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Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy

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Bone Research 2024年第1期12卷 95-106页

作者： Tian Nie Varun S.Venkatesh Suzanne Golub Kathryn S.Stok Haniyeh Hemmatian Reena Desai david j.handelsman jeffrey D.Zajac Mathis Grossmann Rachel A.Davey Department of Medicine Austin HealthUniversity of MelbourneHeidelbergVIC 3084Australia Department of Biomedical Engineering University of MelbourneParkvilleVIC 3010Australia ANZAC Research Institute University of Sydney and AndrologyConcord Repatriation General HospitalConcordNSW 2137Australia

The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent trans girls are *** address this knowledge gap,we developed a mouse model to simulate male-to-female transition in human adolescents in whom puberty is first arrested by using gonadotrophin-releasing hormone analogs with subsequent estradiol *** was suppressed by orchidectomy in male mice at 5 weeks of *** 3 weeks post-surgery,male-to-female mice were treated with a high dose of estradiol(~0.85 mg)by intraperitoneal silastic implantation for 12 *** included intact and orchidectomized males at 3 weeks post-surgery,vehicle-treated intact males,intact females and orchidectomized males at 12 weeks *** to male controls,orchidectomized males exhibited decreased peak bone mass accrual and a decreased maximal force the bone could withstand prior to *** treatment in orchidectomized male-to-female mice compared to mice in all control groups was associated with an increased cortical thickness in the mid-diaphysis,while the periosteal circumference increased to a level that was intermediate between intact male and female controls,resulting in increased maximal force and *** trabecular bone,estradiol treatment increased newly formed trabeculae arising from the growth plate as well as mineralizing surface/bone surface and bone formation rate,consistent with the anabolic action of estradiol on osteoblast *** data support the concept that skeletal integrity can be preserved and that long-term fractures may be prevented in trans girls treated with GnRHa and a sufficiently high dose of *** study is needed to identify an optimal dose of estradiol that protects the bone without adverse side effects.

关键词： treatment treatment strength

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Vlendelian randomization： loosening the Gordian knot of testosterone and male ageing

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Asian journal of Andrology 2013年第5期15卷 579-581页

作者： david j handelsman ANZAC Research Institute University of SydneySydney NSW 2139 Australia

It is unknown whether the reduced blood testosterone among unselected older men （＂andropause＂） compared to healthy younger men is due to ageing per se or as a non-specific adaptive reaction to chronic diseases acc... 详细信息

关键词： Mendelian randomization loosening male ageing

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An old emperor finds new clothing： rejuvenation in our time

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Asian journal of Andrology 2011年第1期13卷 125-129页

作者： david j handelsman ANZAC Research Institute Sydney NSW 2139Australia

Those who don＇t understand their history are condemned to repeat it （Santayana） History repeats itself, first as tragedy and then as farce （Marx）

关键词： emperor finds rejuvenation

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Androgen receptor splice variants and polycystic ovary syndrome： cause or effect？

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Asian journal of Andrology 2016年第3期18卷 442-443页

作者： Kirsty A Waiters david j handelsman Andrology Laboratory ANZAC Research InstituteUniversity of Sydney Concord Hospital NSW 2139Australia

Androgen receptor （AR）-mediated androgen action provides not only a classical pivotal role in male development and functions but also a recently proven role in female reproductive physiology. Splice variants of AR are reported to occur in various androgen-sensitive cancers and now, a recent study by Wang et al. proposed that AR splice variants have an etiological role in polycystic ovary syndrome （PCOS）.

关键词： PROSTATE-CANCER RESISTANCE FEATURES

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DNA damage, NF-κB and accelerated aging

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Asian journal of Andrology 2012年第6期14卷 811-812页

作者： david G Le Couteur david j handelsman ANZAC Medical Research Institute Sydney 2139 Australia Centre for Education and Research on Ageing (CERA) Concord Hospital and University of Sydney Concord NSW 2139 Australia

The aging process is the major risk factor for disease and disability yet the cel- lular mechanisms for aging are uncertain.

关键词： LIFE-SPAN NUCLEAR ABNORMALITIES MICE

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Falling sperm counts and global estrogenic pollution： what have we learned over 20 years？

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Asian journal of Andrology 2013年第2期15卷 159-161页

作者： david j handelsman Trevor G Cooper ANZAC Research Institute Concord Hospital & University of Sydney Sydney New South Wales 2139 Australia Tuen Mun NT Hong Kong SAR PR ChinaGuest Editors for this special issue: Prof. DJ Handelsman

If scandal is the engine of progress in politics, and sensation is that of the media, while anti-modern panic is that of environmentalism, what is the dynamic of medical science？ Certainly discovery and invention represent the admirable high road, whereas competition and controversy represent the quotidian low road. This Special Issue is directed to reviewing the lessons learned from the most public, fervent and durable controversy in the short history of Andrology, the claims of world-wide falling sperm counts, due to global pollution by industrial estrogenic chemicals, published two decades ago.

关键词： EXTERNAL QUALITY-CONTROL SEMEN ANALYSIS REFERENCE RANGE IN-UTERO BIAS MEN ASSOCIATION GUIDELINES FERTILITY

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Falling sperm counts and global oestrogenic pollution：postscript

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Asian journal of Andrology 2013年第2期15卷 208-211页

作者： Trevor G Cooper david j handelsman Tuen Mun NT Hong Kong SAR PR China ANZAC Research Institute Concord Hospital & University of Sydney Sydney New South Wales 2139 Australia

This Special Issue provides reflections after 20 years, summarized in 12 papers, on the controversial issue of alleged decline in human sperm output due to global oestrogen pollution by industrial chemicals.

关键词： SEMEN

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Afterword to Semen Analysis in 21st Century Medicine special issue in Asian journal of Andrology

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Asian journal of Andrology 2010年第1期12卷 118-123页

作者： david j. handelsman Trevor G. Cooper Reproductive Endocrinology ＆ Andrology Director ANZA C Research Institute Sydney Australia Andrology Laboratory Institute of Reproductive Medicine of the University Munster Germany

We summarise and comment on the topics discussed by the contributors to this Special Issue. As an introduction, Ann jequier＇s [ 1 ] generally positive assessment of the new-look manual was tempered with her res- ervations about reference values, on which other chapters dwelt at length. Aspects of laboratory technique were discussed by Charlene Brazil [2], whose offering gives a rare insight into the actual workings of andrology laboratories and highlights the need for greater involvement of laboratory directors （often clinicians） in assessing the quality of data provided.

关键词： no english key word

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Foreword to Semen Analysis in 21st Century Medicine special issue in Asian journal of Andrology

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Asian journal of Andrology 2010年第1期12卷 7-10页

作者： david j. handelsman Trevor G. Cooper Reproductive Endocrinology ＆ Andrology ANZA C Research Institute Sydney Australia Andrology Laboratory Institute of Reproductive Medicine of the University Munster Germany

Semen analysis as an integral part of infertility investigations has a surprisingly long history, emerging only slowly, from under a cloud of disrepute and occupying a solitary niche outside conventional pathology tests, until relatively recently. From origins in the 19th century when spermatozoa were only identified as present or absent in cervical mucus samples from postcoital tests, even then a practice deemed ＂... dabbling incompatible with decency and self-respect...＂（cited in [1]）.

关键词： no english key word

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A classification of genes involved in normal and delayed male puberty

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Asian journal of Andrology 2023年第2期25卷 230-239页

作者： Maleeha Akram Syed Shakeel Raza Rizvi Mazhar Qayyum david j handelsman Department of Zoology Wildlife and FisheriesPir Mehr Ali Shah Arid Agriculture University RawalpindiShamsabadMurree RoadRawalpindi 46300Pakistan Andrology Laboratory The ANZAC Research InstituteHospital RoadConcordNSW 2139Australia

Puberty is a pivotal biological process that completes sexual maturation to achieve full reproductive *** is a major transformational period of life,whose timing is strongly affected by genetic makeup of the individual,along with various internal and external *** the exact mechanism for initiation of the cascade of molecular events that culminate in puberty is not yet known,the process of pubertal onset involves interaction of numerous complex signaling pathways of hypothalamopituitary-testicular(HPT)*** developed a classification of the mechanisms involved in male puberty that allowed placing many genes into physiological *** include(i)hypothalamic development during embryogenesis,(ii)synaptogenesis where gonadotropin releasing hormone(GnRH)neurons form neuronal connections with suprahypothalamic neurons,(iii)maintenance of neuron homeostasis,(iv)regulation of synthesis and secretion of GnRH,(v)appropriate receptors/proteins on neurons governing GnRH production and release,(vi)signaling molecules activated by the receptors,(vii)the synthesis and release of GnRH,(viii)the production and release of gonadotropins,(ix)testicular development,(x)synthesis and release of steroid hormones from testes,and(xi)the action of steroid hormones in downstream effector *** in components of this system during embryonic development,childhood/adolescence,or adulthood may disrupt/nullify puberty,leading to long-term male infertility and/or *** review provides a list of 598 genes involved in the development of HPT axis and classified according to this ***,this review identifies a subset of 75 genes for which genetic mutations are reported to delay or disrupt male puberty.

关键词： delayed puberty gonadotropin releasing hormone hypogonadism male puberty puberty testosterone

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