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Brain metastasis in advanced colorectal cancer： results from the South Australian metastatic colorectal cancer (SAmCRC) registry

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Cancer Biology & Medicine 2017年第4期14卷 371-376页

作者： Gonzalo Tapia Rico Timothy J. Price Christos Karapetis Cynthia Piantadosi Rob Padbury Amitesh Roy Guy Maddern James Moore Scott Carruthers david roder Amanda R. Townsend Department of Medical Oncology The Queen Elizabeth Hospital and University of Adelaide Adelaide SA 5011 Australia Department of Medical Oncology Flinders Medical Center and Flinders University Adelaide SA 5042 Australia Department of Surgery Flinders Medical Center Bedford Park SA 5042 Australia Department of Surgery The Queen Elizabeth Hospital Adelaide SA 5011 Australia Department of Surgery University of South Australia Adelaide SA 5005 Australia Department of Surgery Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Radiation Oncology Royal Adelaide Hospital Adelaide SA 5000 Australia Department of Epidemiology University of South Australia Adelaide SA 5005 Australia

Objective:Brain metastasis is considered rare in metastatic colorectal cancer(mCRC);thus,surveillance imaging does not routinely include the *** reported incidence of brain metastases ranges from 0.6% to 3.2%.Methods:The South Australian mCRC Registry(SAmCRC)was analyzed to assess the number of patients presenting with brain metastasis during their *** to small numbers,a descriptive analysis is ***:Only 59 patients of 4,100 on the registry at the time of analysis had developed brain metastasis(1.4%).The clinical characteristics of those with brain metastasis were as follows:the median age was 65.3 years and 51% were *** the V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)mutation status of the tumor was known,the majority harbored a KRAS mutation(55%);31(53%)underwent craniotomy and 55(93%)underwent whole-brain *** median survival time from diagnosis of brain metastasis was 4.2 months(95% confidence interval 2.9–5.5).Patients who underwent craniotomy and radiotherapy had superior survival compared to those who underwent whole-brain radiotherapy(8.5 months vs.2.2 months,respectively).Data from the SAmCRC(a population-based registry)confirm that brain metastases are rare and the median time to development is approximately 2 ***:Brain metastasis is a rare outcome in advanced *** within the registry tended to be female,young in age,and harbored with higher rates of KRAS *** routine surveillance brain scanning should be considered remains controversial given the relative rarity of developing brain metastases in mCRC and ultimately,most patients with central nervous system involvement die from their extracranial disease.

关键词： Brain metastasis colorectal cancer survival surveillance

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Extent and predictors of grade upgrading and downgrading in an Australian cohort according to the new prostate cancer grade groupings

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Asian Journal of Urology 2019年第4期6卷 321-329页

作者： Kerri Beckmann Michael O’Callaghan Andrew Vincent Penelope Cohen Martin Borg david roder Sue Evans Jeremy Millar Kim Moretti Cancer Research Institute School of Health SciencesUniversity of South AustraliaAdelaideAustralia School of Cancer and Pharmaceutical Sciences King’s College LondonLondonUK Flinders Medical Centre Urology UnitAdelaideAustralia School of Medicine University of AdelaideAdelaideAustralia SA Pathology Health SAAdelaideSouth AustraliaAustralia Genesis Care University of AdelaideAdelaideAustralia Department of Epidemiology and Preventive Medicine Monash UniversityMelbourneAustralia

Object:To determine the extent and impact of upgrading and downgrading among men who underwent radical prostatectomy(RP)according to new grade groupings and to identify predictors of upgrading from biopsy grade Group Ⅰ and Ⅱ,and downgrading to grade Group I,in a community ***:Study participants included 2279 men with non-metastatic prostate cancer diagnosed 2006-2015 who underwent prostatectomy,from the multi-institutional South Australia Prostate Cancer Clinical Outcomes Collaborative *** of up-or down-grading was assessed by comparing biopsy and prostatectomy grade *** of biochemical recurrence(BCR)with upgrading was assessed using multivariable competing risk *** logistic regression was used to identify pre-treatment predictors of upgrading from grade Groups Ⅰ and Ⅱ,and risk group reclassification among men with low risk ***:Upgrading occurred in 35%of cases,while downgrading occurred in 13%of *** percent with grade Group I disease were upgraded following *** from grade Group I was associated with greater risk of BCR compared with concordant grading(Hazard ratio:3.1,95%confidence interval:1.7-6.0).Older age,higher prostate-specific antigen levels(PSA),fewer biopsy cores,higher number of positive cores and more recent diagnosis predicted upgrading from grade Group Ⅰ,while higher PSA and clinical stage predicted upgrading from grade Group Ⅱ.No clinical risk factors for reclassification were ***:Biopsy sampling errors may play an important role in upgrading from grade Group *** clinical assessment of grade is needed to encourage greater uptake of active surveillance.

关键词： Prostate cancer Grade misclassification Biopsy Radical prostatectomy Pathology

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Schoolchildren from disadvantaged backgrounds present a loss of lean tissue mass and significant increase of body fat mass during the COVID-19 lockdown in Germany:results from the MEDdirect study

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World Journal of Pediatrics 2022年第5期18卷 363-367页

作者： david Muhmann Marvin Droste Jorn Schulz Frederike Linge Lea Ladewig Ursula Eisenberg Susanne roder Rainer Buscher University Hospital Essen PediatricsⅡHufelandstr.5545147 EssenGermany Be Strong for Kids E.V Sundernholz 10845134 EssenGermany Schule Am Steeler Tor Engelbertstr.445127 EssenGermany

Children from socio-economically disadvantaged backgrounds receive unequal opportunities to succeed in school,which will lead to a decreased health literacy as adults[U].This is not only directly associated with an impaired eco-nomic and mental health and wellbeing of young people,but above all with an in creased adult mortality[1-4].While this problem is well known and described,only few and even fewer pediatric studies suggest how to interrupt this downward spiral consistently[5,6].

关键词： disadvantage adult impaired

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