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Production and Evaluation of Table Wine Using Two Different Varieties of Pawpaw (Carica papaya)

Journal of Food Science and Engineering 2019年第6期9卷 199-209页

作者： david Barine Kiin-Kabari Queen Igbo Lucretia Ifeoma barber Department of Food Science and Technology Rivers State UniversityNkpolu Oroworukwo PMB 5080Port HarcourtRivers StateNigeria

The aim of this study was to produce and evaluate table wine from two different varieties of pawpaw (rose red and yellow pawpaw). The must was evaluated for physicochemical and microbiological changes during fermentation while the wine was analyzed for physicochemical characteristics, microbiological quality and sensory properties and compared with commercial grape wine. Specific gravity of the “must” during fermentation decreased from 1.059-0.995 for rose red pawpaw and 1.005-0.990 for yellow pawpaw. The sugar content decreased from 13-3% on the 14th day of fermentation for rose red pawpaw while yellow pawpaw “must” decreased from 12.5-3%. pH drop for the yellow pawpaw “must” was 4.7-3.4 on the 14th day and 4.0-3.4 for rose red pawpaw “must”. Titratable acidity of the pawpaw “must” increased from 0.16-0.32% for rose red pawpaw “must” and 0.20-0.52% for yellow pawpaw “must”. Microbial analysis of the “must” during fermentation showed that yeast count increased from no growth to 3.0 × 10^6 cfu/mL for yellow pawpaw must and 4.0 × 10^6 cfu/mL for rose red pawpaw, respectively while total bacterial count decreased from 5.4 × 10^7-l.5 × 10^7 cfu/mL for yellow pawpaw must and 5.2 × 10^7-1.2 × 10^7 cfu/mL for rose red pawpaw “must”. Coliform recorded no growth throughout the period of fermentation. Physicochemical analysis of the wine showed that the yellow pawpaw wine has a specific gravity of 0.999, alcohol content 8.00%, titratable acidity of 0.59%, pH of 3.5 and sugar content of 3%. The rose red pawpaw wine had sugar content of 3%, titratable acidity of 0.38%, alcohol content 7.69%, specific gravity 0.997 and pH of 3.5. Microbial analysis of the wine showed no growth of coliform and yeast while bacterial count was 1.0 × 10^6 cfu/mL for both wines. Sensory results for the pawpaw wine showed no significant (p > 0.05) difference in the clarity and overall acceptability from the commercial wine.

关键词： Red rose yellow pawpaw table wine.

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前瞻性城市儿童出生队列研究--交通源黑碳暴露与注意力之间的相关性

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环境与职业医学 2014年第3期31卷 234-238页

作者： Yueh-Hsiu Mathilda Chiu david C.Bellinger Brent A.Coull Shawn Anderson Rachel barber Robert O.Wright Rosalind J.Wright 王晓宇张伊人汪源金泰廙 Department of Pediatrics Icahn School of Medicine at Mount Sinai Children’s Hospital Boston Department of Environmental Health Harvard School of Public Health Department of Biostatistics Harvard School of Public Health Channing Laboratory Brigham and Women’s Hospital & Harvard Medical School Department of Preventive Medicine Icahn School of Medicine at Mount Sinai Mindich Child Health and Development Institute Icahn School of Medicine at Mount Sinai

[背景]环境空气污染可能对儿童具有神经毒性作用。但目前尚缺乏交通源空气污染与注意力之间相关性的研究数据。[目的]在一项位于马萨诸塞州波士顿地区的出生队列研究中，研究黑碳（BC，一种交通颗粒标志物）与174名7-14岁儿童注意力测... 详细信息

[背景]环境空气污染可能对儿童具有神经毒性作用。但目前尚缺乏交通源空气污染与注意力之间相关性的研究数据。[目的]在一项位于马萨诸塞州波士顿地区的出生队列研究中，研究黑碳（BC，一种交通颗粒标志物）与174名7-14岁儿童注意力测量结果之间的相关性。[方法]根据儿童生活的住所，采用经验证的空间时间土地利用回归模型估计BC水平。采用Conners连续作业测试（CPT）测量儿童的遗漏错误、执行错误和命中反应时间（HRT），分数越高表示错误越多或反应时间越长。使用多变量调整线性回归分析检测BC与各注意力结果之间相关性。[结果]队列中的儿童主要为西班牙裔（56％）和高加索裔（41％），53％为男童。以儿童的智商（IQ）、年龄、性别、血铅水平、母亲的教育程度、产前和产后烟草烟雾暴露以及社区水平的社会压力进行调整后发现，较高水平BC与执行错误增加及HRT较长之间存在正相关。值得注意的是，相对于中间的两个四分位数范围，在最高BC四分位数范围中这一相关性较弱，尽管仍是正性的。性别分层分析显示，在男童中BC-9执行错误和HRT两者均呈统计学显著相关，但在女童中BC与任何CPT结果均无显著相关性。[结论]在这一城市儿童人群中，BC暴露与更多的过失错误和较长的反应时间之间存在相关性。总体而言，这些相关性在男童中比女童中更为显著。

关键词：注意力儿童 Conners连续作业测试命中反应时间交通源空气污染城市

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《李修善:传教士与圣徒》节译

长江文史论丛

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长江文史论丛 2023年第1期 199-219页

作者： W.T.A.barber 陈雅颀(译) 陈新立(校) 不详湖北省社会科学院文史研究所

李修善(david Hlli),1840年出生在英格兰约克郡(York)的一个基督徒家庭。1865年,李修善受英国循道公会(Wesleyan Mthodist Mssionareiy Society)派遣,前往中国湖北省武汉传教。李修善在华31年,其中大部分时间都在湖北省度过,19世纪60至9... 详细信息

李修善(david Hlli),1840年出生在英格兰约克郡(York)的一个基督徒家庭。1865年,李修善受英国循道公会(Wesleyan Mthodist Mssionareiy Society)派遣,前往中国湖北省武汉传教。李修善在华31年,其中大部分时间都在湖北省度过,19世纪60至90年代,曾先后在汉口、武昌、武穴、广济等地从事传教工作。

关键词：循道公会广济基督徒传教士修善圣徒约克郡英格兰

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Prosecution records reveal pangolin trading networks in China, 2014–2019

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Zoological Research 2021年第5期42卷 666-670页

作者： Xiang-Qin Huang Chris Newman Christina D.Buesching Mei-Ling Shao Yun-Chun Ye Sha Liu david W.Macdonald Zhao-Min Zhou Key Laboratory of Southwest China Wildlife Resources Conservation(Ministry of Education) China West Normal UniversityNanchongSichuan 637002China Wildlife Conservation Research Unit The Recanati-Kaplan CentreDepartment of ZoologyUniversity of OxfordOxford OX135QLUK Cook’s Lake Farming Forestry and Wildlife Inc.(Ecological Consultancy)Queens CountyNova Scotia B0J 2H0Canada Department of Biology Irving K.Barber Faculty of ScienceThe University of British Columbia/OkanaganKelownaBC V1V 1V7Canada Key Laboratory of Environmental Science and Biodiversity Conservation(Sichuan Province) China West Normal UniversityNanchongSichuan 637002China

In a precautionary response to the current coronavirus(COVID-19)pandemic,China’s Ministries permanently banned eating and trading in terrestrial wild(non-livestock)animals on 24 February 2020,and extensively updated the list of Fauna under Special State Protection(LFSSP)in 2020 and 2021,in which pangolins(Manidae spp.)were upgraded to the highest protection *** 509 pangolin prosecution records from China Judgements online prior to these changes(01/01/14–31/12/19),we identified that Guangdong,Guangxi and Yunnan Provinces were hotspots for trade in whole pangolins and their scales.

关键词： trading networks mining

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Author Correction: Disrupted Ca2+ homeostasis and immunodeficiency in patients with functional IP3 receptor subtype 3 defects

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Cellular & Molecular Immunology 2023年第1期20卷 114-114页

作者： Julika Neumann Erika Van Nieuwenhove Lara E.Terry Frederik Staels Taylor R.Knebel Kirsten Welkenhuyzen Kourosh Ahmadzadeh Mariah R.Baker Margaux Gerbaux Mathijs Willemsen John S.barber Irina I.Serysheva Liesbeth De Waele François Vermeulen Susan Schlenner Isabelle Meyts david I.Yule Geert Bultynck Rik Schrijvers Stephanie Humblet-Baron Adrian Liston VIB Center for Brain and Disease Research Leuven Belgium Department of Microbiology and Immunology KU Leuven Leuven Belgium UZ Leuven Leuven Belgium Immunology Programme The Babraham Institute Babraham Research Campus Cambridge CB22 3AT UK Pediatric Department Academic Children Hospital Queen Fabiola Université Libre de Bruxelles Brussels Belgium Laboratory for Inborn Errors of Immunity Department of Immunology and Microbiology KU Leuven Leuven Belgium Laboratory for Allergy and Clinical Immunology and Immunogenetics Research Group Department of Microbiology Immunology and Transplantation KU Leuven Leuven Belgium Department of Pharmacology and Physiology University of Rochester Rochester NY 14526 USA Laboratory of Molecular and Cellular Signaling Department of Cellular and Molecular Medicine Leuven Kankerinstituut KU Leuven Leuven Belgium Laboratory of Immunobiology Department Microbiology and Immunology Rega Institute KU Leuven Leuven Belgium Department of Biochemistry and Molecular Biology Structural Biology Imaging Center McGovern Medical School at The University of Texas Health Science Center at Houston Houston TX 77030 USA Department of Pediatric Neurology University Hospitals Leuven Leuven Belgium Department of Pulmonology University Hospitals Leuven Leuven Belgium

In this article the statement in the Acknowledgements section was incorrectly given as “MRB and IIS are supported by the NIH R01GM080139 grant (to IIS), the Welch Foundation Research Grant AU-2014-20190331 (to IIS), and the American Heart Association grant 18CDA34110086 (to MRB)” and should have been, “MRB and IIS are supported by the NIH R01GM072804 grant (to IIS), the Welch Foundation Research Grant AU-2014-20190331 (to IIS), and the American Heart Association grant 18CDA34110086 (to MRB).”

关键词： IIS statement knowledge

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Disrupted Ca^(2+) h homeostasis and immunodeficiency in patients with functional IP_(3) receptor subtype 3 defects

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Cellular & Molecular Immunology 2023年第1期20卷 11-25页

作者： Julika Neumann Erika Van Nieuwenhove Lara E.Terry Frederik Staels Taylor R.Knebel Kirsten Welkenhuyzen Kourosh Ahmadzadeh Mariah R.Baker Margaux Gerbaux Mathijs Willemsen John S.barber Irina I.Serysheva Liesbeth De Waele François Vermeulen Susan Schlenner Isabelle Meyts david IYule Geert Bultynck Rik Schrijvers Stephanie Humblet-Baron Adrian Liston VIB Center for Brain and Disease Research LeuvenBelgium Department of Microbiology and Immunology KU LeuvenLeuvenBelgium UZ Leuven LeuvenBelgium Department of Pharmacology and Physiology University of RochesterRochesterNY14526USA Laboratory of Molecular and Cellular Signaling Department of Cellular and Molecular MedicineLeuven KankerinstituutKU LeuvenLeuvenBelgium Laboratory of Immunobiology Department Microbiology and ImmunologyRega InstituteKU LeuvenLeuvenBelgium Department of Biochemistry and Molecular Biology Structural Biology Imaging CenterMcGovern Medical School at The University of Texas Health Science Center at HoustonHoustonTX77030USA Pediatric Department Academic Children Hospital Queen FabiolaUniversitéLibre de BruxellesBrusselsBelgium Department of Pediatric Neurology University Hospitals LeuvenLeuvenBelgium Department of Pulmonology University Hospitals LeuvenLeuvenBelgium Laboratory for Inborn Errors of Immunity Department of Immunology and MicrobiologyKU LeuvenLeuvenBelgium Laboratory for Allergy and Clinical Immunology and Immunogenetics Research Group Department of MicrobiologyImmunology and TransplantationKU LeuvenLeuvenBelgium Immunology Programme The Babraham InstituteBabraham Research CampusCambridgeCB223ATUK

Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca^(2+)) entry resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IP_(3)R), a homo- or heterotetramer of the IP_(3)R1-3 isoforms, amplifies lymphocyte signaling by releasing Ca^(2+) from endoplasmic reticulum stores following antigen stimulation. Although knockout of all IP_(3)R isoforms in mice causes immunodeficiency, the seeming redundancy of the isoforms is thought to explain the absence of variants in human immunodeficiency. In this study, we identified compound heterozygous variants of ITPR3 (a gene encoding IP_(3)R subtype 3) in two unrelated Caucasian patients presenting with immunodeficiency. To determine whether ITPR3 variants act in a nonredundant manner and disrupt human immune responses, we characterized the Ca^(2+) signaling capacity, the lymphocyte response, and the clinical phenotype of these patients. We observed disrupted Ca^(2+) signaling in patient-derived fibroblasts and immune cells, with abnormal proliferation and activation responses following T-cell receptor stimulation. Reconstitution of IP_(3)R3 in IP_(3)R knockout cell lines led to the identification of variants as functional hypomorphs that showed reduced ability to discriminate between homeostatic and induced states, validating a genotype–phenotype link. These results demonstrate a functional link between defective endoplasmic reticulum Ca^(2+) channels and immunodeficiency and identify IP_(3)Rs as diagnostic targets for patients with specific inborn errors of immunity. These results also extend the known cause of Ca^(2+)-associated immunodeficiency from store-operated entry to impaired Ca^(2+) mobilization from the endoplasmic reticulum, revealing a broad sensitivity of lymphocytes to genetic defects in Ca^(2+) signaling.

关键词： Primary immunodeficiency Calcium signalling Whole exome sequencing

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狗似主人（英文）

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英语画刊(高中版) 2020年第14期 6-6页

作者： david Robson

如果把十张狗狗的照片和十张主人的照片打乱,你能帮狗狗找到各自的主人吗?Go to any park, and you will see something *** it’s a bearded man with a dog that looks like it went to the same barber, or a sportswoman and her Afghan *** do people choose the dog that looks most like themselves? The answer may give you a new understanding of the connection between us and our four-legged *** Roy at the University of California was one of

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