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Perianal disease,small bowel disease,smoking,prior steroid or early azathioprine/biological therapy are predictors of disease behavior change in patients with Crohn's disease

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World Journal of Gastroenterology 2009年第28期15卷 3504-3510页

作者： Peter Laszlo Lakatos Zsofia Czegledi Tamas Szamosi Janos Banai Gyula david Ferenc Zsigmond Tunde Pandur Zsuzsanna Erdelyi Orsolya Gemela Janos Papp Laszlo Lakatos 1st Department of Medicine Semmelweis University H-1083 Budapest Hungary Department of Gastroenterology State Health Center H-1062 Budapest Hungary 1st Department of Medicine Csolnoky F. County Hospital HH8201-Veszprem Hungary

AIM:To assess the combined effect of disease phenotype, smoking and medical therapy [steroid, azathioprine(AZA), AZA/biological therapy] on the probability of disease behavior change in a Caucasian cohort of patients with Crohn's disease(CD).METHODS:Three hundred and forty well-characterized, unrelated, consecutive CD patients were analyzed(M/F:155/185, duration:9.4 ± 7.5 years) with a complete clinical *** records including disease phenotype according to the Montreal classification, extraintestinal manifestations, use of medications and surgical events were analyzed *** were interviewed on their smoking habits at the time of diagnosis and during the regular follow-up ***:A change in disease behavior was observed in 30.8% of patients with an initially non-stricturing, non-penetrating disease behavior after a mean diseaseduration of 9.0 ± 7.2 *** a logistic regression analysis corrected for disease duration, perianal disease, smoking, steroid use, early AZA or AZA/ biological therapy use were independent predictors of disease behavior *** a subsequent Kaplan-Meier survival analysis and a proportional Cox regression analysis, disease location(P = 0.001), presence of perianal disease(P < 0.001), prior steroid use(P = 0.006), early AZA(P = 0.005) or AZA/biological therapy(P = 0.002), or smoking(P = 0.032) were independent predictors of disease behavior ***:Our data suggest that perianal disease, small bowel disease, smoking, prior steroid use, early AZA or AZA/biological therapy are all predictors of disease behavior change in CD patients.

关键词： Crohn's disease Smoking Azathioprine Infliximab Monoclonal antibodies Colectomy Risk Reoperation

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体验商务英语教师用书～4≈(配)1光盘 2

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丛书名：《体验商务英语》系列教材

2012年

作者： Bill Mascull david Heitler

本书分14个单元和2个复习课, 内容涉及现代商务和企业管理, 包括沟通技巧、国际营销、建立永久性客户关系、如何使人成功、工作的满足感、风险、电子商务、团队合作等主题。。

ISBN: (数字)9787040348569

ISBN: (纸本)9787040348569

关键词：商务

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难治性和顽固性高血压:降压治疗抵抗和治疗失败

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中华高血压杂志 2015年第7期23卷 612-615页

作者： david A.Calhoun MD 伯明翰阿拉巴马大学血管生物学和高血压研究室

几十年来难治性高血压被定义为尽管使用包括利尿剂在内的3种降压药,血压仍未能控制达标[1]。美国心脏协会（American Heart Association,AHA）一份科学声明对难治性高血压的定义做了进一步扩展,包括了使用≥4种降压药能使血压控制达标... 详细信息

几十年来难治性高血压被定义为尽管使用包括利尿剂在内的3种降压药,血压仍未能控制达标[1]。美国心脏协会（American Heart Association,AHA）一份科学声明对难治性高血压的定义做了进一步扩展,包括了使用≥4种降压药能使血压控制达标的高血压[2]。

关键词：顽固性高血压难治性高血压降压药治疗失败治疗抵抗美国心脏协会血压控制利尿剂

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Macroinvertebrate　assemblages　of　surface　mine　wetlands　of　Southwest　Virginia，USA

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Journal of Environmental Sciences 1996年第1期8卷 1-14页

作者： david H.Jones Robert B. Atkinson John Cairns,Jr.(Department of Biology,Virginia Polytechnic Institute and State University, Blacksburg,Virginia 24061 USA) Dept Biol Virginia Poly Inst Blacksburg VA 24061 United States

The focus of this study was to investigate the macroinvertebrate community in surface mine wetlands. Nine wetlands were sampled for macroinvertebrates from July 1993 through May *** sites represented a range of physical,chemical, and biological parameters. Macroinvertebrates were found in all sites;a total of 14 orders, 40 families,and 70 genera were identified in the samples. Insects were the most common invertebrates,and most functional feeding groups were represented. Predators dominated with 63% of the taxa, followed by the collector/gathers with 20%,shredders 14%, and scrapers 3%. Sites differed in the number of taxa inhabiting *** ranged from 10 genera to *** lowest richness was found in two seasonal wetlands that were dry for the majority of the year. A permanently flooded site with no water quality problems and a dense growth of aquatic plants had the highest richness.

关键词： macroinvertebrate assemblages surface mine wetlands wetland faunas.

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Productive Response of Brassica rapa *** to Application of VIUSID Agro

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Journal of Agricultural Science and Technology(B) 2019年第2期9卷 103-109页

作者： Kolima Pena Calzada Dilier Olivera Viciedo Alexander Calero Juan Carlos rodríguez Bulent Kukurtcu Yanet Milagros Placenciaálvarez Alexei Castro Salas Department of Agronomy Faculty of Agricultural SciencesUniversity of Sancti Spiritus Jose Marti Perez(UNISS)Sancti Spiritus 60100Cuba School of Agricultural and Veterinarian Sciences Sao Paulo State University(UNESP)Jaboticabal 1480Sao PauloBrazil Scientific Department CatalysisS.L.Madrid 28016Spain Department of Mathematics University of Camagüey Ignacio Agramonte LoynazCamagüey 74650Cuba

In order to evaluate the effect of VIUSID agro on the yield response of a pak choi harvest,a randomised block experiment was designed with four treatments and three *** treatments were dosages of 0.1,0.2 and 0.3 L/ha and one *** number of leaves per plant and the fresh and dry mass of the plant were *** addition,growth indexes were evaluated,such as relative growth rate,active growth rate,harvest index and agricultural *** number of leaves per plant was significantly greater at 35 days after sowing(das)for 0.2 L/ha and 0.3 L/ha treatments,with increases of 15.0%and 14.17%relative to the *** plant length and fresh mass at the final evaluation,the treatments using higher dosages produced the best *** the active growth rate,the 0.2 L/ha dosage produced the best effects,and regarding relative growth rate,the 0.2 L/ha and 0.3 L/ha dosages produced the best results relative to the *** harvest index did not benefit from the used dosages,while a higher agricultural yield was achieved using the 0.2 L/ha and 0.3 L/ha dosages at 18.03%and 12.88%compared to the ***,VIUSID agro positively influenced the yield behaviour of pak choi.

关键词： VIUSID agro pak choi amino acids vegetables.

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Cryptocurrency trading:a comprehensive survey

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Financial Innovation 2022年第1期8卷 404-462页

作者： Fan Fang Carmine Ventre Michail Basios Leslie Kanthan david Martinez-Rego Fan Wu Lingbo Li Department of Informatics Faculty of NaturalMathematical&Engineering ScienceKing’s College LondonStrandLondon WC2R 2LSUK Turing Intelligence Technology LimitedLondonUK

In recent years,the tendency of the number of financial institutions to include crypto-currencies in their portfolios has *** are the first pure digital assets to be included by asset *** they have some commonalities with more traditional assets,they have their own separate nature and their behaviour as an asset is still in the process of being *** is therefore important to summarise existing research papers and results on cryptocurrency trading,including available trading platforms,trading signals,trading strategy research and risk *** paper provides a comprehensive survey of cryptocurrency trading research,by covering 146 research papers on various aspects of cryptocurrency trading(e.g.,cryptocurrency trading systems,bubble and extreme condition,prediction of volatility and return,crypto-assets portfolio construction and crypto-assets,technical trading and others).This paper also analyses datasets,research trends and distribution among research objects(contents/properties)and technologies,concluding with some promising opportunities that remain open in cryptocurrency trading.

关键词： Trading Cryptocurrency Machine learning Econometrics

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右心房异常是心房扑动的病理基础——三维电—解剖标测结果

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中国循环杂志 2004年第1期19卷 7-10页

作者：方丕华 david M Fitzgerald 中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院心律失常诊治中心北京市100037 Section of Cardiology

目的 :应用三维电—解剖标测技术标测典型心房扑动患者的右心房 ,并与房室结折返性心动过速患者比较 ,研究心房扑动患者右心房的解剖及电生理异常情况。方法 :2 0例心房扑动患者 [心房扑动组 ,男 16例 ,女 4例 ,平均年龄 ( 5 5 90± 10... 详细信息

目的 :应用三维电—解剖标测技术标测典型心房扑动患者的右心房 ,并与房室结折返性心动过速患者比较 ,研究心房扑动患者右心房的解剖及电生理异常情况。方法 :2 0例心房扑动患者 [心房扑动组 ,男 16例 ,女 4例 ,平均年龄 ( 5 5 90± 10 68)岁 ]和 2 6例房室结折返性心动过速患者 [对照组 ,男 9例 ,女 17例 ,平均年龄 ( 4 7 5 0± 19 5 6)岁 ]在行射频导管消融前先用电—解剖标测进行研究 ,测量右心房容积 ,下腔静脉—三尖瓣环峡部 (CTI)的长度、宽度和右心房的单极和双极电压等 ,并对心房扑动组和对照组的各项参数进行比较。结果 :各项测量参数在心房扑动组和对照组分别为 :右心房容积 ( 14 3 2 2± 40 72 )mlvs ( 10 4 3 5± 2 1 0 6)ml;峡部长度 ( 3 9 3 1± 8 10 )mmvs ( 3 2 42± 9 77)mm ,峡部宽度 ( 3 0 5 4± 7 48)mmvs ( 2 3 15± 6 61)mm ,右心房单极电压 ( 1 96± 1 2 4)mVvs ( 1 5 3± 0 91)mV及右心房双极电压 ( 1 47± 1 47)mVvs ( 1 2 9± 1 12 )mV。以上各参数心房扑动组和对照组比较 ,P均 <0 0 5～ 0 0 1。结论 :心房扑动与房室结折返性心动过速患者相比 ,其右心房容积增大 ,CTI的长度和宽度增大 ,右心房的单极和双极电位增高。心房扑动患者的这些异常表现提示右心房增大。

关键词：右心房异常心房扑动病理三维电-解剖标测心律失常

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Femtosecond laser fabrication of nanograting-based distributed fiber sensors for extreme environmental applications

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International Journal of Extreme Manufacturing 2021年第2期3卷 139-152页

作者： Mohan Wang Kehao Zhao Jingyu Wu Yuqi Li Yang Yang Sheng Huang Jieru Zhao Thomas Tweedle david Carpenter Guiqiu Zheng Qingxu Yu Kevin P Chen Department of Electrical and Computer Engineering University of PittsburghPittsburghPA 15261United States of America School of Optoelectronic Engineering and Instrument Science Dalian University of TechnologyDalian 116081People’s Republic of China Westinghouse Electric Company LLC PittsburghPA 15235United States of America Nuclear Reactor Laboratory Massachusetts Institute of Technology138 Albany StreetCambridgeMA 02139United States of America

The femtosecond laser has emerged as a powerful tool for micro-and nanoscale device fabrication. Through nonlinear ionization processes, nanometer-sized material modifications can be inscribed in transparent materials for device fabrication. This paper describes femtosecond precision inscription of nanograting in silica fiber cores to form both distributed and point fiber sensors for sensing applications in extreme environmental conditions. Through the use of scanning electron microscope imaging and laser processing optimization,high-temperature stable, Type II femtosecond laser modifications were continuously inscribed,point by point, with only an insertion loss at 1 d B m~(-1) or 0.001 d B per point sensor ***-temperature performance of fiber sensors was tested at 1000℃, which showed a temperature fluctuation of ±5.5℃ over 5 days. The low laser-induced insertion loss in optical fibers enabled the fabrication of a 1.4 m, radiation-resilient distributed fiber sensor. The in-pile testing of the distributed fiber sensor further showed that fiber sensors can execute stable and distributed temperature measurements in extreme radiation environments. Overall, this paper demonstrates that femtosecond-laser-fabricated fiber sensors are suitable measurement devices for applications in extreme environments.

关键词： femtosecond laser manufacturing optical fiber sensor device fabrication extreme environment sensing

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时间序列数据分析与预处理

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小型微型计算机系统 2003年第12期24卷 2228-2232页

作者：郭躬德王晖 david Bell 福建师范大学计算机科学系福建福州350007 School of Information and Software Engineering University of UlsterNewtownabbeyBT370QBN.IrelandUK

时间序列分析中常常遇到的一个问题是如何有效地过滤噪音和约简数据 .本文通过修改传统的离散的傅立叶变换来过滤噪音和进行数据的约简 ,并尽可能保留原始时间序列的全局变化趋势 .为检验该方法的有效性 ,本文同时提出一个新颖的数据分... 详细信息

时间序列分析中常常遇到的一个问题是如何有效地过滤噪音和约简数据 .本文通过修改传统的离散的傅立叶变换来过滤噪音和进行数据的约简 ,并尽可能保留原始时间序列的全局变化趋势 .为检验该方法的有效性 ,本文同时提出一个新颖的数据分类算法MCC ,并用该算法对股票回报率的变化进行预测 ,实验结果显示 ,用MCC算法在预处理后的数据上进行预测 ,其预测的命中率达到 6 3.6 8% ,而在原始数据上进行预测 ,其预测的命中率只有 4 8.98% .显然 ,通过对原始数据进行噪音过滤有效地改善了预测的精度 .另外 ,数据的约简也提高了预测算法的效率 .

关键词：时间序列预测傅立叶变换噪音过滤数据约简数据分类时间序列分析数据库

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如何管理"泛员工队伍"

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商业评论 2024年第8期 150-157页

作者：伊丽莎白·奥尔特曼戴维·基伦杰夫·施瓦茨罗宾·琼斯石小竹马萨诸塞大学洛厄尔分校曼宁商学院《MIT斯隆管理评论》研究部 Gloat公司哥伦比亚大学商学院德勤咨询公司

"你如何定义自己的员工队伍?"我们曾在多项全球管理调查问卷中向数十位高管提出这个问题.最常见的答案也最令人惊讶.少数高管十分确信地表示,他们的员工队伍无非是在职员工罢了.但绝大多数高管,尤其是那些站在组织变革前沿的领导者,采...

"你如何定义自己的员工队伍?"我们曾在多项全球管理调查问卷中向数十位高管提出这个问题.最常见的答案也最令人惊讶.少数高管十分确信地表示,他们的员工队伍无非是在职员工罢了.但绝大多数高管,尤其是那些站在组织变革前沿的领导者,采取了一种更广阔的视角,而不仅仅局限于在职员工的范围.

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