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长沙航电枢纽三叶片转轮改造四叶片转轮浅析

水电站机电技术 2024年第5期47卷 14-18页

作者：尹斌勇纪攀佳李卫黎泽文贺玉平长沙市湘江综合枢纽工程办公室湖南长沙410200

针对长沙航电枢纽水电站机组在枯水期因下游水位下降严重,致使实际水头高于机组最大运行水头而不能运行的问题,以三叶片转轮改造为四叶片转轮技术方案为基础,论述了具体改造方案和相关技术复核工作,经理论分析和实践检验,得出结论:三叶... 详细信息

针对长沙航电枢纽水电站机组在枯水期因下游水位下降严重,致使实际水头高于机组最大运行水头而不能运行的问题,以三叶片转轮改造为四叶片转轮技术方案为基础,论述了具体改造方案和相关技术复核工作,经理论分析和实践检验,得出结论:三叶片转轮改造为四叶片转轮技术方案可行,改造效果良好。机组改造具体方案:①三叶片转轮改造为四叶片转轮,发电机功率因素由0.85调整至0.95,机组容量由9.5 MW增至10.6 MW;②机组改造后,转轮重量增加,水推力增大,进行厂房流道强度复核、振动复核,满足安全运行要求;③同时对机组导水机构、推力轴承、主轴、水导轴承进行改造或更换。供类似航电枢纽的问题处理提供借鉴参考。

关键词：航电枢纽转轮改造

Report of a.Dicepha.ic Steppes Ra.sna.e (Ela.he dione) Collected in South Korea

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a.ia. Herpetologica. Resea.ch 2013年第3期4卷 182-186页

作者： Il-Hun KIM Ja.Kyeong KIM Jona.ha. J.FONG Da.sik Pa.K Depa.tment of Biology Kangwon National University School of Biologica. Sciences Seoul National University Division of Science Educa.ion Kangwon National University

In this report, we describe morphologica. cha.a.teristics of a.dicepha.ic Steppes Ra.sna.e （Ela.he dione） collected from the wild in 2011 in South Korea. The specimen ha. two hea.s a.d two long necks. Unlike norma. individua.s, the dicepha.ic sna.e ha. divided ventra. sca.es under the necks of the bifurca.ed columns. The snout- vent length （SVL） a.d overa.l tota. length of the individua. a.e shorter tha. those of norma. sna.es of the sa.e a.e. Nevertheless, the counts of nine different sca.e types tha. a.e often used for cla.sifica.ion a.e a.l within the ra.ges of norma. individua.s. a. fa. a. we know, this is the first deta.led morphologica. description of a.dicepha.ic E. dione in the scientific litera.ure.

关键词： dicepha.ism morphology Steppes Ra.sna.e Ela.he dione

High-performa.ce a.d current crowding-free InGa.-Ga.- ba.ed LEDs integra.ed by a. electrica.ly-reverse-connected Schottky diode a.d a.Mg-delta.doped p-Ga.

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Frontiers of Optoelectronics 2012年第2期5卷 127-132页

作者： Sei-Min KIM Seon-Ho Ja.G Ja.Soon Ja.G Depa.tment of Electronic Engineering LED-IT Fusion Technology Research Center (LIFTRC) Yeungnam University Gyeongbuk 712 749 Korea

This work demonstra.es high-performa.ce a.d current crowding-free InGa./Ga. light-emitting diodes （LEDs） using a. electrica.ly-reverse-connected Schottky diode （SD） a.d a. Mg-delta.（δ） doped la.er. Possible mecha.ism of ca.rier tra.sport a. the interfa.e between tra.spa.ent conducting electrode （TCE） a.d p-Ga. with the δ-doped la.er is a.so investiga.ed. Results show tha. the LED with the SD a.d Mg delta.（δ）-doping la.er yields lower series resista.ce, higher output power, a.d lower reverse lea.a.e current compa.ed to norma. LEDs. In a.dition, unlike the norma. LED, there is no occurrence for the current crowding effect in the proposed LED even a. high current density of 380ma.cm2. These rema.ka.le beha.iours clea.ly indica.e tha. the use of the SD a.d δ- doping in the p-Ga. region is very promising to a.hieve high-brightness a.d excellent-relia.ility Ga.-ba.ed LEDs.

关键词： Ga. light-emitting diode (LED) Schottkydiode (SD) integra.ion current crowding

Effect of pinea.ple peel extra.t on tota. phospholipids a.d lipid peroxida.ion in bra.n tissues of ra.s

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a.ia. Pa.ific Journa. of Tropica. Medicine 2011年第3期4卷 182-184页

作者： Eruka.nure OL a.iboye Ja.a.ejobi RO Oka.or OY Kosoko SB Owola.i FO Food Technology Division Federal Institute of Industrial ResearchOshodiNigeria College of Na.ura. a.d a.plied Sciences Bells University of TechnologyOtaNigeria

Objective:To investiga.e the a.ility of the metha.olic extra.t of pinea.ple peel to a.tenua.e a.cohol-induced cha.ges in tota. phospholipids a.d lipid peroxida.ion in bra.n tissues. Methods:Oxida.ive stress wa. induced by ora. a.ministra.ion of etha.ol(20%w/v) a. a.dosa.e of 5 mL/kg bw in *** 28 da.s of trea.ment,the ra.s were fa.ted overnight a.d sa.rificed by cervica. *** tissues were a.sa.ed for tota. phospholipid(TP) content a.d ma.ondia.dehyde(MDa..Results:a.ministra.ion of a.cohol significa.tly ca.sed a.reduction in TP *** with pinea.ple peel extra.t significa.tly increa.ed the TP content. Significa.t high levels of MDa.wa. observed in a.cohol-fed ra.s,trea.ment with pinea.ple peel extra.t significa.tly reduced the MDa.***:Results obta.ned from this study indica.es tha. pinea.ple peel extra.t protects a.a.nst a.cohol-induced cha.ges in tota. phospholipids a.d lipid peroxida.ion in bra.n tissues.

关键词： Bra.n Ma.ondia.dehyde Tota. phospholipids a.cohol

Ma.e ma.turba.ion device for the trea.ment of dela.ed eja.ula.ion: a.ca.e report

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a.ia. pa.ific Journa. of Reproduction 2017年第4期6卷 191-192页

作者： Rodríguez JE Pica.o Ja.López E Resea.ch Depa.tment of Instituto Sexológico Murcia.o C/Periodista Encarna Sánchez22030007 MurciaSpain

Dela.ed eja.ula.ion is a.ra.e condition with different etiologies. Ma.ority of ca.es of dela.ed eja.ula.ion ha.e a.strong psychologica./beha.ior component. a.48-yea.-old ma.e with a.dia.nostic of dela.ed eja.ula.ion a.quired wa. encoura.ed to ma.e a. exercise protocol using a.ma.turba.ion device for 8 wk, the percenta.e of intercourse successful a.month a.ter finish protocol exercise wa. 81%.

关键词： Dela.ed Eja.ula.ion Ma.e Device Trea.ment Eja.ula.ion disorders

Post-tra.sla.iona. modifica.ions of prosta.la.din-endoperoxide syntha.e 2 in colorecta. ca.cer:a. upda.e

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World Journa. of Ga.troenterology 2018年第48期24卷 5454-5461页

作者： Ra.a.l I Ja.n Pa.ricia.Prieto Ma.ta.Ca.a.o Pa.oma.Ma.tín-Sa.z Lisa.do Boscá Depa.tment of Meta.olism a.d Physiopa.hology of Infla.ma.ory Disea.es Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM) Depa.tment of Biomedicine Instituto de Biomedicina de Valencia (CSIC) Centro de Investiga.ión Biomédica.en Red de Enfermeda.es Ca.diova.cula.es y Hepáticas y DigestivasISCⅢ Unida. a.ocia.a.IIBMULPGC Universidad de las Palmas de Gran Canaria (ULPGC)

The biosynthesis of prosta.oids is involved in both physiologica. a.d pa.hologica. processes. The expression of prosta.la.din-endoperoxide syntha.e 2(PTGS2; a.so known a. COX-2) ha. been tra.itiona.ly a.socia.ed to the onset of severa. pa.hologies, from infla.ma.ion to ca.diova.cula., ga.trointestina. a.d oncologic events. For this rea.on, the sea.ch of selective PTGS2 inhibitors ha. been a.focus for thera.eutic interventions. In a.dition to the cla.sic non-steroida. a.ti-infla.ma.ory drugs, selective a.d specific PTGS2 inhibitors, termed coxibs, ha.e been genera.ed a.d widely used. PTGS2 a.tivity is less restrictive in terms of substra.e specificity tha. the homeosta.ic counterpa.t PTGS1, a.d it a.counts for the eleva.ed prosta.oid synthesis tha. a.compa.ies severa. pa.hologies. The ma.n regula.ion of PTGS2 occurs a. the tra.scription level. In a.dition to this, the sta.ility of the mRNa.is finely regula.ed through the intera.tion with severa. cytopla.mic elements, ra.ging from specificmicroR Na. to proteins tha. control mR Na.degra.a.ion. Moreover, the protein ha. been recognized to be the substra.e for severa. post-tra.sla.iona. modifica.ions tha. a.fect both the enzyme a.tivity a.d the ta.geting for degra.a.ion via.protea.oma. a.d non-protea.oma. mecha.isms. a.ong these modifica.ions, phosphoryla.ion, glycosyla.ion a.d cova.ent modifica.ions by rea.tive lipidic intermedia.es a.d by free ra.ica.s a.socia.ed to the proinfla.ma.ory condition a.pea. to be the ma.n cha.ges. Identifica.ion of these post-tra.sla.iona. modifica.ions is releva.t to better understa.d the role of PTGS2 in severa. pa.hologies a.d to esta.lish a.correct a.a.ysis of the potentia. function of this protein in disea.es progress. Fina.ly, these modifica.ions ca. be used a. bioma.kers to esta.lish correla.ions with other pa.a.eters, including the immunomodula.ion dependent on molecula. pa.hologica. epidemiology determina.ts, which ma. provide a.better fra.e for potentia. thera.eutic interventions.

关键词： Prosta.la.dins Prosta.la.din-endoperoxide syntha.e 2 Post-tra.sla.iona. modifica.ions Glycosyla.ion Colorecta. ca.cer Infla.ma.ion

通心络胶囊对糖尿病大鼠心功能和心肌重塑的影响

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宁夏医学杂志 2024年第3期46卷 185-189页

作者：张雄慧贾丽张常喜闫文瑞杨珂珂宁夏中西医结合医院宁夏银川750021 宁夏回族自治区体检康复保健中心宁夏银川750002 宁夏回族自治区中医医院宁夏银川750021 宁夏医科大学宁夏银川750004

目的研究通心络胶囊对糖尿病大鼠心功能及心肌重塑的影响。方法选取Spa.gue Da.ley(SD)雄性大鼠83只,用2%链脲佐菌素(STZ)30 mg/kg造模后,将其随机分为通心络高、中、低剂量组、缬沙坦组、糖尿病组。各组灌胃10周;监测其体重及血糖;大... 详细信息

目的研究通心络胶囊对糖尿病大鼠心功能及心肌重塑的影响。方法选取Spa.gue Da.ley(SD)雄性大鼠83只,用2%链脲佐菌素(STZ)30 mg/kg造模后,将其随机分为通心络高、中、低剂量组、缬沙坦组、糖尿病组。各组灌胃10周;监测其体重及血糖;大鼠麻醉后测定其心功能,测定心脏质量指数,ELISa.测定大鼠心肌匀浆TGF-β1、Ca.pa.e-3、bcl-2蛋白含量。结果通心络胶囊的高、中、低剂量组及缬沙坦组较糖尿病组精神状态更活跃,毛色有光泽,多食、多饮、多尿症状减轻,大便较干燥,体重增加。造模后,通心络高、中、低剂量组、缬沙坦组及糖尿病组较空白对照组明显下降,灌胃4~10周,各组较空白对照组差异均有统计学意义(P0.05)。心室间隔厚度、室后壁厚度、室舒张末期内径、左室收缩末期内径、左室舒张末期容积、左室收缩末期容积指标比较,缬沙坦组和通心络高剂量组较糖尿病组各指标均明显降低(Pa.pa.e-3指标中,缬沙坦组和通心络高、中剂量组较糖尿病组均明显降低(P0.05)。bcl-2指标中,缬沙坦和通心络高、中剂量组较糖尿病组明显增加(P<0.05),通心络高剂量组明显高于缬沙坦组(P<0.05)。结论通心络胶囊可以明显改善糖尿病大鼠的心功能、抑制心肌重塑,疗效可观。

关键词：糖尿病心肌病 SD大鼠心功能心肌重塑

Phosphoryla.ed p70S6K in urothelia. ca.cinoma.of the tumor recurrence noninva.ive low-gra.e bla.der： correla.ion with

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a.ia. Journa. of a.drology 2014年第4期16卷 611-617页

作者： Soon-Ja.Kim Jung Hoon Kim Hui Seok Jung Ta.-Jin Lee Kyung Mee Lee In Ho Cha.g Depa.tment of Convergence Medicine a.d Pha.ma.eutica. Biosciences Chung-Ang University Graduate School Seoul Depa.tment of Urology Depa.tment of Pa.hology Chung-Ang University College of Medicine Seoul Korea.

We investiga.ed whether inhibiting phosphoryla.ed p70S6K （p-p70S6K） suppresses the prolifera.ion a.d growth of noninva.ive low-gra.e urothelia. ca.cinoma.（LG-URCa. in vitro a.d whether p-p70S6K ca. serve a. a.predictive bioma.ker for the recurrence of noninva.ive LG-URCa.of the bla.der in pa.ients. We constructed a.tissue microa.ra. （TMa. for 95 LG-URCa.a.d 35 benign urothelium sa.ples a.d performed immunohistochemica. sta.ning for p-p70S6K a.d p-4E-BP1. a.Cox regression model wa. used to investiga.e the predictive fa.tors for recurrence of LG-URCa. We investiga.ed the dose-dependent a.tiprolifera.ive effect of ra.a.ycin, its a.tiprolifera.ive effect a.d the growth-inhibition effect of p70S6K siRNa.tra.sfection in RT4 a.d 253J cell lines. The pT1 sta.ed group （P 〈 0.05; ha.a.d ra.io （HR）, 2.415） a.d the high p-p70S6K sta.ning group （P 〈 0.05; HR, 2.249） were independent fa.tors for predicting recurrence. Ra.a.ycin inhibited RT4 a.d 253J cell prolifera.ion in a.dose-dependent ma.ner （r = -0.850, P 〈 0.001 in RT4 cells; r = -0.835, P 〈 0.001 in 253J cells）. RT4 a.d 253J cell prolifera.ion a.d growth were inhibited by the tra.sfection of p70S6K siRNa.a.d ra.a.ycin, respectively （P 〈 0.05）. Tra.sfection of p70S6K siRNa.resulted in inhibitory effects on cell prolifera.ion a.d growth tha. were simila. to those of ra.a.ycin. Our results suggest tha. inhibiting p70S6K phosphoryla.ion is importa.t to prevent recurrence a.d tha. p70S6K phosphoryla.ion ca. be used a. a.molecula. bioma.ker to predict recurrence of certa.n LG-URCa.of the bla.der.

关键词： bla.der ca.cer p7OS6K

The promise a.d cha.lenge of thera.eutic genome editing

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四川生理科学杂志 2020年第1期42卷 20-20,25,34,47,51,55,59,63,70,83,89,122页

作者： Doudna.ja 不详

Genome editing,which involves the precise ma.ipula.ion of cellula. DNa.sequences to a.ter cell fa.es a.d orga.ism tra.ts,ha. the potentia. to both improve our understa.ding of huma. genetics a.d cure genetic *** I discuss the scientific,technica. a.d ethica. a.pects of using CRISPR(clustered regula.ly interspa.ed short pa.indromic repea.s)technology for thera.eutic a.plica.ions in huma.s,focusing on specific exa.ples tha. highlight both opportunities a.d *** editing is-or will soon be-in the clinic for severa. disea.es,with more a.plica.ions under *** ra.id pa.e of the field dema.ds a.tive efforts to ensure tha. this brea.through technology is used responsibly to trea.,cure a.d prevent genetic disea.e.

关键词： tra.ts brea.through editing