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Propofol with Varied Functions: A Potential Therapeutic Opportunity for Postoperative Nausea, Vomiting and Pruritus—A Narrative Review

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Open Journal of Anesthesiology 2024年第2期14卷 13-24页

作者： Thomas W. Anabah Fidelis Bayor david Z. Kolbila Terence Kunfire Dakurah Sylvanus Kampo Juventus B. Ziem Anaesthesia Unit Habana Medical Services Tamale Ghana Department of Anaesthesiology Lawra Municipal Hospital Ghana Health Service Lawra Ghana Department of Obstetrics and Gynecology School of Medicine University for Development Studies Tamale Ghana Department of Anaesthesia and Intensive care School of Medical Sciences C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana Department of Medical Microbiology School of Medical Sciences C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana

Background: Despite the advances in anesthetics and non-pharmacological techniques, the prevalence of postoperative nausea and vomiting in all patients remains high. It is one of the most common distressing symptoms that cause dissatisfaction among patients after anesthesia and surgery. A sub-hypnotic dose of propofol has been shown to reduce morphine-induced postoperative nausea, vomiting, and pruritus. This review article will provide sufficient knowledge on the role of propofol in minimizing opioid-induced postoperative nausea, vomiting, and pruritus by providing detailed information on propofol antiemetic and antipruritic effects, as well as discussions based on empirically available data. Method: We conducted a narrative review of the literature published between 1990 and 2023 from a range of databases;PubMed, BioMed central, Biosis Previews, Nature, International Pharmaceutical Abstracts, Springer-Link, and Elsevier. Discussion and conclusion: The literatures reviewed in this study have demonstrated that propofol may have diverse therapeutic effects including antiemetic and antipruritic. The antiemetic effect of propofol may be an effective therapeutic approach for the prevention of postoperative nausea and vomiting. The literature also demonstrated that the use of propofol for sedation during surgery may as well ameliorates opioids induced postoperative pruritus, which may be beneficial to surgical patients. Also, it was demonstrated that prophylactic use of propofol may be an effective way of preventing nausea and vomiting and pruritus during opioid use.

关键词： Propofol Nausea Vomiting Antiemetic Antipruritic Surgery

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Exercise immunology:Future directions

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Journal of Sport and Health Science 2020年第5期9卷 432-445页

作者： david c.Nieman Brandt D.Pence Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA School of Health Studies University of MemphisMemphisTN 38152USA

Several decades of research in the area of exercise immunology have shown that the immune system is highly responsive to acute and chronic exercise *** exercise bouts enhance immunosurveillance and when repeated over time mediate multiple health *** of the studies prior to 2010 relied on a few targeted outcomes related to immune *** the past decade,technologic advances have created opportunities for a multi-omics and systems biology approach to exercise *** article provides an overview of metabolomics,lipidomics,and proteomics as they pertain to exercise immunology,with a focus on *** review also summarizes how the composition and diversity of the gut microbiota can be influenced by exercise,with applications to human health and ***-induced improvements in immune function may play a critical role in countering immunosenescence and the development of chronic diseases,and emerging omics technologies will more clearly define the underlying *** review summarizes what is currently known regarding a multi-omics approach to exercise immunology and provides future directions for investigators.

关键词： Exercise Immunology Lipidomics Metabolomics Proteomics

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cardiac Tolerance of Hydroalcoholic Extract of Bark of Terminalia mantaly H. Perrier (HAEBTM) in Wistar Rats

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American Journal of Molecular Biology 2024年第3期14卷 126-137页

作者： Irié Lou Bohila Emilie Kamo Kouakou Serge Kouassi Virginie Atto Allico Joseph Djaman Jean david N’guessan Mireille Dosso Department of Microbiology Institut Pasteur of Cte dIvoire Abidjan Cte dIvoire Biology and Health Laboratory Flix Houphout-Boigny University Abidjan Cte dIvoire Department of Medical and Fundamental Biochemistry Institut Pasteur of Cte dIvoire Abidjan Cte dIvoire

Terminalia mantaly H. Perrier is a plant used in traditional medicine for the treatment of various pathologies. However, Terminalia mantaly H. Perrier could present potential health effects on patients. In order to determine the possible cardiotoxic effects of the hydro-alcoholic extract of the bark of Terminalia mantaly H. Perrier, (HAEBTM) forty (40) rats distributed randomly into 4 groups, including 10 animals per group (5 males and 5 females) were used. Animals in group 1 received distilled water and were used as a control group. On the other hand, groups 2, 3, 4 received oral administration a volume of the hydroalcoholic extract of Terminalia mantaly H. Perrier corresponding to 1 mL/100g of body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The extract was administered daily at the same time for 28 days and serum was collected once a week to evaluate cardiac biochemical markers using spectrophotometric methods using a cobas c311 HITAcHI biochemistry system. After one month of study, all rats were euthanized by overdose of ether, and the hearts of the rats were removed for gross morphological and histopathological analysis. Results were analysed using variance analysis (ANOVA) to compare outcomes as a function of doses administered and treatment times. The biochemical parameters ALT, LDH, cPK, cPKMB showed no significant change (p Terminalia mantaly showed no lesions, edema and necrosis. These results suggest that the hydroalcoholic extract of Terminalia mantaly did not interfere with the functioning or alter the integrity of the heart.

关键词： Terminalia mantaly Bio cardiac Tolerance Biochemical Markers Histopathology

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Physical geology charles c. Plummer, david McGeary, Diane H. carlson 8th ed.

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1999年

作者： charles c. Plummer david McGeary Diane H. carlson

"Featuring the Smithsonian Institution's Journey through geology cD-ROM."

ISBN: (纸本)0697374041

"Featuring the Smithsonian Institution's Journey through geology cD-ROM."

关键词： Physical geology.

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Turbulence Modeling for cFD (Third Edition) 3rd ed.

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2006年

作者： david c. Wilcox

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conversations in accountability:Perspectives from three charities

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Family Medicine and community Health 2016年第1期4卷 15-21页

作者： david c.Kirsch School of Health Policy and Management M3J 1P3Canada

Objective:The conversations in accountability were designed to gain an understanding of the use and changes to accountability in charities over time,including learning how results are ***:As part of a larger study which investigated accountability in charities working to reduce mortality of children younger than 5 years in least developed countries,a multiple-case study comprising semistructured in-depth key informant interviews was conducted to investigate the use and effects of accountability in three charities of differing ***:Smaller charities tend to use fewer accountability mechanisms than larger ones,whereas the variation in their use between small and medium-sized charities is greater than the variation between medium-sized and large ***:Although accountability has changed over time,charities believe that they are providing the correct amount of accountability-that is,enough to satisfy the perceived demands of their stakeholders but not so much that it detracts from the mission or incurs costs in excess of ***,the tools to determine effectiveness and impact are lacking.

关键词： Accountability charity non-government organisation(NGO) mortality of children younger than 5 years

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Breaking out from the neuroprotective logjam:combined treatment with remote ischemic conditioning and minocycline in the prehospital setting

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Neural Regeneration Research 2015年第4期10卷 537-539页

作者： Jung Mi Park david c.Hess Departments of Neurology Georgia Regent’s University

The only two treatments effective for acute ischemic stroke are reperfusion therapies. Despite testing of hundreds of neuroprotective agents and treatments, tissue plasminogen activator （tPA）, approved by the Food and Drug Administration （FDA） in 1996, remains the only FDA-approved drug for the treatment of ischemic stroke. Recently,

关键词： Breaking out from the neuroprotective logjam RIc

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Universal silicon ring resonator for error-free transmission links

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Photonics Research 2024年第4期12卷 701-711页

作者： JUNBO ZHU WEIWEI ZHANG KE LI BHARAT PANT MARTIN EBERT XINGZHAO YAN MEHDI BANAKAR DEHN T.TRAN cALLUM G.LITTLEJOHNS FUWAN GAN GRAHAM REED david J.THOMSON Optoelectronics Research centre University of SouthamptonSouthampton SO171BJUK National Key Laboratory of Materials for Integrated circuits Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China University of chinese Academy of Sciences Beijing 100049China Peng cheng Laboratory ShenzhenChina

We report the design, fabrication, and characterization of a universal silicon PN junction ring resonator for c band error-free communication links operated up to 50 Gb/s with co-designed optical modulation and detection performance. The universal p-n junction ring device shows co-designed detection responsivity up to 0.84 A/W, in conjunction with a modulation efficiency of -4 V·mm and>8 d B optical modulation extinction ratio, enabling c band 50 Gb/s NRZ communication link with a bit error rate≤3×10^(-12).

关键词： Gb/s resonator communication

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The compelling link between physical activity and the body's defense system

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Journal of Sport and Health Science 2019年第3期8卷 201-217页

作者： david c.Nieman Laurel M.Wentz Human Performance Laboratory Appalachian State University North Carolina Research Campus Department of Nutrition and Health care Management Appalachian State University

This review summarizes research discoveries within 4 areas of exercise immunology that have received the most attention from investigators :(1) acute and chronic effects of exercise on the immune system,(2) clinical benefits of the exercise—immune relationship,(3) nutritional influen?ces on the immune response to exercise, and(4) the effect of exercise on immunosenescence. These scientific discoveries can be organized into distinctive time periods: 1900-1979, which focused on exercise-induced changes in basic immune cell counts and function; 1980-1989, during which seminal papers were published with evidence that heavy exertion was associated with transient immune dysfunction, elevated inflammatory biomarkers,and increased risk of upper respiratory tract infections; 1990-2009, when additional focus areas were added to the field of exercise immunology including the interactive effect of nutrition, effects on the aging immune system, and inflammatory cytokines; and 2010 to the present, when technological advances in mass spectrometry allowed system biology approaches(i.e., metabolomics, proteomics, lipidomics, and microbiome characterization) to be applied to exercise immunology studies. The future of exercise irmmunology will take advantage of these technologies to provide new insights on the interactions between exercise, nutrition, and immune function, with application down to the person?alized level. Additionally, these methodologies will improve mechanistic understanding of how exercise-induced immune perturbations reduce the risk of common chronic diseases.

关键词： Aging Exercise Immunology Infection Inflammation Mass Snectrometry Nutrition

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A Strong Stability Preserving Analysis for Explicit Multistage Two-Derivative Time-Stepping Schemes Based on Taylor Series conditions

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communications on Applied Mathematics and computation 2019年第1期1卷 21-59页

作者： Zachary Grant Sigal Gottlieb david c.Seal Department of computational and Applied Mathematics Oak Ridge National LaboratoryOak RidgeUSA Department of Mathematics University of Massachusetts DartmouthDartmouthUSA Department of Mathematics U.S.Naval AcademyAnnapolisUSA

High-order strong stability preserving(SSP)time discretizations are often needed to ensure the nonlinear(and sometimes non-inner-product)strong stability properties of spatial discretizations specially designed for the solution of hyperbolic ***-derivative time-stepping methods have recently been increasingly used for evolving hyperbolic PDEs,and the strong stability properties of these methods are of *** our prior work we explored time discretizations that preserve the strong stability properties of spatial discretizations coupled with forward Euler and a second-derivative ***,many spatial discretizations do not satisfy strong stability properties when coupled with this second-derivative formulation,but rather with a more natural Taylor series *** this work we demonstrate sufficient conditions for an explicit two-derivative multistage method to preserve the strong stability properties of spatial discretizations in a forward Euler and Taylor series *** call these strong stability preserving Taylor series(SSP-TS)*** also prove that the maximal order of SSP-TS methods is p=6,and define an optimization procedure that allows us to find such SSP *** types of these methods are presented and their efficiency ***,these methods are tested on several PDEs to demonstrate the benefit of SSP-TS methods,the need for the SSP property,and the sharpness of the SSP time-step in many cases.

关键词： Strong stability preserving Taylor series.Hyperbolic conservation laws Two derivative Runge Kutta

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