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A vaccination model for COVID-19 in Gauteng,South Africa

Infectious Disease Modelling 2022年第3期7卷 333-345页

作者： Christina J.Edholm Benjamin Levy lee Spence Folashade B.Agusto Faraimunashe Chirove C.Williams Chukwu david Goldsman Moatlhodi Kgosimore Innocent Maposa K.A.Jane White Suzanne Lenhart Department of Mathematics Scripps CollegeClaremontCAUSA Mathematics Department Fitchburg State UniversityFitchburgMAUSA Department of Mathematics University of TennesseeKnoxvilleTNUSA Department of Ecology and Evolutionary Biology University of KansasLawrenceKSUSA Department of Mathematics and Applied Mathematics University of JohannesburgSouth Africa H.Milton Stewart School of Industrial and Systems Engineering Georgia Institute of TechnologyAtlantaGAUSA Biometry and Mathematics Department Botswana University of Agriculture and Natural ResourcesGaboroneBotswana Division of Epidemiology and Biostatistics School of Public HealthFaculty of Health SciencesUniversity of the WitwatersrandJohannesburgSouth Africa Department of Mathematical Sciences University of BathBathUK

The COVID-19 pandemic provides an opportunity to explore the impact of government mandates on movement restrictions and non-pharmaceutical interventions on a novel infection,and we investigate these strategies in early-stage outbreak *** rate of disease spread in South Africa varied over time as individuals changed behavior in response to the ongoing pandemic and to changing government *** a system of ordinary differential equations,we model the outbreak in the province of Gauteng,assuming that several parameters vary over *** data from the time period before vaccination gives the approximate dates of parameter changes,and those dates are linked to government *** parameters are then estimated from available case data and used to assess the impact of each *** forward in time,possible scenarios give projections involving the implementation of two different vaccines at varying *** results quantify the impact of different government policies and demonstrate how vaccinations can alter infection spread.

关键词： COVID-19 Gauteng South Africa ODE epidemiology Model Vaccination Parameter estimation

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利用Cryo-SEM和图像处理技术评价老化和再生沥青低温抗裂性的新方法

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中外公路 2018年第5期38卷 203-208页

作者：冯新军陈旺 Ali Mokhtari Hosin david lee R.Christopher Williams 长沙理工大学道路结构与材料交通行业重点实验室湖南长沙410004 长沙理工大学交通运输工程学院

高掺量RAP沥青混合料的低温抗裂性是一个受到关注的问题,以前的研究中常使用各种再生剂使温度裂缝的数量达到最小。该文采用傅里叶变换红外光谱测定沥青的氧化程度。为了评价老化沥青和再生沥青的低温抗裂性,首先采用低温扫描电镜(CryoS... 详细信息

高掺量RAP沥青混合料的低温抗裂性是一个受到关注的问题,以前的研究中常使用各种再生剂使温度裂缝的数量达到最小。该文采用傅里叶变换红外光谱测定沥青的氧化程度。为了评价老化沥青和再生沥青的低温抗裂性,首先采用低温扫描电镜(CryoSEM)获取断裂表面的图像,然后使用图像处理技术分析Cryo-SEM图像,结合再生沥青产生的断裂面比老化沥青少。最后根据断裂指数对每种沥青的低温抗裂性进行排序。采用Cryo-SEM技术结合图像处理技术可以更加形象地观察沥青断裂表面,而且可以通过计算断裂指数来评价沥青的低温抗裂性。

关键词：老化沥青再生剂低温扫描电镜断裂表面数字图像处理显微分析

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互联网与恐怖主义的“生死劫” 003

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电脑报

作者： david lee

“我正在为‘伊斯兰国’招募战士。” “可是我并不想去叙利亚。” “但你在这里将独一无二，嫁给我，你会成为我的女王。” 这不是小说中的情节，而是“伊斯兰国”（ISIS）通过社交软件Skype的一次招募。女主角是法国女记者Anna Erelle...

“我正在为‘伊斯兰国’招募战士。” “可是我并不想去叙利亚。” “但你在这里将独一无二，嫁给我，你会成为我的女王。” 这不是小说中的情节，而是“伊斯兰国”（ISIS）通过社交软件Skype的一次招募。女主角是法国女记者Anna Erelle(笔名)，她?

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错误印象

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空中英语教室（高级版．彭蒙惠英语） 2019年第4期 30-31页

作者： Wendy lee david Pierson 不详

In the darkened Wiltern Theatre, hundreds of people couldn't wait to see legendary rocker Roy Orbison. A live orchestra pumped up the crowd with a medley of his hits. Old photos of him flashed across a giant screen.

关键词：摇滚音乐

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Keeping an eye on the diabetic foot: The connection between diabetic eye disease and wound healing in the lower extremity

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World Journal of Diabetes 2022年第12期13卷 1035-1048页

作者： david J Ramsey James T Kwan Arjun Sharma Department of Ophthalmology Lahey Hospital and Medical CenterBurlingtonMA 01805United States Department of Ophthalmology Tufts University School of MedicineBostonMA 02111United States

Diabetic eye disease is strongly associated with the development of diabetic foot ulcers(DFUs).DFUs are a common and significant complication of diabetes mellitus(DM)that arise from a combination of micro-and macrovascular *** and associated metabolic dysfunction in DM lead to impaired wound healing,immune dysregulation,peripheral vascular disease,and diabetic neuropathy that predisposes the lower extremities to repetitive injury and progressive tissue damage that may ultimately necessitate *** retinopathy(DR)is caused by cumulative damage to the retinal microvasculature from hyperglycemia and other diabetes-associated *** severity of DR is closely associated with the development of DFUs and the need for lower extremity revascularization procedures and/or *** the lower extremity,the eye may also suffer end-organ damage from macrovascular compromise in the form of cranial neuropathies that impair its motility,cause optic neuropathy,or result in partial or complete ***,poor perfusion of the eye can cause ischemic retinopathy leading to the development of proliferative diabetic retinopathy or neovascular glaucoma,both serious,visionthreatening ***,diabetic corneal ulcers and DFUs share many aspects of impaired wound healing resulting from neurovascular,sensory,and immunologic ***,alterations in serum biomarkers,such as hemoglobin A1c,ceruloplasmin,creatinine,low-density lipoprotein,and highdensity lipoprotein,are associated with both DR and *** these parameters can aid in prognosticating long-term outcomes and shed light on shared pathogenic mechanisms that lead to end-organ *** frequent cooccurrence of diabetic eye and foot problems mandate that patients affected by either condition undergo reciprocal comprehensive eye and foot evaluations in addition to optimizing diabetes management.

关键词： Foot ulcer Diabetic Wound healing Diabetes complications Amputation Diabetic retinopathy Corneal ulcer

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Progressive trends in timing and imaging of lower extremity reconstruction

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Plastic and Aesthetic Research 2019年第12期6卷 26-36页

作者： Andrew Y.Zhang david Cholok Gordon K.lee Department of Plastic Surgery University of Texas Southwestern Medical CenterDallasTXUSA Division of Plastic and Reconstructive Surgery Stanford UniversityPalo AltoCAUSA

The salvage of mangled lower-extremities after severe injury remains a daunting operative dilemma,but one that continues to evolve with advances in microsurgical and orthopedic ***,trends in clinical practice including the decision to salvage and timing of soft-tissue coverage are changing in concordance with improvements in wound care,flap selection for soft-tissue provision,and preoperative *** to these improvements,more complex wounds are increasingly eligible for *** remains unclear,however,whether success in limb salvage confers improved functional patient *** present a review of the literature tracing recent advances in the salvage of mangled extremities following traumatic injury,with a focus on practice trends regarding timing of reconstruction,operative approaches,and preoperative imaging.

关键词： Lower extremity reconstruction propeller flaps amputation microsurgery trauma

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Evaluation of Guardrail Posts Installed in Asphalt Mow Strips by Static Finite Element Simulation

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Open Journal of Civil Engineering 2017年第1期7卷 141-164页

作者： Esmaeel Bakhtiary Seo-Hun lee david W. Scott Lauren K. Stewart Donald W. White School of Civil and Environmental Engineering Georgia Institute of Technology Atlanta USA

Asphalt mow strips are typically used as vegetation barriers around guardrail posts in the design of roadside safety structures. Asphalt mow strips have historically been modeled as a rigid layer in simulations;this assumption results in significant ground level restraint on the guardrail post. However, experiments have shown that asphalt rupture should be considered in the analysis of the response of guardrail posts embedded in mow strips. The present study investigates the effect of asphalt material properties and mow strip geometry on guardrail post performance using finite element simulations. Numerical simulations are performed and correlated with results from static experiments and material testing. The test simulations and experimental results are used to evaluate the response of guardrail posts with various mow strip designs to predict the level of restraint from the asphalt layer. The model is then used to investigate the effects of asphalt material properties and mow strip geometry on the overall performance of the system. The results demonstrate that including asphalt rupture in numerical simulations is essential in accurately predicting the behavior of guardrail posts installed in asphalt mow strips. In addition, mow strip geometry along with asphalt material properties significantly affect the guardrail post response.

关键词： Guardrail Posts Asphalt Mow Strips LS-DYNA Finite Element Simulations Roadway Safety

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应用中国商环包皮环切手术标准化方案对328例成年男性包皮环切的临床报告

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中华男科学杂志 2009年第7期15卷 584-592页

作者：程跃彭弋峰刘毅东田龙吕年青苏新军严泽军胡嘉盛 Richard lee Howard KIM david C. SOKAL 李石华宁波大学医学院附属宁波市第一医院泌尿中心浙江宁波315010 皖南医学院弋矶山医院性医学科安徽芜湖241001 上海交通大学医学院附属仁济医院泌尿科上海200127 首都医科大学附属北京朝阳医院泌尿科北京100034 江苏省计划生育科学技术研究所江苏南京210036 Center for Male Reproductive Medicine and Microsurgery Cornell Institute for Reproductive MedicineDepartment of UrologyThe New York Presbyterian HospitalWeill Medical College of Cornell UniversityNew YorkNY 10065-4870USA Family Health International Research Triangle ParkNC 27709USA

目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环... 详细信息

目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环切手术标准化和培训制度,便于临床医生和相关医护人员学习和掌握包皮环切器的临床应用技巧,以中国商环(简称"商环,ShangRing")包皮环切技术为例,根据商环的技术特点和临床实践经验,特别制订了商环包皮环切手术标准化方案,并将其标准化操作运用于临床。方法:采用商环包皮环切手术标准化方案对328例受术者(年龄18～58岁,平均27.8岁;已婚134例,未婚194例;包茎25例,包皮过长303例)进行包皮环切手术。对手术时间、疼痛评分(视觉模拟评分法,VAS)、术后并发症、包皮创口愈合时间、术后外观满意情况进行观察和随访。结果:手术时间为(4.70±1.31)min。手术时受术者疼痛(VAS)评分为(0.24±0.59)分,术后24h疼痛评分为(1.59±0.95)分,去环前24h内疼痛评分(1.72±1.11)分,去环时疼痛评分为(2.72±1.37)分。主要并发症发生率为术后感染0.6%(2/328)、出血0.6%(2/328)、伤口裂开0.6%(2/328)和水肿4.89%(16/328)。在发生出血和伤口裂开的受术者中无1例需要缝合。术后包皮创口完全愈合时间为(20.30±6.69)d。受术者对术后外观满意率99.7%(327/328)。结论:商环包皮环切术具有手术方式易于标准化、手术时间短、术中疼痛轻、术后无须特殊护理、容易完整保留系带,并完全暴露冠状沟、术后外观满意度高、受术者易于接受等优点。初步证明了中国商环包皮环切手术标准化方案的可接受性,严格按照此方案实施手术和随访护理,能最大化地实现商环包皮环切技术的诸多临床优势,将并发症发生率控制在可接受的范围内。

关键词：包皮环切术中国商环标准化方案并发症男性成年人

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RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts

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Cellular & Molecular Immunology 2023年第1期20卷 94-109页

作者： Seyeon Bae Kibyeong Kim Keunsoo Kang Haemin Kim Minjoon lee Brian Oh Kaichi Kaneko Sungkook Ma Jae Hoon Choi Hojoong Kwak Eun Young lee Sung Ho Park Kyung-Hyun Park-Min Arthritis and Tissue Degeneration Program David Z.Rosensweig Genomics Research CenterHospital for Special SurgeryNew YorkNY10021USA Department of Medicine Weill Cornell Medical CollegeNew YorkNY10065USA Department of Biological Science Ulsan National Institute of Science&Technology(UNIST)Ulsan44919Republic of Korea Department of Life Science College of Natural SciencesResearch Institute for Natural SciencesHanyang UniversitySeoulKorea Department of Microbiology Dankook UniversityCheonan3116Republic of Korea Department of Molecular Biology and Genetics Cornell UniversityIthacaUSA Division of Rheumatology Department of Internal MedicineSeoul National University College of MedicineSeoulKorea BCMB Allied Program Weill Cornell Graduate School of Medical SciencesNew YorkNY10021USA

Monocyte/macrophage lineage cells are highly plastic and can differentiate into various cells under different environmental stimuli. Bone-resorbing osteoclasts are derived from the monocyte/macrophage lineage in response to receptor activator of NF-κB ligand (RANKL). However, the epigenetic signature contributing to the fate commitment of monocyte/macrophage lineage differentiation into human osteoclasts is largely unknown. In this study, we identified RANKL-responsive human osteoclast-specific superenhancers (SEs) and SE-associated enhancer RNAs (SE-eRNAs) by integrating data obtained from ChIP-seq, ATAC-seq, nuclear RNA-seq and PRO-seq analyses. RANKL induced the formation of 200 SEs, which are large clusters of enhancers, while suppressing 148 SEs in macrophages. RANKL-responsive SEs were strongly correlated with genes in the osteoclastogenic program and were selectively increased in human osteoclasts but marginally presented in osteoblasts, CD4+ T cells, and CD34+ cells. In addition to the major transcription factors identified in osteoclasts, we found that BATF binding motifs were highly enriched in RANKL-responsive SEs. The depletion of BATF1/3 inhibited RANKL-induced osteoclast differentiation. Furthermore, we found increased chromatin accessibility in SE regions, where RNA polymerase II was significantly recruited to induce the extragenic transcription of SE-eRNAs, in human osteoclasts. Knocking down SE-eRNAs in the vicinity of the NFATc1 gene diminished the expression of NFATc1, a major regulator of osteoclasts, and osteoclast differentiation. Inhibiting BET proteins suppressed the formation of some RANKL-responsive SEs and NFATc1-associated SEs, and the expression of SE-eRNA:NFATc1. Moreover, SE-eRNA:NFATc1 was highly expressed in the synovial macrophages of rheumatoid arthritis patients exhibiting high-osteoclastogenic potential. Our genome-wide analysis revealed RANKL-inducible SEs and SE-eRNAs as osteoclast-specific signatures, which may contribute to t

关键词： Osteoclasts super-enhancers enhancer RNAs Rheumatoid arthritis

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Time-resolved Rresonance Raman Study of Hydroxyphenacyl Compounds

Time-resolved Rresonance Raman Study of Hydroxyphenacyl Comp...

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第十三届全国光散射学术会议

作者： david lee Phillips Chensheng Ma Wai Ming Kwok Wing Sum Chan Peng Zou The University of Hong Kong Department of Chemistry The University of Hong Kong

＜正＞Real-time monitoring of physiological responses in biological systems needs compounds called phototriggers that release the biological stimulant in a very fast and localized *** need for the fast and localized release of biological stimulants has driven the design and development of efficient phototngger *** p-hydroxyphenacyl（pHP）caged class of phototriggers was recently observed to undergo a

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