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The involvement of interleukin-22 in the expression of pancreatic beta cell regenerative Reg genes

Cell Regeneration 2013年第1期2卷 7-17页

作者： Thomas Hill Olga Krougly Enayat Nikoopour Stacey Bellemore Edwin Lee-Chan Lynette A Fouser david j Hill Bhagirath singh Department of Microbiology and Immunology University of Western OntarioLondonONCanada Inflammation and Immunology Biotherapeutics Research and DevelopmentPfizerCambridgeMA 02140USA Department of Physiology and Pharmacology University of Western OntarioLondonONCanada Lawson Health Research Institute LondonONCanada Centre for Human Immunology University of Western OntarioLondonONCanada Robarts Research Institute University of Western OntarioLondonONCanada

Background:In Type 1 diabetes,the insulin-producingβ-cells within the pancreatic islets of Langerhans are *** showed previously that immunotherapy with Bacillus Calmette-Guerin(BCG)or complete Freund’s adjuvant(CFA)of non-obese diabetic(NOD)mice can prevent disease process and pancreaticβ-cell *** was associated with increased islet Regenerating(Reg)genes expression,and elevated IL-22-producing Th17 T-cells in the ***:We hypothesized that IL-22 was responsible for the increased Reg gene expression in the *** therefore quantified the Reg1,Reg2,and Reg3δ(INGAP)mRNA expression in isolated pre-diabetic NOD islets treated with *** measured IL-22,and IL-22 receptor(R)-αmRNA expression in the pancreas and spleen of pre-diabetic and diabetic NOD *** results showed:1)Reg1 and Reg2 mRNA abundance to be significantly increased in IL-22-treated islets in vitro;2)IL-22 mRNA expression in the pre-diabetic mouse pancreas increased with time following CFA treatment;3)a reduced expression of IL-22Rαfollowing CFA treatment;4)a down-regulation in Reg1 and Reg2 mRNA expression in the pancreas of pre-diabetic mice injected with an IL-22 neutralizing antibody;and 5)an increased isletβ-cell DNA synthesis in vitro in the presence of ***:We conclude that IL-22 may contribute to the regeneration ofβ-cells by up-regulating Regenerating Reg1 and Reg2 genes in the islets.

关键词： Adjuvant immunotherapy Interleukin-22 Regenerating(Reg)genes Beta-cell regeneration Type 1 diabetes

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Omental flaps reduces complications after pancreaticoduodenectomy

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Hepatobiliary & Pancreatic Diseases International 2015年第3期14卷 313-319页

作者： Omar j Shah Sadaf A Bangri Manmohan singh Reyaz A Lattoo Mohammad Y Bhat Department of Surgical Gastroenterology Sher-i-Kashmir Institute of Medical Sciences

BACKGROUND： Major complications after pancreaticoduo- denectomy are usually caused by a leaking pancreaticojejunal anastomosis. Omental flaps around various anastomoses were used to prevent the formation of fistula.

关键词： pancreaticoduodenectomy omental flaps periampullary neoplasms

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Heat transfer and fluid flow analysis of an artificially roughened solar air heater： a CFD based investigation

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Frontiers in Energy 2014年第2期8卷 201-211页

作者： Anil singh YADAV j. L. BHAGORIA Mechanical Engineering Department Technocrats Institute of Technology-Excellence Bhopal MP 462021 Mechanical Engineering Department Maulana Azad National Institute of Technology Bhopal MP 462051 India

In this paper, the effect of rib （circular sectioned） spacing on average Nusselt number and friction factor in an artificially roughened solar air heater （duct aspect ratio, AR= 5：1） is studied by adopting the computational fluid dynamics （CFD） approach. Numerical solutions are obtained using commercial software ANSYS FLUENT v12.1. The computations based on the finite volume method with the semi-implicit method for pressure-linked equations （SIMPLE） algorithm have been conducted. Circular sectioned transverse ribs are applied at the underside of the top of the duct, i.e., on the absorber plate. The rib-height-to-hydraulic diameter ratio （e/D） is 0.042. The rib-pitch-to-fib-height （P/e） ratios studied are 7.14, 10.71, 14.29 and 17.86. For each rib spacing simulations are executed at six different relevant Reynolds numbers from 3800 to 18000. The thermo-hydraulic performance parameter for P/e = 10.71 is found to be the best for the investigated range of parameters at a Reynolds number of 15000.

关键词： heat transfer pressure drop thermo-hydraulic performance parameter

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Tree species composition and diversity in montane forests of Garhwal Himalaya in relation to environmental and soil properties

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journal of Mountain Science 2020年第12期17卷 3097-3111页

作者： Dinesh singh RAWAT P.TIWARI Sudipta Kumar DAS j.K.TIWARI Department of Botany&Microbiology HNB Garhwal UniversitySrinagar(Garhwal)-246174UttarakhandIndia Central National Herbarium Botanical Survey of IndiaHowrah-711103West BengalIndia

The montane forests of Garhwal Himalaya were investigated for tree species composition and diversity in relation to environmental and edaphic variables.A stratified random sampling approach was adopted to collect the field data from each forest.A total of 39 tree species belonging to 31 genera and 23 families were recorded from the sampling area(6 forest stands ×10 plots in each).Lauraceae with 5 species was the largest family while Quercus(4 species) emerged as the largest ***-area curve(asymptote) predicted more species than the observed number of *** analysis has shown that the two Abies pindrow dominant forest stands had the highest similarity in tree species *** tree stem density ranged from 540-1170 ha-1,basal area 23.01-55.94 m^2 ha-1,ShannonWiener diversity index 1.69-2.49,evenness index0.42-0.74,beta diversity 0.40-0.82 and similarity index 0.17-0.54 in the six studied ***-way indicator species analysis(TWINSPAN) identified four distinct tree communities in the study area with Daphniphyllum himalayense,Abies pindrow,Quercus oblongata,and Pinus roxburghii as indicator species of corresponding *** correspondence analysis(CCA) ascertained the TWINSPAN results and revealed the relation of tree species with environmental and edaphic *** phytosociological attributes of tree species varied from one forest stand to another;however,the tree species richness,density,and diversity peaked at intermediate elevation on the north *** reveal that tree composition and diversity in the montane forests of Garhwal Himalaya are influenced by both environmental(elevation and slope aspect)and soil variables(texture,water holding capacity,moisture content,available N,exchangeable P,and pH).This study will help in understanding the forest distribution across the western Himalaya,guiding the conservationists and policymakers in carrying out conservation-related management activities,designing the long-

关键词： Diversity Tree species Montane forests Soil properties Western Himalaya

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Resolution Enhancement of Optical Surface Plasmon Resonance Sensor Using Metamaterial

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Photonic Sensors 2015年第4期5卷 330-338页

作者： Sarika PAL Y. K. PRAjAPATI j. P. SAINI V. singh Sarika Pal Department of Electronics & Communication Engineering KIET Ghaziabad (U.P.) India yogendra Kumar Prajapati Department of Electronics & Communication Engineering MNNIT Allahabad-211004 (U.P.) India jai Prakash Saini Department of Electronics & Communication Engineering BIET Jhansi-284128 (U.P.) India Vivek singh Department of Physics Faculty of Science Banaras Hindu University Varanasi (U.P.) India

In this paper, we present and discuss a an optical surface plasmon resonance （SPR） path to extend the enhancement of the resolution of sensor. Basically, our approach is to combine bi-metamaterial layers to design the SPR sensor. The calculation shows that the proposed SPR sensor structure has a preference over the conventional SPR sensors and bimetallic SPR sensors since it gives a much sharper reflectance dip and can achieve considerable sensitivity improvement when compared to the recently reported investigations. The effects of the metamaterial permittivity, permeability, and thickness on the reflectance curve are studied. It is also seen that metamaterial layers improve the field of the proposed SPR structure, which may provide a novel tool to significantly enhance the sensitivity and resolution of the sensors.

关键词： Surface plasmon resonance sensor metamaterials Fresnel equations reflectance

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Relative effects of different leaf attributes on sapling growth in tropical dry forest

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journal of Plant Ecology 2014年第6期7卷 544-558页

作者： Ravi K.Chaturvedi A.S.Raghubanshi j.S.singh Institute of Environment and Sustainable Development Banaras Hindu UniversityVaranasi 221005India Ecosystems Analysis laboratory Department of BotanyBanaras Hindu UniversityVaranasi 221005India

Aims Soil moisture content(SMC)influences establishment,survival and development of plant species and is considered as the most important limiting factor in tropical dry forest(TDF).In this study we attempt to establish the relationship between leaf attributes and of tree saplings in TDF and address the following questions:(i)how are the functional attributes of dominant tree saplings of TDF affected by seasonal changes in SMC at different habitats?,(ii)what is the relationship of functional attributes with each other?,(iii)how are the functional attributes and their plasticity affected by habitat con-ditions?and(iv)can the functional attributes in single or in com-bination predict the growth rate of tree saplings of TDF?The study was conducted on four sites(Hathinala,Gaighat,Harnakachar and Ranitali,listed in order of decreasing SMC)within the tropical dry deciduous forest in northern *** We analysed eight leaf attributes,specific leaf area(SLA);leaf dry matter content(LDMC);leaf nitrogen concentration(leaf N);leaf phosphorus concentration(leaf P);chlorophyll concentration(Chl);mass-based photosynthetic rate(Amass);mass-based stomatal con-ductance(Gsmass);intrinsic water use efficiency(WUEi)and three growth attributes,relative diameter increment(RDI);relative height increment(RHI);relative growth rate(RGR)of the 10 dominant tree saplings(viz.,Acacia catechu,Anogeissus latifolia,Boswellia serrata,Buchanania lanzan,Diospyros melanoxylon,Hardwickia binata,Lagerstroemia parviflora,Lannea coromandelica,Shorea robusta and Terminalia tomentosa)of a TDF and observed the effects of site,season and species for a period of 2 *** were selected in gradients of ***-wise multiple regression was performed to predict RDI,RHI and RGR from mean values of SMC and leaf *** Findings All the 11 attributes were interrelated and differed significantly among the 10 *** response varied across sites and *** the SMC g

关键词： tropical dry forest soil moisture content deciduousness tree saplings leaf attributes relative growth rate

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Role of adjunctive nonpharmacological strategies for treatment of rapid-cycling bipolar disorder

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世界精神病学杂志 2023年第8期13卷 495-510页

作者： Subho Chakrabarti Amal j jolly Pranshu singh Nidhi Yadhav Department of Psychiatry Postgraduate Institute of Medical Education and ResearchChandigarh 160012Chandigarh UTIndia Department of Psychiatry Black Country Healthcare NHS Foundation TrustDudley DY28PSWest MidlandsUnited Kingdom Department of Psychiatry All India Institute of Medical SciencesJodhpur 342005RajasthanIndia

Rapid-cycling bipolar disorder(RCBD)is a phase of bipolar disorder defined by the presence of≥4 mood episodes in a *** is a common phenomenon characterized by greater severity,a predominance of depression,higher levels of disability,and poorer overall *** is resistant to treatment by conventional *** existing literature underlines the scarcity of evidence and the gaps in knowledge about the optimal treatment strategies for ***,most reviews have considered only pharmacological treatment options for *** the treatment-refractory nature of RCBD,nonpharmacological interventions could augment medications but have not been adequately *** review carried out an updated and comprehensive search for evidence regarding the role of nonpharmacological therapies as adjuncts to medications in *** identified 83 reviews and meta-analyses concerning the treatment of ***,we found 42 reports on adjunctive nonpharmacological treatments in *** of the evidence favoured concomitant electroconvulsive therapy as an acute and maintenance *** was preliminary evidence to suggest that chronotherapeutic treatments can provide better outcomes when combined with *** research on adjunctive psychotherapy was particularly scarce but suggested that psychoeducation,cognitive behavioural therapy,family interventions,and supportive psychotherapy may be *** overall quality of evidence was poor and suffered from several methodological *** is a need for more methodologically sound research in this area,although clinicians can use the existing evidence to select and individualize nonpharmacological treatment options for better management of *** summaries are included to highlight some of the issues concerning the implementation of adjunctive nonpharmacological treatments.

关键词： Rapid-cycling bipolar disorder Bipolar disorder Adjunctive therapy Nonpharmacological treatment

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EFFECTS OF DELAY AND SEASONALITY ON TOXIN PRODUCING PHYTOPLANKTON-ZOOPLANKTON SYSTEM

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International journal of Biomathematics 2012年第5期5卷 239-259页

作者： SUNITA GAKKHAR ANURAj.singh BRAHAM PAL singh Department of MathematicsIndian Institute of Technology Roorkee Roorkee 247667 Uttarakhand India Department of Mathematics j. V. jain Degree CollegeSaharanpur 2~001 U.P. India

A dynamical model for toxin producing phytoplankton and zooplankton has been formu- lated and analyzed. Due to gestation of prey, a discrete time delay is incorporated in the predator dynamics. The stability of the delay model is discussed and Hopf bifurcation to a periodic orbit is established. Stability and direction of bifurcating periodic orbits are investigated using normal form theory and center manifold arguments. Global existence of periodic orbits is also established. To substantiate analytical findings, numerical simu- lations are performed. The system shows rich dynamic behavior including chaos and limit cycles. The influence of seasonality in intrinsic growth parameter of the phytoplankton population is also investigated. Seasonality leads to complexity in the system.

关键词： Time delay stability Hopf bifurcation period chaos.

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Structure inversion asymmetry enhanced electronic structure and electrical transport in 2D A3SnO(A=Ca,Sr,and Ba)antiperovskite monolayers

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Nano Research 2023年第1期16卷 1779-1791页

作者： Syed Muhammad Alay-e-Abbas Ghulam Abbas Waqas Zulfiqar Muhammad Sajjad Nirpendra singh j.Andreas Larsson Applied Physics Division of Materials ScienceDepartment of Engineering Sciences and MathematicsLuleåUniversity of Technology97187 LuleåSweden Computational Materials Modeling Laboratory Department of PhysicsGovernment College UniversityFaisalabad 38040Pakistan Department of Energy Conversion and Storage Technical University of Denmark2800 Kgs.LyngbyDenmark Department of Physics Khalifa University of Science and TechnologyAbu Dhabi-127788United Arab Emirates Center for Catalysis and Separation(CeCaS) Khalifa University of Science and TechnologyAbu Dhabi-127788United Arab Emirates

Anti-perovskites A3SnO(A=Ca,Sr,and Ba)are an important class of materials due to the emergence of Dirac cones and tiny mass gaps in their band structures originating from an intricate interplay of crystal symmetry,spin–orbit coupling,and band *** provides an exciting playground for modulating their electronic properties in the two-dimensional(2D)***,we employ first-principles density functional theory(DFT)calculations by combining dispersion-corrected SCAN+rVV10 and mBj functionals for a comprehensive side-by-side comparison of the structural,thermodynamic,dynamical,mechanical,electronic,and thermoelectric properties of bulk and monolayer(one unit cell thick)A3SnO *** results show that 2D monolayers derived from bulk A3SnO anti-perovskites are structurally and energetically ***,Rashba-type splitting in the electronic structure of Ca3SnO and Sr3SnO monolayers is observed owing to strong spin–orbit coupling and inversion *** the other hand,monolayer Ba3SnO exhibits Dirac cone at the high-symmetryΓpoint due to the domination of band *** on the predicted electronic transport properties,it is shown that inversion asymmetry plays an essential character such that the monolayers Ca3SnO and Sr3SnO outperform thermoelectric performance of their bulk counterparts.

关键词： electrical transport anti-perovskites low-dimensional materials electronic structure mechanical properties

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A new four-dimensional hyperjerk system with stable equilibrium point, circuit implementation, and its synchronization by using an adaptive integrator backstepping control

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Chinese Physics B 2018年第10期27卷 231-239页

作者： j P singh V T Pham T Hayat S jafari F E Alsaadi B K Roy Department of Electrical Engineering National Institute of Technology Silchar 788010 India School of Electronics and Telecommunications Hanoi University of Science and Technology 01 Dai Co Viet Hanoi Viet Nam Department of Mathematics Faculty of Science King Abdulaziz University Jeddah 21589 Saudi Arabia Department of Mathematics Quaid-I-Azam University Islamabad 44000 Pakistan Ambikar University of Technology Tehran 15875-4413Iran Department of Information Technology Faculty of Computing and IT King Abdulaziz University Jeddah Saudi Arabia

This paper reports a new simple four-dimensional（4 D） hyperjerk chaotic system. The proposed system has only one stable equilibrium point. Hence, its strange attractor belongs to the category of hidden attractors. The proposed system exhibits various dynamical behaviors including chaotic, periodic, stable nature, and coexistence of various attractors. Numerous theoretical and numerical methods are used for the analyses of this system. The chaotic behavior of the new system is validated using circuit implementation. Further, the synchronization of the proposed systems is shown by designing an adaptive integrator backstepping controller. Numerical simulation validates the synchronization strategy.

关键词： new hyperjerk chaotic system stable equilibrium hidden attractors adaptive backstepping control synchronization

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