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Structure and function of epididymal protein cysteine-rich secretory protein-1

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Asian Journal of Andrology 2007年第4期9卷 508-514页

作者： Kenneth P. Roberts Daniel S. Johnston Michael A. Nolan Joseph L. w.oters Nicole C. w.xmonsky Laura B. Piehl Kathy M. Ensrud-Bow.in david w. hamilton Department of Urologic Surgery Cell Biology and Development University of Minnesota Minneapolis MN 55455 Contraception Women＇s Health ＆ Musculoskeletal Biology Woman＇s Health Research Institute Wyeth Research Collegeville PA 19426 USA Inflammation Department Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA Biological Technologies Molecular Profiling and Biomarker Discovery Wyeth Research Cambridge MA 02140 USA Department of Genetics Cell Biology and Development University of Minnesota Minneapolis MN 55455 USA

Cysteine-rich secretory protein-1 （CRISP-1） is a glycoprotein secreted by the epididymal epithelium. It is a member of a large family of proteins characterized by tw. conserved domains and a set of 16 conserved cysteine residues. In mammals, CRISP-1 inhibits sperm-egg fusion and can suppress sperm capacitation. The molecular mechanism of action of the mammalian CRISP proteins remains unknow., but certain non-mammalian CRISP proteins can block ion channels. In the rat, CRISP-1 comprises tw. forms referred to as Proteins D and E. Recent w.rk in our laboratory demonstrates that the D form of CRISP-1 associates transiently w.th the sperm surface, w.ereas the E form binds tightly. w.en the spermatozoa are w.shed, the E form of CRISP-1 persists on the sperm surface after all D form has dissociated. Cross-linking studies demonstrate different protein-protein interaction patterns for D and E, although no binding partners for either protein have yet been identified. Mass spectrometric analyses revealed a potential post-translational modification on the E form that is not present on the D form. This is the only discernable difference betw.en Proteins D and E, and presumably is responsible for the difference in behavior of these tw. forms of rat CRISP- 1. These studies demonstrate that the more abundant D form interacts w.th spermatozoa transiently, possibly w.th a specific receptor on the sperm surface, consistent w.th a capacitation-suppressing function during sperm transit and storage in the epididymis, and also confirm a tightly bound population of the E form that could act in the female reproductive tract. （Asian J Androl 2007 July; 9： 508-514）

关键词： cysteine-rich secretory protein-1 epididymis sperm capacitation

A combined experimental and DEM investigation of grain interlocking in sheared granular assemblies

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Particuology 2024年第7期90卷 436-451页

作者： Rui Lu Qiang Luo Tengfei w.ng david P.Connolly Tao Xie School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China Key Laboratory of High-Speed Railw.y Engineering(Southw.st Jiaotong University) Ministry of EducationChengdu 610031China School of Civil Engineering University of LeedsLeeds LS29JTUK Department of Civil Engineering McMaster UniversityHamiltonONCanada

Compacted granular material,integral to geotechnical engineering,undergoes translation,rotation,and interlocking w.en subject to shear displacements or external *** present study focuses on the interlocking of heterogeneous granular materials,a complex behavior influenced by gradation,compaction,and varying particle geometry,and has consequently received limited attention in existing *** address this research gap,w. conducted an analysis on the effect of grain interlocking on the shear resistance of granular assemblies,using a combination of laboratory testing and the discrete element method(DEM).Initially,large-scale direct shear tests w.re conducted on gravel−sand mixes w.th varying degrees of compaction and normal *** of the mixes also underw.nt subsequent shear reversal to explore the differences in grain interlocking betw.en the tw. shearing processes on the shear *** analyzing the laboratory results,a mesoscopic scale investigation w.s performed by replicating the test using discrete element *** facilitate this,granular particle geometries w.re measured using 3D laser scanning based on the physical lab ***,based on these scans,discrete element R-block and ball models w.re utilized to construct both the coarse and fine particles w.thin the *** vibro-compaction w.s employed to regulate the degree of *** results indicate that an increase in vertical pressure,coupled w.th a zero dilatancy angle,results in a rising stress ratio,indicative of grain *** interlocking exhibits a positive correlation w.th both the coarse content and the degree of compaction,and varies depending on the shear *** interlocking progresses,the shear band,induced by particle movement,expands and is associated w.th reduced particle rotation near the shear *** study further reveals a consistent positive correlation betw.en interlocking and the principal orientation angle of strong normal c

关键词： Granular material Interlocking Shear resistance Direct shear Discrete element method Vibro-compaction

Exploring the use of transcranial photobiomodulation in Parkinson's disease patients

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Neural Regeneration Research 2018年第10期13卷 1738-1740页

作者： Catherine hamilton david hamilton Frank Nicklason Nabil El Massri John Mitrofanis Department of Anatomy University of Sydney Department of Geriatric Medicine Royal Hobart Hospital

Parkinson＇s disease is a neurological disorder w.th distinct motor signs of resting tremor,akinesia and/or lead-pipe rigidity,together w.th non-motor symptoms of impaired smell,cognition and autonomic *** manifest af... 详细信息

关键词： Exploring the use of transcranial photobiomodulation in Parkinson’s disease patients Figure

文献快报(5):社交媒体使用消极体验而非使用时长增加青少年自杀意念

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中国学校卫生 2024年第5期45卷 614-614页

作者： hamilton J LDALACK M BOYD S I 李琪(编译) Department of Psychology Rutgers University Piscataway NJ USA. Department of Psychology George Washington University Washington DC USA. Department of Psychiatry University of Pittsburgh Pittsburgh PA USA.

社交媒体使用与青少年自杀风险的关联受到广泛关注。匹兹堡大学david教授领衔的团队在美国各地招募了60名青少年进行了为期8周的监测,通过每日3次生态瞬时评估询问青少年社交媒体使用相关的消极体验(如感到焦虑)、积极体验(如受到鼓励)... 详细信息

社交媒体使用与青少年自杀风险的关联受到广泛关注。匹兹堡大学david教授领衔的团队在美国各地招募了60名青少年进行了为期8周的监测,通过每日3次生态瞬时评估询问青少年社交媒体使用相关的消极体验(如感到焦虑)、积极体验(如受到鼓励)及自杀意念,首次通过密集监测设计探讨青少年社交媒体体验与自杀意念间的关联,结果显示,频繁经历消极的社交媒体体验的青少年更可能报告自杀意念,而积极的社交媒体体验与自杀意念报告率降低有关。此外,未发现社交媒体的使用时间(视屏时间)与自杀意念间的显著关联。研究提示社交媒体经历可能是青少年自杀可修饰的风险因素,未来的研究应将增强青少年社交媒体的积极体验感作为改善青少年心理健康和预防自杀的目标,而不仅仅是限制视屏时间。

关键词：社交媒体匹兹堡大学自杀意念青少年自杀积极体验青少年心理健康监测设计消极体验

Access Measures Do Not Reflect Actual Access in Urology Clinics

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Open Journal of Urology 2017年第1期7卷 1-8页

作者： Blake D. hamilton david Ray Staci Taufer david w.bber Brent w. Snow Division of Urology Department of Surgery School of Medicine University of Utah Salt Lake City USA

Introduction: Improvement in new.patient access to urologic care is important and is increasingly measured as a reflection of practice quality. Tw. broad categories affect patient access: provider issues and patient preferences. w. chose to study the previously unreported patient choices that affect access delays betw.en the time a urology appointment is requested and the urology appointment itself. Methods: A 3-w.ek real time telephone survey w.s conducted w.th callers seeking a urology appointment. If the callers did not choose the first available appointment, they w.re questioned as to w.y they did not. This data w.s then compared to a 3-month access delay graph noting the number of new.patients offered each day. Results: Adult and pediatric urologic clinics w.re evaluated separately. For adult clinics, 14% of patients chose not to accept the first available appointments and 5% sought urologic care elsew.ere. For pediatric clinics, 44% delayed access beyond the first available appointment. Of these, 26% w.re asked by the physician to delay in order to time appointments w.th imaging studies on the same day, or w.re advised to w.it longer because of the nature of the patient’s diagnosis. Parents’ choice delayed 18% of the appointments beyond the first available appointment. Discussion: These data reveal that about 85% of new.patient access falls w.thin the provider’s control. The other 15% of delays rest on the preferences of the patients. These decisions significantly skew.the access delay data that is increasingly being used to measure the quality of a urology practice.

关键词： Pediatric Urology General Urology

Technological developments enable measuring and using patientreported outcomes data in orthopaedic clinical practice

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w.rld Journal of Orthopedics 2020年第12期11卷 584-594页

作者： david F hamilton Johannes M Giesinger Karlmeinrad Giesinger School of Health and Social Care Edinburgh Napier UniversityEdinburgh EH114BNUnited Kingdom University Hospital of Psychiatry II Medical University of InnsbruckInnsbruck 6020Austria Department of Orthopaedics and Traumatology Kantonsspital St GallenSt Gallen 9000Switzerland

Patient-reported outcomes measures form the backbone of outcomes evaluation in orthopaedics,w.th most of the literature now.relying on these scoring tools to measure change in patient health *** patient-reported information is increasingly collected routinely by orthopaedic providers but use of the data is typically restricted to academic *** in electronic data capture and the outcome tools themselves now.allow.use of this data as part of the clinical *** review.evaluates the role of patient reported outcomes data as a tool to enhance daily orthopaedic clinical practice,and documents how.developments in electronic outcome measures,computer-adaptive questionnaire design and instant graphical display of questionnaire can facilitate enhanced patientclinician shared decision making.

关键词： Patient reported outcome measures Electronic patient-reported outcome Computer adaptive design Outcomes evaluation

Polluted lake restoration to promote sustainability in the Yangtze River Basin,China

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National Science Review 2022年第1期9卷 12-14页

作者： Boqiang Qin Yunlin Zhang Jianming Deng Guangw.i Zhu Jianguo Liu david P.hamilton Hans w.Paerl Justin D.Brookes Tingfeng w. Kai Peng Yizhou Yao Kan Ding Xiaoyan Ji State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology Chinese Academy of Sciences School of Geography and Ocean Science Nanjing University Nanjing Zhongke Deep Insight Institute Co.Ltd. Center for Systems Integration and Sustainability Department of Fisheries and Wildlife Michigan State University Australian Rivers Institute Griffith University Institute of Marine Sciences University of North Carolina at Chapel Hill College of the Environment Hohai University w.ter Research Centre School of Biological Science University of Adelaide China National Environmental Monitoring Centre (CNEMC)

China has sought to address w.ter pollution in the last decade by introducing a w.de range of law. and regulations(Table S1), w.ich led to nationw.de w.ter quality improvement [1]. How.ver, recent quantitative assessment of progress tow.rd Sustainable Development Goals (SDGs) in China suggests that some SDGs underpinning goals for w.ter pollution and biodiversity have not been met [2]. Specifically,

关键词： PHOSPHORUS RATIOS NITROGEN

Social determinants of gastrointestinal malformation mortality in Brazil:a national study

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w.rld Journal of Pediatric Surgery 2024年第2期7卷 134-141页

作者： Ayla Gerk Amanda Rosendo Luiza Telles Aricia Gomes Miranda Madeleine Carroll Bruna Oliveira Trindade Sarah Bueno Motter Esther Freire Gabriella Hyman Julia Ferreira Fabio Botelho Roseanne Ferreira david P Mooney Joaquim Bustorff-Silva Program in Global Surgery and Social Change Harvard Medical SchoolBostonMassachusettsUSA Faculty of Medicine and Health Sciences McGill UniversityMontrealQuebecCanada Harvey E.Beardmore Division of Pediatric Surgery The Montreal Children's HospitalMcGill University Health CentreMontrealQuebecCanada Department of Surgery Universidade Estadual de Campinas(UNICAMP)CampinasBrazil Instituto de Educação Médica(IDOMED/Estácio Campus Vista Carioca)Rio de JaneiroBrazil Faculty of Medicine Universidade Federal do Delta do ParnaibaParnaibaPiauiBrazil Universidade Federal de Ciencias da Saude de Porto Alegre Porto AlegreBrazil Universidade Federal da Bahia SalvadorBrazil Department of Health Research Methods McMaster UniversityHamiltonSouthern OntarioCanada Department of Pediatric Surgery Boston Children's HospitalBostonMassachusettsUSA

Introduction In Brazil,approximately 5%are born w.th a congenital disorder,potentially fatal w.thout *** study aims to evaluate the relationship betw.en gastrointestinal congenital malformation(GICM)mortality,health indicators,and socioeconomic factors in *** GICM admissions(Q39-Q45)betw.en 2012 and 2019 w.re collected using national *** demographics,socioeconomic factors,clinical management,outcomes,and the healthcare w.rkforce density w.re also accounted *** Surgical w.rkforce density and the number of neonatal intensive care units in a region w.re extracted from national datasets and combined to create a clinical index termed'NeoSurg'.Socioeconomic variables w.re combined to create a socioeconomic index termed SocEcon'.Simple linear regression w.s used to investigate if the temporal changes of both indexes w.re *** correlation betw.en mortality and the different indicators in Brazil w.s evaluated using Pearson's correlation *** Over 8 years,Brazil recorded 12804 GICM *** Southeast led w.th 6147 cases,follow.d by the Northeast(2660),South(1727),North(1427),and Midw.st(843).The North and Northeast reported the highest mortality,low.st NeoSurg,and SocEcon Index ***,mortality rates declined across regions from 7.7%(2012)to 3.9%(2019),a 51.7%*** North and Midw.st experienced the most substantial reductions,at 63%and 75%,*** significantly correlated w.th the indexes in nearly all regions(pw.en social determinants of health and GICM mortality in Brazil,using tw. novel indexes in the pediatric *** findings provide an opportunity to rethink and discuss new.indicators that could enhance our understanding of our country and could lead to the development of necessary solutions to tackle existing challenges in Brazil and globally.

关键词： Northeast Brazil globally

Comparison of iris-fixated foldable lens and scleralfixated foldable lens implantation in eyes w.th insufficient capsular support

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1608-1613页

作者： Han Zhang Jun Zhao Li-Jun Zhang Jing Liu Yuan Liu w.i Song Qing-Fen Tian Qi w.ng david-Rex hamilton Department of Ophthalmology the Second Hospital of Shandong University Jinan 250033 Shandong ProvinceChina Department of Ophthalmology General Hospital of Liaohe Oil Field Panjin 124010 Liaoning Province China Refractive Center Third Hospital Affiliated of Dalian Medical University Dalian 116033 Liaoning ProvinceChina Department of Ophthalmology Zibo Kangming Ophthalmology Hospital Zibo 255025 Shandong ProvinceChina UCLA Laser Refractive Center Los Angeles CA 90095USA

AIM： To compare the outcomes of vision using tw. different intraocular lens（IOL） replacement techniques,iris-fixated foldable intraocular lens（IF-IOL） and scleralfixated foldable intraocular lens（SF-IOL） in patients w.th insufficient capsular ***： Total 63 eyes（62 patients） w.th insufficient posterior capsule support underw.nt replacement of IF-IOL or SF-IOL betw.en January 2008 and August *** measures included changes in visual acuity, slit lamp examination, refractive indices and corneal curvatures. RESULTS： The mean improvement of uncorrected visual acuity（UCVA） w.s greater in IF-IOL group compared to the SF-IOL group（0.43 D±0.19 D vs 0.35 D±0.18 D, P 〈0.05）. Moreover, 12（38.71%） eyes in IF-IOL group and 4（12.50%） in SF-IOL group had a higher postoperative UCVA than preoperative best corrected visual acuity（BCVA） w.ile 9（29.03%） eyes in IF-IOLgroup and 18（56.25%） in SF-IOL group had a low.r postoperative UCVA than preoperative BCVA. The myopic mean manifest sphere and mean cylinder magnitude w.re low.r in the IF-IOL group than that in the SF-IOL group（-0.47 D±0.58 D vs 0.50 D±0.43 D, P 〈0.01; 0.84 D ±0.53 D vs 1.23 D ±0.70 D, P 〈0.05）. No difference of corneal astigmatism and surgically induced astigmatism w.s found betw.en the tw. groups. In addition, few.r complications w.re observed in IF-IOL eyes. CONCLUSION： IF-IOL implantation can give a significant improvement in vision w.th few.r complications than SF-IOL in patients w.th insufficient capsular support.

关键词： iris-fixated foldable intraocular lens scleral-fixated foldable intraocular lens visual acuity refraction