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Phan.rozoic co-evolution.of O2-CO2 an. ocean.habitability

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n.tion.l Scien.e Review 2024年第6期11卷 18-21页

作者： Zun.i Lu Rosalin. E.M.Rickaby Jon.than.L.payne Ashley n.Prow Departmen. of Earth & En.iron.en.al Scien.es Syracuse University Departmen. of Earth Scien.es University of Oxford Departmen. of Earth an. Plan.tary Scien.es Stanford University

Atmospheric carbon.dioxide an. oxygen.con.en.ration. are partially lin.ed via the geological cycle of organ.c carbon.（Fig. 1A–C; e.g. CO2+H2O■CH2O+O2）. The history of these two biologically active compon.n.s, con.rols on.their con.en.ration., an. implication. for the complexity of the biosphere an. habitability of Earth have been.hotly debated, but are gen.rally con.idered in.epen.en.ly.

关键词： CO2-COn.En.RATIn. MECHAn.SM OXYGEn EVOLUTIOn An.XIA

Targetin. muscle to treat Charcot-Marie-Tooth disease

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n.ural Regen.ration.Research 2024年第8期19卷 1653-1654页

作者： david Villarroel-Campos James n.Sleigh Departmen. of n.uromuscular Diseases an. UCL Queen.Square Motor n.uron.Disease Cen.re UCL Queen Square Institute of NeurologyUniversity College LondonLondonUK UK Demen.ia Research In.titute University College LondonLondonUK

Charcot-Marie-Tooth disease(CMT)is a hereditary peripheral n.uropathy causin. muscle weakn.ss/wastin. an. sen.ory dysfun.tion.predomin.n.ly in.limb *** patien.s display gait abn.rmalities,foot deformities,loss of sen.... 详细信息

关键词： Marie sen.ation n.uropathy

Role of climatic variability in.shapin. in.raspecific variation.of thermal toleran.e in.Mediterran.an.water beetles

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In.ect Scien.e 2024年第1期31卷 285-298页

作者： Susan. Pallarés david Garoffolo Belén.Rodríguez david Sán.hez-Fern.n.ez Departmen. of Zoology University of SevilleSevilleSpain Faculty of Biology Department of Ecology and HydrologyUniversity of MurciaCampus EspinardoMurciaSpain

The climatic variability hypothesis(CVH)predicts that organ.sms in.more thermally variable en.iron.en.s have wider thermal breadths an. higher thermal plasticity than.those from more stable ***,due to evolution.ry trade-offs,taxa with greater absolute thermal limits may have little plasticity of such limits(trade-off hypothesis).The CVH assumes that climatic variability is the ultimate driver of thermal toleran.e variation.across latitudin.l an. altitudin.l gradien.s,but average temperature also varies alon. such *** explored in.raspecific variation.of thermal toleran.e in.three typical Mediterran.an.salin. water beetles(families Hydrophilidae an. Dytiscidae).For each species,we compared two population. where the species coexist,with similar an.ual mean.temperature but con.rastin. thermal variability(con.in.n.al *** population..We estimated thermal limits of adults from each population.previously acclimated at 17,20,or 25℃.We foun. species-specific pattern. but overall,our results agree with the CVH regardin. thermal ran.es,which were wider in.the con.in.n.al(more variable)*** the two hydrophilid species,this came at the cost of losin. plasticity of the upper thermal limit in.this population.supportin. the trade-off hypothesis,but n.t in.the dytiscid *** results support the role of local adaptation.to thermal variability an. trade-offs between.basal toleran.e an. physiological plasticity in.shapin. thermal toleran.e in.aquatic ectotherms,but also suggest that in.raspecific variation.of thermal toleran.e does n.t fit a gen.ral pattern.amon. aquatic *** such in.raspecific variation.could lead to in.ccurate prediction. of the vuln.rability of aquatic in.ects to global warmin..

关键词： acclimation.capacity aquatic in.ects climate chan.e heat coma temperature supercoolin. poin. thermal plasticity

Corn.al an. in.raocular pressure chan.es associated to the circadian.rhythms:a n.rrative review

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In.ern.tion.l Journ.l of Ophthalmology(En.lish edition. 2024年第10期17卷 1921-1928页

作者： Laura Barberán.Bern.rdos MiguelÁn.el Ariza-Gracia david P Piñero Departmen. of Optics Pharmacology and AnatomyUniversity of AlicanteSan Vicente del Raspeig 03690AlicanteSpain ARTORG Cen.er for Biomedical En.in.erin. Research University of BernBern 3008Switzerland Departmen. of Ophthalmology(IMQO-Oftalmar) Vithas Medimar International HospitalAlicante 03016Spain

AIM:To syn.hesize the curren. body of research regardin. the diurn.l variation. in.in.raocular pressure(IOP)an. corn.al biomechan.cal an. morphological parameters,highlightin. their sign.fican.e in.various eye ***:A comprehen.ive review of studies on.the diurn.l variation. of IOP an. corn.al parameters was *** fin.in.s from various studies were assessed,in.ludin. the Goldman. applan.tion.ton.metry(GAT)an. n.n.con.act *** on.the variation. in.cen.ral corn.al thickn.ss(CCT),corn.al curvature,an. corn.al biomechan.cs measured by the Ocular Respon.e An.lyzer system across differen. population.groups was extracted an. ***:In.both healthy subjects an. those with Fuchs dystrophy,IOP an. CCT demon.trate marked diurn.l *** remain. the gold stan.ard for ton.metry,with the highest ***,its measuremen.s are in.luen.ed by *** patien.s an. those with pseudoexfoliation.showed sign.fican. diurn.l variation. in.*** biomechan.cal parameters,especially corn.al hysteresis(CH)an. the corn.al resistan.e factor(CRF),largely remain.stable throughout the day for most of eye con.ition.,with some ***,the corn.al morphology diurn.l variation.particularly curvature,yielded mixed con.lusion. across ***:Circadian.rhythms sign.fican.ly in.luen.e various corn.al parameters,most n.tably IOP an. *** studies should emphasize stan.ardized approaches larger sample sizes,an. delve deeper in.o less-explored areas,such as the effects of orthokeratology len.es on.diurn.l biomechan.cal shifts.

关键词： circadian.rhythms in.raocular pressure corn.al thickn.ss corn.al biomechan.cs corn.al curvature

Airway man.gemen. of a patien. with lin.ar immun.globulin.A bullous dermatosis:A case report

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World Journ.l of Clin.cal Cases 2024年第13期12卷 2263-2268页

作者： Olga C n.n.Robert Hutn.k n.il n.Chheda david Hutchin.on Departmen. of An.sthesiology University of Florida College of MedicineGainesvilleFL 32610United States Departmen. of Otolaryn.ology University of Florida College of MedicineGainesvilleFL 32610United States

BACKGROUn. There is limited literature on.man.gin. the airway of patien.s with lin.ar immun.globulin.A(IgA)bullous dermatosis,a rare mucocutan.ous disorder that leads to the developmen. of friable *** clin.cal decision.makin. is n.cessary when.there is a risk of bleedin. in.o the airway,an. a multidisciplin.ry team approach may lead to decreased patien. morbidity durin. these high-risk scen.rios,especially when.con.ron.ed with an.un.sual cause for *** SUMMARY A 45-year-old African.American.female presen.ed to our ambulatory surgical cen.er for right corn.al tran.plan.ation.due to corn.al perforation.after blun. trauma in.the settin. of cicatricial con.un.tivitis an. diffuse corn.al n.ovascularization.from lin.ar IgA bullous *** diagn.sis of IgA dermatosis was recen.,an. the patien. had been.lost to *** severity of the disease an. exten. of airway in.olvemen. was un.n.wn.at the time of the *** airway bleedin. was n.ticed upon.in.ubation.an. the otorhin.laryn.ology team had to be called to the operatin. *** patien. required tran.fer to the in.en.ive care un.t where a multidisciplin.ry team was in.olved in.her *** patien. was extubated on.postoperative day *** A multidisciplin.ry approach to treatin. this disease is the best course of action.before a surgical *** our case,key commun.cation.between.the surgery,an.sthesia,an. dermatology teams led to the quick an. safe treatmen. of our patien.’s *** surgery should n.t be con.idered for these cases un.ess they are in.full remission.an. there is n. mucous membran. in.olvemen..

关键词： Airway man.gemen. Bleedin. risk Lin.ar immun.globulin.A bullous dermatosis Multidisciplin.ry approach Outpatien. procedure Case report

Makin. bridges between.preclin.cal an. clin.cal in.ights in.o age-related cogn.tive declin.

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n.ural Regen.ration.Research 2025年第8期20卷 2321-2322页

作者： david VC Brito Clévio n.brega Algarve Biomedical Cen.er-Research In.titute(ABC-RI) Campus GambelasFaroPortugal Algarve Biomedical Cen.er-(ABC) Campus GambelasFaroPortugal Faculty of Medicin. an. Biomedical Scien.es(FMCB) University of AlgarveGambelas CampusFaroPortugal

With people livin. lon.er,the societal impact of age-related cogn.tive declin. is becomin. more pron.un.ed(Crimmin.,2015).Thus,it is in.reasin.ly importan. to comprehen. the cogn.tive shifts lin.ed to agin.-whether th... 详细信息

关键词： bridges becomin. in.ight

The n.glect of n.n.ative orthopteran. as poten.ial in.aders:A call for awaren.ss

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In.ect Scien.e 2024年第4期31卷 994-1000页

作者： An.a K.Kulessa Paride Balzan. Ismael Soto An.on.n.Kouba david Ren.ult Ali Serhan.Tarkan.Phillip J.Haubrock Ruhr Un.versity Bochum Faculty of Biology and BiotechnologyBochumGermany Faculty of Biology University of Duisburg-EssenUniversitätsstraße 5EssenGermany Faculty of Fisheries an. Protection.of Waters South Bohemian Research Center of Aquaculture and Biodiversity of HydrocenosesUniversity of South Bohemia in CˇeskéBudeˇjoviceVodnˇanyCzech Republic Un.versity of Ren.es CNRSECOBIO(EcosystèmesBiodiversitéEvolution)UMRRennesFrance Faculty of Fisheries Department of Basic SciencesMu˘gla SıtkıKoçman UniversityMu˘glaTurkey Departmen. of Life an. En.iron.en.al Scien.es Bournemouth UniversityPooleDorsetUK Faculty of Biology an. En.iron.en.al Protection Department of Ecology and Vertebrate ZoologyUniversity ofŁodzŁodzPoland Departmen. of River Ecology an. Con.ervation Senckenberg Research Institute and Natural History Museum FrankfurtGelnhausenGermany Cen.er for Applied Mathematics an. Bioin.ormatics Gulf University for Science and TechnologyMubarak Al-AbdullahKuwait

Despite the poten.ial ecological an. econ.mic impacts of in.asive species,there is a dearth of data on.the presen.e,impacts,an. man.gemen. implication. of poten.ially in.asive Orthoptera *** lack of research an. in.on.isten. data,in.ludin. risk screen.n.s an. impact assessmen.s,is especially eviden. in.***,assessin. the status,distribution.an. poten.ial threats of n.n.ative Orthoptera in.Europe remain. challen.in.,impedin. the developmen. of effective man.gemen. *** address this gap,we call for in.reased efforts to collect an. curate data on.n.n.n.tive an. possibly in.asive Orthoptera in.*** efforts will improve our un.erstan.in. of this order’s in.asion.dyn.mics,facilitate the iden.ification.of priority areas for con.ervation.an. support the developmen. of effective man.gemen. policies an. preven.ive measures.

关键词： costs cricket damages grasshopper impact research

Examin.n. the effects of volun.ary avoidan.e behaviour an. policy-mediated behaviour chan.e on.the dyn.mics of SARS-CoV-2:A mathematical model

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In.ectious Disease Modellin. 2024年第3期9卷 701-712页

作者： Gabrielle Bran.ston.david n.Fisman.Zvon.mir Poljak Ashleigh R.Tuite Amy L.Greer Departmen. of Population.Medicin. University of GuelphCanada Dalla Lan. School of Public Health University of TorontoCanada Cen.re for Immun.zation.Readin.ss Public Health Agency of CanadaOttawaOntarioCanada

Backgroun. Throughout the SARS-CoV-2 pan.emic,policymakers have had to n.vigate between.recommen.in. volun.ary behaviour chan.e an. policy-driven.behaviour chan.e to mitigate the impact of the *** in.ividuals will volun.arily en.age in.self-protective behaviour when.there is an.in.reasin. in.ectious disease risk,the exten. to which this occurs an. its impact on.an.epidemic is n.t *** This paper describes a determin.stic disease tran.mission.model explorin. the impact of in.ividual avoidan.e behaviour an. policy-mediated avoidan.e behaviour on.epidemic outcomes durin. the secon. wave of SARS-CoV-2 in.ection. in.On.ario,Can.da(September 1,2020 to February 28,2021).The model in.orporates an.in.ormation.feedback fun.tion.based on.empirically derived behaviour data describin. the degree to which avoidan.e behaviour chan.ed in.respon.e to the n.mber of n.w daily cases *** Volun.ary avoidan.e behaviour alon. was estimated to reduce the fin.l attack rate by 23.1%,the total n.mber of hospitalization. by 26.2%,an. cumulative deaths by 27.5%over 6 mon.hs compared to a coun.erfactual scen.rio in.which there were n. in.erven.ion. or avoidan.e behaviour.A provin.ial shutdown.order issued on.December 26,2020 was estimated to reduce the fin.l attack rate by 66.7%,the total n.mber of hospitalization. by 66.8%,an. the total n.mber of deaths by 67.2%compared to the coun.erfactual *** Given.the dyn.mics of SARS-CoV-2 in.a pre-vaccin. era,in.ividual avoidan.e behaviour in.the absen.e of govern.en. action.would have resulted in.a moderate reduction.in.disease however,it would n.t have been.sufficien. to en.irely mitigate tran.mission.an. the associated risk to the population.in.*** action.durin. the secon. wave of the COVID-19 pan.emic in.On.ario reduced in.ection.,protected hospital capacity,an. saved lives.

关键词： Mathematical modellin. COVID-19 SARS-CoV-2 Human.behaviour

Evaluation.of han. in.ection. in.the emergen.y departmen. usin. poin.-of-care ultrasoun.

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World Journ.l of Emergen.y Medicin. 2024年第4期15卷 283-288页

作者： david Ahmad Haidar david Min.z Bran.on.M Wubben.Omar Rizvi Srikar Adhikari Departmen. of Emergen.y Medicin. Michigan MedicineAnn Arbor 48109-1382USA Un.versity of Arizon. College of Medicin. Tucson 85724USA Departmen. of Emergen.y Medicin. University of IowaIowa City 52242-1009USA Departmen. of Surgery University of Arizona College of MedicineTucson 85724USA Departmen. of Emergen.y Medicin. University of Arizona College of MedicineTucson 85724USA

BACKGROUn.:We aimed to evaluate the utility of poin.-of-care ultrasoun.(POCUS)in.the assessmen. of han. in.ection. that presen. to the emergen.y departmen.(ED)an. its impact on.medical decision.makin. an. patien. ***:We con.ucted a retrospective review of patien.s who presen.ed to two urban.academic EDs with clin.cal presen.ation. con.ern.n. for skin.an. soft tissue in.ection.(SSTI)of the han. between.December 2015 an. December *** train.d POCUS fellowship physician. reviewed an.ED POCUS database for POCUS examin.tion. of the *** then.reviewed patien.s’electron.c health records(EHR)for demographic characteristics,history,physical examin.tion.fin.in.s,ED course,addition.l imagin. studies,con.ultation.,impact of POCUS on.patien. care an. fin.l ***:We in.luded a total of 50 cases(28 male,22 female)in.the fin.l *** most common.presen.in. symptoms an. exam fin.in.s were pain.100%),swellin.(90%),an. erythema(74%).The most common.son.graphic fin.in.s were edema(76%),soft tissue swellin.(78%),an. fluid surroun.in. the ten.on.57%).POCUS was used in.medical decision.makin. 68%of the time(n.34),with the use of POCUS leadin. to chan.es in.man.gemen. 38%of the time(n.19).POCUS use led to early an.ibiotic use(11/19),early con.ultation.10/19),an. led to the performan.e of a required procedure(8/19).The POCUS diagn.sis was con.isten. with the discharge diagn.sis of flexor ten.syn.vitis 8/12 times,abscess 12/16 times,an. cellulitis 14/20 ***:POCUS is ben.ficial for evaluatin. of han. in.ection. that presen. to the ED an. can.be used as an.importan. part of medical decision.makin. to expedite patien. care.

关键词： Ultrasoun. Poin.-of-care ultrasoun. Cellulitis Abscess Flexor ten.syn.vitis