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Semisynthetic Derivatives of Sissotrin Isolated from Trifolium baccarinii Chiov. (Fabaceae) and Evaluation of Their Antibacterial Activities

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Advances in Biological Chemistry 2024年第1期14卷 27-39页

作者： Donald Léonel Feugap Tsamo Cyrille Ngoufack Tagousop Arnaud Joseph Nguetse Dongmo Laurence Voutquenne-Nazabadioko david ngnokam Research Unit of Applied and Environmental Chemistry Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Department of Organic Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon Department of Basic Scientific Studies University Institute of Technology University of Ngaoundéré Ngaoundéré Cameroon Groupe Isolement et Structure Institut de Chimie Moléculaire de Reims (ICMR) Reims France

Starting from sissotrin (1), a natural isoflavonoid isolated from Trifolium baccarinii (Fabaceae), one new semisynthetic derivative, 6-nitrobiochanin A (1b) and two known derivatives, 8-nitrobiochanin A (1a) and 2",3",4",6"-tetraacetylsissotrin (1c) have been obtained after performing nitration and acetylation reactions. Their structures were assigned after interpretation of their spectrometric (HR-ESI-MS) and spectroscopic (NMR 1D and 2D) data and by comparison with those reported in the literature. The substrate as well as the semisynthetic derivatives were evaluated for their antibacterial activities against six strains. The results reveal that they are inactive or weakly active on the strains tested with the exception of 8-nitrobiochanin A (1a) which showed moderate activity (MIC = 62.5 μg∙mL−1) on Staphylococcus aureus ATCC 43300.

关键词： Trifolium baccarinii Isoflavonoid Nitration Acetylation Antibacterial Activity

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New Hemisynthetic Oleanane Saponin with Antimicrobial Activities

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Advances in Biological Chemistry 2021年第1期11卷 1-11页

作者： Cyrille Ngoufack Tagousop Jean-De-Dieu Tamokou Leonel Donald Tsamo Feugap Dominique Harakat Laurence Voutquenne-Nazabadioko david ngnokam Department of Basic Scientific Studies University Institute of Technology University of Ngaoundere Ngaoundere Cameroon Research Unit of Environmental and Applied Chemistry Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Research Unit of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Service Commun d’Analyses Institut de Chimie Moléculaire de Reims (ICMR) CNRS UMR 7312 Reims France Groupe Isolement et Structure Institut de Chimie Moléculaire de Reims (ICMR) CNRS UMR 7312 Reims France

A new hemisynthetic oleanane saponin: 4',2",3",4",6"-penta-O-acetyl-6'-O- methyl-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranosyl oleanolic acid (2) was obtained after acetylation and methylation reaction on 3-O... 详细信息

关键词： Saponin Acetylation Methylation Antimicrobial Activities

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A New Ceramide (Rumexamide) and Other Chemical Constituents from <i>Rumex abyssinicus</i>Jacq (Polygonaceae): Isolation, Characterization, Antibacterial Activities and Chemophenetic Significance

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Advances in Biological Chemistry 2021年第5期11卷 266-282页

作者： Léonel Donald Feugap Tsamo Lorette Victorine Yimgang Steven Collins N. Wouamba Pierre Mkounga Augustin Ephrem Nkengfack Laurence Voutquenne-Nazabadioko david ngnokam Bruno Ndjakou Lenta Norbert Sewald Research Unit of Applied and Environmental Chemistry Department of Chemistry Faculty of Science University of Dschang Dschang Cameroon Department of Organic Chemistry Faculty of Science University of Yaoundé I Yaoundé Cameroon Antimicrobial Agents Unit Laboratory for Phytobiochemistry and Medicinal Plants Studies University of Yaoundé I Yaoundé Cameroon Department of Chemistry Higher Teacher Training College University of Yaounde I Yaoundé Cameroon Groupe Isolement et Structure Institut de Chimie Moléculaire de Reims (ICMR) Reims France Organic and Bioorganic Chemistry Faculty of Chemistry Bielefeld University Bielefeld Germany

The chemical study of Rumex abyssinicus Jacp (Polygonaceae) led to the isolation of a new ceramide named (R)-2'-hydroxy-N-[(2S,3S,4R,16E)-1,3,4-trihydroxyhexacos-16-en-2-yl]hexadecanamide (rumexamide) (1) together with sixteen known compounds: bis-(2-ethylhexyl) phthalate (2), chrysophanol (3), physcion (4), citreorosein (5), emodin (6), chrysophanein (7), physcionin (8), lupeol (9), 3β,28-dihydroxylup-20(29)-ene (10), 3β-dihydroxylup-20(29)-en-28-oic acid (11), oleanolic acid (12), ergosta-6,22-diene-3,5,8-triol (13), stigmastane-3,6-dione (14), a mixture of β-sitosterol (15) and stigmasterol (16), and stigmasterol 3-O-β-D-glucoside (17). Their structures were determined by interpretation of their spectroscopic 1D NMR (1H and 13C NMR), 2D NMR (COSY 1H-1H, HSQC and HMBC) data in conjunction with mass spectrometry (TOFESIMS and HR-TOFESIMS) and by comparison with those reported in the literature. Among all the known compounds, twelve (2, 5, 8-17) were firstly isolated from Rumex abyssinicus, seven (2, 10-14 and 17) from the genus Rumex and three (13, 14, 17) from family Polygonaceae. The in vitro antibacterial activities of extracts (MeOH, n-BuOH and EtOAc), as well as compounds 9,

关键词： Polygonaceae Rumex abyssinicus Rumexamide Antibacterial Activities Chemophenetic Significance

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