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Trans-Gulf of Mexico loop migration of tree sw.llow. revealed by solar geolocation

Current Zoology 2014年第5期60卷 653-659页

作者： david w. BRADLEY Robert G. CLARK Peter O. DUNN Andrew.J. LAUGHLIN Caz M. TAYLOR Carol VLECK Linda A. w.ITTINGHAM david w. winkler D. Ryan NORRIS Department of Integrative Biology University of Guelph Guelph Ontario N1G 2W 1 Canada Bird Studies Canada Port Rowan Ontario N0E 1M0 Canada Environment Canada. Saskatoon. Saskatchew.n S7N 0X4. Canada Behavioral and Molecular Ecology Group Department of Biological Sciences University of Wisconsin Milwaukee Wisconsin 53201 USA Department of Ecology and Evolutionary Biology Tulane University New Orleans Louisiana 70118 USA Department of Ecology Evolution and Organismal Biology Iowa State University Ames IA 50011-1020 USA Department of Ecology and Evolutionary Biology Museum of Vertebrates and Lab of Ornithology Comell University Ithaca New York 14853 USA

One of the greatest feats of avian migration is the non-stop crossing of extensive areas of inhospitable habitat such as deserts and seas. Differences in spring and autumn migration routes have been reported in species that cross such barriers, and are thought to have evolved in response to seasonal variation in prevailing w.nd direction. w. tested the hypothesis that migration routes vary seasonally w.th respect to the Gulf of Mexico in the tree sw.llow.Tachycineta bicolor using solar geolocators attached and retrieved at 4 breeding sites in central North America. w. found that 100 % of birds （n = 10） made a trans-Gulf flight of 〉850 km from Louisiana south to their w.ntering grounds in the Yucatan Peninsula in 12-36 hours, achieving minimum ground speeds as high as 32 m/s. Although most days during autumn migration w.re characterized by unfavorable headw.nds blow.ng to the northw.st, migration over the Gulf mostly occurred on days w.th strong w.nds blow.ng to the south. In contrast, in 8 of 9 （88 %） birds on spring migration returned from the w.ntering grounds tow.rds Louisiana follow.ng a clockw.se loop pat- tern flying over land to the w.st around the Gulf. During this spring period there w.re few.days w.th prevailing w.nds from the south to assist northw.rd migration. Results suggest that, despite being up to three times further （ca. 2,700 kin）, a coastal circum-Gulf spring migration represents the less risky route w.en w.nd conditions are not favorable. These findings also help to resolve a long-standing dispute in the literature concerning migration patterns betw.en the US Gulf coast and Mexico, and provide insight into the factors shaping migration strategies of small songbirds migrating across large bodies of w.ter [Current Zoology 60（5）： 653-559, 2014].

关键词： Ecological Barrier Geolocation Gulf of Mexico Tachycineta bicolor Tree sw.llow Migration

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Probing enzyme-nanoparticle interactions using combinatorial gold nanoparticle libraries

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Nano Research 2015年第4期8卷 1293-1308页

作者： Yanyan Liu david A. winkler V. Chandana Epa Bin Zhang Bing Yan School of Chemistry and Chemical Engineering Shandong University Jinan 250100 China CSIRO Manufacturing Flagship Bag 10 Clayton South MDC 3169 Australia Monash Institute of Pharmaceutical Sciences Parkville 3052 Australia CSIRO Manufacturing Flagship Parkville 3052 Australia

The interaction of nanoparticles w.th proteins is extremely complex, important for understanding the biological properties of nanomaterials, but is very poorly understood. w. have employed a combinatorial library of surface modified gold nanoparticles to interrogate the relationships betw.en the nanoparticle surface chemistry and the specific and nonspecific binding to a common, important, and representative enzyme, acetylcholinesterase （ACHE）. w. also used Bayesian neural netw.rks to generate robust quantitative structure-property relationship （QSPR） models relating the nanoparticle surface to the AChE binding that also provided significant understanding into the molecular basis for these interactions. The results illustrate the insights that result from a synergistic blending of experimental combinatorial synthesis and biological testing of nanoparticles w.th quantitative computational methods and molecular modeling.

关键词： gold nanoparticles surface modification enzyme inhibition acetylcholinesterase protein binding modeling quantitative structure-property relationship(QSPR) neural netw.rk

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Machine learning property prediction for organic photovoltaic devices

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npj Computational Materials 2020年第1期6卷 279-286页

作者： Nastaran Meftahi Mykhailo Klymenko Andrew.J.Christofferson Udo Bach david A.winkler Salvy P.Russo ARC Centre of Excellence in Exciton Science School of ScienceRMIT UniversityMelbourneVIC 3001Australia School of Science College of ScienceEngineering and HealthRMIT UniversityMelbourneVIC 3001Australia ARC Centre of Excellence in Exciton Science Department of Chemical EngineeringMonash UniversityWellington RoadClaytonVIC 3800Australia La Trobe Institute for Molecular Science La Trobe UniversityKingsbury DriveBundooraVIC 3086Australia Monash Institute of Pharmaceutical Sciences Monash UniversityParkvilleVIC 3052Australia School of Pharmacy University of NottinghamNottingham NG72QLUK CSIRO Data61 PullenvaleQLD 4069Australia

Organic photovoltaic(OPV)materials are promising candidates for cheap,printable solar ***,there are a very large number of potential donors and acceptors,making selection of the best materials ***,w. show.that machine-learning approaches can leverage computationally expensive DFT calculations to estimate important OPV materials properties quickly and *** generate quantitative relationships betw.en simple and interpretable chemical signature and one-hot descriptors and OPV pow.r conversion efficiency(PCE),open circuit potential(Voc),short circuit density(Jsc),highest occupied molecular orbital(HOMO)energy,low.st unoccupied molecular orbital(LUMO)energy,and the HOMO–LUMO *** most robust and predictive models could predict PCE(computed by DFT)w.th a standard error of±0.5 for percentage PCE for both the training and test *** model is useful for pre-screening potential donor and acceptor materials for OPV applications,accelerating design of these devices for green energy applications.

关键词： occupied property prediction

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Considerations w.en using the activPAL monitor in field-based research w.th adult populations

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Journal of Sport and Health Science 2017年第2期6卷 162-178页

作者： Charlotte L.Edw.rdson Elisabeth A.H.winkler Danielle H.Bodicoat Tom Yates Melanie J.Davies david w.Dunstan Genevieve N.Healy diabetes research centre leicester general hospitaluniversity of leicesterLeicester LE5 4PWUK nihr leicester-loughborough diet lifestyleand physical activity biomedical research unitLeicester LE5 4PWUK school of population health the university of queenslandBrisbaneQLD 4006Australia baker idi heart and diabetes institute MelbourneVIC 3004Australia school of exercise and nutrition sciences deakin universityBurwoodVIC 3125Australia department of epidemiology and preventive medicine monash universityMelbourneVIC 3800Australia school of sport science exercise and healththe university of western australiaPerthWA 6009Australia central clinical school monash universityMelbourneVIC 3800Australia school of physiotherapy and exercise science curtin universityPerthWA 6102Australia

Research indicates that high levels of sedentary behavior(sitting or lying w.th low.energy expenditure) are adversely associated w.th health. A key factor in improving our understanding of the impact of sedentary behavior(and patterns of sedentary time accumulation) on health is the use of objective measurement tools that collect date and time-stamped activity information. One such tool is the activP AL monitor. This thigh-w.rn device uses accelerometer-derived information about thigh position to determine the start and end of each period spent sitting/lying, standing, and stepping, as w.ll as stepping speed, step counts, and postural transitions. The activP AL is increasingly being used w.thin field-based research for its ability to measure sitting/lying via posture. w. summarise key issues to consider w.en using the activP AL in physical activity and sedentary behavior field-based research w.th adult populations. It is intended that the findings and discussion points be informative for researchers w.o are currently using activP AL monitors or are intending to use them. Pre-data collection decisions, monitor preparation and distribution, data collection considerations, and manual and automated data processing possibilities are presented using examples from current literature and experiences from 2 research groups from the UK and Australia.

关键词： populations monitor lying collection accelerometer expenditure Australia stepping currently intended

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电流感测电阻的挑战:开放式金属元件电阻与金属带状线贴片电阻

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电子产品世界 2006年第3X期13卷 84-84,87页

作者： david winkler TT

为了操作安全或对电流进行控制,现在的电子产品越来越多地使用各种电流感测装置.电流感测常用于以下两方面:1)过电流保护,监测流过发动机或电源输出线的电流,如果负载过大就降低电压;2)多相负载平衡,监测每条有电流的线上的安培数值,并... 详细信息

为了操作安全或对电流进行控制,现在的电子产品越来越多地使用各种电流感测装置.电流感测常用于以下两方面:1)过电流保护,监测流过发动机或电源输出线的电流,如果负载过大就降低电压;2)多相负载平衡,监测每条有电流的线上的安培数值,并对实时响应产生影响.使用电流感测电阻能够提供简单的电流感测信号,对电流变化作出线性响应,从而能够保证电路在很大温度范围内可靠工作.

关键词：贴片电阻金属元件流感带状线开放式过电流保护负载平衡操作安全电子产品实时响应

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Using compositional data analysis to explore accumulation of sedentary behavior,physical activity and youth health

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Journal of Sport and Health Science 2022年第2期11卷 234-243页

作者： Simone J.J.M.Versw.jveren Karen E.Lamb Josep A.Martín-Fernández Elisabeth winkler Rebecca M.Leech Anna Timperio Jo Salmon Robin M.Daly Ester Cerin david w.Dunstan Rohan M.Telford Richard D.Telford Lisa S.Olive Nicola D.Ridgers Institute for Physical Activity and Nutrition School of Exercise and Nutrition SciencesDeakin UniversityGeelongVIC 3216Australia Melbourne School of Population and Global Health University of MelbourneParkvilleVIC 3053Australia Department of Computer Science Applied Mathematics and StatisticsUniversity of GironaGirona 17003Spain School of Public Health University of QueenslandHerstonQLD 4006Australia Mary MacKillop Institute for Health Research Australian Catholic UniversityFitzroyVIC 3065Australia School of Public Health University of Hong KongHong KongChina Baker Heart and Diabetes Institute MelbourneVIC 3004Australia Research Institute for Sport and Exercise University of CanberraBruceACT 2617Australia School of Psychology Deakin UniversityBurwoodVIC 3125Australia IMPACT Research Institute Deakin UniversityBurwoodVIC 3125Australia ANU Medical School Australian National UniversityGarranACT 2605Australia

Purpose:The study aimed to describe youth time-use compositions,focusing on time spent in shorter and longer bouts of sedentary behavior and physical activity(PA),and to examine associations of these time-use compositions w.th cardiometabolic ***:Accelerometer and cardiometabolic biomarker data from 2 Australian studies involving youths 7-13 years old w.re pooled(complete cases w.th accelerometry and adiposity marker data,n=782).A 9-component time-use composition w.s formed using compositional data analysis:time in shorter and longer bouts of sedentary behavior;time in shorter and longer bouts of light-,moderate-,or vigorous-intensity PA;and"other time"(i.e.,non-w.ar/sleep).Shorter and longer bouts of sedentary time w.re defined as5 min,*** bouts of light-,moderate-,and vigorous-intensity PA w.re defined asw.re defined as≥1 *** models examined associations betw.en overall time-use composition and cardiometabolic ***,associations w.re derived betw.en ratios of longer activity patterns relative to shorter activity patterns,and of each intensity level relative to the other intensity levels and"other time",and cardiometabolic ***:Confounder-adjusted models show.d that the overall time-use composition w.s associated w.th adiposity,blood pressure,lipids,and the summary ***,more time in longer bouts of light-intensity PA relative to shorter bouts of light-intensity PA w.s significantly associated w.th greater body mass index z-score(zBMI)(β=1.79;SE=0.68)and w.ist circumference(β=18.35,SE=4.78).w.en each activity intensity w.s considered relative to all higher intensities and"other time",more time in light-and vigorous-intensity PA,and less time in sedentary behavior and moderate-intensity PA,w.re associated w.th low.r w.ist ***:Accumulating PA,particularly light-intensity PA,in frequent short bursts may be more beneficial for limiting adi

关键词： Accumulation patterns Cardiometabolic health Children Compositional data analysis Time-use

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4号染色体短臂微卫星多态性与鼻咽癌相关性的研究

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遗传 2006年第7期28卷 783-790页

作者：郭秀婵 O’BRIEN Stephen J winkler Cheryl SCOTT Kevin HUTCHESON Holli david Victor KESSING Bailey 郑裕明廖建刘彦 GUY de The 曾毅中国疾病预防控制中心病毒病预防控制所北京100052 美国国家癌症研究所基因组多样性研究室 frederickmd21702 广西梧州市肿瘤防治研究所梧州543002 广西苍梧县鼻咽癌防治所苍梧543100 法国巴士德研究所 parisfrance75724

鼻咽癌（NPC）是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中，那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发... 详细信息

鼻咽癌（NPC）是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中，那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发展中两个关键步骤相关的遗传变异，即EB病毒持续性感染鼻咽部上皮细胞和鼻咽癌的形成。我们在广西梧州市及苍梧县鼻咽癌高发区收集汉族鼻咽癌患者350例、EB病毒壳抗原IgA抗体阳性者（IgA／VCA＋）288例和EB病毒壳抗原IgA抗体阴性者（IgA／VCA—）346例。对先前鼻咽癌家系研究显示的鼻咽癌易感区4号染色体短臂（4p15．1～q12）进行了微卫星精细扫描，在18Mb的范围内选择34个微卫星标记，包括319个等位基因，对其进行基因分型。比较分析NPC组和IgA／VCA＋组等位基因频率结果显示，9个等位基因与鼻咽癌呈相关，其中5个为易感等位基因（OR=1．51～5．36，P=0．01～0．03），4个为限制性等位基因（OR值为0．3～0．71，P值为0．02～0．045）。比较分析IgA／VCA＋组和IgA／VCA-组及比较所有IgA／VCA＋者（包括NPC患者）和IgA／VCA-者等位基因频率的结果显示，12个等位基因与EB病毒壳抗原IgA抗体持续存在相关，其中3个在两组比较中均呈显著相关。等位基因D4S3241～136（P=0．004，OR=1．9，95％CI=1．2～3．0）和D4S3347-213（P=0．001，OR=1．6，95％CI=1．2～2．1）可增加EB病毒IgA／VCA抗体形成的危险，为易感基因；而等位基因D4S174．202（P=0．001，OR=0．5，95％CI=0．3～0．7）可限制IgA／VCA抗体的形成。但上述结果经多因素比较校正后，均失去相关性。结果不能确定该区域与非家族性鼻咽癌的形成相关，但本研究却提供了进一步发现鼻咽癌相关基因的研究模式。有关4号染色体短臂与EB病毒慢性持续感染及鼻咽癌的形成仍值得进一步深入研究。

关键词：鼻咽癌 4号染色体微卫星相关研究

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井眼声波基础

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国外测井技术 2007年第6期22卷 58-66页

作者： Jakob B.U.Haldorsen david Linton Johnson Tom Plona Bikash Sinha Henri-Pierre Valero Kenneth winkler 美国康涅狄格州Ridgefield

在井眼和地层中传播的声波与地层一样,可能非常简单,也可能非常复杂。了解声波传播的基础知识对于利用好现代声波测井技术是十分必要的。

关键词：声波测井技术基础知识井眼声波传播地层

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4号染色体短臂微卫星多态性与鼻咽癌相关性的研究

4号染色体短臂微卫星多态性与鼻咽癌相关性的研究

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第六次全国医学遗传学学术会议

作者：郭秀婵 Stephen J．O’Brien Cheryl winkler Kevin Scott Holli Hutcheson Victor david Bailey Kessing 刘彦郑裕明廖建 Guy de The 和曾毅中国疾病预防控制中心病毒病所肿瘤室美国国家癌症研究所基因组多样性研究室广西梧州市肿瘤防治研究所广西苍梧县鼻咽癌防治所法国巴士德研究所

鼻咽癌(NPC)是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中,那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发展中... 详细信息

鼻咽癌(NPC)是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中,那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发展中两个关键步骤相关的遗传变异, 即EB病毒持续性感染鼻咽部上皮细胞和鼻咽癌的形成。我们在广西梧州市及苍梧县鼻咽癌高发区收集汉族鼻咽癌患者350例、EB病毒壳抗原IgA抗体阳性者(IgA／VCA+)288例和EB病毒壳抗原IgA 抗体阴性者(IgA／VCA-)346例。对先前鼻咽癌家系研究显示的鼻咽癌易感区4号染色体短臂 (4p15．1-q12)进行了微卫星精细扫描,在18 Mb的范围内选择34个微卫星标记,包括319个等位基因,对其进行基因分型。比较分析NPC组和IgA／VCA+组等位基因频率结果显示,9个等位基因与鼻咽癌呈相关,其中5个为易感等位基因(OR=1．51-5．36,p=0．01-0．03),4个为限制性等位基因(OR 值为0．3-0．71,p值为0．02-0．045)。比较分析IgA／VCA+组和IgA／VCA-组及比较所有IgA／VCA+者(包括NPC患者)和IgA／VCA-者等位基因频率的结果显示,12个等位基因与EB病毒壳抗原IgA抗体持续存在相关,其中3个在两组比较中均呈显著相关。等位基因D4S3241-136(p=0．004,OR=1．9, 95％CI=1．2-3．0)和D4S3347-213(p=0．001,OR=1．6,95％CI=1．2-2．1)可增加EB病毒IgA／VCA抗体形成的危险,为易感基因;而等位基因D4S174-202(p=0．001,OR=0．5,95％CI=0．3-0．7)可限制IgA／VCA 抗体的形成。但上述结果经多因素比较校正后,均失去相关性。我们的研究结果不能确定该区域与非家族性鼻咽癌的形成相关,另一个家系研究的结果也未得出相关的结果,但本研究却提供了进一步发现鼻咽癌相关基因的研究模式。有关4号染色体短臂与EB病毒慢性持续感染及鼻咽癌的形成仍值得进一步深入研究。

关键词：鼻咽癌 4号染色体相关研究微卫星

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