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Praziquantel efficacy against Schistosoma mansoni among HIV-1 infected and uninfected adults living in fishing villages along Lake Victoria, Northwest Tanzania

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Infectious Diseases of Poverty 2014年第1期3卷 440-448,439页

作者： Humphrey D Mazigo david w dunne Safari M Kinung’hi Fred Nuwaha Department of Medical Parasitology and Entomology School of MedicineCatholic University of Health and Allied SciencesP.O.Box 1464MwanzaTanzania Department of Disease Control and Environmental Health School of Public HealthCollege of Health SciencesMakerere UniversityP.O.Box 7072KampalaUganda Department of Pathology Division of Microbiology and ParasitologyCambridge UniversityTennis Court RoadCambridge CB21QPUK National Institute for Medical Research Mwanza Research CentreP.O.Box 1462 MwanzaTanzania

Background:Animal studies have demonstrated that functional immune responses,as determined by the levels of CD4+cell counts and anti-schistosome antibodies responses,determine the efficacy of *** on this evidence,it has been hypothesised that the immunodeficiency effects of the human immunodeficiency virus(HIV)-1 infection may affect the efficacy of praziquantel in co-infected human ***,the present study assessed the efficacy of praziquantel by comparing parasitological cure rates and the reduction in infection intensity in HIV-1 seronegative individuals infected with *** and HIV-1 seropositive individuals co-infected with ***,following treatment with a single oral dose of ***:This was a prospective longitudinal study which included,at baseline,555 *** infected adults aged 21-55 years,who were either co-infected or not with HIV-1 and who lived in fishing villages along Lake Victoria in Northwest *** individuals were treated with a single oral dose of praziquantel(40 mg/kg)and,at 12 weeks,single stool samples were obtained and examined for *** eggs using the Kato-Katz *** prick and venous blood samples were collected for HIV-1 screening and CD4+cell ***:The parasitological cure rate did not differ significantly from the HIV-1 serostatus(P=0.12):among the co-infected individuals,the cure rate was 48.3%(14/29),and among the individuals infected only with ***,the cure rate was 62.6%(329/526).The egg reduction rate did not vary with the HIV-1 serostatus(P=0.22):77.22%for HIV-1 seronegative and 75%for HIV-1 seropositive *** level of CD4^(+) cell counts(median 228 cells/μL:range 202-380 cells)did not influence the cure rate(P=0.23)or the reduction in the intensity of the infection(P=0.37).Conclusion:The HIV-1 infection per se or its moderate immunodeficiency effects,demonstrated by the range of CD4^(+) cell counts observed in co-infected individuals,d

关键词： HIV-1 S.mansoni Co-infection Praziquantel Efficacy Tanzania

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Epidemiology andinteractions of Human Immunodeficiency Virus - 1 and Schistosoma mansoni in sub-SaharanAfrica

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Infectious Diseases of Poverty 2013年第1期2卷 6-16页

作者： Humphrey D Mazigo Fred Nuwaha Shona wilson Safari M Kinunghi Domenica Morona Rebecca waihenya Jorg Heukelbach david w dunne Department of Medical Parasitology and Entomology School of MedicineCathollc University of Health and Aled SclencesP.O.Box 1464MwanzaTanzanla Department of Environmental Health and Communicable Disease Control School of Public HealthCollege of Health SclencesMakerere UniversiyP.O.Box 7072KampalaUganda National Institute for Medical.Research Mwanza Research CentreP.Q.Box 1462MwanzaTanzanla Department of Pathology University of CambidgeTennis Court RoadCambridge CB21OPUK Department of Zoology Faculty of SclenceJomo Kenyatta University of Agriculture and TechnologyP.O.Box ***NairobiKenya Department of Community Health School of MedicineFederal University of CearaCearaBail

Human Immunodeficiency Virus-1/AIDS and Schis tosoma mansoni are widespread in sub Saharan Africa and co-infection occurs *** the early 1990s,it has been suggested that the two infections may interact and potentiate the effects of each other within co-infected human ***,S mansoni infection has been suggested to be a risk factor for HIV transmission and progression in *** so,it would follow that mass deworming could have beneficial effects on HIV-1 transmission *** epidemiology of HIV in African countries is changing,shifting from urban to rural areas where the prevalence of Schistosoma mansoni is high and public health services are *** the other side,the consequent pathogenesis of HIV-1/*** co-infection remains *** we give an account of the epidemiology of HIV-1 and ***,discuss co-infection and possible biological causal relationships between the two infections,and the potential impact of praziquantel treatment on HIV-1 viral loads,CD4^(+) counts and CD4^(+)/CD8^(+) *** review of the available literature indicates that there is evidence to support the hypothesis that *** infections can influence the replication of the HIV-1,cel-to-cell transmission,as well as increase HIV progression as measured by reduced CD4^(+) T lymphocytes *** so,then deworming of HIV positive individuals living in endemic areas may impact on HV-1 viral loads and CD4^(+) T lymphocyte counts.

关键词： Schitosoma mansoni HIV-1 Co-infections Immunological interactions Deworming

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Harnessing the synergy of perfusable muscle flap matrix and adipose-derived stem cells for prevascularization and macrophage polarization to reconstruct volumetric muscle loss

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Bioactive Materials 2023年第4期22卷 588-614页

作者： Qixu Zhang Yulun Chiu Youbai Chen Yewen wu Lina w.dunne Rene D.Largo Edward I.Chang david M.Adelman Mark V.Schaverien Charles E.Butler Department of Plastic Surgery The University of Texas MD Anderson Cancer CenterHoustonTX77030USA Department of Melanoma Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTX77030USA Department of Plastic Surgery Chinese PLA General HospitalBeijing100853China

Muscle flaps must have a strong vascular network to support a large tissue volume and ensure successful *** developed porcine stomach musculofascial flap matrix(PDSF)comprising extracellular matrix(ECM)and intact *** had a dominant vascular pedicle,microcirculatory vessels,a nerve network,well-retained 3-dimensional(3D)nanofibrous ECM structures,and no allo-or ***-depth proteomic analysis demonstrated that PDSF was composed of core matrisome proteins(e.g.,collagens,glycoproteins,proteoglycans,and ECM regulators)that,as shown by Gene Ontology term enrichment analysis,are functionally related to musculofascial biological ***,PDSF􀀀human adipose-derived stem cell(hASC)synergy not only induced monocytes towards IL-10􀀀producing M2 macrophage polarization through the enhancement of hASCs’paracrine effect but also promoted the proliferation and interconnection of both human skeletal muscle myoblasts(HSMMs)and human umbilical vein endothelial cells(HUVECs)in static triculture ***,PDSF was successfully prevascularized through a dynamic perfusion coculture of hASCs and HUVECs,which integrated with PDSF and induced the maturation of vascular networks in *** a xenotransplantation model,PDSF demonstrated myoconductive and immunomodulatory properties associated with the predominance of M2 macrophages and regulatory T *** a volumetric muscle loss(VML)model,prevascularized PDSF augmented neovascularization and constructive remodeling,which was characterized by the predominant infiltration of M2 macrophages and significant musculofascial tissue *** results indicate that hASCs’integration with PDSF enhances the cells’dual function in immunomodulation and *** in part to this PDSF-hASC synergy,our platform shows promise for vascularized muscle flap engineering for VML reconstruction.

关键词： Muscle flap fabrication Extracellular matrix Decellularization Vascularization Macrophage polarization Volumetric muscle loss

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Oesophageal cancer metastases:An observational study of a more aggressive approach

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world Journal of Gastrointestinal Surgery 2022年第9期14卷 997-1007页

作者： Lianne Pickett Mary dunne Orla Monaghan Liam Grogan Oscar Breathnach Thomas N walsh Department of Surgery Connolly HospitalBlanchardstownDublin D15 X40DIreland Clinical Trials Resource Unit St Luke's Radiation Oncology NetworkDublin D06 HH36Ireland Department of Radiation Oncology St Luke's Radiation Oncology NetworkDublin D06 HH36Ireland Department of Medical Oncology Beaumont HospitalDublin D09 V2N0Ireland Department of Surgery RCSI BahrainAdliya 15503Bahrain

BACKGROUND The prognosis for oesophageal carcinoma is poor,but once distant metastases emerge the prognosis is considered *** is no consistent protocol for the early identification and aggressive management of *** To examine the outcome of a policy of active postoperative surveillance with aggressive treatment of confirmed *** A prospectively maintained database of 205 patients diagnosed with oesophageal carcinoma between 1998 and 2019 and treated with curative intent was interrogated for patients with metastases,either at diagnosis or on follow-up surveillance and treated for *** cohort was compared with incomplete clinical responders to neoadjuvant chemoradiotherapy(nCRT)who subsequently underwent surgery on their primary *** survival was estimated using the Kaplan-Meier method,and the log-rank test was used to compare survival differences between *** Of 205 patients,11(5.4%)had metastases treated for cure(82%male;median age 60 years;9 adenocarcinoma and 2 squamous cell carcinomas).All had undergone neoadjuvant chemotherapy or chemoradiotherapy,followed by surgery in all but 1 *** the 11 patients,4 had metastatic disease at diagnosis,of whom 3 were successfully downstaged with nCRT before definitive surgery;2 of these 4 also developed oligometastatic recurrence and were treated with curative *** definitive treatment,7 had treatment for metachronous oligometastatic disease;5 of whom underwent metastasectomy(adrenal×2;lung×2;liver×1).The median overall survival was 10.9 years[95%confidence interval(CI):0.7-21.0 years],which was statistically significantly longer than incomplete clinical responders undergoing surgery on the primary tumour without metastatic intervention[n=62;median overall survival=1.9(95%CI:1.1-2.7;P=0.012].The cumulative proportion surviving 1,3,and 5 years was 100%,91%,and 61%,respectively compared to 71%,36%,and 25%for incomplete clinical responders undergoing surge

关键词： Oesophageal metastases Oligometastases Active surveillance Treatment for cure Metastasectomy Survival

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Isolated left ventricular apical hypoplasia:Systematic review and analysis of the 37 cases reported so far

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世界临床病例杂志 2023年第23期11卷 5494-5503页

作者： Pier Paolo Bassareo Sophie Duignan Adam James Esme dunne Colin J McMahon Kevin P walsh University College of Dublin School of Medicine and Department of Cardiology at Mater Misericordiae University HospitalDublin D07 R2WYIreland Department of Cardiology Children's Health CrumlinDublin D12 N512Ireland University College of Dublin School of Medicine and Department of CardiologyChildren's Health IrelandDublin D12 N512Ireland

BACKGROUND Isolated left ventricular apical hypoplasia(ILVAH),also known as truncated left ventricle(LV),is a very unusual *** is characterised by a truncated,spherical,and non-apex forming *** true apex is occupied by the right *** to the rarity of the disease,just a few case reports and limited case series have been published in the *** To analysing the so far 37 reported ILVAH cases *** The electronic databases PubMed and Scopus were investigated from their establishment up to December 13,*** The majority of cases reported occurred in males(52.7%).Mean age at diagnosis was 26.1±19.6 *** than a third of the patients were asymptomatic(35.1%).The most usual clinical presentation was breathlessness(40.5%).The most commonly detected electrocardiogram changes were T wave abnormalities(29.7%)and right axis deviation with poor R wave progression(24.3%).Atrial fibrillation/flutter was detected in 24.3%.Echocardiography was performed in 97.3%of cases and cardiac MRI in 91.9%of *** fraction was reduced in more than a half of patients(56.7%).An associated congenital heart disease was found in 16.2%.Heart failure therapy was administered in 35.1%of *** outcome was favorable in the vast majority of patients,with just one *** ILVAH is a multifaceted entity with a so far unpredictable course,ranging from benign until the elderly to sudden death during adolescence.

关键词： Isolated left ventricular apical hypoplasia Truncated left ventricle Electrocardiography Echocardiography Cardiac magnetic resonance imaging Heart failure

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Effect of microporosity on scaffolds for bone tissue engineering

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Regenerative Biomaterials 2018年第2期5卷 115-124页

作者： Ke Zhang Yubo Fan Nicholas dunne Xiaoming Li Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 102402China Centre for Medical Engineering Research School of Mechanical and Manufacturing EngineeringDublin City UniversityStokes BuildingCollins AvenueDublin 9Ireland State Key Laboratory of New Ceramic and Fine Processing Tsinghua UniversityBeijing 100084China

Microporosity has a critical role in improving the osteogenesis of scaffolds for bone tissue *** the exact mechanism,by which it promotes new bone formation,is not well recognized yet,the related hypothesis can be found in many previous *** review presents those possible mechanisms about how the microporosity enhances the osteogenic-related functions of cells in vitro and the osteogenic activity of scaffolds in *** summary,the increased specific surface areas by microporosity can offer more protein adsorption sites and accelerate the release of degradation products,which facilitate the interactions between scaffolds and ***,the unique surface properties of microporous scaffolds have a considerable effect on the protein ***,capillary force generated by the microporosity can improve the attachment of bone-related cells on the scaffolds surface,and even make the cells achieve penetration into the micropores smaller than *** review also pays attention to the relationship between the biological and mechanical properties of microporous *** lots of achievements have been obtained,there is still a lot of work to do,some of which has been proposed in the conclusions and perspectives part.

关键词： bone tissue engineering mechanism microporosity

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Predicting phosphorus sorption isotherm parameters in soil using data of routine laboratory tests

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Pedosphere 2021年第5期31卷 694-704页

作者： Kathleen S.dunne Nicholas M.HOLDEN Karen DALY Teagasc Johnstown CastleEnvironmental Research CentreCo.Wexford Y35TC97(Ireland) UCD School of Biosystems and Food Engineering University College DublinBelfieldDublin 4 D04VIW8(Ireland)

Knowledge of phosphorus(P)sorption dynamics across different soil types could direct agronomic and environmental management of *** objective of this study was to predict P isotherm parameters for a national soil population using data of routine laboratory *** and Freundlich sorption parameters were calculated from two different ranges(0-25 and 0-50 mg P L^(-1))using an archive of representative agricultural soil types from *** linear regression(MLR)identified labile forms of aluminium(Al)and iron(Fe),organic matter(OM),cation exchange capacity(CEC),and clay as significant *** and Freundlich sorption capacities,Freundlich affinity constant,and Langmuir buffer capacity were predicted reliably,with R^(2) of independent validation>*** isotherm parameters were predicted from P sorbed at a single concentration of 50 mg P L^(-1)(S_(50)).An MLR prediction of P sorption maximum in the 0-50 mg P L-1 range was achieved,to an accurate standard,using S_(50),OM,and Mehlich-3 Fe(R^(2) of independent calibration and validation being 0.91 and 0.95,respectively).Using Giles’four shapes of isotherms(C,L,H,and S),L non-strict-and C-shaped isotherm curves accounted for 64% and 27% of the soils,*** clustering identified a separation of isotherm curves influenced by two ranges of Mehlich-3 *** with a low range of Mehlich-3 Al(2.5-698 mg kg^(-1))had no incidence of rapid sorption(C shape).Single point indices,Al,or available soil data make the regression approach a feasible way of predicting Langmuir parameters that could be included with standard agronomic soil P testing.

关键词： available phosphorus binding fertilizer soil test sorption maximum

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Drug resistance in the sexually transmitted protozoan Trichomonas vaginalis

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Cell Research 2003年第4期13卷 239-249页

作者： REBECCA L dunne,LINDA A DUNN,PETER UPCROFT,PETERJO’DONOGHUE,JACQUELINE A UPCROFT The Queensland Institute of Medical Research The Australian Centre for International and Tropical Health and Nutrition Brisbane Queensland 4029 Australia Tie School of Molecular and Microbial Science University of Queensland Brisbane Queensland 4072 Australia The Queensland Institute of Medical Research The Australian Centre for International and Tropical Health and Nutrition Brisbane Queensland 4029 Australia The Queensland Institute of Medical Research The Australian Centre for International and Tropical Health and Nutrition Brisbane Queensland 4029 Australia The School of Molecular and Microbial Science University of Queensland Brisbane Queensland 4072 Australia The Queensland Institute of Medical Research The Australian Centre for International and Tropical Health and Nutrition Brisbane Queensland 4029 Australia

Trichomoniasis is the most common, sexually transmitted infection. It is caused by the flagellated protozoan parasite Trichomonas vaginalis. Symptoms include vaginitis and infections have been associated with preterm delivery, low birth weight and increased infant mortality, as well as predisposing to HIV/AIDS and cervical cancer. Trichomoniasis has the highest prevalence and incidence of any sexually transmitted infection. The 5-nitroimidazole drugs, of which metronidazole is the most prescribed, are the only approved, effective drugs to treat trichomoniasis. Resistance against metronidazole is frequently reported and cross resistance among the family of 5-nitroimidazole drugs is common, leaving no alternative for treatment, with some cases remaining unresolved. The mechanism of metronidazole resistance in T. vaginalis from treatment failures is not well understood, unlike resistance which is developed in the laboratory under increasing metronidazole pressure. In the latter situation, hydrogenosomal fu

关键词： Trichomonas vaginalis metronidazole pyruvate: ferredoxin oxidoreductase ferredoxin hydrogenase drug resistance.

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隐伏逆冲断层系

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宝石和宝石学杂志(中英文) 1988年第4期 28-33页

作者： william M. dunne david A.Ferrill 宋利好

隐伏断层已从全世界20个逆冲断层系中得到证实.隐伏断层从单条断层、断层组或整个逆冲断层系的形式产出.上覆盖层通过反冲作用、互冲作用(Coupling)、前冲作用和沉积作用与隐伏逆冲断层系统的形式相适应.其中,前三者与前构造盖层的有关... 详细信息

隐伏断层已从全世界20个逆冲断层系中得到证实.隐伏断层从单条断层、断层组或整个逆冲断层系的形式产出.上覆盖层通过反冲作用、互冲作用(Coupling)、前冲作用和沉积作用与隐伏逆冲断层系统的形式相适应.其中,前三者与前构造盖层的有关重要性,表示在反冲作用-互冲作用-前冲作用的三元图中.隐伏系统的前构造盖层的变形,或者通过互冲作用与前冲作用的联合作用产生,或通过反冲作用与互冲作用的联合作用而形成.

关键词：逆冲断层冲断层盖层地层反冲作用双冲构造

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Impact of radiotherapy on the immune landscape in oesophageal adenocarcinoma

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world Journal of Gastroenterology 2022年第21期28卷 2302-2319页

作者： Noel E Donlon Maria Davern Fiona O'Connell Andrew Sheppard Aisling Heeran Anshul Bhardwaj Christine Butler Ravi Narayanasamy Claire Donohoe James J Phelan Niamh Lynam-Lennon Margaret R dunne Stephen Maher Jacintha O'Sullivan John V Reynolds Joanne Lysaght Department of Surgery Trinity Translational Medicine InstituteSt James HospitalDublin D08Ireland

BACKGROUND In the contemporary era of cancer immunotherapy,an abundance of clinical and translational studies have reported radiotherapy(RT)and immunotherapies as a viable option for immunomodulation of many cancer subtypes,with many related clinical trials *** locally advanced disease,chemotherapy or chemoradiotherapy followed by surgical excision of the tumour remain the principal treatment strategy in oesophageal adenocarcinoma(OAC),however,the use of the host immune system to improve anti-tumour immunity is rapidly garnering increased support in the curative *** To immunophenotype OAC patients’immune checkpoint(IC)expression with and without radiation and evaluate the effects of checkpoint blockade on cell *** In the contemporary era of cancer immunotherapy,an abundance of studies have demonstrated that combination RT and IC inhibitors(ICIs)are effective in the immunomodulation of many cancer subtypes,with many related clinical trials *** surgical excision and elimination of tumour cells by chemotherapy or chemoradiotherapy remains the gold standard approach in OAC,the propagation of anti-tumour immune responses is rapidly garnering increased support in the curative *** aim of this body of work was to immunophenotype OAC patients’IC expression with and without radiation and to establish the impact of checkpoint blockade on cell *** study was a hybrid combination of in vitro and ex vivo *** of serum immune proteins was performed by enzyme-linked immunosorbent *** cytometry staining was performed to evaluate IC expression for in vitro OAC cell lines and ex vivo OAC *** viability in the presence of radiation with and without IC blockade was assessed by a cell counting kit-8 *** we identified that conventional dosing and hypofractionated approaches resulted in increased IC expression(PD-1,PD-L1,TIM3,TIGIT)in vitro and ex vivo in *** were two distinct subco

关键词： Oesophageal Cancer Radiotherapy Immunotherapy Immunology Surgery Oncology

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