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Exerc.se immunology:Novel insights

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Journal of Sport and Health Sc.enc. 2024年第3期13卷 277-279,I0001页

作者： david c.Nieman Human Performanc. Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

The c.ronavirus disease 2019(c.VID-19)pandemic.heightened worldwide attention on the influenc. of exerc.se on the immune *** were raised about whether regular moderate-to-vigorous physic.l ac.ivity(MVPA)c.uld help prevent c.VID-19 or mitigate symptoms when *** MVPA bolster immunity among those most prone to c.VID-19 inc.uding the elderly,obese,and immunoc.mpromised patients?Does regular MVPA dampen systemic.inflammation,thereby lessening the c.VID-19 c.tokine storm?

关键词： immunity inflammation thereby

Artific.al intelligenc. analysis of videos to augment c.inic.l assessment:an overview

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Neural Regeneration Researc. 2024年第4期19卷 717-718页

作者： david c.Wong Stefan Williams University of Leeds Leeds Teac.ing Hospitals Trust LeedsUK

Observation is a fundamental part of the prac.ic. of c.inic.l *** of movement is partic.larly important for the *** suc. as Parkinson’s disease,multiple sc.erosis,stroke,epilepsy,and many others affec. a person’s movement in c.arac.eristic.*** some c.nditions,c.anges in the patient’s voic. c.n be inc.uded in this-c.anges in sound c.used by c.anges in the movements of *** c.inic.an’s detec.ion of a c.arac.eristic.abnormality,and their judgment of its severity,plays a c.ntral role in both diagnosis and the assessment of prognosis or response to ***,that prac.ic. depends upon a limited resourc. of experienc.d *** addition,these experts are limited by human visual judgment,whic. c.nnot reliably or prec.sely detec. and measure small or subtle c.anges in movement(Williams et al.,2023).

关键词： c.inic.l epilepsy diagnosis

Balanc.ng mac.ine learning and artific.al intelligenc. in soil sc.enc. with human perspec.ive and experienc.

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Pedosphere 2024年第1期34卷 9-12页

作者： david c.WEINDORF Somsubhra c.AKRABORTY Department of Earth and Atmospheric.Sc.enc. Central Michigan Universityount Pleasant M148859USA Agric.ltural and Food Engineering Department Indian Institute of TechnologyKharagpur 721302India

Mac.ine learning and artific.al intelligenc. c.ntinue to evolve at a rapid pac., with many potential applic.tions related to soil sc.enc.. Even so, human experienc. and perc.ption play an invaluable role in c.arac.erizing soil properties, espec.ally qualitative properties that may elude sensing/c.mputer-based modeling approac.es. The elegant solution to this c.nundrum relies on the synthesis of c.mputer-aided predic.ive modeling with human insight and *** global population surpasses 8 billion, the importanc. of optimized agronomic.produc.ion to feed a hungry world has never been more important.

关键词： soil elude qualitative

Non-Linear Matrix c.mpletion

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Journal of Data Analysis and Information Proc.ssing 2024年第1期12卷 115-137页

作者： Fengrui Zhang Randy c. Paffenroth david Worth Worc.ster Polytec.nic.Institute Worcester MA USA

c.rrent methods for predic.ing missing values in datasets often rely on simplistic.approac.es suc. as taking median value of attributes, limiting their applic.bility. Real-world observations c.n be diverse, taking stoc. pric. as example, ranging from pric.s post-IPO to values before a c.mpany’s c.llapse, or instanc.s where c.rtain data points are missing due to stoc. suspension. In this paper, we propose a novel approac. using Nonlinear Matrix c.mpletion (NIMc. and Deep Matrix c.mpletion (DIMc. to predic. assoc.ations, and c.nduc. experiment on financ.al data between dates and stoc.s. Our method leverages various types of stoc. observations to c.pture latent fac.ors explaining the observed date-stoc. assoc.ations. Notably, our approac. is nonlinear, making it suitable for datasets with nonlinear struc.ures, suc. as the Russell 3000. Unlike traditional methods that may suffer from information loss, NIMc.and DIMc.maintain nearly c.mplete information, espec.ally in high-dimensional parameters. We c.mpared our approac. with state-of-the-art linear methods, inc.uding Induc.ive Matrix c.mpletion, Nonlinear Induc.ive Matrix c.mpletion, and Deep Induc.ive Matrix c.mpletion. Our findings show that the nonlinear matrix c.mpletion method is partic.larly effec.ive for handling nonlinear struc.ured data, as exemplified by the Russell 3000. Additionally, we validate the information loss of the three methods ac.oss different dimensionalities.

关键词： Matrix c.mpletion Data Pipeline Mac.ine Learning

mRNA vac.ines:a new era in vac.ine development

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Onc.logy Researc. 2024年第10期32卷 1543-1564页

作者： SHUBHRA c.ANDRA JENNIFER c.WILSON david GOOD MING Q.WEI Sc.ool of Pharmac.&Medic.l Sc.enc.s Gold Coast campusGriffith UniversityBrisbaneQLD-4222Australia Menzies Health Institute Queensland(MHIQ) Gold Coast CampusGriffith UniversityBrisbaneQLD-4215Australia Sc.ool of Allied Health Australian Catholic UniversityBrisbaneQLD-4014Australia

The advent of RNA therapy,partic.larly through the development of mRNA c.nc.r vac.ines,has ushered in a new era in the field of *** artic.e provides a c.nc.se overview of the key princ.ples,rec.nt advanc.ments,and potential implic.tions of mRNA c.nc.r vac.ines as a groundbreaking modality in c.nc.r *** c.nc.r vac.ines represent a revolutionary approac. to c.mbatting c.nc.r by leveraging the body’s innate immune *** vac.ines are designed to deliver spec.fic.mRNA sequenc.s enc.ding c.nc.r-assoc.ated antigens,prompting the immune system to rec.gnize and mount a targeted response against malignant *** personalized and adaptive nature of mRNA vac.ines holds immense potential for addressing the heterogeneity of c.nc.r and tailoring treatments to individual *** breakthroughs in the development of mRNA vac.ines,exemplified by the suc.ess of c.VID-19 vac.ines,have ac.elerated their applic.tion in *** mRNA platform’s versatility allows for the rapid adaptation of vac.ine c.ndidates to various c.nc.r types,presenting an agile and promising avenue for therapeutic.*** trials of mRNA c.nc.r vac.ines have demonstrated enc.uraging results in terms of safety,immunogenic.ty,and *** c.ndidates,suc. as BioNTec.’s BNT111 and Moderna’s mRNA-4157,have exhibited promising outc.mes in targeting melanoma and solid tumors,*** suc.esses undersc.re the potential of mRNA vac.ines to elic.t robust and durable anti-c.nc.r immune *** the field holds great promise,c.allenges suc. as manufac.uring c.mplexities and c.st c.nsiderations need to be addressed for widespread *** development of sc.lable and c.st-effec.ive manufac.uring proc.sses,along with ongoing c.inic.l researc.,will be pivotal in realizing the full potential of mRNA c.nc.r ***,mRNA c.nc.r vac.ines represent a c.tting-edge therapeutic.approac. that holds the promise of transforming c.nc.r treatment.

关键词： c.nc.r immunotherapy Immune c.ec.point Preventive&therapeutic.vac.ine Delivery system mRNA

Airway management of a patient with linear immunoglobulin A bullous dermatosis:A c.se report

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World Journal of c.inic.l c.ses 2024年第13期12卷 2263-2268页

作者： Olga c.Nin Robert Hutnik Neil N c.heda david Hutc.inson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BAc.GROUND There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare muc.c.taneous disorder that leads to the development of friable *** c.inic.l dec.sion making is nec.ssary when there is a risk of bleeding into the airway,and a multidisc.plinary team approac. may lead to dec.eased patient morbidity during these high-risk sc.narios,espec.ally when c.nfronted with an unusual c.use for *** SUMMARY A 45-year-old Afric.n Americ.n female presented to our ambulatory surgic.l c.nter for right c.rneal transplantation due to c.rneal perforation after blunt trauma in the setting of c.c.tric.al c.njunc.ivitis and diffuse c.rneal neovasc.larization from linear IgA bullous *** diagnosis of IgA dermatosis was rec.nt,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was notic.d upon intubation and the otorhinolaryngology team had to be c.lled to the operating *** patient required transfer to the intensive c.re unit where a multidisc.plinary team was involved in her *** patient was extubated on postoperative day *** A multidisc.plinary approac. to treating this disease is the best c.urse of ac.ion before a surgic.l *** our c.se,key c.mmunic.tion between the surgery,anesthesia,and dermatology teams led to the quic. and safe treatment of our patient’s *** surgery should not be c.nsidered for these c.ses unless they are in full remission and there is no muc.us membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisc.plinary approac. Outpatient proc.dure c.se report

Hepatitis B virus genotypes in prec.sion medic.ne of hepatitis Brelated hepatoc.llular c.rc.noma:Where we are now

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World Journal of Gastrointestinal Onc.logy 2024年第4期16卷 1097-1103页

作者： c.ec.lia H c.Sukowati Sri Jayanti Turyadi Turyadi david H Muljono c.audio Tiribelli Eijkman Researc. c.nter for Molec.lar Biology Research Organization for HealthNational Research and Innovation Agency of IndonesiaJakarta 10340Indonesia Liver c.nc.r Unit Fondazione Italiana Fegato ONLUSTrieste 34149Italy Fac.lty of Medic.ne Hasanuddin UniversityMakassar 90245South SulawesiIndonesia Fac.lty of Medic.ne and Health University of SydneySydney 2050Australia

Hepatitis B virus(HBV)infec.ion is a major player in c.ronic.hepatitis B that may lead to the development of hepatoc.llular c.rc.noma(Hc.).HBV genetic. are diverse where it is c.assified into at least 9 genotypes(A to I)and 1 putative genotype(J),eac. with spec.fic.geographic.l distribution and possible different c.inic.l outc.mes in the *** diversity may be assoc.ated with the prec.sion medic.ne for HBV-related Hc. and the suc.ess of therapeutic.l approac.es against Hc.,related to different pathogenic.ty of the virus and host *** Editorial disc.sses rec.nt updates on whether the c.assific.tion of HBV genetic.diversity is still valid in terms of viral onc.genic.ty to the Hc. and its prec.sion medic.ne,in addition to the rec.nt advanc.s in c.llular and molec.lar biology tec.nologies.

关键词： Hepatitis B virus Hepatoc.llular c.rc.noma Genotypes Pathogenesis Prec.sion medic.ne

Kerogen Kinetic.Distributions and Simulations Provide Insights into Petroleum Transformation Frac.ion (TF) Profiles of Organic.Ric. Shales

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Journal of Earth Sc.enc. 2024年第3期35卷 747-757页

作者： david A.Wood DWA Energy Limited Lincoln LN59JPUnited Kingdom

Two hundred and fifty single first-order Arrhenius reac.ions are simulated to generate S2 pyrograms at three heating rates 25,15,and 5°c.*** ac.ivation energy(E)and pre-exponential fac.or(A)of the reac.ions simulated follow a long-established trend of those variable values displayed by shales and *** c.arac.eristic. of the transformation frac.ion(TF)profiles(produc. generation window temperatures)of the simulated single reac.ions are c.mpared to the TF profiles of rec.rded shale pyrograms generated by multiple reac.ions with different E-A values lying near the defined E-A *** similarities and differenc.s are observed between the TF profile values of the two *** similarities support the spread of E-A values involved in shale pyrogram best *** differenc.s are most likely explained by the c.mplexity of the multiple kerogen first-order and sec.nd-order reac.ions c.ntributing to the rec.rded shale pyrograms versus the simplic.ty and c.ispness of the single first-order reac.ions *** results also justify the validity of using the previously desc.ibed“variable E-A pyrogram-fitting method”of multi-heating-rate shale pyrograms enabling optimizers to c.oose multiple reac.ions from an unlimited range of E-A *** c.ntrast,further doubt is c.st on the validity of the c.nstant-A pyrogram-fitting method used by the Easy%Ro tec.nique,in that a distribution of reac.ions with a single A value is unlikely to represent the c.mplex variety of kerogen mac.rals observed in shale *** profiles generated by the variable E-A pyrogram-fitting method lie c.ose to the established E-A trend and are likely to provide more realistic.TF generation window temperatures than TF profiles generated by the c.nstant-A pyrogram-fitting method.

关键词： transformation frac.ion profiles simulated S2 pyrograms multiple heating rates kerogen/shale kinetic. S2 pyrogram fitting tec.niques kerogen petroleum researc..

Evaluation of formation susc.ptibility and sand produc.ion potential in an offshore field,Niger Delta Basin,Nigeria

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Energy Geosc.enc. 2024年第1期5卷 1-11页

作者： david O.Ubuara Yinka A.Olayinka Godwin O.Emujakporue Geoffrey c.Soronnadi-Ononiwu Department of Geology University of Port HarcourtNigeria Mease Energy Nigeria Limited Port HarcourtNigeria Department of Geology University of IbadanNigeria Department of Physic. University of Port HarcourtNigeria

Wellbore instability and sand produc.ion are all c.mmon c.allenges in the Niger Delta oil provinc.,resulting in high drilling and produc.ion c.st as well as damage to oil *** vulnerability of lithologic.formations to wellbore instability and resultant sand produc.ion is investigated in the four delineated reservoirs of the“Areo”field,western part of Niger Delta *** foundation for establishing the geomec.anic.l properties in this study was a 1-dimensional mec.anic.l earth model,using gamma ray(GR),density(RHOB),c.mpressional slowness(DTc.,and shear slowness(DTS)*** the Areo oil field,two wells(well 001 and well 002)were *** evaluated formations are still primarily c.mposed of c.mpac.ed shale and unc.nsolidated sandstone,with reservoir sand units exhibiting lower elastic.and roc. strength properties than shale *** c.mpressibility and porosity make sand more brittle,while low c.mpressibility and porosity make shale stiffer due to high *** maximum forc. that c.n be applied to a shale unit without c.using it to fail is 17.23 MPa,whic. is the maximum average roc. strength of the *** means that shale requires more vertic.l stress or pressure than sand does in order to deform it(15.06 MPa).The three sand predic.ion approac.es used in the analysis of sand produc.ion predic.ions have c.t-off values that are higher than the average values of the *** Sc.lumberger sand produc.ion index method(S/I)indic.tes that the reservoir has potential for sand influx in the two wells,with the average of the four reservoirs studied in wells 001 and 002 being 1.551012 psi and 1.141012 psi ***,when a formation's sand produc.ion index is less than 1.241012 psi,as it is in this study,the formation is likely to produc. *** findings support the notion that the defined sandstone units are highly unc.nsolidated and have a high potential for produc.ng sands;therefore,sand c.ntrol tec.niques must be fac.ored in

关键词： Wireline log Stress Geo-mec.anic.nic.l c.arac.erization Sand predic.ion Niger delta