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牛乳的酸──碱缓冲性能

中国乳品工业 1994年第1期22卷 42-46页

作者： Lucey,Ja.潘文彪

牛乳的酸──碱缓冲性能ＬＵＣＥＹＪ．Ａ．等１前言牛乳的缓冲性能由于在加工过程中控制ＰＨ值而影响牛乳诸多理化性质。从滴定曲线上计算出的牛乳和干酪的缓冲能力已有不少报导。然而，根据所使用的方法所获得的滴定曲线，如往前和往... 详细信息

牛乳的酸──碱缓冲性能ＬＵＣＥＹＪ．Ａ．等１前言牛乳的缓冲性能由于在加工过程中控制ＰＨ值而影响牛乳诸多理化性质。从滴定曲线上计算出的牛乳和干酪的缓冲能力已有不少报导。然而，根据所使用的方法所获得的滴定曲线，如往前和往回滴定的曲线是不一致的（７，８，９...

关键词：牛乳酸碱缓冲性能

Conditioned secretome of a.ipose-derived stem cells improves dextra. sulfa.e sodium-induced colitis in mice

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World Journa. of Ga.troenterology 2021年第23期27卷 3342-3356页

作者： Seunghun Lee Jeonghoon Heo Eun-Kyung a.n Ja. Hyun Kim Young-Ho Kim Hee-Kyung Cha.g Sa.g-Joon Lee Jongsik Kim Seun-Ja.Pa.k Depa.tment of Colorecta. Surgery Kosin University College of MedicineBusan 49267South Korea Depa.tment of Molecula. Biology a.d Immunology Kosin University College of MedicineBusan 49267South Korea Depa.tment of Ga.troenterology Kosin University College of MedicineBusan 49267South Korea Depa.tment of Pa.hology Kosin University College of MedicineBusan 49267South Korea Depa.tment of Ophtha.mology Kosin University College of MedicineBusan 49267South Korea Depa.tment of a.a.omy Kosin University College of MedicineBusan 49267South Korea

Ba.KGROUND Infla.ma.ory bowel disea.es(IBD)is rela.ed to uncontrolled immune ***,there is no successful trea.ment for significa.t improvement in *** cells displa. their thera.eutic effects through their repopula.ing ca.a.ity or secreting *** To investiga.e the effects of conditioned mouse a.ipose-derived stem cells(ma.SCs)secretome on colitis-induced *** ma.SCs were isola.ed from a.ipose tissue of C57BL/6 *** ma.SCs secrectome wa. obta.ned by culturing of ma.SCs with lipopolysa.cha.ides(LPS,1μg/mL)for 24 *** colitis wa. induced by 2%dextra. sulfa.e sodium(DSS)drinking wa.er for 7 d a.d then norma. drinking wa.er for 4 *** mice were trea.ed with norma. culture medium(NM group),conditioned ma.SCs secretome(CM group)or ma.SCs(SC group).The length of colon a.d histopa.holgy of colon tissues were *** mRNa.expression levels of infla.ma.ory cytokines in colon tissue a.d the serum interleukin(IL)-6 levels were *** The isola.ed ma.SCs ma.nta.ned the ma.SCs specific gene expression profiles during *** conditioned ma.SCs secretome relea.ed by the trea.ment of ma.SCs with LPS conta.ned ma.nly infla.ma.ory chemokines,colony-stimula.ing fa.tors a.d infla.ma.ory *** loss of body weight a.d reduction in colon length were a.eliora.ed in the CM *** conditioned ma.SCs secretome reduced the histologica. score in colon *** expression of IL-1b a.d IL-6 mRNa. in colon tissues significa.tly inhibited in the CM group compa.ed to SC group a.d NM group,*** eleva.ion of serum IL-6 levels wa. a.so a.eliora.ed in the CM *** results indica.e tha. the conditioned ma.SCs secretome suppressed the synthesis of infla.ma.ory cytokines in da.a.ed colon tissue a.d the eleva.ion of serum IL-6 concentra.ion in DSS-induced mice CONCLUSION Conditioned ma.SCs secretome might pla. regenera.ive roles by the suppression of IL-6 in serum a.d tissue during a.ute colitis,a.d ma. be

关键词： a.ipose-derived stem cells Conditioned secretome Cytokines Interleukin-6 Colitis Regenera.ion

Meta.olomic a.d tra.scriptomic study to understa.d cha.ges in meta.olic a.d immune responses in steers under hea. stress

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a.ima. Nutrition 2022年第4期11卷 87-101页

作者： Jun Sik Eom Da.Som Pa.k Sa.g Jin Lee Bon-Hee Gu Shin Ja.Lee Sa.g-Suk Lee Seon-Ho Kim Byeong-Woo Kim Sung Sill Lee Myunghoo Kim Institute of a.riculture a.d Life Science Gyeongsang National UniversityJinju52828Republic of Korea Depa.tment of a.ima. Science College of Natural Resources&Life SciencePusan National UniversityMiryang50463Republic of Korea Life a.d Industry Convergence Resea.ch Institute Pusan National UniversityMiryang50463Republic of Korea University-Centered La.s Gyeongsang National UniversityJinju52828Republic of Korea Rumina.t Nutrition a.d a.a.robe La.ora.ory Department of Animal Science and TechnologySunchon National UniversitySuncheon57922Republic of Korea Division of a.plied Life Science(BK21) Gyeongsang National UniversityJinju52828Republic of Korea

Hea. stress(HS)da.a.es livestock by a.versely a.fecting physiologica. a.d immunologica. ***,funda.enta. understa.ding of the meta.olic a.d immunologica. mecha.isms in a.ima.s under HS rema.ns elusive,pa.ticula.ly in *** understa.d the cha.ges on meta.olic a.d immune responses in steers under HS condition,we performed RNa.sequencing a.d proton nuclea. ma.netic resona.ce spectroscopy-ba.ed meta.olomics on HS-free(tempera.ure humidity index[THI]va.ue:64.92±0.56)a.d HS-exposed(THI va.ue:79.13±0.56)Jersey steer(n=8,body weight:559.67±32.72 kg).This study cla.ifies the meta.olic cha.ges in 3 biofluids(rumen fluid,serum,a.d urine)a.d the immune responses observed in the periphera. blood mononuclea. cells of HS-exposed *** integra.ed a.proa.h a.lowed the discovery of HS-sensitive meta.olic a.d immunologica. *** meta.olomic a.a.ysis indica.ed tha. HS-exposed steers showed potentia. HS bioma.kers such a. isocitra.e,forma.e,crea.ine,a.d ribofla.in(Pa.ong them,there were severa. integra.ive meta.olic pa.hwa.s between rumen fluid a.d ***,HS a.tered mRNa.expression a.d immune-rela.ed signa.ing pa.hwa.s.a.meta.a.a.ysis revea.ed tha. HS decrea.ed ribofla.in meta.olism a.d the expression of glyoxyla.e a.d dica.boxyla.e meta.olism-rela.ed ***,meta.olic pa.hwa.s,such a. the hypoxia.inducible fa.tor-1 signa.ing pa.hwa.,were downregula.ed in immune cells by HS(Pa.ong with the da.a.ets of pa.hwa.s a.d phenotypic differences a. potentia. bioma.kers in steers,ca. support more in-depth resea.ch to elucida.e the interrela.ed meta.olic a.d immunologica. *** would help suggest new stra.egies to a.eliora.e the effects of HS,including disea.e susceptibility a.d meta.olic disorders,in Jersey steers.

关键词： Hea. stress Jersey steer Meta.olome Tra.scriptome Immunity Meta.olism

Optima. postopera.ive surveilla.ce stra.egies for sta.e III colorecta. ca.cer

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World Journa. of Ga.trointestina. Surgery 2021年第9期13卷 1012-1024页

作者： Min Young Pa.k In Ja.Pa.k Hyo Seon Ryu Ja. Jung Minsung Kim Seok-Byung Lim Cha.g Sik Yu Jin Cheon Kim Colon a.d Recta. Surgery Asan Medical CenterSeoul 05505South Korea Colon a.d Recta. Surgery Asan Medical Center and University of Ulsan College of MedicineSeoul 05505South Korea

Ba.KGROUND Optima. surveilla.ce stra.egies for sta.e III colorecta. ca.cer(CRC)a.e la.king,a.d intensive surveilla.ce ha. not conferred a.significa.t surviva. *** To exa.ine the a.socia.ion between surveilla.ce intensity a.d recurrence a.d surviva. ra.es in pa.ients with sta.e III *** Da.a.from pa.ients with pa.hologic sta.e III CRC who underwent ra.ica. surgery between Ja.ua.y 2005 a.d December 2012 a. a.a. Medica. Center,Seoul,Korea.were retrospectively *** consisted of a.dominopelvic computed tomogra.hy(CT)every 6 mo a.d chest CT a.nua.ly during the 5 yea. follow-up period,resulting in a. a.era.e of three ima.ing studies per *** who underwent more tha. the a.era.e number of ima.ing studies a.nua.ly were ca.egorized a. high intensity(HI),a.d those with less tha. the a.era.e were ca.egorized a. low intensity(LI).RESULTS a.ong 1888 pa.ients,864(45.8%)were in HI ***,sex,a.d loca.ion were not different between *** group ha. more a.va.ced T a.d N sta.e(P=0.002,0.010,ea.h).Perineura. inva.ion(PNI)wa. more identified in the HI group(21.4%vs 30.3%,Pa. overa.l surviva.(OS)a.d recurrence-free interva.(RFI)wa. longer in the LI group(Pa.h).Multiva.ia.e a.a.ysis indica.ed tha. surveilla.ce intensity[odds ra.io(OR)=1.999;95%confidence interva.(CI):1.680–2.377;Pa.hologic T sta.e(OR=1.596;95%CI:1.197–2.127;P=0.001),PNI(OR=1.431;95%CI:1.192–1.719;Pa.d circumferentia. resection ma.gin(OR=1.565;95%CI:1.083–2.262;P=0.017)in recta. ca.cer were significa.tly a.socia.ed with *** mea. post-recurrence surviva.(PRS)wa. longer in pa.ients who received cura.ive resection(Pa.ive resection ra.e of recurrence wa. not different between HI(29.3%)a.d LI(23.8%)groups(P=0.160).PRS did not differ a.cording to surveilla.ce intensity(P=0.802).CONCLUSION Frequent surveilla.ce with CT sca. do not improve OS in sta.e III CRC *** need to eva.ua.e role of other surveilla.ce method ra.her tha

关键词： Colorecta. ca.cer Surveilla.ce intensity Surviva. Recurrence

Successful outcome following resection of a.pa.crea.ic liposa.coma.with solita.y meta.ta.is

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World Journa. of Ga.troenterology 2005年第48期11卷 7684-7685页

作者： IM Dodo Ja.a.a.thwa.te P Ja.n a.Roy PJ Guillou KV Menon Depa.tment of a.a.emic Surgery

Liposa.coma. a.e ra.e soft tissue tumors, commonly a.fecting the lower limbs a.d less commonly the retroperitoneum. a.though other orga.s ca. be a.fected,the pa.crea. is one of the ra.est, a.d meta.ta.is a. presenta.ion ha. never been reported. We describe the ca.e of a.76-yea.-old gentlema. presenting with a.domina. pa.n a.d a. a.domina. ma.s. Ima.ing confirmed a.prima.y tumor in the body a.d ta.l of the pa.crea., with a.meta.ta.ic deposit in the mesentery a.ja.ent to the second pa.t of the duodenum. Biopsy confirmed a.liposa.coma. a.d subsequently a.complete surgica. excision wa. a.hieved. He then received a.juva.t ra.iothera.y a.d ha. rema.ned disea.e free for the next 26 mo.

关键词： Pa.crea. Liposa.coma Meta.ta.is

Entomopa.hogenic fungi isola.ed from Yukon soil a.a.nst unfed la.va. of the winter tick,Derma.entor a.bipictus

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Studies in Fungi 2019年第1期4卷 123-134页

作者： Dobrotka.CJ Krieger M Oa.ley M Trotter J Rodell BM Stein KL Klever La.Fisher Ka.Yoder ja Depa.tment of Biology Wittenberg UniversitySpringfieldOH45501USA Cha.pa.ne a.d a.shihik First Na.ions Haines JunctionYTY0B 1L0CAN Oa.ley Veterina.y Services HainesAK99827USA

Funga. composition of Yukon soil sa.ples consisted of 29 soil sa.robes common to a.idified forest,suba.ctic *** of the fungi identified a.e psychrotrophs,ca.a.le of growth a. both 4℃ a.d 20℃.Of these,a.tota. of 17 fungi were found to be entomopa.hogenic by winter tick(Derma.entor a.bipictus)la.va. bioa.sa.s:a.pergillus fla.us,Bea.veria.na.ely ***,Mucor,Pa.cilomyces yielded>~70%la.va. morta.ity a.d the rema.nder,mostly Mortierella.a.d Penicillium,a.era.ed~40%la.va. *** where elk(Cervus ela.hus ca.a.ensis)a.e observed ha. a. overa.l grea.er qua.tity,a.d diversity of entomopa.hogenic soil fungi tha. sites where elk a.e not *** diversity of fungi a. elk-inha.ited sites is likely a.product of wa.mer soil microclima.e(hillsides where elk a.e seen,lose snow ea.lier tha. other a.ea.),a.ima. presence,a.d increa.ed nutrient *** conclude tha. Yukon soils conta.n fungi tha. na.ura.ly regula.e popula.ions of *** fungi a.e a.chived a. the Wittenberg University Fungus Collection,Springfield,OH,USa.

关键词： Biologica. control mycoflora moose tick elk tick horse tick Ca.a.a a.a.ka

a.e a.e, a.thropometry a.d components of meta.olic syndrome-risk fa.tors interrela.ed with lower urina.y tra.t symptoms in pa.ients with erectile dysfunction？ a.prospective study

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a.ia. Journa. of a.drology 2007年第2期9卷 213-220页

作者： Ja.-Seung Pa.ck Ji-Hyun Ya.g Soo-Woong Kim Ja.Hyeon Ku Depa.tment of Urology Seoul National University College of Medicine Seoul 111744 Korea Depa.tment of Urology Seoul Veterans Hospital Seoul 134791 Korea

a.m： To eva.ua.e the effects of meta.olic profiles on lower urina.y tra.t symptoms （LUTS） in men with erectile dysfunction （ED）. Methods： a.tota. of 75 impotent men a.ed 25-75 yea.s old （mea. 58.1 yea.s） were included in the study on a.prospective ba.is. Pa.ients were eva.ua.ed with a.complete history, physica. exa.ina.ion, a.thropometry a.d meta.olic profiles. LUTS were a.sessed using the Interna.iona. Prosta.e Symptom Score （IPSS）. Results： Overa.l, there wa. no correla.ion between the IPSS a.d continuous pa.a.eters. However, when continuous va.ia.les were ca.egorized, some pa.a.eters were significa.tly a.socia.ed with LUTS. Pa.ients with triglyceride level of 150 mg/dL or higher ha. more severe symptoms tha. those with tiglyceride levels less tha. 150 mg/dL （19.4±2.4 vs. 14.3±1.1, P = 0.033）. When 40 mg/dL wa. chosen a. the high-density lipoprotein （HDL）-cholesterol cut-off level, the IPSS wa. significa.tly different between the two groups divided by 40 mg/dL （19.4±2.6 for HDL-cholesterol 〈 40 mg/dL vs. 14.4±1.0 for HDL-cholesterol 2 40 mg/dL, P = 0.042）. The a.ea.under the receiver opera.ing cha.a.teristic curve （a.ROCC） of triglyceride wa. 65.7% （95% confidence interva. [CI], 52.6%-82.3%; P = 0.034） for severe LUTS. However, the a.ROCC for ＇HDL-cholesterol＇ wa. not significa.t （a.ea. 65.4%; 95% CI, 48.2%-82.7%; P = 0.062）. No other fa.tors were determined to be significa.t in this rega.d. Conclusion： The results of the present study indica.e tha. some meta.olic profiles might influence LUTS in men with ED.

关键词： lower urina.y tra.t symptoms erectile dysfunction meta.olic syndrome body ma.s index testosterone

a.sessment of colon polyp morphology: Is educa.ion effective?

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World Journa. of Ga.troenterology 2017年第34期23卷 6281-6286页

作者： Ja. Hyun Kim Kyoung Sik Na. Hye Jung Kwon Youn Jung Choi Kyoungwon Jung Sung Eun Kim Won Moon Moo In Pa.k Seun Ja.Pa.k Division of Ga.troenterology Department of Internal MedicineKosin University College of Medicine

a.M To determine the inter-observer va.ia.ility for colon polyp morphology a.d to identify whether educa.ion ca. improve a.reement a.ong *** For purposes of the tests, we recorded colonoscopy video clips tha. included scenes visua.izing the polyps. a.tota. of 15 endoscopists a.d 15 nurses pa.ticipa.ed in the study. Pa.ticipa.ts wa.ched 60 video clips of the polyp morphology scenes a.d then estima.ed polyp morphology(pre-test). a.ter educa.ion for 20 min, pa.ticipa.ts performed a.second test in which the order of 60 video clips wa. cha.ged(post-test). To determine if the effectiveness of educa.ion wa. susta.ned, four months la.er, a.third, follow-up test wa. performed with the sa.e *** The overa.l Fleiss' ka.pa.va.ue of the inter-observer a.reement wa. 0.510 in the pre-test, 0.618 in the post-test, a.d 0.580 in the follow-up test. The overa.l dia.nostic a.cura.y of the estima.ion for polyp morphology in the pre-, post-, a.d follow-up tests wa. 0.662, 0.797, a.d 0.761, respectively. a.ter educa.ion, the inter-observer a.reement a.d dia.nostic a.cura.y of a.l pa.ticipa.ts improved. However, a.ter four months, the inter-observer a.reement a.d dia.nostic a.cura.y of expert groups were ma.kedly decrea.ed, a.d those of beginner a.d nurse groups rema.ned simila. to pre-test levels. CONCLUSION The educa.ion progra. used in this study ca. improve inter-observer a.reement a.d dia.nostic a.cura.y in a.sessing the morphology of colon polyps; it is especia.ly effective when first lea.ning endoscopy.

关键词： Colon polyp Morphology Educa.ion

以《联合国海洋法公约》促进海洋及其资源的养护和可持续利用

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太平洋学报 2022年第8期30卷 96-98页

作者：贾宇自然资源部海洋发展战略研究所北京100860

《联合国海洋法公约》(以下简称《公约》)在确立现代国际海洋法律制度的基本框架、维护全球和地区海洋秩序等方面发挥了重要作用。《公约》兼容其他国际法规则,有效顾及各种利益诉求,确认并丰富了可持续发展的重要理念。促进联合国可持... 详细信息

《联合国海洋法公约》(以下简称《公约》)在确立现代国际海洋法律制度的基本框架、维护全球和地区海洋秩序等方面发挥了重要作用。《公约》兼容其他国际法规则,有效顾及各种利益诉求,确认并丰富了可持续发展的重要理念。促进联合国可持续发展目标14所涉各领域工作,提升海洋及其资源的养护和可持续利用,应坚定维护以国际法为基础的国际秩序,全面、准确、善意地解释和适用《公约》,深化各领域务实合作。中国为落实《公约》制度框架,加强海洋污染的源头治理,实现养护和可持续利用海洋及其资源的平衡等方面做出了不懈的努力。

关键词：海洋大会《联合国海洋法公约》可持续发展目标