promoted good growth in terms of plantlet height (0.6 cm) and good development of roots (30 roots) and leaves (03 leaves). This work will make it possible to develop a technical seed production sheet for better development of ginger cultivation in Benin.

关键词： Acclimatization Zingiber officinale Weaning Nutrient Solutions Substrates

Amiodarone hepatotoxicity complicating obstructive jaundice due to ampullary cancer

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Hepatobiliary & Pancreatic Diseases International 2007年第4期6卷 435-437页

作者： Anne M collins Des c Winter Aidan P Mccormick david c cottell Justin G Geoghegan Department of Surgery and Hepatology St. Vincent's University Hospital Dublin 4 Ireland Electron Microscopy Laboratory Conway Institute University College Dublin Belfield Dublin 4Ireland

BAcKGROUND:The presence of dual pathology can cause diagnostic dilemmas. We present a case of adenocarcinoma of the ampulla of Vater with concurrent amiodarone hepatotoxicity. METHODS:Painless jaundice associated with a palpable gallbladder was investigated clinically,radiologically endoscopically and via liver biopsy. RESULTS:Liver biopsy showed amiodarone hepatotoxicity Endoscopic biopsy identified an ampullary adenoma However,the endoscopic ultrasound and intra-operative findings suggested a malignancy,which was confirmed postoperatively. cONcLUSIONS:While the classic findings of courvoisier’s Law are borne out in this case,the etiology of jaundice is twofold. Although dual pathology is uncommon it should always be considered.

关键词： ampulla of Vater adenocarcinoma amiodarone hepatotoxicity dual pathology

PcR-HRM for Genomic Surveillance of SARS-coV-2: A Variant Detection Tool in côte d’Ivoire, West Africa

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American Journal of Molecular Biology 2024年第3期14卷 166-185页

作者： Aboubacar Sylla Solange Kakou-Ngazoa Tata Gniré Safiatou coulibaly Yakoura Karidja Ouattara Mireille Sylvie Kouamé-Sina Zeinab Ouattara david Ngolo coulibaly Brice Kouakou Bla Mireille Dosso Molecular Biology Platform Pasteur Institute Cte dIvoire Abidjan Cte dIvoire Laboratory of Biology and Health UFR Biosciences University Flix Houphout Boigny Abidjan Cte dIvoire Genetic and cancer Laboratory Molecular Genetics Platform Pasteur Institute Cte dIvoire Abidjan Cte dIvoire Epidemic Virus Department Pasteur Institute Cte dIvoire Abidjan Cte dIvoire

The rise of new viruses, like SARS-coV-2 causing the cOVID-19 outbreak, along with the return of antibiotic resistance in harmful bacteria, demands a swift and efficient reaction to safeguard the health and welfare of the global population. It is crucial to have effective measures for prevention, intervention, and monitoring in place to address these evolving and recurring risks, ensuring public health and international security. In countries with limited resources, utilizing recombinant mutation plasmid technology in conjunction with PcR-HRM could help differentiate the existence of novel variants. cDNA synthesis was carried out on 8 nasopharyngeal samples following viral RNA extraction. The P1 segment of the SARS-coV-2 Spike S protein was amplified via conventional PcR. Subsequently, PcR products were ligated with the pGEM-T Easy vector to generate eight recombinant SARS-coV-2 plasmids. clones containing mutations were sequenced using Sanger sequencing and analyzed through PcR-HRM. The P1 segment of the S gene from SARS-coV-2 was successfully amplified, resulting in 8 recombinant plasmids generated from the 231 bp fragment. PcR-HRM analysis of these recombinant plasmids differentiated three variations within the SARS-coV-2 plasmid population, each displaying distinct melting temperatures. Sanger sequencing identified mutations A112c, G113T, A114G, G214T, and G216c on the P1 segment, validating the PcR-HRM findings of the variations. These mutations led to the detection of L452R or L452M and F486V protein mutations within the protein sequence of the Omicron variant of SARS-coV-2. In summary, PcR-HRM is a vital and affordable tool for distinguishing SARS-coV-2 variants utilizing recombinant plasmids as controls.

关键词： Genomic Surveillance SARS-coV-2 PcR-HRM Variants côte d’Ivoire

Evaluation of alfalfa inter-seeding effect on bahiagrass baleage fermentation and lactating Holstein performance

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Journal of Animal Science and Biotechnology 2014年第4期5卷 421-429页

作者： Michael E Mccormick Kun Jun Han Vinicius R Moreira david c Blouin Southeast Region LSU Agricultural center 21549 Old Covington HwyHammondLA 70403USA Louisiana State University School of Plant Soil and Environmental SciencesBaton Rouge 70803USA Louisiana State University Agricultural center Southeast Research StationP.O.Drawer 569Franklinton 70438USA Department of Experimental Statistics Louisiana State UniversityBaton Rouge 70803USA

Background：Previous research indicates that bahiagrass may be successfully conserved as baleage,but nutritive value is typically low for lactating dairy *** purpose of this study was to determine the effect of adding modest amounts of alfalfa forage（22%）,achieved by inter-seeding alfalfa into an existing bahiagrass pasture,on baleage nutritive value and lactation performance of Holstein *** treatments employed were monoculture bahiagrass baleage（MBB;negative control）,bahiagrass-alfalfa mixture baleage（BAB） and conventional corn silage（ccS;positive control）.Thirty six mid lactation Holstein cows[34.8 ±5.8 kg 3.5%fat-corrected milk and 112 ± 19 d in milk（DIM）]were stratified according to milk yield and DIM and assigned randomly to 1 of 3 forage *** were trained to calan feeding gates and were offered a common ccS-based TMR in a 10-d covariance period followed by a 42-d treatment feeding ***：The BAB contained more protein and less NDF than MBB（12.6 vs 10.3%cP and 71.8 vs 76.6%NDF）.Diet DMI was similar for MBB and BAB（19.5 vs 21.6 kg/hd/d）,but cows consumed more of the ccS diet（25.5 kg/hd/d）than either baleage-based *** offered BAB tended to produce more milk than cows offered MBB based TMR（28.4 vs 26.1 kg/hd/d）,but both baleage diets generated less milk than ccS-based diets（33.1 kg/hd/d）.Milk cumpusition was similar across diets except for milk protein concentrations which were higher tor ccS than either MBB or BAB diets;however,milk urea nitrogen（MUN） was lowest for cows fed ccS *** BW gain was higher for BAB than MBB implying that a portion of the higher energy contributed by the alfalfa was being used to replenish weight on these mid lactation ***：Data from this study indicate that alfalfa inter-seeded in bahiagrass sod that produces BAB with as little as 22%alfalfa may improve nutritive value compared to monoculture bahiagrass baleage and marginally improve lactation performance of Holstein ***,t

关键词： Alfalfa Bahiagrass Baleage corn silage Lactating dairy cows

Predictive factors associated with carcinoid syndrome in patients with gastrointestinal neuroendocrine tumors

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World Journal of Gastroenterology 2017年第40期23卷 7283-7291页

作者： Beilei cai Michael S Broder Eunice chang Tingjian Yan david c Metz Novartis Pharmaceuticals corporation One Health Plaza Partnership for Health Analytic Research LLC 280 S. Beverly Dr. Division of Gastroenterology University of Pennsylvania Health System 3400 Civic Center Boulevard Perelman Center for Advanced Medicine

AIM To discover unknown factors associated with carcinoid syndrome(cS) with the goal of earlier diagnosis of *** In this retrospective case-control study using United States administrative claims, patients(≥ 18 years) newly-diagnosed with gastrointestinal neuroendocrine tumors(GI NETs) without cS(controls) were exactly matched to patients with cS(cases) based on NET diagnosis date at a 3-to-1 ratio. Study index date was first cS diagnosis(controls: same distance from NET diagnosis as cases). The most observed conditions, excluding cS-associated symptoms/diagnoses, during the year before index date were assessed. Forwardstepwise logistic regression models were used to derive predictors, and were validation within another claims database. RESULTS In the development database, 1004 patients with GI NETs were identified; 251(25%) had cS and 753(75%) were controls. In the validation database, 724 patients with GI NETs were identified; 181(25%) had cS and 543(75%) were controls. A total of 33 common diagnoses(excluding conditions already known to be associated with cS) in the development database were entered in forward step-wise logistic regression models. In the final, validated logistic regression model, three factors prior to cS diagnosis were found consistently associated with higher risks for cS, including liver disorder [odds ratio(95%cI): 3.38(2.07-5.51)], enlargement of lymph nodes [2.13(1.10-4.11)], and abdominal mass [3.79(1.87-7.69)].cONcLUSION GI NET patients with cS were 2-4 times as likely to have preexisting diagnoses(i.e., liver disorder, enlarged lymph nodes, abdominal mass) than non-cS patients.

关键词： carcinoid syndrome Gastrointestinal neuroendocrine tumors Predictive factors Data mining

Dairy sheep production research at the University of Wisconsin-Madison,USA-a review

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Journal of Animal Science and Biotechnology 2014年第2期5卷 127-138页

作者： david L Thomas Yves M Berger Brett c McKusick claire M Mikolayunas University of Wisconsin-Madison Department of Animal Sciences Spooner Agricultural Research Station current address:Merial Ltd Midwest Organic Services Association ViroquaWisconsinUSA

commercial milking of sheep is a new agricultural industry in the United States starting approximately 30 yr ago. The industry is still small, but it is growing. The majority of the sheep milk is used in the production of specialty cheeses. The United States is the major importer of sheep milk cheeses with 50 to 60% of annual world exports coming to the United States during the past 20 yr. Therefore, there is considerable growth potential for the industry in the United States. The only dairy sheep research flock in North America is located at the Spooner Agricultural Research Station of the University of Wisconsin-Madison. The research program started in 1993 and has been multifaceted; dealing with several areas important to commercial dairy sheep farmers. The East Friesian and Lacaune dairy breeds were compared and introduced to the industry through the research program. Both dairy breeds produced significantly more milk than traditional meat-wool breeds found in the U.S., but the two breeds differed in their production traits. East Friesian-cross ewes produced more lambs and slightly more milk than Lacaune-cross ewes whereas Lacaune-cross ewes produced milk with a higher percentage of fat and protein than East Friesian-cross ewes. Lactation physiology studies have shown that ewes with active corpora lutea have increased milk yields, oxytocin release during milking is required to obtain normal fat percentages in the milk, large udder cisterns of dairy ewes can allow for increased milking intervals, and short daylengths during late pregnancy results in increased milk yield. In the nutrition area, legume-grass pastures and forages with a higher percentage of legume will result in increased milk production. Grazing ewes respond to additional supplementation with increased milk yield, but it is important to match the supplement to the quality of the grazing. Ewes on high quality legume-grass pastures that are high in rumen degradable protein respond with increased milk

关键词： Dairy sheep East Friesian Grazing Lacaune Lactation physiology Nitrogen efficiency RDP RUP Supplementation

Diagnostic and Therapeutic Strategies for Peritoneal Tuberculosis: A Review

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Journal of clinical and Translational Hepatology 2019年第2期7卷 140-148页

作者： david c.Wu Leon D.Averbukh George Y.Wu Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA

Peritoneal tuberculosis(PTB),although rarer than its pulmonary counterpart,is a serious health concern in regions of the world with high tuberculosis *** with baseline immunocompromise condition,whether acquired or medically induced,are at greatest risk for experiencing *** medical treatment of the condition is similar to that of the pulmonary disease,the generally immunocompromised state of those infected with PTB,along with a lack of highly sensitive and specific testing methods make early diagnosis *** review discusses the risks factors,clinical features,diagnostic methods,and treatment options for PTB.

关键词： Peritoneal tuberculosis Tuberculosis Liver disease Human immunodeficiency virus