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Lattice Boltzmann Method for Reacting Flows in Porous Media

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Advances in Applied Mathematics and Mechanics 2010年第5期2卷 545-563页

作者： Qinjun Kang Peter c.Lichtner david R.Janecky computational Earth Sciences Group Los Alamos National LaboratoryLos AlamosNM 87545U.S.A Ecology and Air Quality Group Los Alamos National LaboratoryLos AlamosNM 87545U.S.A

We review recent developments in lattice Boltzmann method for reacting flows in porous *** present the lattice Boltzmann approaches for incompressible flow,solute transport and chemical reactions in both the pore space and at the fluid/solid *** discuss in detail the methods to update solid phase when significant mass transfer between solids and fluids is involved due to dissolution and/or *** in different areas are presented and perspectives of applying this method to a few important fields are discussed.

关键词： Reactive flows lattice Boltzmann method porous media pore scale

Synthesis of 11β-ether-17α-ethinyl-3,17β-estradiols with strong ER antagonist activities

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chinese chemical Letters 2014年第4期25卷 567-570页

作者： Jing-Xin Zhang david c.Labaree Richard B.Hochberg Department of Obstetrics Gynecology & Reproductive SciencesYale University School of Medicine

We have previously found that several families of nonpolar short chain 11β-ethers and esters ofestradiol are selective estrogen receptor modulators （SERMs）. Surprisingly, the transformation from potent estrogen to anti-estrogen occurs when the 11β-side chain is increased slightly in length from four to five non-hydrogen atoms. To generate strong antagonists for preclinical development, we have synthesized other similar ER ligands with 11β-ethers and with an additional ethinyl group at the 17β-position in order to slow metabolism of the steroidal moiety. Here we report the synthesis and biological activity of two such compounds （11β-i-PrO-propyl and 11β-t-BuO-propyl ethers） with extremely strong antagonist activities.

关键词： Estrogen receptor SERM Antagonist Estradiol

Geomechanical properties will constrain cO_(2)injection into the lower Ordovician Rose Run sandstone deep saline reservoir,Appalachian Basin,Kentucky,USA

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第5期13卷 947-960页

作者： John Richard Bowersox Stephen F.Greb Junfeng Zhu david c.Harris Kentucky Geological Survey University of KentuckyLexingtonKY40506-0107USA

The Kentucky Geological Survey(KGS)1 Hanson Aggregates stratigraphic research well,carter county,Kentucky,USA,was drilled to a total depth of 1474 m as a field-scale test of potential cO2 storage reservoir properties in the central Appalachian *** properties of the Rose Run sandstone(upper Ordovician Knox group)were tested for its suitability as a storage reservoir.A 9.8-m thick section of the Rose Run was penetrated at 1000 m drilled depth and a whole-diameter core and rotary sidewall cores were *** porosity and permeability measured in core plugs were 9.1%and 44.6 mD,*** vertical stress gradient calculated in the wellbore was 26 MPa/*** fractures in dolomites underlying and overlying the Rose Run follow the contemporary N53E Appalachian Basin stress *** Rose Run elastic geomechanical properties were calibrated to values measured in core plugs to evaluate its fracturing risk as a cO2 storage *** Young’s modulus and Poisson’s ratio values of the Rose Run were 45 GPa and 0.23,respectively,whereas Young’s modulus and Poisson’s ratio values were 77.1 GPa and 0.28,respectively,in the overlying Beekmantown dolomite,suggesting the Rose Run may fracture if overpressured during cO2 injection but be confined by the *** compressive strength measured in core plugs found the Rose Run and Beekmantown fractured at mean axial stresses of 156.5 MPa and 282.2 MPa,respectively,confirming the Beekmantown as suitable for confining cO2 injected into the Rose Run.A step-rate test was conducted in a mechanically-isolated 18.6-m interval bracketing the Rose *** Rose Run reservoir pressure was 9.3 MPa,and fracture gradient under injection was 13.6 MPa/km,suggesting step-rate testing before cO2 injection,and subsequent pressure monitoring to ensure *** the region around the KGS 1 Hanson Aggregates well is underpressured and adjacent to faulted Precambrian basement,further research is neede

关键词： Appalachian Basin Rose Run sandstone Geomechanics carbon sequestration Step-rate testing

Preparing for Iiver surgery with "Alphabet Soup": PVE, ALPPS, TAE-PVE, LVD and RL

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 136-151页

作者： DaeHee Kim Joshua cornman-Homonoff david c.Madoff Department of Radiology Division of Interventional RadiologyMemorial Sloan Kettering Cancer CenterNew YorkNYUSA Department of Radiology and Biomedical Imaging Section of Interventional RadiologyYale School of MedicineNew HavenCTUSA

Future liver remnant(FLR)is a critical limiting factor for treatment eligibility and postoperative prognosis when considering surgical ***-operative portal vein embolization(PVE)has been proven effective in modulating FLR and now widely accepted as a standard of ***,PVE is not always effective due to potentially inadequate augmentation of the FLR as well as tumor progression while awaiting liver *** concerns have prompted exploration of alternative techniques:associating liver partition and portal vein ligation for staged hepatectomy(ALPPS),transarterial embolization-portal vein embolization(TAE-PVE),liver venous deprivation(LVD),and radiation lobectomy(RL).The article aims to review the principles and applications of PVE and these newer hepatic regenerative techniques.

关键词： Hepatic regeneration future liver remnant embolization

Recent Advances in Dissecting Stress-Regulatory crosstalk in Rice

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Molecular Plant 2013年第2期6卷 250-260页

作者： Rita Sharma david De Vleesschauwer Manoj K. Sharma Pamela c. Ronald Department of Plant Pathology and Genome center University of California Davis CA 95616 USA Joint BioEnergy Institute Emeryville CA 94710 USA Laboratory of Phytopathology Faculty of Bioscience Engineering Ghent University B-9000 Ghent Belgium Department of Plant Molecular Systems Biotechnology and crop Biotech Institute Kyung Hee University Yongin 446-701 Korea

Biotic and abiotic stresses impose a serious limitation on crop productivity worldwide. Prior or simultaneous exposure to one type of stress often affects the plant response to other stresses, indicating extensive overlap and cross-talk between stress-response signaling pathways. Systems biology approaches that integrate large genomic and prot-eomic data sets have facilitated identification of candidate genes that govern this stress-regulatory crosstalk. Recently, we constructed a yeast two-hybrid map around three rice proteins that control the response to biotic and abiotic stresses, namely the immune receptor XA21, which confers resistance to the Gram-negative bacterium, Xanthomonas oryzae pv. oryzae; NH1, the rice ortholog of NPR1, a key regulator of systemic acquired resistance; and the ethylene-responsive transcription factor, SUBIA, which confers tolerance to submergence stress. These studies coupled with transcriptional profiling and co-expression analyses identified a suite of proteins that are positioned at the interface of biotic and abiotic stress responses, including mitogen-activated protein kinase 5 （OsMPK5）, wall-associated kinase 25 （WAK25）, sucrose non-fermenting-l-related protein kinase-1 （SnRK1）, SUBIA binding protein 23 （SAB23）, and several WRKY family tran- scription factors. Emerging evidence suggests that these genes orchestrate crosstalk between biotic and abiotic stresses through a variety of mechanisms, including regulation of cellular energy homeostasis and modification of synergistic and/or antagonistic interactions between the stress hormones salicylic acid, ethylene, jasmonic acid, and abscisic acid.

关键词： abiotic biotic crosstalk defense response hormone systems biology stress.

The Long Road to Understanding the Baculovirus P10 Protein

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Virologica Sinica 2009年第4期24卷 227-242页

作者： david c. J. carpentier Linda A. King School of Life Sciences Oxford Brookes University Headington Campus Oxford United Kingdom Oxford Expression Technologies Ltd Oxford Brookes University Headington Campus Oxford United Kingdom

The baculovirus P 10 protein has always represented a mystery in the field of insect virology. Like the baculovirus polyhedrin protein it is expressed at high levels very late in infection. Homologues of the Autographa californica nucleopolyhedrovirus p10 gene are conserved in all Alphabaculoviruses and in other viruses of lepidopteran hosts yet is completely dispensable for virus replication and transmission. PIO is a microtubule interacting protein whose expression has been associated with the formation of a variety of complex and extensive cytoplasmic and nuclear structures. PIO has been associated with a number of roles during infection ranging from the formation of virus occlusion bodies, to affecting the rate of cellular and/or nuclear lysis during the final stages of the virus replication cycle. In this article we review recent work aimed at understanding the role of this enigmatic protein, putting them into context with recent advances in understanding of protein structure and function. We look back at a number of historical studies and observations, reanalysing their conclusions based on recent data and our own observations. The role of the P 10 protein during baculovirus replication remains elusive, however, novel avenues of investigation have been identified that will, we are sure, eventually lead to an understanding of this protein.

关键词： Baculovirus P10 microtubule Polyhedral occlusion body Fibrous body/fibrillar structure

Infrared chemical imaging through non-degenerate two-photon absorption in silicon-based cameras

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Light(Science & Applications) 2020年第1期9卷 813-822页

作者： david Knez Adam M.Hanninen Richard c.Prince Eric O.Potma Dmitry A.Fishman Department of chemistry University of CaliforniaIrvineCA 92697USA Department of Biomedical Engineering University of CaliforniaIrvineCA 92697USA

chemical imaging based on mid-infrared(MIR)spectroscopic contrast is an important technique with a myriad of applications,including biomedical imaging and environmental *** MIR cameras,however,lack performance and are much less affordable than mature Si-based devices,which operate in the visible and nearinfrared ***,we demonstrate fast MIR chemical imaging through non-degenerate two-photon absorption(NTA)in a standard Si-based charge-coupled device(ccD).We show that wide-field MIR images can be obtained at 100 ms exposure times using picosecond pulse energies of only a few femtojoules per pixel through NTA directly on the ccD *** this on-chip approach does not rely on phase matching,it is alignment-free and does not necessitate complex postprocessing of the *** emphasize the utility of this technique through chemically selective MIR imaging of polymers and biological samples,including MIR videos of moving targets,physical processes and live nematodes.

关键词： absorption Infrared chemical

Keratoconus in a patient with Alport syndrome: A case report

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World Journal of clinical cases 2019年第19期7卷 3012-3017页

作者： Majid Moshirfar david F Skanchy Aaron T Gomez Yasmyne c Ronquillo Benjamin Buckner Phillip c Hoopes John A.Moran Eye center Department of Ophthalmology and Visual SciencesUniversity of Utah School of MedicineSalt Lake CityUT 84101United States Utah Lions Eye Bank Salt Lake CityUT 84101United States Hoopes Durrie Rivera Research center Hoopes VisionDraperUT 84020United States Kellogg Eye center Department of OphthalmologyUniversity of Michigan Medical SchoolAnn ArborMI 48103United States The University of Texas Rio Grande Valley School of Medicine EdinburgTX 78542United States

BAcKGROUND Known ocular manifestations of Alport syndrome include features such as anterior lenticonus and fleck retinopathy. Reports of keratoconus in such patients are limited. We report tomographic findings consistent with keratoconus in a patient with Alport *** SUMMARY A 52-year-old female was referred to our ophthalmology clinic with decreased vision and increased tearing. She was diagnosed with stage Ⅲ Alport syndrome two years prior. Upon examination she was found to have average keratometries of 48D bilaterally with tomographic evidence of *** Although a rare presentation, concurrent Alport syndrome and keratoconus should be considered when reviewing the ocular health of Alport syndrome patients and appropriate management steps should be taken upon the diagnosis.

关键词： Alport syndrome,Keratoconus Type Ⅳ collagen cOL4A genes corneal ectasia case report

Roundtable： Research Opportunities and challenges for Large-Scale Software Systems

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Journal of computer Science & Technology 2016年第5期31卷 851-860页

作者： Xusheng Xiao Jian-Guang Lou Shan Lu david c. Shepherd Xin Peng Qian-Xiang Wang NEc Laboratories America Princeton NJ 08540 U.S.A. Microsoft Research Asia Beijing 100080 China Department of computer Science University of Chicago Chicago IL 60637 U.S.A. ABB corporate Research Raleigh NC 27606 U.S.A. School of computer Science Fudan University Shanghai 201203 China School of Electronics Engineering and computer Science Peking University Beijing 100871 China

For this special section on software systems, six research leaders in software systems, as guest editors tor this special section, discuss important issues that will shape this field＇s future research directions. The essays included in this roundtable article cover research opportunities and challenges for large-scale software systems such as querying organization- wide software behaviors （Xusheng Xiao）, logging and log analysis （Jian-Ouang Lou）, engineering reliable cloud distributed systems （Shan Lu）, usage data （david c. Shepherd）, clone detection and management （Xin Peng）, and code search and beyond （Qian-Xiang Wang）. - Tao Xie, Leading Editor of Software Systems.

关键词： organization-wide software behavior log analysis reliable cloud distributed system usage data clone detection and management code search