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Comparative Study of Gut Microbiota in Breast Cancer patients versus Controls in Abidjan, Côte d’Ivoire

Advances in Microbiology 2024年第9期14卷 405-415页

作者： M’Bengue Gbonon Valérie Gnahore Djeda Franck Kouadio Kouamé Assohoun Stanislas Coulibaly Safiatou Diplo Flore Bernadette Sekongo Mamadou Osseni Akandji Afran Sidje Arlette N’Guessan Jean-david Dosso Mireille Molecular Genetics platform Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Laboratory of Biology and Health UFR Biosciences Flix Houphout Boigny University Abidjan Cte dIvoire Department of Environment and Health Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Bioinformatics & Computational Biology Group National Computing Center of Cte dIvoire Flix Houphout Boigny University Bingerville Cte dIvoire National Blood Transfusion Center Abidjan Cte dIvoire Oncology Department Treichville University Hospital Abidjan Cte dIvoire

Context: The gut microbiota represents a complex ecosystem encompassing all unicellular microorganisms residing in the digestive tract, primarily bacteria, fungi, archaea, and even viruses. The relationship between the host and the microbiota is symbiotic: bacteria benefit from a stable environment, while the host gains numerous capabilities in terms of digestion, metabolism, nutrition, and immunity. However, numerous studies suggest that the gut microbiota plays a crucial role in various non-communicable diseases, including obesity, chronic inflammatory bowel diseases, allergic and immune disorders, behavioral disorders, and even certain cancers. The objective of our study was to characterize the gut microbiota of a group of breast cancer patients by comparing it to that of control subjects in Côte d’Ivoire, using a metagenomic approach. Method: A case-control study was conducted from May 2020 to September 2023. A total of 85 women (39 cases and 46 controls) were recruited, and stool samples were collected from both breast cancer patients and healthy women. Among these, ten (10) samples from patients and ten (10) samples from healthy women were randomly selected for the study of the gut microbiota. The gut microbiota was characterized by sequencing the V4 region of 16S rRNA using metagenomic NGS technology, and bioinformatic analysis was performed using the mothur pipeline. Results: In women with breast cancer, we observed a reduction in the relative abundance of the phyla Firmicutes and Bacteroidetes, as well as an increase in the phyla Actinobacteria and Verrucomicrobia. Additionally, their microbiota exhibited lower Chao1 and Sobs diversities compared to the control women (p ps (p phyla within the gut microbiota of cases compared to healthy controls. It wil

关键词： Gut Microbiota 16S Metagenomic Sequencing Breast Cancer Dysbiosis

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Synchronous colorectal liver metastases:therapeutic considerations

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 711-713页

作者： Michael R.Driedger Sean p.Cleary david M.Nagorney Division of Hepatobiliary and pancreatic Surgery Atrium HealthCharlotteNCUSA Division of Hepatobiliary and pancreatic Surgery Mayo ClinicRochesterMNUSA

More than 50%of patients will develop colorectal cancer(CRC)liver metastases(CRCLM)during the course of their disease,while 15-25%of patients will have metastatic disease present at the time of initial *** of CRCLM is possible in approximately one-in-four patients and 5-year overall survival(OS)rates have improved to nearly 60%in selected patients who undergo resection.

关键词： colorectal metastases patients

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Recent Advances in Understanding proteins Involved in Lipid Droplet Formation, Growth and Fusion

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Journal of Genetics and Genomics 2014年第5期41卷 251-259页

作者： Jolene S.Y.Tan Colin J.p.Seow Vera J.Goh david L.Silver Signature Research program in Cardiovascular & Metabolic Disorders Duke-NUS Graduate Medical School Singapore

Lipid droplets （LDs） were once viewed as simple, inert lipid micelles. However, they are now known to be organelles with a rich proteome involved in a myriad of cellular processes. LDs are heterogeneous in nature with different sizes and compositions of phospholipids, neutral lipids and proteins. This review takes a focused look at the roles of proteins involved in the regulation of LD formation, expansion, and morphology. The related proteins are summarized such as the fat-specific protein （Fsp27）, fat storage-inducing trans- membrane （FIT） proteins, seipin and ADp-ribosylation factor 1-coat protein complex I （Arf-COpI）. Finally, we present important challenges in LD biology for a deeper understanding of this dynamic organelle to be achieved.

关键词： Lipid droplets LD-associated proteins perilipin phospholipids

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Age as a predictor of clinical outcomes and determinant of therapeutic measures for emergency medical services treated cardiogenic shock

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Journal of Geriatric Cardiology 2023年第1期20卷 1-10页

作者： Xiaoman Xiao Jason E Bloom Emily Andrew Luke p Dawson Ziad Nehme Michael Stephenson david Anderson Himawan Fernando Samer Noaman Shelley Cox William Chan david M Kaye Karen Smith Dion Stub Department of Cardiology Alfred Health55 Commercial RoadMelbourneAustralia Baker Heart and Diabetes Institute 75 Commercial RoadMelbourneAustralia Department of Cardiology Western HealthFurlong RoadSt AlbansAustralia Ambulance Victoria 31 Joseph StreetBlackburnAustralia School of public Health and preventive Medicine Monash University553 St Kilda RoadMelbourneAustralia Department of paramedicine Monash UniversityMcMahons RoadFrankstonAustralia

BACKGROUND The impact of age on outcomes in cardiogenic shock(CS)is poorly described in the pre-hospital *** assessed the impact of age on outcomes of patients treated by emergency medical services(EMS).METHODS This population-based cohort study included consecutive adult patients with CS transported to hospital by *** linked patients were stratified into tertiles by age(18-63,64-77,and>77 years).predictors of 30-day mortality were assessed through regression *** primary outcome was 30-day all-cause *** A total of 3523 patients with CS were successfully linked to state health *** average age was 68±16 years and 1398(40%)were *** patients were more likely to have comorbidities including pre-existing coronary artery disease,hypertension,dyslipidemia,diabetes mellitus,and cerebrovascular *** incidence of CS was significantly greater with increasing age(incidence rate per 100,000 person years 6.47[95%CI:6.1-6.8]in age 18-63 years,34.34[32.4-36.4]in age 64-77 years,74.87[70.6-79.3]in age>77 years,pp-wise increase in the rate of 30-day mortality with increasing age *** adjustment,compared to the lowest age tertile,patients aged>77 years had increased risk of 30-day mortality(adjusted hazard ratio=2.26[95%CI:1.96-2.60]).Older patients were less likely to receive inpatient coronary *** Older patients with EMS-treated CS have significantly higher rates of short-term *** reduced rates of invasive interventions in older patients underscore the need for further development of systems of care to improve outcomes for this patient group.

关键词： assessed services shock

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Impact of oxygation on soil respiration, yield and water use efficiency of three crop species

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Journal of plant Ecology 2011年第4期4卷 236-248页

作者： Xinming Chen Jay Dhungel Surya p.Bhattarai Manouchehr Torabi Lance pendergast david J.Midmore Key Laboratory of Agricultural Soil and Water Engineering in Arid and Semiarid Areas Ministry of EducationNorthwest A&F UniversityYanglingShaanxi 712100China Centre for plant and Water Science Faculty of ScienceEngineering and HealthCQUniversityRockhamptonQueensland 4702Australia

Oxygation refers to irrigation of crops with aerated water,through air injection using the venturi principle or the supply of hydrogen peroxide in the root zone,both using subsurface drip irrigation(SDI)*** improves water use efficiency(WUE),producing more yield and,and therefore,optimizes the use of drip and *** the efficiency of oxygation is quite possibly dependent on a number of *** primary objective of this study was,therefore,to quantify the effects of oxygation,emitter depths and soil type on crop root zone oxygen content,soil respiration,plant physiological response,biomass yield,quality and WUE of three crop *** This study investigated the potential of oxygation to enhance soil respiration,plant growth,yield and water use efficiencies(WUE)of cotton and wheat in experiments in enclosed heavy-duty concrete troughs(tubs)and pineapple and cotton in field *** treatments in tubs for wheat included comparisons between two soil types(vertisol and ferrosol)and superimposed were two oxygation methods(Mazzei air injector and Seair Diffusion System)compared to a control,and for cotton,emitters at two depths using Mazzei air injectors were compared to a *** field experiments compared Mazzei air injectors and a control for cotton in Emerald and pineapple in Yeppoon,both in central Queensland,*** findings In all experiments,soil oxygen content and soil respiration markedly increased in response to the oxygation *** O2 concentration in the crop root zone increased by 2.4–32.6%,for oxygation compared to control at the same *** soil respiration increased by 42–100%.The number of wheat ears,leaf dry weight and total dry matter were significantly greater in Mazzei and Seair oxygation compared to the *** biomass of wheat increased by 11 and 8%,and dry weight of wheat increased by 8 and 3%in Mazzei and Seair oxygation treatments compared to the control,***

关键词： oxygation subsurface drip irrigation soil respiration yield water use efficiencies

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The Transference Number

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Energy & Environmental Materials 2022年第2期5卷 366-369页

作者： Kevin W.Gao Chao Fang david M.Halat Aashutosh Mistry John Newman Nitash p.Balsara Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Chemical and Biomolecular Engineering University of CaliforniaBerkeleyCA 94720USA Joint Center for Energy Storage Research Argonne National LaboratoryLemontIL 60439USA Chemical Sciences and Engineering Division Argonne National LaboratoryLemontIL 60439USA

The performance of rechargeable batteries and other electrochemical systems depends on the rate at which the working ion(often a cation)is transported from one electrode to the *** cation transference number is an important transport parameter that affects this *** purpose of this perspective is to distinguish between approximate and rigorous methods used in the literature to measure the transference *** emphasize the fact that this parameter is dependent on the reference frame used in the analysis;care must be taken when comparing values obtained from different sources to account for differences in reference *** present data obtained from a well-characterized *** compare rigorously determined transference numbers in two reference frames with values obtained by an approximate *** conclude with a qualitative discussion of the relationship between the transference number and salt concentration gradients that are obtained when current is drawn through a battery。

关键词： battery electrolytes concentrated solution theory ion transport reference frames transference number

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The SARD variety of multi-fractality of ventricular epicardial mapping during ischemia

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Chinese Science Bulletin 2006年第7期51卷 809-814页

作者： CHEN Ying Martyn p. Nash NING Xinbao WANG Yelin david J. paterson WANG Jun State Key Laboratory of Modern Acoustics Institute for Biomedical Electronical Engineering Nanjing University Nanjing 210093 China Engineering Science and Bioengineering Institute University of Auckland Private Bag 92019 NZ Laboratory of physiology University of Oxford Parks Road Oxford OX13PT UK

We have analyzed cardiac ische- mia-reperfusion in an animal model using epicardial electropotential mapping. We investigated the rela- tionship between ischemia and variability of multi- fractality in epicardial electrograms. We present a new parameter called the singularity spectrum area reference dispersion (SARD) that clearly demon- strates the change in multifractility with the extent of myocardiaischemia. By contrasting the 3D ventricular epicardial SARD map with the activation map, we conclude that myocardial ischemia significantly in- fluences the variety of multifractality of ventricular epicardium electrograms and the SARD parameter is useful in correlating multifractality of epicardial elec- trograms with location of ischemia closely.

关键词：局部缺血 SARD 非线性基因定位室性心外膜

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阿尔泰—阿尔金地学断面地壳结构

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地球物理学报 2004年第2期47卷 240-249页

作者：王有学韩果花姜枚袁学诚 Walter D mooney Robert G Coleman 桂林工学院资源与环境工程系中国地质科学院地质研究所中国地质调查局发展研究中心 United State Geological Survey Menlo Park CA 94025 USA Department of Geology and Environment Sciences Stanford University California 94305 USA

根据阿尔泰—阿尔金地学断面的地震纵、横波资料 ,建立了地壳速度及泊松比结构 .测区的地壳具有明显的三分结构特征 ,其纵波速度自上而下依次为 6 .0～ 6 .3km s、6 .3～ 6 .6km s及 6 .9～ 7.0km s ;阿尔泰南缘的地壳最厚 ,为 5 6km ,... 详细信息

根据阿尔泰—阿尔金地学断面的地震纵、横波资料 ,建立了地壳速度及泊松比结构 .测区的地壳具有明显的三分结构特征 ,其纵波速度自上而下依次为 6 .0～ 6 .3km s、6 .3～ 6 .6km s及 6 .9～ 7.0km s ;阿尔泰南缘的地壳最厚 ,为 5 6km ,准噶尔盆地的地壳最薄 ,为 4 6km ,大部分地区的地壳厚度为 5 0km左右 .准噶尔盆地与天山之间上地幔顶部的纵波速度为 7.7～ 7.8km s ;阿尔泰南缘及塔里木盆地上地幔顶部的纵波速度较高 ,为 7.9～ 8.0km s.测线南部 ,包括东天山及塔里木东缘 ,自地表至 30km深处的地壳纵波速度低 ,泊松比为 0 .2 5 ,表明上地壳主要为石英及花岗质成分 ;而测线北部 (包括阿尔泰及准噶尔盆地 )的中、上地壳则呈现较高的泊松比 (0 .2 6～ 0 .2 7) ,可能为基性地壳的体现 .厚 15～ 30km的下地壳纵波速度 (6 .9～ 7.0km s)较高 ,泊松比为 0 .2 6～ 0 .2 8,可能以镁铁质的麻粒岩成分为主 .位于天山及其南侧地壳中部的低速层 (Vp=5 .9km s,σ=0 .2 5 )则可能为晚古生代的构造热事件中的花岗质侵入岩 .

关键词：地学断面地壳结构地震波地幔

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Amiodarone hepatotoxicity complicating obstructive jaundice due to ampullary cancer

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Hepatobiliary & pancreatic Diseases International 2007年第4期6卷 435-437页

作者： Anne M Collins Des C Winter Aidan p McCormick david C Cottell Justin G Geoghegan Department of Surgery and Hepatology St. Vincent's University Hospital Dublin 4 Ireland Electron Microscopy Laboratory Conway Institute University College Dublin Belfield Dublin 4Ireland

BACKGROUND:The presence of dual pathology can cause diagnostic dilemmas. We present a case of adenocarcinoma of the ampulla of Vater with concurrent amiodarone hepatotoxicity. METHODS:painless jaundice associated with a palpable gallbladder was investigated clinically,radiologically endoscopically and via liver biopsy. RESULTS:Liver biopsy showed amiodarone hepatotoxicity Endoscopic biopsy identified an ampullary adenoma However,the endoscopic ultrasound and intra-operative findings suggested a malignancy,which was confirmed postoperatively. CONCLUSIONS:While the classic findings of Courvoisier’s Law are borne out in this case,the etiology of jaundice is twofold. Although dual pathology is uncommon it should always be considered.

关键词： ampulla of Vater adenocarcinoma amiodarone hepatotoxicity dual pathology

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Characterizing Uncertainty in City-Wide Disaster Recovery through Geospatial Multi-Lifeline Restoration Modeling of Earthquake Impact in the District of North Vancouver

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International Journal of Disaster Risk Science 2020年第6期11卷 807-820页

作者： Andrew Deelstra david Bristow Department of Civil Engineering University of VictoriaVictoriaBC V8P 5C2Canada

Restoring lifeline services to an urban neighborhood impacted by a large disaster is critical to the recovery of the city as a *** cities are comprised of many dependent lifeline systems,the pattern of the restoration of each lifeline system can have an impact on one or more *** to the often uncertain and complex interactions between dense lifeline systems and their individual operations at the urban scale,it is typically unclear how different patterns of restoration will impact the overall recovery of lifeline system functioning.A difficulty in addressing this problem is the siloed nature of the knowledge and operations of different types of ***,a city-wide,multi-lifeline restoration model and simulation are provided to address this *** approach uses the Graph Model for Operational Resilience,a data-driven discrete event simulator that can model the spatial and functional cascade of hazard effects and the pattern of restoration over time.A novel case study model of the District of North Vancouver is constructed and simulated for a reference magnitude 7.3 *** model comprises municipal water and wastewater,power distribution,and transport *** model includes 1725 entities from within these sectors,connected through 6456 dependency *** of the model shows that water distribution and wastewater treatment systems recover more quickly and with less uncertainty than electric power and road *** this uncertainty will provide the opportunity to improve data collection,modeling,and collaboration with stakeholders in the future.

关键词： City-wide earthquake recovery Disaster loss and impact assessment Multi-infrastructure restoration Risk modeling and simulation Vulnerability and resilience analysis

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