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Effect of exogenous fibrolytic enzymes on performance and blood profile in early and mid-lactation Holstein cows

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Animal Nutrition 2015年第3期1卷 229-238页

作者： Anja peters Ulrich Meyer Sven Danicke Institute of Animal Nutrition Friedrich-Loeffler-Institute(FLI)Federal Research Institute for Animal Health

The supplementation of exogenous fibrolytic enzymes(EFE) to dairy cows diets could be a strategy to improve fiber degradation in the rumen which is especially important for the early lactating cows characterized by a high milk energy output and an insufficient energy intake. The objective of this study was to examine the effects of a fibrolytic enzyme product(Roxazyme G2 Liquid, 3.8 and 3.9 mL/kg total mixed ration [TMR] DM) supplemented to a TMR on production performance and blood parameters of dairy cows during early(trial 1) and mid-lactation(trail 2). In addition, rumination activity was measured in trial 2. The nutrient digestibility of the experimental TMR was obtained by using wethers. In the digestibility trial, EFE was supplemented at a rate of 4.4 m L/kg Roxazyme G2 Liquid TMR-DM. The TMR contained 60% forage and 40% concentrate(DM basis). Twenty eight 50 ± 16 days in milk(DIM)and twenty six 136 ± 26 DIM Holstein cows were used in two 8-wk completely randomized trails,stratified by parity and milk yield level. One milliliter of the enzyme product contained primarily cellulase and xylanase activities(8,000 units endo-1,4-? glucanase, 18,000 units endo-1,3(4)-? glucanase and 26,000 units 1,4-? xylanase). No differences in digestibility of DM, OM, CP, NDF and ADF were observed(P >0.05) between the control and the EFE supplemented TMR. Addition of EFE to the TMR fed to early(trial 1) and mid-lactation cows(trial 2) did not affect daily dry matter intake(DMI), milk yield,4% fat-corrected milk, energy-corrected milk(ECM), concentration of milk fat, protein, fat-protein-quotients, somatic cell score, energy balance, and gross feed efficiency of early and mid-lactation cows(P >0.05). Mid-lactation cows(trial 2) fed with TMR enzyme showed a tendency of a slightly higher ECM yield(P = 0.09). The tested blood parameters were not affected by treatment in trials 1 and 2(P >0.05).Exogenous fibrolytic enzymes supplementation did not alter daily time spent ruminating in t

关键词： Fibrolytic enzymes Dairy cows Milk yield Feed efficiency

Statins markedly potentiate aminopeptidase inhibitor activity against(drug-resistant)human acute myeloid leukemia cells

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Cancer Drug Resistance 2023年第3期6卷 430-446页

作者： Gerrit Jansen Marjon Al Yehuda G.Assaraf Sarah Kammerer Johan van Meerloo Gert J.Ossenkoppele Jacqueline Cloos Godefridus J.peters Department of Rheumatology and Clinical Immunology Amsterdam Rheumatology and immunology CenterAmsterdam University Medical Centerlocation VUmcAmsterdam 1081 HVThe Netherlands The Fred Wyszkowsky Cancer Research Laboratory Faculty of BiologyThe Technion-Israel Institute of TechnologyHaifa 3200003Israel Department of Medical Oncology Amsterdam University Medical Centerlocation VUmcAmsterdam 1081 HVThe Netherlands Institute of Biotechnology Molecular Cell BiologyBrandenburg University of Technology Cottbus-SenftenbergSenftenberg 01968Germany Department of Hematology Amsterdam University Medical Centerlocation VUmcAmsterdam 1081 HVThe Netherlands Department of Biochemistry Medical University of GdanskGdansk 80-210Poland

Aim: This study aimed to decipher the molecular mechanism underlying the synergistic effect of inhibitors of the mevalonate-cholesterol pathway (i.e., statins) and aminopeptidase inhibitors (APis) on APi-sensitive and -resistant acute myeloid leukemia (AML) ***: U937 cells and their sublines with low and high levels of acquired resistance to (6S)-[(R)-2-((S)-Hydroxy-hydroxycarbamoyl-methoxy-methyl)-4-methyl-pentanoylamino]-3,3 dimethyl-butyric acid cyclopentyl ester (CHR2863), an APi prodrug, served as main AML cell line models. Drug combination effects were assessed with CHR2863 and in vitro non-toxic concentrations of various statins upon cell growth inhibition, cell cycle effects, and apoptosis induction. Mechanistic studies involved analysis of Rheb prenylation required for mTOR ***: A strong synergy of CHR2863 with the statins simvastatin, fluvastatin, lovastatin, and pravastatin was demonstrated in U937 cells and two CHR2863-resistant sublines. This potent synergy between simvastatin and CHR2863 was also observed with a series of other human AML cell lines (e.g., THP1, MV4-11, and KG1), but not with acute lymphocytic leukemia or multiple solid tumor cell lines. This synergistic activity was: (i) specific for APis (e.g., CHR2863 and Bestatin), rather than for other cytotoxic agents;and (ii) corroborated by enhanced induction of apoptosis and cell cycle arrest which increased the sub-G1 fraction. Consistently, statin potentiation of CHR2863 activity was abrogated by co-administration of mevalonate and/or farnesyl pyrophosphate, suggesting the involvement of protein prenylation;this was experimentally confirmed by impaired Rheb prenylation by ***: These novel findings suggest that the combined inhibitory effect of impaired Rheb prenylation and CHR2863-dependent mTOR inhibition instigates a potent synergistic inhibition of statins and APis on human AML cells.

关键词： Aminopeptidase statins mevalonate pathway carboxyl esterase Rheb mTOR

XDEM multi-physics and multi-scale simulation technology: Review of DEM-CFD coupling, methodology and engineering applications

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Particuology 2019年第3期17卷 176-193页

作者： Bernhard peters Maryam Baniasadi Mehdi Baniasadi Xavier Besseron Alvaro Estupinan Donoso Mohammad Mohseni Gabriele Pozzetti Universite du Luxembourg 6. rue Coudenhove-Kalergi L-1359 Luxembourg

The extended discrete element method (XDEM) multi-physics and multi-scale simulation platform is being developed at the Institute of Computational Engineering, the University of Luxembourg. The platform is an advanced multi-physics simulation technology that combines flexibility and versatility to establish the next generation of multi-physics and multi-scale simulation tools. For this purpose, the simulation framework relies on coupling various predictive tools based on an Eulerian and Lagrangian approach. The Euleria n approach represents the wide field of con tinuum models;the Lagra ngian approach is perfect for characterising discrete phases. Continuum models thus include classical simulation tools, such as computational fluid dynamics simulation and finite element analysis, while an extended configuration of the classical discrete element method addresses the discrete (e.g., particulate) phase. Apart from predicting the trajectories of in dividual particles, XDEM-suite extends the application of the XDEM to estimating the thermodynamic state of each particle using advanced and optimised algorithms. The thermodynamic state may include temperature and species distributions due to chemical reaction and external heat sources. Hence, coupling these extended features with either computational fluid dynamics simulation or finite element analysis opens a wide range of applications as diverse as pharmaceuticals, agriculture, food processing, mining, construction and agricultural machinery, metals manufacturing, energy production and systems biology.

关键词： Multi-phase modelling Coupled computational fluid dynamics-discrete element method

Comparison of Nitric Oxide Concentrations in μs-and ns-Atmospheric Pressure Plasmas by UV Absorption Spectroscopy

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Plasma Science and Technology 2016年第4期18卷 406-411页

作者： F.peters J.HIRSCHBERG N.MERTENS S.WIENEKE W.VIOL HAWK University of Applied Sciences and Arts Von-Ossietzky-Straβe 9937085 Gottingen Germany Fraunhofer Application Center for Plasma and Photonics Fraunhofer Institute for Surface Engineering and Thin Films IST Von-Ossietzky-Stratte 100 37085 Gottingen Germany

In this paper,an absorption spectroscopy measurement method was applied on two atmospheric pressure plasma sources to determine their production of nitric *** concentrations are essential for evaluating the plasma sources based on the principle of the Dielectric Barrier Discharge（DBD）for applications in plasma *** described method is based on a setup with an electrodeless discharge lamp filled with a mixture of oxygen and *** of the emitted wavelengths is an important resonance wavelength of nitric oxide（λ = 226.2 nm）.By comparing the absorption behaviour at the minimum and maximum of the spectral absorption cross section of nitric oxide around that wavelength,and measuring the change in intensity by the absorbing plasma,the concentration of nitric oxide inside the plasma can be *** produced nitric oxide concentrations depend on the pulse duration and are in the range of 180 ppm to 1400 ppm,so that a distance of about 10 cm to the respiratory tract is enough to conform to the VDI Guideline 2310.

关键词： nitric oxide(NO)concentration dielectric barrier discharge(DBD) ultraviolet(UV)absorption spectroscopy plasma medicine pulse duration ns-source μs-source

Brent prices and oil stock behaviors: evidence from Nigerian listed oil stocks

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Financial Innovation 2018年第1期4卷 146-160页

作者： Amarachi Uzo-peters Temitope Laniran Adeola Adenikinju Centre for Petroleum Energy Economics and LawUniversity of IbadanIbadanNigeria Bradford Centre for International Development University of BradfordBradfordUK

Background:Given the shale oil glut that culminated in the most recent and continuing oil price drop from June 2014 and the global financial crisis of 2008 that triggered a cyclical downturn in oil prices and stock market activity,this study investigates the impact of Brent oil price shocks on oil related stocks in ***:This study uses a vector autoregressive(VAR)model with the impulse response function and the forecast variance decomposition ***:The empirical evidence reveals that oil price shocks have a negative impact on Nigerian oil and gas company *** theory,this situation should apply to oil importing countries and is therefore uncharacteristic of an oil exporting country like ***:The findings suggest that oil companies operating in Nigeria should diversify their investments to protect their business from single-sector market forces,and can also embrace the advantages of outsourcing some of their operations to specialist providers to increase flexibility and reduce operating ***,for vertically integrated oil and gas companies,oil price hedging and energy risk management will be beneficial because it will mean that these companies will take a position in the crude oil futures *** will allow for better cash flow management and ***/value:This study extends the existing literature in two distinct ***,it provides,to the best of our knowledge,the first examination of the impact of oil price shocks on stock market activities with a focus on the market returns of oil and gas companies listed in the Nigerian Stock ***,this study uses daily data because high frequency data contain more information than lower frequency data does,and lower frequency data average out too much important information.

关键词： Oil price shock Stock markets VAR Impulse response Nigeria

Postdigital Knowledge Cultures and Their Politics

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ECNU Review of Education 2018年第2期1卷 23-43页

作者： Michael A.peters Tina Besley Petar Jandrić Beijing Normal University Zagreb University of Applied Sciences

Purpose-This paper aims at exploring politics of contemporary knowledge cultures and possible directions for responding to the postdigital ***/Approach/Methods-This paper researches history and present of several prominent strands and readings of the knowledge *** Caruso’s work(2016),it examines more closely the differences between the managerial paradigm and the cognitive capitalism *** the postdigital nature of contemporary knowledge cultures,it points towards a postdigital merger between the managerial paradigm and the cognitive capitalism ***-The paper identifies individual and social tensions between industrial and post-industrial modes of production and rapidly changing dynamic of social *** examines the relationships between knowledge cultures and digital *** on recent insights by the father of the World Wide Web Tim Berners-Lee and his non-determinist views to digital technologies,it identifies knowledge cultures as sites of political struggle against various(material and non-material,technological and non-technological)closures over access to information and ***,it briefly outlines possible directions for responding to the postdigital challenge of knowledge ***/Value-The paper provides an original contribution to theory of knowledge cultures and its relationships to the postdigital condition.

关键词： Knowledge cultures postdigital knowledge economy managerial capitalism cognitive capitalism

Clinical implications of the molecular characterization of intraductal papillary mucinous neoplasms of the pancreas

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 430-447页

作者： Nicholas V.peters John W.Kunstman Department of Surgery Yale University School of MedicineNew Haven 06510CTUSA.

Intraductal papillary mucinous neoplasm(IPMN)is a pre-malignant,mucin-producing epithelial lesion arising from pancreatic *** reports define IPMN behavior as ranging from indolent,asymptomatic lesions to dysplasia that sometimes degenerate into pancreatic *** goal of IPMN management is risk-reducing surgery for high-risk cysts and observation of the *** high-from low-risk IPMN disease still relies on imaging and clinical cyst ***,we review the accepted classification of IPMN including the most common histological subtypes,their clinical features,and currently-accepted high-risk *** then deeply examine the known molecular landscape of IPMN,which has largely been derived from post-resection *** includes those gene variants unique to IPMN,chiefly GNAS and RNF43,but also examines the overlap between IPMN and conventional pancreatic *** molecular markers in the clinical setting relies on endoscopically-obtained cyst fluid and presumes that it accurately represents the molecular characteristics of the cystic *** synthesize existing data on mutational analysis from IPMN cyst fluid and consider the benefits and proper role of current commercially-available cyst fluid molecular analysis *** conclude that carefully interpreted molecular analysis of resected IPMN tissue reveals insights into its biology and natural history while cyst fluid analysis offers prognostication and data to guide treatment ***,knowledge gaps remain,especially in characterizing IPMN molecular heterogeneity,time to progression,and correlating cyst fluid genotype data with surveillance *** such,substantial additional research is required before the promise of true molecular guidance of IPMN management can be realized.

关键词： Intraductal papillary mucinous neoplasm pancreatic cancer molecular analysis GNAS KRAS RNF43

Predicting Ailanthus altissima presence across a managed forest landscape in southeast Ohio

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Forest Ecosystems 2019年第4期6卷 261-273页

作者： Louis R.Iverson Joanne Rebbeck Matthew P.peters Todd Hutchinson Timothy Fox Northern Research Station USDA Forest Service

Background: The negative impacts of the exotic tree, Ailanthus altissima(tree-of-heaven, stink tree), is spreading throughout much of the Eastern United States. When forests are disturbed, it can invade and expand quickly if seed sources are ***: We conducted studies at the highly dissected Tar Hollow State Forest(THSF) in southeastern Ohio USA,where Ailanthus is widely distributed within the forest, harvests have been ongoing for decades, and prescribed fire had been applied to about a quarter of the study area. Our intention was to develop models to evaluate the relationship of Ailanthus presence to prescribed fire, harvesting activity, and other landscape characteristics, using this Ohio location as a case study. Field assessments of the demography of Ailanthus and other stand attributes(e.g., fire, harvesting, stand structure) were conducted on 267 sample plots on a 400-m grid throughout THSF,supplemented by identification of Ailanthus seed-sources via digital aerial sketch mapping during the dormant season. Statistical modeling tools Random Forest(RF), Classification and Regression Trees(CART), and Maxent were used to assess relationships among attributes, then model habitats suitable for Ailanthus ***: In all, 41 variables were considered in the models, including variables related to management activities, soil characteristics, topography, and vegetation structure(derived from LiDAR). The most important predictor of Ailanthus presence was some measure of recent timber harvest, either mapped harvest history(CART) or LiDARderived canopy height(Maxent). Importantly, neither prescribed fire or soil variables appeared as important predictors of Ailanthus presence or absence in any of the models of the ***: These modeling techniques provide tools and methodologies for assessing landscapes for Ailanthus invasion, as well as those areas with higher potentials for invasion should seed sources become available. Though a case study on

关键词： Ohio Random Forest CART Maxent Landscape model Non-native invasive species

Wnt genes in colonic polyposis predisposition

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Genes & Diseases 2023年第3期10卷 753-757页

作者： Isabel Quintana Mariona Terradas Pilar Mur Iris B.A.Wte Paske Sophia peters Isabel Spier Verena Steinke-Lange Claudia Maestro david Torrents Montserrat Puiggròs Romina Royo Raul Tonda Genís Parra davide Piscia Sergi Beltrán Matilde Navarro Virginia Piñol Joan Brunet Noemi Gonzalez-Abuin Gemma Aiza Anna Sommer Yasmijn van Herwaarden Galuh Astuti Elke Holinski-Feder Nicoline Hoogerbrugge Richarda Mde Voer Stefan Aretz Gabriel Capellá Laura Valle Hereditary Cancer Program Catalan Institute of OncologyOncobell ProgramIDIBELLHospitalet de LlobregatBarcelona 08908Spain Centro de Investigación Biomédica en Red de Cáncer(CIBERONC) Madrid 28029Spain Department of Human Genetics Radboud Institute for Molecular Life SciencesRadboud University Medical CenterGA Nijmegen 6525the Netherlands Member of SOLVE-RD ERN-GENTURIS Institute of Human Genetics Medical FacultyUniversity of BonnBonn 53127Germany National Center for Hereditary Tumor Syndromes University Hospital BonnBonn 53127Germany Medizinische Klinik Und Poliklinik IV Campus InnenstadtKlinikum Der Universität MünchenMunich 80336Germany MGZ-Medizinisch Genetisches Zentrum Munich 80335Germany Life Sciences Department Barcelona Supercomputing Center(BSC)Barcelona 08034Spain ICREA Barcelona 08010Spain CNAG-CRG Centre for Genomic Regulation(CRG)Barcelona Institute of Science and TechnologyBarcelona 08028Spain Universitat Pompeu Fabra(UPF) Barcelona 08002Spain Department of Genetics Microbiology and StatisticsSchool of BiologyUniversitat de Barcelona(UB)Barcelona 08028Spain Gastroenterology Unit Hospital Universitario de Girona Dr Josep TruetaGirona 17007Spain Catalan Institute of Oncology IDIBGiGirona 17007Spain Department of Gastroenterology and Hepatology Radboud University Medical CenterGA Nijmegen 6525the Netherlands Department of Human Genetics Radboud University Medical CenterGA Nijmegen 6525the Netherlands

Much of the genetic predisposition to polyposis,and particularly to serrated polyposis(SP),remains *** germline pathogenic variants in RNF43,a tumor suppressor that exerts negative feedback in the Wnt/β-catenin signaling pathway,have been causally linked to some SP cases(<2%),a disease associated with increased risk of colorectal cancer(CRC).^(1) Most known hereditary CRC and polyposis genes affect DNA repair,BMP/TGF-β,or Wnt signaling,being the latter associated with adenomatous and serrated polyposis phenotypes.2 Based on this observation,we evaluated the presence and role of germline variants in those pathways in unsolved polyposis patients.

关键词： polyposis suppressor colorectal